• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Tra-0062
PFK

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: ATP-dependent 6-phosphofructokinase
Gene Name: PFK
Ensembl Gene: TraesCS7D02G101300
Ensembl Protein: TraesCS7D02G101300.1
Organism: Triticum aestivum
Taxa ID: 4565
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblTraesCS7D02G101300.1TraesCS7D02G101300.1
UniProtA0A3B6TKL9, A0A3B6TKL9_WHEAT

▼ SEQUENCE

Protein Sequence (FASTA)
1     MPSSPTDAAT  TDPHPTPDPD  PGRPSNAPPQ  SPSPARGNLC  TGTCTTCSTA  AREAQRATPA  60
61    MDGTPPPKPE  AKLAAGEAGY  VLEDVPHVSD  YLPDLPTYPN  PLQDNTAYSV  VKQYFVDPDD  120
121   TVCQKIVVHK  DGPRGNHFRR  AGPRQRVYFE  PDEVHACIVT  CGGLCPGLNT  VIREIVCGLS  180
181   DMYGVTKILG  IQGGYRGFYA  RNTIDLTPKS  VNDIHKRGGT  ILGSSRGGHD  TMKIVDSIQY  240
241   RGINQVYVIG  GDGSQRGAGV  IFEEVRKRGL  KVAVAGIPKT  IDNDIPVIDK  SFGFDSAVEE  300
301   AQRAINAAHV  EAGSADNGIG  LVKLMGRYSG  FIAHYATLAS  RDVDCCLIPE  SPFYLEGEGG  360
361   LFKYIEKRLK  ENGHMVIVVA  EGAGQKLIAE  NMKEMGQDAS  GNALLLDVGL  WLSQKINEHF  420
421   KKNKTTINLK  YIDPTYMIRA  IPSNASDNVY  CTLLAHSVVH  GAMAGYTGFT  VGQVNGRHCY  480
481   IPFYRITEKQ  NKVSITDRMW  ARLLSSTNQP  SFLSKQDVDD  AKVEDERTAK  LLDGSPSNPK  540
541   VEDEVASSNS  NGVK  554
Nucleotide CDS Sequence (FASTA)
1     ATGCCGTCGT  CGCCGACCGA  CGCCGCCACC  ACTGATCCCC  ACCCGACCCC  CGACCCCGAC  60
61    CCCGGCCGGC  CCAGCAACGC  CCCGCCCCAA  TCGCCGTCCC  CAGCCCGCGG  GAACCTCTGC  120
121   ACCGGCACCT  GCACCACCTG  CTCGACCGCC  GCGCGGGAGG  CCCAGAGGGC  GACGCCCGCG  180
181   ATGGACGGGA  CTCCGCCGCC  CAAGCCCGAG  GCGAAGCTGG  CGGCCGGCGA  GGCCGGGTAC  240
241   GTCCTCGAGG  ACGTGCCGCA  CGTCTCCGAC  TACCTCCCCG  ATCTCCCGAC  CTACCCAAAC  300
301   CCCCTGCAAG  ATAACACGGC  GTACTCGGTT  GTCAAGCAGT  ACTTCGTTGA  CCCGGATGAC  360
361   ACTGTCTGCC  AGAAGATTGT  TGTTCACAAG  GATGGCCCAA  GAGGGAACCA  CTTCCGACGT  420
421   GCTGGACCTC  GCCAAAGGGT  CTATTTTGAA  CCTGACGAGG  TCCATGCCTG  CATTGTCACC  480
481   TGTGGAGGAC  TCTGCCCAGG  ACTTAATACT  GTTATTAGGG  AAATTGTATG  CGGCTTATCT  540
541   GACATGTACG  GTGTCACCAA  GATACTTGGG  ATTCAGGGTG  GGTATAGAGG  TTTCTACGCT  600
601   CGCAACACCA  TCGACTTGAC  TCCAAAGAGT  GTAAATGACA  TTCACAAAAG  GGGCGGAACT  660
661   ATTCTTGGCT  CGTCACGAGG  AGGCCATGAC  ACCATGAAGA  TTGTTGATAG  CATTCAGTAC  720
721   CGTGGTATAA  ATCAGGTGTA  TGTTATTGGT  GGTGATGGTA  GTCAAAGGGG  TGCAGGAGTG  780
781   ATTTTTGAAG  AGGTTAGAAA  GCGTGGTCTC  AAAGTTGCTG  TTGCTGGCAT  TCCTAAGACT  840
841   ATTGATAACG  ACATCCCAGT  AATTGATAAG  TCATTTGGTT  TCGACAGTGC  AGTTGAGGAA  900
901   GCTCAACGTG  CCATAAATGC  CGCTCATGTA  GAAGCTGGAA  GTGCTGATAA  TGGAATTGGA  960
961   CTTGTAAAGC  TAATGGGTCG  ATACAGTGGT  TTCATCGCAC  ATTATGCCAC  CCTAGCAAGC  1020
1021  AGAGATGTGG  ATTGTTGCTT  AATTCCGGAG  TCACCTTTCT  ATCTGGAAGG  TGAAGGTGGA  1080
1081  CTCTTCAAAT  ATATAGAAAA  GCGGCTGAAG  GAGAATGGCC  ATATGGTCAT  TGTCGTTGCG  1140
1141  GAGGGTGCAG  GACAGAAACT  TATTGCTGAA  AACATGAAGG  AAATGGGGCA  AGATGCTTCT  1200
1201  GGCAATGCAC  TGCTTCTTGA  TGTTGGTCTT  TGGTTGTCTC  AGAAGATAAA  TGAGCATTTC  1260
1261  AAGAAAAACA  AGACAACCAT  AAATCTGAAG  TACATAGATC  CTACATACAT  GATTCGCGCC  1320
1321  ATTCCTAGCA  ACGCATCGGA  TAATGTTTAT  TGCACATTGC  TGGCTCACAG  TGTGGTCCAC  1380
1381  GGAGCCATGG  CTGGATACAC  CGGTTTTACC  GTTGGCCAAG  TAAACGGTCG  GCATTGCTAC  1440
1441  ATCCCCTTCT  ACAGGATCAC  GGAGAAGCAG  AACAAGGTCT  CGATAACGGA  CAGGATGTGG  1500
1501  GCAAGGCTTC  TCTCCTCTAC  CAACCAGCCA  AGCTTCCTCA  GCAAGCAAGA  CGTTGACGAT  1560
1561  GCCAAGGTCG  AGGACGAGAG  GACGGCCAAG  CTCTTGGACG  GCTCGCCTTC  CAACCCCAAG  1620
1621  GTCGAAGATG  AAGTTGCGTC  TTCCAACTCC  AACGGTGTGA  AGTGA  1665

▼ KEYWORD

ID
Family
Allosteric enzyme
ATP-binding
Complete proteome
Cytoplasm
Glycolysis
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Molecular Function
6-phosphofructokinase activity
Molecular Function
ATP binding
Molecular Function
Metal ion binding
Biological Process
Fructose 6-phosphate metabolic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Hov-0252Hordeum vulgare98.180.01009
LLPS-Brd-0195Brachypodium distachyon92.670.0 954
LLPS-Sob-1961Sorghum bicolor91.90.0 900
LLPS-Zem-2480Zea mays88.530.0 912
LLPS-Orbr-0719Oryza brachyantha88.110.0 905
LLPS-Sei-1924Setaria italica88.050.0 902
LLPS-Coc-2271Corchorus capsularis82.930.0 774
LLPS-Amt-0078Amborella trichopoda82.040.0 778
LLPS-Prp-2415Prunus persica81.520.0 788
LLPS-Mua-1967Musa acuminata80.920.0 802
LLPS-Brr-2009Brassica rapa80.810.0 777
LLPS-Art-0803Arabidopsis thaliana80.650.0 772
LLPS-Thc-2290Theobroma cacao79.790.0 782
LLPS-Viv-0705Vitis vinifera79.660.0 777
LLPS-Gor-2030Gossypium raimondii79.490.0 775
LLPS-Brn-2516Brassica napus79.380.0 776
LLPS-Via-2380Vigna angularis79.250.0 786
LLPS-Bro-1417Brassica oleracea79.170.0 774
LLPS-Mae-2519Manihot esculenta78.860.0 792
LLPS-Arl-1096Arabidopsis lyrata78.250.0 738
LLPS-Phv-2540Phaseolus vulgaris78.240.0 768
LLPS-Sol-1883Solanum lycopersicum78.210.0 756
LLPS-Nia-1787Nicotiana attenuata78.210.0 760
LLPS-Met-2270Medicago truncatula78.130.0 764
LLPS-Tru-1652Triticum urartu77.320.0 746
LLPS-Orp-1330Oryza punctata77.120.0 748
LLPS-Hea-1588Helianthus annuus76.820.0 746
LLPS-Org-0009Oryza glaberrima76.690.0 745
LLPS-Ors-0900Oryza sativa76.690.0 745
LLPS-Lep-1767Leersia perrieri76.390.0 766
LLPS-Glm-1088Glycine max75.640.0 784
LLPS-Vir-0185Vigna radiata75.360.0 746
LLPS-Pot-2480Populus trichocarpa75.150.0 763
LLPS-Orni-0591Oryza nivara74.90.0 773
LLPS-Ori-0655Oryza indica74.90.0 773
LLPS-Orb-1034Oryza barthii74.90.0 773
LLPS-Orr-0831Oryza rufipogon74.90.0 773
LLPS-Orgl-0453Oryza glumaepatula74.740.0 751
LLPS-Dac-2369Daucus carota74.740.0 744
LLPS-Orm-1308Oryza meridionalis74.640.0 750
LLPS-Sot-0352Solanum tuberosum72.840.0 729
LLPS-Cus-1362Cucumis sativus71.810.0 673
LLPS-Sem-0561Selaginella moellendorffii69.80.0 698
LLPS-Chc-1089Chondrus crispus54.025e-157 467
LLPS-Gas-1104Galdieria sulphuraria53.797e-148 443
LLPS-Php-0236Physcomitrella patens53.072e-129 396
LLPS-Cym-0836Cyanidioschyzon merolae50.921e-143 431
LLPS-Osl-1292Ostreococcus lucimarinus48.36e-112 347
LLPS-Meg-1133Meleagris gallopavo32.842e-1377.8
LLPS-Cas-1179Carlito syrichta31.512e-1274.3
LLPS-Fud-4456Fukomys damarensis31.176e-1479.0
LLPS-Paa-4204Papio anubis30.971e-1687.8
LLPS-Eqc-3401Equus caballus30.869e-1684.7
LLPS-Mal-2659Mandrillus leucophaeus30.778e-1478.6
LLPS-Ora-0863Ornithorhynchus anatinus30.741e-1275.1
LLPS-Maf-3368Macaca fascicularis30.741e-1481.3
LLPS-Mam-1643Macaca mulatta30.749e-1581.6
LLPS-Hos-4968Homo sapiens30.749e-1581.6
LLPS-Pat-4530Pan troglodytes30.749e-1581.6
LLPS-Chs-4099Chlorocebus sabaeus30.61e-1687.4
LLPS-Anc-2842Anolis carolinensis30.594e-1582.8
LLPS-Fia-1639Ficedula albicollis30.595e-1685.9
LLPS-Dio-4205Dipodomys ordii30.562e-1480.9
LLPS-Urm-1637Ursus maritimus30.456e-1892.0
LLPS-Cae-0984Caenorhabditis elegans30.412e-1171.2
LLPS-Gaa-2758Gasterosteus aculeatus30.313e-1583.2
LLPS-Caj-3275Callithrix jacchus30.222e-1687.0
LLPS-Pap-2887Pan paniscus30.223e-1686.3
LLPS-Tar-3767Takifugu rubripes30.21e-1481.3
LLPS-Aon-4656Aotus nancymaae30.24e-1170.1
LLPS-Myl-3619Myotis lucifugus30.179e-1478.6
LLPS-Gaga-1065Gallus gallus30.152e-1687.0
LLPS-Bot-3173Bos taurus30.112e-1686.7
LLPS-Fec-0079Felis catus30.081e-1481.3
LLPS-Abg-0238Absidia glauca30.064e-0654.3
LLPS-Loa-1417Loxodonta africana29.962e-1274.3
LLPS-Man-4011Macaca nemestrina29.961e-1687.4
LLPS-Sah-2879Sarcophilus harrisii29.896e-1685.5
LLPS-Scm-0523Scophthalmus maximus29.886e-1479.0
LLPS-Caf-0713Canis familiaris29.86e-1582.4
LLPS-Gog-2307Gorilla gorilla29.762e-1584.0
LLPS-Tag-2200Taeniopygia guttata29.513e-1064.3
LLPS-Pes-2933Pelodiscus sinensis29.443e-1480.1
LLPS-Dar-1857Danio rerio29.269e-1581.6
LLPS-Leo-1200Lepisosteus oculatus28.845e-1479.3
LLPS-Sus-4399Sus scrofa28.844e-1686.3
LLPS-Asm-2203Astyanax mexicanus28.688e-1065.9
LLPS-Scf-2914Scleropages formosus28.634e-1582.8
LLPS-Xet-2537Xenopus tropicalis28.631e-1171.6
LLPS-Nef-1245Neosartorya fischeri28.575e-1375.9
LLPS-Mel-1375Melampsora laricipopulina28.58e-0859.7
LLPS-Orl-3989Oryzias latipes28.293e-1170.1
LLPS-Asc-0084Aspergillus clavatus28.173e-1377.0
LLPS-Asf-1112Aspergillus flavus28.063e-1273.6
LLPS-Aso-1342Aspergillus oryzae28.064e-1273.2
LLPS-Icp-2024Ictalurus punctatus27.951e-1274.7
LLPS-Xim-4111Xiphophorus maculatus27.895e-1376.3
LLPS-Ten-2750Tetraodon nigroviridis27.893e-1479.7
LLPS-Asfu-1419Aspergillus fumigatus27.83e-1377.0
LLPS-Ast-0349Aspergillus terreus27.781e-1171.6
LLPS-Orn-2342Oreochromis niloticus27.744e-1376.3
LLPS-Ova-1289Ovis aries27.725e-1582.8
LLPS-Cap-2401Cavia porcellus27.727e-1582.0
LLPS-Pof-3822Poecilia formosa27.495e-1375.9
LLPS-Asni-0090Aspergillus niger27.383e-1273.6
LLPS-Cea-1426Cercocebus atys27.342e-1480.9
LLPS-Mea-3354Mesocricetus auratus27.347e-1479.0
LLPS-Rhb-4328Rhinopithecus bieti27.342e-1480.9
LLPS-Orc-3475Oryctolagus cuniculus27.344e-1479.7
LLPS-Otg-4170Otolemur garnettii27.343e-1480.1
LLPS-Poa-3391Pongo abelii27.036e-1272.4
LLPS-Mup-0465Mustela putorius furo26.971e-1378.2
LLPS-Ran-2738Rattus norvegicus26.976e-1479.3
LLPS-Mum-4455Mus musculus26.977e-1479.0
LLPS-Nol-1703Nomascus leucogenys26.973e-1480.1
LLPS-Ict-3662Ictidomys tridecemlineatus26.972e-1377.0
LLPS-Aim-0056Ailuropoda melanoleuca26.592e-1377.4
LLPS-Cog-0759Colletotrichum gloeosporioides26.261e-0965.5
LLPS-Sac-0412Saccharomyces cerevisiae26.252e-0965.1
LLPS-Asn-1372Aspergillus nidulans26.122e-1273.9
LLPS-Kop-1480Komagataella pastoris25.947e-1066.2
LLPS-Asg-1356Ashbya gossypii25.785e-0963.5
LLPS-Mod-4084Monodelphis domestica25.473e-0858.2
LLPS-Spr-0794Sporisorium reilianum25.358e-1065.9
LLPS-Usm-1259Ustilago maydis25.328e-0859.3
LLPS-Lem-1131Leptosphaeria maculans25.12e-0964.7
LLPS-Phn-1026Phaeosphaeria nodorum24.01e-0965.5
LLPS-Dos-0945Dothistroma septosporum23.91e-0758.5
LLPS-Pytr-1140Pyrenophora triticirepentis23.42e-0861.6