• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Xet-2353
mcm7

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: DNA replication licensing factor mcm7; CDC47 homolog; Minichromosome maintenance protein 7
Gene Name: mcm7, TGas137h09.1
Ensembl Gene: ENSXETG00000009104.2
Ensembl Protein: ENSXETP00000019971.2
Organism: Xenopus tropicalis
Taxa ID: 8364
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Chromatin, Nucleolus, Centrosome/Spindle pole body, P-body, Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION


Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. The existence of maternal and zygotic forms of mcm3 and mcm6 suggests that specific forms of mcm2-7 complexes may be used during different stages of development (By similarity).

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MPRDYQAEKG  EEGKPQYHQF  VSTESLGEGN  PAQKSLHANI  AHREQVALYI  DLDDLAEEDP  60
61    ELVDAICENT  RRYTNLFADA  VQELLPQYKE  REVVVHKDAL  DVYIEHRLMM  EQRGRDPSET  120
121   RDPHNQYPPE  LMRRFELYFK  APSSSKARVV  RDVKADSIGK  LVTVRGIVTR  VTEVKPMMVV  180
181   ATYTCDQCGA  ETYQPIQSPT  FMPLIMCPSR  ECQTNRSGGR  LYLQTRGSKF  IKFQELKIQE  240
241   HSDQVPVGNI  PRCMSVYVRG  ENTRLAQPGD  HVSITGVFLP  MLRTGFRQVV  QGLLSETYLE  300
301   SHRLVKMNKT  EDDELGTEEL  SEEELRQITV  TPEEDFYEKL  AASIAPEIYG  HEDVKKALLL  360
361   LLVGGVDNSP  RGMKIRGNIN  ICLMGDPGVA  KSQLLSYIDR  LAPRSKCSGR  DRSNCWCALV  420
421   ALHLSRSDSV  GKTLQCLSAS  GSPCRKERNK  GETNTYNTPI  KVAIRALLTS  FASASYLTNC  480
481   VQSFSSAQRD  LFGRFTQNLQ  ASPALVLRWD  SPAGVCSSSQ  DSSQDLSLQV  QGQLLLVQLL  540
541   SLSPRAASGV  LGLSVSSLWL  PLPGCFATSG  SPELAVHLVA  RQQLTAQSLS  ASSPTGNSSR  600
601   RGVSAGTQHY  LARLRLEDVV  EKEDVNEAMR  LTEMSKDSLL  GDKGQTSRTQ  RPADVIFSTI  660
661   REMVPEKGAR  SVKYSEAEQR  AVSKGFTPAQ  FEAALEEYEE  LNVWLVNQAR  TKITFV  716
Nucleotide CDS Sequence (FASTA)
1     ATGCCCAGGG  ATTACCAAGC  CGAGAAAGGT  GAGGAGGGGA  AGCCGCAGTA  TCACCAGTTC  60
61    GTTTCCACAG  AGAGCTTAGG  GGAAGGGAAC  CCTGCCCAAA  AGAGCTTACA  CGCTAATATT  120
121   GCTCACAGAG  AGCAGGTTGC  GCTGTACATC  GATCTGGATG  ACCTGGCCGA  GGAGGACCCC  180
181   GAGTTAGTGG  ATGCAATCTG  TGAAAACACA  AGGAGGTACA  CAAACCTGTT  TGCTGATGCC  240
241   GTTCAGGAGC  TGCTGCCCCA  GTATAAAGAG  CGAGAGGTGG  TGGTACATAA  AGATGCTTTG  300
301   GATGTATATA  TTGAGCACCG  CTTAATGATG  GAGCAGAGAG  GCCGAGACCC  CAGTGAGACC  360
361   CGTGATCCTC  ACAACCAGTA  CCCCCCAGAG  CTTATGCGCA  GATTCGAACT  GTACTTCAAA  420
421   GCTCCGAGCA  GCTCAAAAGC  CCGCGTGGTG  CGAGATGTCA  AAGCCGATTC  CATCGGCAAG  480
481   TTGGTTACAG  TTCGGGGCAT  AGTCACGAGG  GTCACAGAAG  TCAAGCCTAT  GATGGTGGTG  540
541   GCAACATACA  CATGTGACCA  GTGTGGTGCC  GAGACCTACC  AACCGATTCA  ATCTCCAACT  600
601   TTTATGCCGC  TTATAATGTG  TCCCAGCAGG  GAGTGTCAGA  CAAACCGCTC  TGGGGGCAGG  660
661   CTCTACTTGC  AGACCCGGGG  CTCTAAATTT  ATTAAGTTCC  AAGAGCTGAA  GATTCAAGAA  720
721   CATAGTGATC  AAGTTCCAGT  TGGGAACATC  CCTCGCTGTA  TGTCTGTGTA  TGTACGTGGG  780
781   GAGAACACGC  GGCTCGCTCA  GCCCGGGGAC  CATGTCAGTA  TCACTGGAGT  CTTCCTGCCG  840
841   ATGCTAAGAA  CTGGCTTCCG  TCAGGTGGTA  CAGGGGCTCC  TTTCAGAGAC  GTACCTCGAA  900
901   TCTCACCGTT  TGGTGAAAAT  GAACAAGACC  GAGGATGATG  AACTCGGAAC  AGAAGAGCTG  960
961   AGTGAAGAGG  AGCTGCGACA  GATTACTGTA  ACACCAGAGG  AAGATTTCTA  TGAGAAGCTG  1020
1021  GCAGCCTCCA  TTGCGCCTGA  GATTTATGGG  CACGAGGATG  TGAAGAAGGC  TCTACTTCTG  1080
1081  CTCTTAGTGG  GAGGAGTTGA  CAATTCTCCC  CGTGGCATGA  AGATAAGAGG  GAACATTAAC  1140
1141  ATCTGCCTGA  TGGGTGACCC  AGGAGTTGCA  AAATCACAGC  TGCTTTCTTA  TATTGATCGT  1200
1201  CTAGCACCTC  GGAGTAAGTG  TTCAGGCAGA  GACAGGAGCA  ACTGCTGGTG  TGCCTTGGTA  1260
1261  GCATTGCACT  TGTCTCGGTC  TGACAGTGTC  GGCAAAACCC  TCCAATGTCT  TTCTGCTTCA  1320
1321  GGTTCTCCCT  GCAGGAAGGA  AAGAAATAAA  GGGGAAACTA  ATACATATAA  CACTCCTATC  1380
1381  AAAGTGGCAA  TAAGGGCCTT  ACTAACTAGC  TTTGCCAGCG  CAAGCTATCT  CACTAACTGT  1440
1441  GTACAGTCCT  TTAGCTCAGC  CCAAAGGGAT  CTCTTTGGGC  GATTCACACA  GAATCTTCAG  1500
1501  GCGAGTCCAG  CACTCGTACT  CAGATGGGAT  TCCCCTGCAG  GTGTTTGTTC  CTCCAGTCAG  1560
1561  GACTCCTCAC  AGGATCTGTC  TCTCCAGGTA  CAGGGCCAGC  TTCTCCTTGT  GCAGCTCCTC  1620
1621  TCTCTGAGCC  CACGTGCAGC  TTCTGGAGTT  CTGGGACTTT  CTGTCTCCTC  CCTCTGGCTT  1680
1681  CCTCTCCCAG  GCTGCTTTGC  AACTTCCGGC  AGCCCTGAGC  TTGCTGTTCA  CCTTGTTGCT  1740
1741  AGGCAGCAGC  TCACAGCACA  AAGTCTCAGT  GCCAGCTCCC  CTACAGGGAA  CAGCAGCAGG  1800
1801  AGGGGGGTAA  GTGCAGGGAC  CCAGCACTAC  CTCGCTCGTC  TGCGTCTGGA  AGATGTCGTG  1860
1861  GAGAAAGAGG  ATGTAAACGA  GGCCATGAGG  TTGACTGAAA  TGTCTAAGGA  CTCGTTGCTT  1920
1921  GGCGACAAGG  GGCAAACGTC  AAGGACGCAA  CGCCCGGCCG  ACGTGATCTT  CTCCACTATC  1980
1981  CGAGAGATGG  TCCCGGAGAA  AGGCGCCCGC  AGCGTCAAAT  ACTCGGAGGC  GGAGCAGCGC  2040
2041  GCCGTGTCTA  AAGGCTTCAC  CCCCGCCCAG  TTCGAGGCGG  CTCTGGAGGA  GTACGAGGAG  2100
2101  CTGAACGTCT  GGCTGGTTAA  TCAGGCCCGC  ACCAAGATCA  CATTTGTGTA  A  2151

▼ KEYWORD


ID
Family
ATP-binding
Cell cycle
Complete proteome
DNA replication
DNA-binding
Helicase
Hydrolase
Metal-binding
Nucleotide-binding
Nucleus
Reference proteome
Zinc
Zinc-finger

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Chromatin
Cellular Component
MCM complex
Cellular Component
Nucleus
Molecular Function
ATP binding
Molecular Function
DNA binding
Molecular Function
DNA helicase activity
Molecular Function
Metal ion binding
Biological Process
Cell cycle
Biological Process
DNA replication initiation
Biological Process
DNA unwinding involved in DNA replication
Biological Process
Regulation of DNA-dependent DNA replication initiation

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Lac-0987Latimeria chalumnae87.743e-43 169
LLPS-Dar-1180Danio rerio82.871e-168 505
LLPS-Ict-0114Ictidomys tridecemlineatus79.253e-44 173
LLPS-Pap-0600Pan paniscus79.252e-44 174
LLPS-Pat-1350Pan troglodytes79.252e-44 174
LLPS-Hos-1113Homo sapiens79.252e-44 174
LLPS-Gog-2030Gorilla gorilla79.252e-44 174
LLPS-Eqc-1664Equus caballus78.31e-43 171
LLPS-Caf-0177Canis familiaris78.39e-44 172
LLPS-Poa-1362Pongo abelii78.38e-44 172
LLPS-Rhb-0826Rhinopithecus bieti78.33e-44 173
LLPS-Orc-0284Oryctolagus cuniculus78.34e-44 173
LLPS-Fec-1644Felis catus78.37e-44 172
LLPS-Aim-0110Ailuropoda melanoleuca78.36e-43 169
LLPS-Dio-1502Dipodomys ordii78.33e-46 172
LLPS-Caj-1589Callithrix jacchus78.34e-44 173
LLPS-Aon-2388Aotus nancymaae78.33e-44 173
LLPS-Sus-0950Sus scrofa78.39e-44 172
LLPS-Nol-1428Nomascus leucogenys77.361e-43 171
LLPS-Cap-0510Cavia porcellus77.361e-43 171
LLPS-Ova-0334Ovis aries77.361e-42 168
LLPS-Myl-1003Myotis lucifugus77.367e-43 169
LLPS-Mal-2610Mandrillus leucophaeus77.364e-43 169
LLPS-Paa-0631Papio anubis77.361e-43 171
LLPS-Bot-0778Bos taurus77.364e-43 170
LLPS-Chs-0360Chlorocebus sabaeus77.365e-44 172
LLPS-Cea-0607Cercocebus atys77.361e-43 171
LLPS-Leo-2618Lepisosteus oculatus77.361e-43 171
LLPS-Mod-2290Monodelphis domestica76.642e-43 171
LLPS-Mam-1978Macaca mulatta76.426e-43 169
LLPS-Man-1394Macaca nemestrina76.425e-43 169
LLPS-Ran-1358Rattus norvegicus76.422e-43 171
LLPS-Fud-0420Fukomys damarensis76.422e-43 171
LLPS-Mea-2244Mesocricetus auratus76.425e-43 169
LLPS-Mum-1489Mus musculus76.423e-42 167
LLPS-Maf-0261Macaca fascicularis76.425e-43 169
LLPS-Otg-1868Otolemur garnettii75.475e-42 166
LLPS-Loa-0128Loxodonta africana75.473e-42 167
LLPS-Mup-0469Mustela putorius furo75.472e-42 167
LLPS-Sah-1054Sarcophilus harrisii74.772e-41 166
LLPS-Cas-0994Carlito syrichta74.532e-41 164
LLPS-Pes-0904Pelodiscus sinensis74.533e-43 169
LLPS-Orn-1852Oreochromis niloticus74.072e-38 156
LLPS-Icp-0471Ictalurus punctatus71.036e-38 155
LLPS-Anc-0281Anolis carolinensis70.752e-38 156
LLPS-Pof-0090Poecilia formosa70.642e-37 153
LLPS-Xim-0956Xiphophorus maculatus70.648e-38 154
LLPS-Ten-0068Tetraodon nigroviridis69.644e-36 149
LLPS-Tar-1272Takifugu rubripes69.644e-30 130
LLPS-Scm-0687Scophthalmus maximus68.751e-35 148
LLPS-Scf-1283Scleropages formosus66.671e-35 148
LLPS-Asm-0402Astyanax mexicanus66.670.0 583
LLPS-Orl-0074Oryzias latipes65.184e-34 143
LLPS-Gaa-1044Gasterosteus aculeatus64.560.0 575
LLPS-Cii-1377Ciona intestinalis58.262e-159 485
LLPS-Cis-0181Ciona savignyi57.83e-30 130
LLPS-Drm-1371Drosophila melanogaster53.561e-151 465
LLPS-Phv-0349Phaseolus vulgaris47.815e-91 306
LLPS-Vir-0823Vigna radiata47.818e-91 306
LLPS-Glm-2621Glycine max47.524e-91 306
LLPS-Via-0304Vigna angularis46.769e-91 305
LLPS-Cym-0052Cyanidioschyzon merolae44.212e-72 257
LLPS-Nef-0323Neosartorya fischeri43.861e-1481.6
LLPS-Asfu-0062Aspergillus fumigatus43.812e-1171.6
LLPS-Abg-0453Absidia glauca43.179e-90 303
LLPS-Crn-0189Cryptococcus neoformans43.018e-94 315
LLPS-Scj-0023Schizosaccharomyces japonicus42.955e-90 304
LLPS-Php-0604Physcomitrella patens42.792e-93 312
LLPS-Prp-0681Prunus persica42.75e-96 319
LLPS-Gor-1001Gossypium raimondii42.487e-97 322
LLPS-Cae-0175Caenorhabditis elegans42.393e-100 331
LLPS-Met-1535Medicago truncatula42.33e-94 315
LLPS-Miv-0752Microbotryum violaceum42.142e-89 303
LLPS-Ast-1043Aspergillus terreus42.111e-1378.6
LLPS-Asc-0781Aspergillus clavatus42.118e-1479.3
LLPS-Thc-0260Theobroma cacao42.052e-95 318
LLPS-Coc-1470Corchorus capsularis41.963e-86 305
LLPS-Amt-1936Amborella trichopoda41.899e-90 303
LLPS-Pug-0144Puccinia graminis41.831e-88 301
LLPS-Viv-0356Vitis vinifera41.831e-94 316
LLPS-Spr-0390Sporisorium reilianum41.83e-93 315
LLPS-Trr-0880Trichoderma reesei41.798e-80 274
LLPS-Pot-0200Populus trichocarpa41.744e-93 311
LLPS-Sei-0391Setaria italica41.741e-90 305
LLPS-Scp-0701Schizosaccharomyces pombe41.743e-88 300
LLPS-Nec-0824Neurospora crassa41.631e-90 307
LLPS-Art-0744Arabidopsis thaliana41.618e-94 313
LLPS-Cus-0285Cucumis sativus41.611e-93 313
LLPS-Org-0639Oryza glaberrima41.526e-91 306
LLPS-Orr-0417Oryza rufipogon41.524e-91 306
LLPS-Orm-1216Oryza meridionalis41.526e-91 306
LLPS-Ors-0299Oryza sativa41.526e-91 306
LLPS-Orni-0603Oryza nivara41.523e-91 306
LLPS-Ori-0565Oryza indica41.525e-91 306
LLPS-Orb-0135Oryza barthii41.524e-91 306
LLPS-Arl-0638Arabidopsis lyrata41.393e-93 312
LLPS-Mel-0180Melampsora laricipopulina41.394e-85 292
LLPS-Asn-0241Aspergillus nidulans41.312e-90 306
LLPS-Orgl-1284Oryza glumaepatula41.38e-91 305
LLPS-Asni-0253Aspergillus niger41.235e-1376.6
LLPS-Bro-0700Brassica oleracea41.185e-93 311
LLPS-Sol-0375Solanum lycopersicum41.182e-90 304
LLPS-Brn-0069Brassica napus41.186e-93 311
LLPS-Beb-0877Beauveria bassiana41.162e-86 296
LLPS-Tru-1912Triticum urartu41.098e-89 300
LLPS-Zem-0832Zea mays41.092e-90 304
LLPS-Sem-0262Selaginella moellendorffii41.091e-89 303
LLPS-Aso-0187Aspergillus oryzae41.077e-1376.3
LLPS-Usm-0478Ustilago maydis40.982e-91 310
LLPS-Mae-0228Manihot esculenta40.961e-92 310
LLPS-Brr-0710Brassica rapa40.961e-91 308
LLPS-Sot-0357Solanum tuberosum40.964e-91 306
LLPS-Trv-0158Trichoderma virens40.941e-86 296
LLPS-Fus-0248Fusarium solani40.949e-85 291
LLPS-Sob-0464Sorghum bicolor40.871e-89 302
LLPS-Orp-0050Oryza punctata40.877e-88 297
LLPS-Lep-0317Leersia perrieri40.792e-89 301
LLPS-Nia-1476Nicotiana attenuata40.742e-89 301
LLPS-Hea-1096Helianthus annuus40.744e-94 314
LLPS-Blg-0288Blumeria graminis40.61e-82 286
LLPS-Fuo-0025Fusarium oxysporum40.515e-86 295
LLPS-Orbr-0476Oryza brachyantha40.432e-90 304
LLPS-Asf-0806Aspergillus flavus40.381e-0965.9
LLPS-Coo-0200Colletotrichum orbiculare40.382e-85 293
LLPS-Yal-0763Yarrowia lipolytica40.376e-87 296
LLPS-Dac-0092Daucus carota40.315e-87 296
LLPS-Brd-0828Brachypodium distachyon40.285e-91 306
LLPS-Gag-0266Gaeumannomyces graminis40.263e-84 290
LLPS-Cog-0510Colletotrichum gloeosporioides39.961e-89 304
LLPS-Fuv-0684Fusarium verticillioides39.839e-86 294
LLPS-Scc-0192Schizosaccharomyces cryophilus39.71e-88 301
LLPS-Sac-0488Saccharomyces cerevisiae39.641e-76 270
LLPS-Tra-0534Triticum aestivum39.622e-1274.7
LLPS-Hov-0021Hordeum vulgare39.622e-1274.7
LLPS-Ved-0080Verticillium dahliae39.615e-81 281
LLPS-Mua-0804Musa acuminata39.574e-91 306
LLPS-Mao-0779Magnaporthe oryzae39.494e-87 297
LLPS-Pytr-0050Pyrenophora triticirepentis39.414e-87 298
LLPS-Pyt-0117Pyrenophora teres39.411e-86 296
LLPS-Put-0063Puccinia triticina39.221e-71 254
LLPS-Phn-0681Phaeosphaeria nodorum39.192e-84 291
LLPS-Lem-0592Leptosphaeria maculans39.191e-85 293
LLPS-Cogr-0622Colletotrichum graminicola39.112e-85 293
LLPS-Dos-0376Dothistroma septosporum38.99e-85 291
LLPS-Zyt-0009Zymoseptoria tritici38.647e-84 287
LLPS-Chc-0192Chondrus crispus38.641e-62 229
LLPS-Kop-0209Komagataella pastoris38.523e-77 270
LLPS-Asg-0209Ashbya gossypii38.061e-84 291
LLPS-Tum-0440Tuber melanosporum37.932e-83 287
LLPS-Osl-0040Ostreococcus lucimarinus37.478e-66 237
LLPS-Gas-0055Galdieria sulphuraria36.492e-78 273
LLPS-Chr-0378Chlamydomonas reinhardtii35.241e-64 234