Bos taurus      Nuclear speckle


※ Nuclear speckle introduction

    Nuclear speckles or splicing speckles, also known as interchromatin granule clusters, are membrane-less nuclear organelles enriched in pre-mRNA splicing and transcription factors and play important roles in RNA metabolism, such as transcription, pre-mRNA splicing, 3′-end mRNA processing, and execution of mRNA nuclear export (1; 2). They are dynamic subnuclear structures, and their size, shape, and number can vary accompanied with RNA regulation, nuclear speckles disperse in high activity of mRNA processing when transcription or pre-mRNA splicing is inhibited, GSK-3β can regulate assembly of nuclear speckles (2). Because many naturally intronless mRNAs, including eight exogenously expressed and four endogenous ones, are proved to be associate with NSs, So Nuclear speckles (NSs) are thought to serve as splicing factor storage sites (3).

Reference
1. Lee, K. H., Zhang, P., Kim, H. J., Mitrea, D. M., Sarkar, M., Freibaum, B. D., et al. (2016) C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Cell, 167(3), 774-788 e717. PMID: 27768896
2. Wang, K., Wang, L., Wang, J., Chen, S., Shi, M., & Cheng, H. (2018) Intronless mRNAs transit through nuclear speckles to gain export competence. J Cell Biol, 217(11), 3912-3929. PMID: 30194269
3. An, Y., Zou, Y., Cao, Y., Yao, M., Ma, N., Wu, Y., et al. (2019) The nuclear GSK-3beta regulated post-transcriptional processing of mRNA through phosphorylation of SC35. Mol Cell Biochem, 451(1-2), 55-67. PMID: 30030778


There are 120 genes.  Reviewed (13 or Unreviewed (107

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Bot-0243
ENSBTAG00000009615.4
P04272
ANXA2
2
LLPS-Bot-0207
ENSBTAG00000010109.3
P48734
CDK1
3
LLPS-Bot-0000
ENSBTAG00000007658.6
F1MMG3
CTNNBL1
4
LLPS-Bot-0077
ENSBTAG00000005757.6
Q28009
FUS
5
LLPS-Bot-0192
ENSBTAG00000021131.5
Q3T0D0
HNRNPK
6
LLPS-Bot-0150
ENSBTAG00000012471.4
F2Z4E7
ILF2
7
LLPS-Bot-0203
ENSBTAG00000040076.4
F1MMA0
ILF3
8
LLPS-Bot-0199
ENSBTAG00000012225.4
Q3SYV6
KPNA2
9
LLPS-Bot-0244
ENSBTAG00000012152.5
G3N361
NONO
10
LLPS-Bot-0221
ENSBTAG00000008985.5
Q5E9A3
PCBP1
11
LLPS-Bot-0175
ENSBTAG00000003934.6
Q1LZD9
PSPC1
12
LLPS-Bot-0044
ENSBTAG00000045828.2
Q8WN55
PTBP1
13
LLPS-Bot-0222
ENSBTAG00000016328.6
E1BQ37
SFPQ
14
LLPS-Bot-0424
ENSBTAG00000048057.2
15
LLPS-Bot-1185
ENSBTAG00000017770.6
G3MY01
16
LLPS-Bot-2301
ENSBTAG00000017352.6
17
LLPS-Bot-2516
ENSBTAG00000014771.6
G5E5I0
18
LLPS-Bot-3109
ENSBTAG00000048812.1
19
LLPS-Bot-3180
ENSBTAG00000026995.3
20
LLPS-Bot-3300
ENSBTAG00000005584.5
21
LLPS-Bot-3912
ENSBTAG00000054242.1
G5E5M6
22
LLPS-Bot-4656
ENSBTAG00000015504.6
23
LLPS-Bot-1928
ENSBTAG00000001579.6
B0JYP5
AGO2
24
LLPS-Bot-1908
ENSBTAG00000008498.3
Q3T0I4
ALYREF
25
LLPS-Bot-2149
ENSBTAG00000004944.6
F1MB53
ANXA10
26
LLPS-Bot-1069
ENSBTAG00000001594.6
F1N671
ARL6IP4
27
LLPS-Bot-1638
ENSBTAG00000011529.6
F1MLY7
ATR
28
LLPS-Bot-1210
ENSBTAG00000016705.3
Q5E9D4
BCAS2
29
LLPS-Bot-0975
ENSBTAG00000020307.5
Q1JQC8
C11H9orf78
30
LLPS-Bot-1366
ENSBTAG00000012048.6
F1MBG0
CARM1
31
LLPS-Bot-0316
ENSBTAG00000006250.5
A5D7H5
CASC3
32
LLPS-Bot-4579
ENSBTAG00000003851.5
E1BJ67
CCNL1
33
LLPS-Bot-3929
ENSBTAG00000020012.6
Q2KJC1
CDC5L
34
LLPS-Bot-0678
ENSBTAG00000011046.6
Q08DX5
CDK7
35
LLPS-Bot-1693
ENSBTAG00000004695.6
Q5EAB2
CDK9
36
LLPS-Bot-0264
ENSBTAG00000007428.6
E1BKX9
CDKL5
37
LLPS-Bot-4234
ENSBTAG00000020662.5
Q2TBX1
CIP29
38
LLPS-Bot-1617
ENSBTAG00000014393.6
E1B9Q2
CLK2
39
LLPS-Bot-1423
ENSBTAG00000031385.4
F1MHX1
COP1
40
LLPS-Bot-3303
ENSBTAG00000005326.6
P67827
CSNK1A1
41
LLPS-Bot-0629
ENSBTAG00000014490.6
Q3T147
DDX39B
42
LLPS-Bot-2215
ENSBTAG00000021520.6
F1MX40
DDX46
43
LLPS-Bot-0448
ENSBTAG00000019869.5
A6QR44
DGCR8
44
LLPS-Bot-1335
ENSBTAG00000016874.4
Q3MI00
DNAJB1
45
LLPS-Bot-0796
ENSBTAG00000013480.4
Q2KI83
DNAJC17
46
LLPS-Bot-4677
ENSBTAG00000013294.4
F6PR52
DYRK3
47
LLPS-Bot-0403
ENSBTAG00000017798.6
Q3SZC0
ERH
48
LLPS-Bot-1776
ENSBTAG00000020748.5
E1BI86
FAM76B
49
LLPS-Bot-2503
ENSBTAG00000038682.3
E1B8J6
FAM83H
50
LLPS-Bot-2056
ENSBTAG00000010077.6
E1BE83
FANCD2
51
LLPS-Bot-2756
ENSBTAG00000009097.6
E1BDI4
FANCI
52
LLPS-Bot-4558
ENSBTAG00000010264.5
F6PQR5
FBXL18
53
LLPS-Bot-2287
ENSBTAG00000015457.6
A4IFL5
FGFR1
54
LLPS-Bot-4638
ENSBTAG00000002039.5
A5PK03
FRMD8
55
LLPS-Bot-4872
ENSBTAG00000014874.5
Q17QU6
FYTTD1
56
LLPS-Bot-4138
ENSBTAG00000010671.5
F1N215
GLI3
57
LLPS-Bot-0721
ENSBTAG00000020935.6
A0JND0
HIF1A
58
LLPS-Bot-4063
ENSBTAG00000018948.6
A7Z028
HIF3A
59
LLPS-Bot-3360
ENSBTAG00000017860.6
F1MW00
HIPK2
60
LLPS-Bot-4070
ENSBTAG00000001553.6
P09867
HNRNPA1
61
LLPS-Bot-0622
ENSBTAG00000005726.6
Q2HJ60
HNRNPA2B1
62
LLPS-Bot-4660
ENSBTAG00000039035.3
F1MWU9
HSPA6
63
LLPS-Bot-4837
ENSBTAG00000005012.4
Q0IIM3
HSPH1
64
LLPS-Bot-2637
ENSBTAG00000014249.6
G3MYD5
IVNS1ABP
65
LLPS-Bot-1273
ENSBTAG00000016568.4
F1MMH3
LUC7L
66
LLPS-Bot-2476
ENSBTAG00000003485.3
Q3ZBV3
MAGOH
67
LLPS-Bot-3893
ENSBTAG00000014668.4
Q3SZM9
NAGK
68
LLPS-Bot-3015
ENSBTAG00000010884.6
G5E5D9
NKAP
69
LLPS-Bot-3954
ENSBTAG00000014450.4
Q3SWY5
NOSIP
70
LLPS-Bot-3602
ENSBTAG00000009017.4
Q04752
NR5A1
71
LLPS-Bot-1932
ENSBTAG00000019341.6
Q2KIC0
NSRP1
72
LLPS-Bot-1684
ENSBTAG00000007777.6
F1MPV2
OGG1
73
LLPS-Bot-4134
ENSBTAG00000015837.6
Q0IIL0
P2RY12
74
LLPS-Bot-4173
ENSBTAG00000006884.6
Q28165
PABPN1
75
LLPS-Bot-0719
ENSBTAG00000007234.5
Q2KID6
PLRG1
76
LLPS-Bot-3739
ENSBTAG00000027789.5
A8E658
PPIG
77
LLPS-Bot-2144
ENSBTAG00000014366.6
Q08E38
PRPF19
78
LLPS-Bot-2075
ENSBTAG00000011488.5
A7Z025
PRPF8
79
LLPS-Bot-4114
ENSBTAG00000002808.5
Q58DU5
PSMA3
80
LLPS-Bot-4501
ENSBTAG00000020791.6
F1MJY2
RAPGEF1
81
LLPS-Bot-2385
ENSBTAG00000021951.6
A7MB77
RBM17
82
LLPS-Bot-3925
ENSBTAG00000038333.2
F1MY46
RBM23
83
LLPS-Bot-3760
ENSBTAG00000009536.5
Q2TBT8
RNF151
84
LLPS-Bot-1279
ENSBTAG00000009969.5
A6QR16
RNPS1
85
LLPS-Bot-2267
ENSBTAG00000001035.6
A2VDM7
SF1
86
LLPS-Bot-4071
ENSBTAG00000003390.6
A2VDN6
SF3A1
87
LLPS-Bot-0980
ENSBTAG00000025452.5
G3MW14
SF3A2
88
LLPS-Bot-1566
ENSBTAG00000007299.3
Q3SWY7
SF3A3
89
LLPS-Bot-1505
ENSBTAG00000008915.6
F1MX61
SF3B1
90
LLPS-Bot-3478
ENSBTAG00000012599.6
Q1W668
SMAD2
91
LLPS-Bot-0432
ENSBTAG00000000848.6
E1BH78
SNRNP200
92
LLPS-Bot-2035
ENSBTAG00000008060.6
Q1LZH0
SNRNP35
93
LLPS-Bot-0604
ENSBTAG00000048800.1
Q1RMR2
SNRNP70
94
LLPS-Bot-3197
ENSBTAG00000009077.5
Q2KIR1
SNRPA
95
LLPS-Bot-0693
ENSBTAG00000013593.6
A6H788
SNRPA1
96
LLPS-Bot-0567
ENSBTAG00000027506.4
G5E5Y0
SNRPB2
97
LLPS-Bot-4480
ENSBTAG00000008482.6
F1MYN8
SON
98
LLPS-Bot-4379
ENSBTAG00000005824.6
Q0VCW1
SPOP
99
LLPS-Bot-0508
ENSBTAG00000013772.7
E1BP16
SRRM1
100
LLPS-Bot-0770
ENSBTAG00000012683.6
F1MI03
SRRM2
101
LLPS-Bot-1743
ENSBTAG00000014766.4
Q0VCY7
SRSF1
102
LLPS-Bot-1635
ENSBTAG00000008072.6
Q3ZBU5
SRSF10
103
LLPS-Bot-3172
ENSBTAG00000015474.6
Q148M1
SRSF11
104
LLPS-Bot-0698
ENSBTAG00000018258.4
Q3MHR5
SRSF2
105
LLPS-Bot-2668
ENSBTAG00000040006.3
Q3SZR8
SRSF3
106
LLPS-Bot-1160
ENSBTAG00000013309.6
A7MB38
SRSF4
107
LLPS-Bot-3884
ENSBTAG00000014891.6
Q3T106
SRSF7
108
LLPS-Bot-3316
ENSBTAG00000021523.6
F1MX38
STAT3
109
LLPS-Bot-2484
ENSBTAG00000049402.1
Q5E9D1
SUMO1
110
LLPS-Bot-1052
ENSBTAG00000008953.6
A6QPZ6
TAP1
111
LLPS-Bot-2054
ENSBTAG00000018035.5
O46680
TGFBR1
112
LLPS-Bot-1669
ENSBTAG00000001697.6
Q3ZBT6
TRA2B
113
LLPS-Bot-3012
ENSBTAG00000001968.6
A6QNT7
TTC14
114
LLPS-Bot-3803
ENSBTAG00000023610.5
Q3T127
U2AF1L4
115
LLPS-Bot-1527
ENSBTAG00000002830.6
Q24JZ8
U2AF2
116
LLPS-Bot-1528
ENSBTAG00000009154.5
F1MHP1
U2SURP
117
LLPS-Bot-0305
ENSBTAG00000013254.6
E1BE98
XPO1
118
LLPS-Bot-3043
ENSBTAG00000015572.6
F1MIW9
YTHDC1
119
LLPS-Bot-4149
ENSBTAG00000004079.6
F1MC90
ZNF106
120
LLPS-Bot-3255
ENSBTAG00000019357.5
F1MHA2
ZNF688