• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Eqc-3401
PFKL

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: ATP-dependent 6-phosphofructokinase
Gene Name: PFKL
Ensembl Gene: ENSECAG00000017863.2
Ensembl Protein: ENSECAP00000016072.2
Organism: Equus caballus
Taxa ID: 9796
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSECAT00000019626.2ENSECAP00000016072.2
UniProtF7AMM0, F7AMM0_HORSE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MATVDLEKLR  MSGAGKAIGV  LTSGGDAQGM  NAAVRAVTRM  GIYVGAKVFL  IYEGYEGLVE  60
61    GGENIKKANW  LSVSNIIQLG  GTIIGSARCK  AFTTREGRLA  AAYNLVQRGI  TNLCVIGGDG  120
121   SLTGANVFRS  EWGSLLEELV  REGKISESTA  QTYSHLNIAG  LVGSIDNDFC  GTDMTIGTDS  180
181   ALHRIMEVID  AITTTAQSHQ  RTFVLEVMGR  HCGYLALVSA  LASGADWLFI  PEAPPEDGWE  240
241   NFMCERLGET  RSRGSRLNII  IIAEGAIDRH  GKPISSRYVK  DLVVQRLGFD  TRVTVLGHVQ  300
301   RGGTPSAFDR  ILSSKMGMEA  VMALLEATPD  TPACVVSLSG  NQSVRLPLME  CVQVTKEVQK  360
361   AMDEKRFDEA  IQLRGRSFEN  NWNIYKLLAH  QKVSKEKTNF  SLAILNVGAP  AAGMNAAVRS  420
421   AVRCGISQGH  TVYVVHDGFE  GLAKGQVQEV  GWHDVAGWLG  RGGSMLGTKR  TLPKSYMEKI  480
481   ADSVRAYNIH  ALLVIGGFEA  YEGVLQLVEA  RGRYEELCIV  LCVIPATISN  NVPGTDFSLG  540
541   CDTAVNAAME  SCDRIKQSAS  GTKRRVFIVE  TMGGYCGYLA  TVTGIAVGAD  AAYVFEDPFN  600
601   IQDLKANVEH  LTEKMKTDIQ  RGLVLRNEKC  HEYYTTEFLY  NLYSSEGKGV  FDCRTNVLGH  660
661   LQQGGAPTPF  DRNYGTKLGM  KAMLWMSEKL  QAVYRKGRVF  ANAPDSACVI  GLRKKVVAFS  720
721   PVTELKKDTD  FEHRMPREQW  WLNLRLMLKM  LAHYRISMAD  YVSGQLEHVT  RRTLSMEKGF  780
Nucleotide CDS Sequence (FASTA)
1     ATGGCCACCG  TGGACCTGGA  GAAGCTGCGG  ATGTCGGGGG  CCGGCAAGGC  CATCGGCGTG  60
61    CTCACCAGCG  GCGGCGACGC  GCAAGGTATG  AATGCCGCCG  TCAGAGCTGT  GACGCGCATG  120
121   GGCATTTACG  TGGGAGCCAA  AGTCTTCCTC  ATCTATGAGG  GCTACGAGGG  CCTCGTGGAA  180
181   GGAGGAGAGA  ACATCAAGAA  GGCCAACTGG  CTTAGCGTTT  CCAACATCAT  CCAGCTGGGT  240
241   GGCACCATCA  TTGGCAGCGC  CCGCTGCAAG  GCCTTCACCA  CTCGGGAGGG  ACGCCTGGCG  300
301   GCTGCCTACA  ACCTGGTCCA  GCGTGGCATC  ACTAACCTGT  GTGTCATCGG  CGGGGACGGG  360
361   AGCCTCACGG  GCGCCAACGT  CTTCCGCAGC  GAGTGGGGCA  GCCTGCTGGA  GGAGCTGGTG  420
421   AGGGAAGGCA  AGATCTCGGA  GAGCACAGCT  CAGACCTACT  CGCACCTCAA  CATCGCTGGG  480
481   CTGGTGGGCT  CCATCGATAA  CGACTTCTGC  GGCACCGACA  TGACCATCGG  CACAGACTCA  540
541   GCCCTGCACC  GCATCATGGA  GGTCATTGAC  GCCATCACCA  CCACCGCCCA  GAGCCACCAG  600
601   AGGACGTTCG  TGCTGGAGGT  GATGGGGCGG  CACTGCGGGT  ACCTGGCCCT  GGTGTCCGCC  660
661   CTGGCCTCGG  GGGCCGACTG  GCTGTTCATC  CCCGAGGCCC  CCCCTGAGGA  CGGCTGGGAG  720
721   AACTTCATGT  GCGAGAGGCT  TGGCGAGACT  CGGAGCCGAG  GGTCCCGACT  AAACATCATC  780
781   ATCATCGCGG  AGGGTGCCAT  CGACCGCCAC  GGGAAGCCCA  TCTCCTCCCG  CTACGTGAAG  840
841   GATCTGGTGG  TCCAGAGGCT  GGGCTTCGAC  ACGCGTGTGA  CGGTGCTGGG  CCATGTGCAG  900
901   AGGGGAGGGA  CCCCCTCGGC  GTTCGACCGC  ATCCTGAGCA  GCAAGATGGG  CATGGAGGCG  960
961   GTGATGGCAC  TGCTGGAGGC  CACGCCCGAC  ACACCGGCCT  GTGTGGTCAG  CCTCTCGGGG  1020
1021  AACCAGTCGG  TGCGGCTGCC  CCTCATGGAG  TGTGTGCAGG  TGACAAAGGA  GGTGCAGAAG  1080
1081  GCCATGGATG  AGAAGCGCTT  CGACGAGGCC  ATCCAGCTCC  GCGGCAGGAG  CTTTGAGAAC  1140
1141  AACTGGAACA  TTTACAAGCT  GCTTGCACAC  CAGAAGGTCT  CCAAAGAGAA  GACCAACTTC  1200
1201  TCCTTGGCCA  TCCTGAACGT  GGGGGCCCCG  GCGGCCGGCA  TGAACGCGGC  CGTGCGCTCG  1260
1261  GCCGTGCGCT  GCGGCATTTC  CCAAGGCCAC  ACCGTGTACG  TCGTGCATGA  CGGCTTTGAG  1320
1321  GGCCTGGCCA  AGGGTCAGGT  GCAAGAAGTG  GGCTGGCACG  ACGTGGCTGG  CTGGCTGGGG  1380
1381  CGTGGTGGCT  CCATGCTGGG  GACCAAGAGG  ACGCTGCCCA  AGAGCTACAT  GGAGAAAATC  1440
1441  GCAGACAGTG  TCCGCGCCTA  CAACATCCAC  GCCCTGCTGG  TCATCGGCGG  CTTCGAGGCC  1500
1501  TACGAGGGGG  TGCTGCAGCT  GGTGGAGGCC  CGCGGGCGCT  ACGAGGAGCT  GTGCATCGTC  1560
1561  CTGTGCGTCA  TCCCGGCCAC  CATCAGCAAC  AACGTGCCGG  GCACCGACTT  CAGCCTGGGC  1620
1621  TGTGACACTG  CTGTCAATGC  TGCCATGGAG  AGCTGTGACC  GCATCAAGCA  GTCGGCCTCG  1680
1681  GGGACCAAGC  GCCGCGTGTT  CATCGTGGAG  ACCATGGGAG  GCTACTGTGG  CTACCTGGCC  1740
1741  ACTGTGACTG  GCATCGCCGT  GGGGGCCGAC  GCTGCCTACG  TCTTCGAGGA  CCCTTTCAAC  1800
1801  ATCCAAGACT  TAAAGGCCAA  CGTGGAGCAC  CTGACGGAGA  AGATGAAGAC  GGACATCCAG  1860
1861  AGGGGCCTGG  TGCTCCGAAA  CGAGAAGTGC  CACGAATACT  ACACCACGGA  GTTTCTGTAC  1920
1921  AACCTGTACT  CCTCCGAGGG  GAAGGGTGTC  TTTGACTGCA  GGACCAATGT  CCTGGGCCAC  1980
1981  CTGCAGCAGG  GTGGGGCTCC  AACCCCCTTT  GACCGGAACT  ATGGTACCAA  GCTGGGGATG  2040
2041  AAGGCCATGC  TCTGGATGTC  GGAGAAGCTG  CAGGCAGTCT  ACCGCAAGGG  TCGGGTGTTC  2100
2101  GCCAACGCCC  CCGACTCAGC  CTGCGTGATC  GGCCTGCGGA  AGAAGGTGGT  GGCATTCAGC  2160
2161  CCTGTCACCG  AGCTCAAGAA  GGACACTGAC  TTTGAGCACC  GCATGCCCCG  GGAGCAGTGG  2220
2221  TGGCTGAACC  TGCGGCTCAT  GCTGAAGATG  CTGGCGCACT  ACCGCATCAG  CATGGCCGAC  2280
2281  TACGTGTCCG  GGCAGCTGGA  GCACGTCACC  CGCCGCACGC  TGAGCATGGA  GAAGGGCTTC  2340
2341  TGA  2343

▼ KEYWORD

ID
Family
Allosteric enzyme
ATP-binding
Coiled coil
Complete proteome
Cytoplasm
Glycolysis
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
6-phosphofructokinase complex
Molecular Function
6-phosphofructokinase activity
Molecular Function
AMP binding
Molecular Function
ATP binding
Molecular Function
Fructose binding
Molecular Function
Fructose-6-phosphate binding
Molecular Function
Identical protein binding
Molecular Function
Kinase binding
Molecular Function
Metal ion binding
Molecular Function
Monosaccharide binding
Biological Process
Canonical glycolysis
Biological Process
Fructose 1,6-bisphosphate metabolic process
Biological Process
Fructose 6-phosphate metabolic process
Biological Process
Glucose catabolic process
Biological Process
Negative regulation of insulin secretion
Biological Process
Protein complex oligomerization
Biological Process
Response to glucose

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Fec-0079Felis catus95.640.01526
LLPS-Caf-0713Canis familiaris95.640.01525
LLPS-Myl-3619Myotis lucifugus95.610.01476
LLPS-Cas-1179Carlito syrichta94.560.01424
LLPS-Pat-4530Pan troglodytes93.720.01493
LLPS-Hos-4968Homo sapiens93.720.01493
LLPS-Paa-2942Papio anubis93.720.01495
LLPS-Dio-3134Dipodomys ordii93.620.01466
LLPS-Maf-3368Macaca fascicularis93.590.01492
LLPS-Aon-4656Aotus nancymaae92.70.01468
LLPS-Mal-2659Mandrillus leucophaeus91.880.01449
LLPS-Caj-4305Callithrix jacchus91.558e-138 413
LLPS-Mam-1643Macaca mulatta91.410.01445
LLPS-Ora-0863Ornithorhynchus anatinus90.680.01407
LLPS-Fud-4456Fukomys damarensis90.410.01371
LLPS-Gog-2307Gorilla gorilla90.00.01425
LLPS-Sah-2879Sarcophilus harrisii89.320.01434
LLPS-Mod-4084Monodelphis domestica89.24e-133 400
LLPS-Anc-2842Anolis carolinensis89.190.01439
LLPS-Fia-1639Ficedula albicollis88.750.01422
LLPS-Meg-1133Meleagris gallopavo88.130.01337
LLPS-Gaga-1065Gallus gallus87.950.01415
LLPS-Loa-1417Loxodonta africana83.360.01258
LLPS-Dar-1019Danio rerio80.820.01323
LLPS-Icp-2024Ictalurus punctatus79.790.01308
LLPS-Asm-2203Astyanax mexicanus76.790.01252
LLPS-Scm-0523Scophthalmus maximus76.670.01271
LLPS-Pof-3822Poecilia formosa75.480.01239
LLPS-Tag-2200Taeniopygia guttata75.273e-95 302
LLPS-Xim-4111Xiphophorus maculatus75.130.01239
LLPS-Orn-2342Oreochromis niloticus74.90.01228
LLPS-Gaa-2531Gasterosteus aculeatus74.740.01238
LLPS-Sus-4399Sus scrofa71.220.01136
LLPS-Rhb-4328Rhinopithecus bieti71.090.01131
LLPS-Man-4089Macaca nemestrina71.090.01132
LLPS-Pap-4644Pan paniscus71.090.01132
LLPS-Cea-1426Cercocebus atys71.090.01132
LLPS-Chs-3978Chlorocebus sabaeus71.090.01131
LLPS-Ran-2738Rattus norvegicus71.090.01130
LLPS-Leo-1200Lepisosteus oculatus71.060.01115
LLPS-Nol-1703Nomascus leucogenys71.040.01132
LLPS-Mum-4455Mus musculus70.960.01127
LLPS-Bot-1957Bos taurus70.960.01134
LLPS-Cap-2401Cavia porcellus70.830.01131
LLPS-Mea-3354Mesocricetus auratus70.830.01124
LLPS-Orc-3475Oryctolagus cuniculus70.810.01131
LLPS-Ict-3662Ictidomys tridecemlineatus70.70.01123
LLPS-Ova-1289Ovis aries70.590.01123
LLPS-Tar-3767Takifugu rubripes70.540.01140
LLPS-Otg-4170Otolemur garnettii70.270.01131
LLPS-Aim-0056Ailuropoda melanoleuca70.250.01121
LLPS-Xet-2537Xenopus tropicalis70.150.01076
LLPS-Mup-0465Mustela putorius furo70.120.01122
LLPS-Ten-2750Tetraodon nigroviridis69.720.01124
LLPS-Lac-2556Latimeria chalumnae68.150.0 988
LLPS-Pes-2933Pelodiscus sinensis68.130.01034
LLPS-Orl-3989Oryzias latipes68.090.01129
LLPS-Scf-2914Scleropages formosus67.310.01130
LLPS-Urm-3158Ursus maritimus66.890.01045
LLPS-Poa-3391Pongo abelii65.150.0 970
LLPS-Abg-0238Absidia glauca49.340.0 702
LLPS-Asf-1112Aspergillus flavus48.294e-175 525
LLPS-Nef-1245Neosartorya fischeri48.280.0 647
LLPS-Asfu-1419Aspergillus fumigatus48.150.0 643
LLPS-Asc-0084Aspergillus clavatus47.760.0 639
LLPS-Cog-0759Colletotrichum gloeosporioides47.630.0 662
LLPS-Aso-0853Aspergillus oryzae47.10.0 635
LLPS-Asni-0090Aspergillus niger47.030.0 630
LLPS-Asn-1372Aspergillus nidulans46.70.0 636
LLPS-Ast-0349Aspergillus terreus46.60.0 650
LLPS-Dos-0945Dothistroma septosporum45.790.0 640
LLPS-Scc-0468Schizosaccharomyces cryophilus45.760.0 611
LLPS-Map-0973Magnaporthe poae45.640.0 637
LLPS-Pytr-1140Pyrenophora triticirepentis45.090.0 647
LLPS-Phn-1026Phaeosphaeria nodorum44.990.0 642
LLPS-Asg-0716Ashbya gossypii44.920.0 617
LLPS-Kop-0294Komagataella pastoris44.820.0 590
LLPS-Lem-1131Leptosphaeria maculans44.660.0 644
LLPS-Sac-0412Saccharomyces cerevisiae44.120.0 604
LLPS-Spr-0794Sporisorium reilianum43.650.0 635
LLPS-Usm-1259Ustilago maydis42.660.0 583
LLPS-Cae-0984Caenorhabditis elegans40.342e-177 535
LLPS-Mel-1375Melampsora laricipopulina40.255e-179 541
LLPS-Ori-2089Oryza indica40.075e-45 168
LLPS-Put-0611Puccinia triticina39.44e-168 511
LLPS-Met-2270Medicago truncatula33.331e-1378.2
LLPS-Via-2380Vigna angularis32.341e-1378.2
LLPS-Zem-2480Zea mays32.028e-1375.9
LLPS-Dac-2369Daucus carota31.631e-1275.1
LLPS-Orp-1193Oryza punctata31.196e-1479.7
LLPS-Orr-2153Oryza rufipogon31.197e-1479.7
LLPS-Orgl-0453Oryza glumaepatula31.197e-1479.7
LLPS-Nia-1787Nicotiana attenuata30.982e-1584.0
LLPS-Sol-1883Solanum lycopersicum30.985e-1582.8
LLPS-Ors-1378Oryza sativa30.548e-1375.9
LLPS-Org-1039Oryza glaberrima30.548e-1375.9
LLPS-Orb-1034Oryza barthii30.548e-1375.9
LLPS-Sem-1118Selaginella moellendorffii30.548e-1168.9
LLPS-Phv-2540Phaseolus vulgaris30.492e-1378.2
LLPS-Prp-2415Prunus persica30.355e-1376.3
LLPS-Vir-0185Vigna radiata30.049e-1375.9
LLPS-Sob-1961Sorghum bicolor29.967e-1479.3
LLPS-Sei-1924Setaria italica29.961e-1378.6
LLPS-Coc-2271Corchorus capsularis29.847e-1582.4
LLPS-Tra-0062Triticum aestivum29.816e-1376.3
LLPS-Hov-0252Hordeum vulgare29.813e-1377.0
LLPS-Gor-2030Gossypium raimondii29.464e-1377.0
LLPS-Brd-0195Brachypodium distachyon29.431e-1275.5
LLPS-Orbr-0719Oryza brachyantha29.215e-1376.6
LLPS-Thc-2290Theobroma cacao29.183e-1377.4
LLPS-Glm-1088Glycine max29.131e-1378.6
LLPS-Mua-1967Musa acuminata29.027e-1479.0
LLPS-Amt-2312Amborella trichopoda28.779e-1066.2
LLPS-Mae-2519Manihot esculenta28.692e-1378.2
LLPS-Orm-1308Oryza meridionalis28.684e-1480.5
LLPS-Chc-1089Chondrus crispus28.571e-1068.9
LLPS-Art-1722Arabidopsis thaliana28.462e-1480.9
LLPS-Sot-0352Solanum tuberosum28.464e-1479.7
LLPS-Arl-1096Arabidopsis lyrata28.352e-1377.4
LLPS-Tru-1652Triticum urartu28.39e-1479.3
LLPS-Bro-1417Brassica oleracea28.32e-1480.9
LLPS-Orni-0222Oryza nivara28.35e-1479.7
LLPS-Brn-2516Brassica napus28.31e-1481.3
LLPS-Lep-1650Leersia perrieri28.38e-1479.0
LLPS-Hea-1588Helianthus annuus27.997e-1169.7
LLPS-Brr-1803Brassica rapa27.954e-1376.6
LLPS-Php-0343Physcomitrella patens27.734e-1067.4
LLPS-Pot-1922Populus trichocarpa27.391e-0759.3
LLPS-Cus-1362Cucumis sativus27.24e-1273.6
LLPS-Viv-0705Vitis vinifera27.066e-1376.3
LLPS-Gas-1104Galdieria sulphuraria27.061e-0656.2
LLPS-Cym-0836Cyanidioschyzon merolae26.387e-0756.6
LLPS-Osl-1292Ostreococcus lucimarinus25.956e-1066.6