LLPS-Bot-0192
HNRNPK
Integrated Annotations
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Heterogeneous nuclear ribonucleoprotein K |
| Gene Name: | HNRNPK, HNRPK |
| Ensembl Gene: | ENSBTAG00000021131.5 |
| Ensembl Protein: | ENSBTAP00000028162.4 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nucleolus | "...The proteomic analysis of the MDBK cell nucleoli identified a total of 311 proteins." | MDBK cells | 20970743 |
| Nuclear speckle, Sam68 nuclear body, Stress granule, Postsynaptic density | Predicted from orthologs | N/A | (View) |
▼ FUNCTION
| One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000028162.5 | ENSBTAP00000028162.4 |
| Ensembl | ENSBTAT00000080396.1 | ENSBTAP00000067919.1 |
| UniProt | Q3T0D0, HNRPK_BOVIN | |
| GeneBank | BC102450 | AAI02451.1 |
| RefSeq | NM_001034562.1, XM_005210329.3, XM_005210330.2, XM_005210331.3 | NP_001029734.1, XP_005210386.1, XP_005210387.1, XP_005210388.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 METEQPEETF PNTETNGEFG KRPAEDMEEE QAFKRSRNTD EMVELRILLQ SKNAGAVIGK 60 61 GGKNIKALRT DYNASVSVPD SSGPERILSI SADIETIGEI LKKIIPTLEE GLQLPSPTAT 120 121 SQLPLESDAV ECLNYQHYKG SDFDCELRLL IHQSLAGGII GVKGAKIKEL RENTQTTIKL 180 181 FQECCPQSTD RVVLIGGKPD RVVECIKIIL DLISESPIKG RAQPYDPNFY DETYDYGGFT 240 241 MMFDDRRGRP VGFPMRGRGG FDRMPPGRGG RPMPPSRRDY DDMSPRRGPP PPPPGRGGRG 300 301 GSRARNLPLP PPPPPRGGDL MAYDRRGRPG DRYDGMVGFS ADETWDSAID TWSPSEWQMA 360 361 YEPQGGSGYD YSYAGGRGSY GDLGGPIITT QVTIPKDLAG SIIGKGGQRI KQIRHESGAS 420 421 IKIDEPLEGS EDRIITITGT QDQIQNAQYL LQNSVKQYAD VEGF 464 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAAACTG AACAGCCAGA GGAAACCTTT CCCAACACTG AAACCAATGG CGAATTTGGT 60 61 AAACGCCCTG CTGAAGATAT GGAAGAGGAA CAAGCTTTTA AAAGATCTAG AAACACTGAT 120 121 GAGATGGTTG AATTACGCAT TCTGCTTCAG AGCAAGAATG CTGGGGCAGT GATTGGAAAA 180 181 GGAGGCAAGA ATATTAAGGC TCTCCGTACA GACTACAATG CCAGTGTTTC AGTCCCAGAC 240 241 AGCAGTGGCC CCGAGCGCAT ATTGAGTATC AGTGCTGATA TTGAAACGAT TGGAGAAATT 300 301 CTGAAGAAAA TCATCCCTAC CTTGGAAGAG GGCCTGCAGT TGCCATCACC CACTGCAACC 360 361 AGCCAGCTCC CGCTCGAATC TGATGCTGTG GAATGCTTAA ATTACCAACA CTATAAAGGA 420 421 AGCGACTTTG ACTGCGAGTT GAGACTGTTG ATTCATCAGA GTCTGGCAGG AGGAATTATT 480 481 GGAGTCAAAG GTGCTAAAAT CAAAGAACTT CGAGAGAACA CTCAGACAAC AATCAAGCTT 540 541 TTCCAGGAAT GTTGTCCTCA ATCTACTGAC AGAGTCGTTC TTATCGGAGG AAAACCTGAT 600 601 AGGGTTGTAG AGTGCATAAA GATCATCCTT GATCTTATAT CAGAGTCTCC CATCAAAGGA 660 661 CGTGCTCAGC CTTATGATCC CAATTTTTAT GATGAAACCT ATGATTATGG TGGTTTTACA 720 721 ATGATGTTTG ATGACCGCCG TGGACGTCCT GTGGGATTTC CCATGCGGGG AAGAGGTGGT 780 781 TTTGACAGAA TGCCGCCTGG TCGGGGTGGG CGTCCCATGC CTCCCTCCAG AAGAGATTAT 840 841 GATGATATGA GCCCTCGTCG AGGACCTCCT CCACCCCCTC CCGGACGAGG TGGCCGGGGA 900 901 GGTAGTAGAG CTCGGAATCT TCCTCTTCCA CCACCACCAC CACCTAGAGG AGGAGATCTA 960 961 ATGGCCTATG ACAGAAGAGG AAGACCTGGA GACCGTTATG ATGGCATGGT TGGTTTCAGT 1020 1021 GCTGATGAAA CCTGGGACTC TGCAATAGAT ACATGGAGCC CATCAGAGTG GCAGATGGCT 1080 1081 TATGAACCAC AGGGTGGCTC TGGATATGAT TATTCCTATG CAGGGGGTCG TGGCTCATAT 1140 1141 GGTGATCTTG GTGGACCTAT TATTACTACA CAAGTAACTA TTCCCAAAGA TTTGGCTGGA 1200 1201 TCTATTATTG GCAAAGGTGG TCAGCGGATT AAACAAATCC GTCATGAGTC AGGAGCTTCG 1260 1261 ATCAAAATTG ATGAGCCTTT AGAAGGATCC GAAGATCGGA TCATTACCAT TACGGGAACA 1320 1321 CAGGACCAGA TACAGAATGC ACAGTATTTG CTGCAGAACA GTGTGAAGCA GTATGCAGAT 1380 1381 GTTGAAGGAT TCTAA 1395 |
▼ KEYWORD
ID | Family |
Acetylation | |
Activator | |
Cell junction | |
Cell projection | |
Complete proteome | |
Cytoplasm | |
DNA-binding | |
Glycoprotein | |
Isopeptide bond | |
Methylation | |
mRNA processing | |
mRNA splicing | |
Nucleus | |
Phosphoprotein | |
Reference proteome | |
Repeat | |
Repressor | |
Ribonucleoprotein | |
RNA-binding | |
Spliceosome | |
Transcription | |
Transcription regulation | |
Ubl conjugation
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Catalytic step 2 spliceosome | |
Cellular Component | Cell junction | |
Cellular Component | Cell projection | |
Cellular Component | Cytoplasmic stress granule | |
Cellular Component | Nuclear chromatin | |
Cellular Component | Nucleoplasm | |
Cellular Component | Podosome | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | Identical protein binding | |
Molecular Function | Protein domain specific binding | |
Molecular Function | RNA binding | |
Molecular Function | RNA polymerase II proximal promoter sequence-specific DNA binding | |
Biological Process | MRNA processing | |
Biological Process | Negative regulation of apoptotic process | |
Biological Process | Negative regulation of mRNA splicing, via spliceosome | |
Biological Process | Positive regulation of low-density lipoprotein particle receptor biosynthetic process | |
Biological Process | Positive regulation of receptor-mediated endocytosis | |
Biological Process | Regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | |
Biological Process | Regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter | |
Biological Process | Regulation of low-density lipoprotein particle clearance | |
Biological Process | RNA splicing |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pes-2569 | Pelodiscus sinensis | 100.0 | 2e-23 | 105 |
| LLPS-Ova-0242 | Ovis aries | 100.0 | 0.0 | 649 |
| LLPS-Ict-0235 | Ictidomys tridecemlineatus | 99.78 | 0.0 | 648 |
| LLPS-Eqc-2228 | Equus caballus | 99.78 | 0.0 | 648 |
| LLPS-Poa-2757 | Pongo abelii | 99.78 | 0.0 | 648 |
| LLPS-Mam-0839 | Macaca mulatta | 99.78 | 0.0 | 648 |
| LLPS-Rhb-4295 | Rhinopithecus bieti | 99.78 | 0.0 | 648 |
| LLPS-Fec-1129 | Felis catus | 99.78 | 0.0 | 648 |
| LLPS-Hos-1907 | Homo sapiens | 99.78 | 0.0 | 648 |
| LLPS-Pat-0821 | Pan troglodytes | 99.78 | 0.0 | 648 |
| LLPS-Urm-2140 | Ursus maritimus | 99.78 | 0.0 | 648 |
| LLPS-Man-0590 | Macaca nemestrina | 99.78 | 0.0 | 648 |
| LLPS-Ran-0590 | Rattus norvegicus | 99.78 | 0.0 | 648 |
| LLPS-Myl-3628 | Myotis lucifugus | 99.78 | 0.0 | 648 |
| LLPS-Paa-2687 | Papio anubis | 99.78 | 0.0 | 648 |
| LLPS-Mal-2558 | Mandrillus leucophaeus | 99.78 | 0.0 | 648 |
| LLPS-Caj-1424 | Callithrix jacchus | 99.78 | 0.0 | 648 |
| LLPS-Fud-1356 | Fukomys damarensis | 99.78 | 0.0 | 648 |
| LLPS-Chs-0644 | Chlorocebus sabaeus | 99.78 | 0.0 | 625 |
| LLPS-Maf-2877 | Macaca fascicularis | 99.78 | 0.0 | 648 |
| LLPS-Aon-3252 | Aotus nancymaae | 99.78 | 0.0 | 648 |
| LLPS-Mup-0590 | Mustela putorius furo | 99.56 | 0.0 | 636 |
| LLPS-Mum-2748 | Mus musculus | 99.56 | 0.0 | 636 |
| LLPS-Cas-0779 | Carlito syrichta | 99.35 | 0.0 | 644 |
| LLPS-Orc-0570 | Oryctolagus cuniculus | 99.35 | 0.0 | 635 |
| LLPS-Ora-2265 | Ornithorhynchus anatinus | 99.35 | 0.0 | 644 |
| LLPS-Loa-1135 | Loxodonta africana | 98.71 | 0.0 | 644 |
| LLPS-Aim-0489 | Ailuropoda melanoleuca | 98.71 | 0.0 | 648 |
| LLPS-Dio-0090 | Dipodomys ordii | 97.62 | 0.0 | 631 |
| LLPS-Scf-0301 | Scleropages formosus | 97.44 | 4e-19 | 93.2 |
| LLPS-Pof-1554 | Poecilia formosa | 97.22 | 2e-15 | 82.0 |
| LLPS-Orl-0621 | Oryzias latipes | 97.22 | 3e-15 | 82.0 |
| LLPS-Gaa-1232 | Gasterosteus aculeatus | 96.15 | 8e-19 | 92.4 |
| LLPS-Icp-1300 | Ictalurus punctatus | 96.15 | 8e-19 | 92.4 |
| LLPS-Tut-0451 | Tursiops truncatus | 95.26 | 0.0 | 617 |
| LLPS-Orn-0161 | Oreochromis niloticus | 94.87 | 2e-18 | 91.3 |
| LLPS-Xim-2234 | Xiphophorus maculatus | 94.87 | 2e-18 | 91.3 |
| LLPS-Sus-0418 | Sus scrofa | 94.83 | 0.0 | 588 |
| LLPS-Otg-0362 | Otolemur garnettii | 94.61 | 0.0 | 587 |
| LLPS-Mod-1177 | Monodelphis domestica | 94.61 | 0.0 | 586 |
| LLPS-Sah-0775 | Sarcophilus harrisii | 94.61 | 0.0 | 587 |
| LLPS-Cea-0098 | Cercocebus atys | 94.59 | 0.0 | 594 |
| LLPS-Xet-2298 | Xenopus tropicalis | 94.44 | 8e-15 | 80.1 |
| LLPS-Scm-0787 | Scophthalmus maximus | 94.44 | 8e-15 | 80.5 |
| LLPS-Caf-0132 | Canis familiaris | 93.46 | 0.0 | 566 |
| LLPS-Nol-0670 | Nomascus leucogenys | 93.26 | 0.0 | 598 |
| LLPS-Pap-2220 | Pan paniscus | 93.08 | 0.0 | 603 |
| LLPS-Gog-2747 | Gorilla gorilla | 93.08 | 0.0 | 603 |
| LLPS-Mea-3197 | Mesocricetus auratus | 92.71 | 0.0 | 613 |
| LLPS-Tar-2327 | Takifugu rubripes | 89.74 | 1e-16 | 86.3 |
| LLPS-Fia-3750 | Ficedula albicollis | 87.93 | 2e-171 | 496 |
| LLPS-Gaga-2150 | Gallus gallus | 87.72 | 9e-171 | 494 |
| LLPS-Tag-0931 | Taeniopygia guttata | 86.77 | 8e-166 | 483 |
| LLPS-Anp-1053 | Anas platyrhynchos | 86.7 | 4e-180 | 520 |
| LLPS-Cap-1987 | Cavia porcellus | 85.4 | 2e-161 | 470 |
| LLPS-Anc-1693 | Anolis carolinensis | 84.82 | 1e-175 | 508 |
| LLPS-Leo-0500 | Lepisosteus oculatus | 82.87 | 3e-165 | 482 |
| LLPS-Lac-2142 | Latimeria chalumnae | 81.21 | 8e-154 | 452 |
| LLPS-Asm-0531 | Astyanax mexicanus | 76.46 | 5e-139 | 414 |
| LLPS-Dar-0145 | Danio rerio | 75.05 | 5e-147 | 434 |
| LLPS-Ten-1778 | Tetraodon nigroviridis | 74.71 | 4e-114 | 352 |
| LLPS-Cae-2032 | Caenorhabditis elegans | 43.22 | 4e-35 | 139 |
| LLPS-Drm-0866 | Drosophila melanogaster | 42.31 | 1e-30 | 127 |
| LLPS-Cii-1564 | Ciona intestinalis | 41.63 | 6e-39 | 151 |
| LLPS-Cis-0473 | Ciona savignyi | 36.22 | 1e-17 | 85.1 |
| LLPS-Meg-2091 | Meleagris gallopavo | 30.3 | 5e-16 | 84.3 |