LLPS-Osl-0040
MCM7
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | DNA replication licensing factor MCM7 |
| Gene Name: | MCM7, OSTLU_48809 |
| Ensembl Gene: | OSTLU_48809 |
| Ensembl Protein: | ABO94502 |
| Organism: | Ostreococcus lucimarinus |
| Taxa ID: | 436017 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Chromatin, Nucleolus, Centrosome/Spindle pole body, P-body, Stress granule, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ABO94502 | ABO94502 |
| UniProt | A4RSQ3, A4RSQ3_OSTLU | |
| GeneBank | CP000582 | ABO94502.1 |
| RefSeq | XM_001416172.1 | XP_001416209.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MADEAYTRER ELIREFLQTF EGRDGSPHYR RALQKVLDRQ SCCVDIDLQD VKEFCGALEE 60 61 REELLDRITS NCKRYATLFA EEIDGLIKNL ASSSASLSEV GEDDLDVFLQ RHSDDIGERS 120 121 ENPAPEVLRR AFDVFFKPLK GTKSLKMRDI RANMIGHYVT FKGMCTRITD VKPLIKVACY 180 181 TCEGCGHEYF QEINGNEFIP KQFCQSQTCN KKFALFIETR ASKFAKYQEV KVQEMSEDVP 240 241 IGHVPRSMSI SLIGEMTRKL APGDTIDISG VFLPRPSVGY LGNSSLVSTT YLYAMSVTPH 300 301 KSKTTSSDAT PEVLERLHKL RETPDIYTHL AKSIAPEIYG HVDIKKALLL LLCGGVTRTL 360 361 QDGVKIRGDV HVCLMGDPGV AKSQLLKQIV SIATRGVYTT GRGSSGVGLT ASIQRDNITS 420 421 ELVLEGGALV LADKGICCID EFDKMEESDR TAIHEVMEQQ TVSIAKAGIT TTLNARTTVL 480 481 AAANPAFGRY NTAATPQENI NLPAALLSRF DLMWLILDVP DPDSDIELAR HVMSVHREGR 540 541 PPSTSFDPVS TSELRAYIDV ARHFDPYIPE DLADDIASAY AGIRQVEDEA GSEATGYTTA 600 601 RTLLSIIRLA EALARLRWAP IVSGKDIEQA LNLMKMSKAS LEIHKSSTAL RSDPVENLYL 660 661 LLRNWASDHS NQFISASIVR QLATKSGLSG VLDACMSEYT ALGVWVMDSD SNITFVD 717 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCGATG AAGCATACAC GCGAGAGCGG GAGCTTATAC GAGAGTTTCT TCAGACATTC 60 61 GAAGGGAGAG ACGGCAGCCC ACATTACCGG CGCGCGCTGC AAAAAGTTTT GGACCGCCAA 120 121 AGTTGTTGCG TGGACATCGA TTTGCAGGAC GTGAAAGAGT TTTGCGGGGC ACTTGAAGAG 180 181 CGCGAGGAAC TCTTAGACCG GATCACGTCG AATTGCAAAC GCTACGCTAC TTTATTTGCG 240 241 GAAGAAATTG ACGGATTGAT AAAAAACCTG GCGTCTTCGA GTGCTTCACT CTCTGAAGTC 300 301 GGTGAAGATG ATCTAGACGT GTTTCTGCAG CGGCATTCCG ATGATATTGG CGAGCGAAGC 360 361 GAAAATCCAG CACCCGAAGT GTTACGACGT GCATTTGATG TTTTCTTCAA ACCCCTGAAA 420 421 GGAACTAAAT CTCTCAAGAT GCGCGACATA CGGGCTAATA TGATAGGGCA CTATGTCACT 480 481 TTCAAAGGCA TGTGTACACG GATAACTGAT GTGAAGCCGC TCATCAAGGT AGCCTGCTAT 540 541 ACATGTGAAG GTTGTGGACA CGAGTACTTC CAAGAAATCA ATGGCAACGA ATTCATCCCG 600 601 AAGCAGTTCT GCCAATCGCA AACTTGCAAC AAAAAGTTTG CACTATTCAT TGAAACACGG 660 661 GCGTCAAAAT TTGCAAAATA CCAGGAGGTC AAAGTGCAAG AAATGTCAGA AGACGTGCCG 720 721 ATCGGTCACG TTCCTAGGTC AATGTCGATA TCACTGATCG GTGAAATGAC TAGAAAGCTT 780 781 GCTCCGGGAG ATACAATTGA TATCAGTGGA GTTTTCCTAC CACGTCCAAG TGTTGGATAC 840 841 TTGGGCAACT CAAGTCTTGT TTCGACCACA TACTTGTATG CAATGTCGGT CACACCGCAT 900 901 AAGTCGAAGA CAACTAGCTC GGATGCGACT CCGGAGGTGC TGGAGAGGCT GCATAAGCTC 960 961 AGAGAAACCC CAGACATATA CACGCACTTA GCAAAATCTA TTGCCCCTGA AATTTATGGC 1020 1021 CACGTTGACA TAAAAAAAGC TCTTTTACTG TTGCTATGTG GTGGAGTAAC GAGAACACTC 1080 1081 CAAGATGGTG TCAAGATTCG TGGTGATGTT CATGTTTGTC TTATGGGCGA TCCCGGTGTT 1140 1141 GCCAAATCCC AGCTGTTGAA ACAGATAGTC TCTATTGCAA CTCGCGGAGT TTATACAACT 1200 1201 GGGCGGGGCA GCAGTGGTGT AGGTCTTACA GCGTCAATTC AAAGAGATAA CATTACAAGC 1260 1261 GAATTAGTGC TAGAAGGTGG TGCGCTCGTA CTAGCTGATA AAGGTATATG CTGCATAGAC 1320 1321 GAATTCGATA AAATGGAAGA AAGCGATCGA ACGGCTATAC ATGAAGTCAT GGAGCAGCAA 1380 1381 ACCGTCAGTA TCGCGAAAGC TGGGATAACC ACAACTCTAA ATGCACGAAC AACAGTCCTC 1440 1441 GCAGCAGCAA ATCCGGCATT TGGTAGATAC AATACAGCTG CTACACCCCA GGAGAATATT 1500 1501 AATCTACCGG CGGCACTCCT AAGTAGGTTT GATTTGATGT GGCTTATTTT GGACGTTCCT 1560 1561 GATCCCGACT CTGACATTGA ACTGGCTCGC CATGTTATGA GCGTACATCG CGAAGGTCGC 1620 1621 CCACCGTCCA CAAGTTTTGA TCCAGTCTCA ACCTCTGAAC TGCGAGCTTA CATAGATGTC 1680 1681 GCGCGGCATT TTGACCCTTA CATCCCGGAA GACCTTGCAG ACGACATCGC CAGTGCATAT 1740 1741 GCCGGTATTC GTCAGGTTGA AGATGAAGCT GGAAGTGAGG CGACTGGTTA TACCACCGCT 1800 1801 CGTACGCTAC TATCTATCAT TCGACTTGCA GAAGCTCTCG CACGGCTCCG TTGGGCACCT 1860 1861 ATTGTCTCCG GGAAAGATAT CGAACAGGCA CTCAACCTGA TGAAGATGTC GAAGGCGAGT 1920 1921 CTAGAAATTC ACAAGTCGTC AACAGCACTA CGCTCGGATC CCGTCGAGAA TTTGTATTTG 1980 1981 CTTCTACGGA ACTGGGCTAG TGATCACTCG AATCAATTCA TAAGCGCTTC TATAGTTCGT 2040 2041 CAGCTGGCGA CGAAAAGTGG CTTATCAGGT GTCCTTGATG CTTGCATGAG TGAGTATACG 2100 2101 GCTCTCGGGG TGTGGGTTAT GGACAGTGAC AGCAACATAA CGTTCGTAGA CTAG 2154 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | MCM complex | |
Cellular Component | THO complex | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA helicase activity | |
Biological Process | Cell cycle | |
Biological Process | DNA replication initiation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Dio-1502 | Dipodomys ordii | 54.93 | 2e-112 | 350 |
| LLPS-Brd-0828 | Brachypodium distachyon | 50.89 | 0.0 | 661 |
| LLPS-Php-0604 | Physcomitrella patens | 50.76 | 0.0 | 671 |
| LLPS-Tra-0534 | Triticum aestivum | 50.76 | 0.0 | 657 |
| LLPS-Hov-0021 | Hordeum vulgare | 50.76 | 0.0 | 657 |
| LLPS-Coc-1470 | Corchorus capsularis | 50.66 | 0.0 | 625 |
| LLPS-Crn-0189 | Cryptococcus neoformans | 50.63 | 0.0 | 585 |
| LLPS-Orbr-0476 | Oryza brachyantha | 50.62 | 0.0 | 658 |
| LLPS-Tru-1912 | Triticum urartu | 50.62 | 0.0 | 655 |
| LLPS-Ors-0299 | Oryza sativa | 50.21 | 0.0 | 652 |
| LLPS-Org-0639 | Oryza glaberrima | 50.21 | 0.0 | 652 |
| LLPS-Sem-1236 | Selaginella moellendorffii | 50.21 | 0.0 | 635 |
| LLPS-Ori-0565 | Oryza indica | 50.21 | 0.0 | 652 |
| LLPS-Mua-0804 | Musa acuminata | 50.07 | 0.0 | 651 |
| LLPS-Sei-0391 | Setaria italica | 50.0 | 0.0 | 655 |
| LLPS-Orgl-1284 | Oryza glumaepatula | 49.93 | 0.0 | 640 |
| LLPS-Cus-0285 | Cucumis sativus | 49.86 | 0.0 | 671 |
| LLPS-Orr-0417 | Oryza rufipogon | 49.79 | 0.0 | 639 |
| LLPS-Orm-1216 | Oryza meridionalis | 49.79 | 0.0 | 628 |
| LLPS-Orni-0603 | Oryza nivara | 49.79 | 0.0 | 639 |
| LLPS-Orb-0135 | Oryza barthii | 49.79 | 0.0 | 639 |
| LLPS-Sob-0464 | Sorghum bicolor | 49.73 | 0.0 | 651 |
| LLPS-Zem-0832 | Zea mays | 49.73 | 0.0 | 653 |
| LLPS-Amt-1936 | Amborella trichopoda | 49.59 | 0.0 | 657 |
| LLPS-Lep-0317 | Leersia perrieri | 49.59 | 0.0 | 632 |
| LLPS-Orp-0050 | Oryza punctata | 49.45 | 0.0 | 630 |
| LLPS-Prp-0681 | Prunus persica | 49.45 | 0.0 | 666 |
| LLPS-Brn-1232 | Brassica napus | 49.31 | 0.0 | 671 |
| LLPS-Met-1535 | Medicago truncatula | 49.24 | 0.0 | 660 |
| LLPS-Dac-0092 | Daucus carota | 49.22 | 0.0 | 654 |
| LLPS-Miv-0752 | Microbotryum violaceum | 49.21 | 0.0 | 559 |
| LLPS-Bro-0700 | Brassica oleracea | 49.18 | 0.0 | 669 |
| LLPS-Phv-0349 | Phaseolus vulgaris | 49.1 | 0.0 | 654 |
| LLPS-Vir-0823 | Vigna radiata | 49.1 | 0.0 | 655 |
| LLPS-Via-0304 | Vigna angularis | 49.1 | 0.0 | 655 |
| LLPS-Sot-0357 | Solanum tuberosum | 49.04 | 0.0 | 669 |
| LLPS-Mae-0228 | Manihot esculenta | 48.97 | 0.0 | 660 |
| LLPS-Glm-2462 | Glycine max | 48.96 | 0.0 | 650 |
| LLPS-Nia-1476 | Nicotiana attenuata | 48.9 | 0.0 | 660 |
| LLPS-Brr-0710 | Brassica rapa | 48.9 | 0.0 | 664 |
| LLPS-Art-0744 | Arabidopsis thaliana | 48.84 | 0.0 | 660 |
| LLPS-Thc-0260 | Theobroma cacao | 48.84 | 0.0 | 650 |
| LLPS-Pot-0200 | Populus trichocarpa | 48.83 | 0.0 | 661 |
| LLPS-Sol-0375 | Solanum lycopersicum | 48.77 | 0.0 | 669 |
| LLPS-Viv-0356 | Vitis vinifera | 48.56 | 0.0 | 645 |
| LLPS-Asm-0402 | Astyanax mexicanus | 48.54 | 2e-162 | 488 |
| LLPS-Gor-1001 | Gossypium raimondii | 48.42 | 0.0 | 653 |
| LLPS-Lac-0987 | Latimeria chalumnae | 48.25 | 1e-169 | 508 |
| LLPS-Hea-1096 | Helianthus annuus | 48.21 | 0.0 | 661 |
| LLPS-Arl-0638 | Arabidopsis lyrata | 48.14 | 0.0 | 659 |
| LLPS-Tar-1272 | Takifugu rubripes | 48.11 | 0.0 | 561 |
| LLPS-Pes-0904 | Pelodiscus sinensis | 47.66 | 3e-172 | 515 |
| LLPS-Coo-0200 | Colletotrichum orbiculare | 47.17 | 0.0 | 573 |
| LLPS-Trr-0880 | Trichoderma reesei | 47.04 | 0.0 | 546 |
| LLPS-Fuo-0025 | Fusarium oxysporum | 46.99 | 0.0 | 574 |
| LLPS-Abg-0453 | Absidia glauca | 46.97 | 0.0 | 583 |
| LLPS-Scj-0023 | Schizosaccharomyces japonicus | 46.93 | 0.0 | 570 |
| LLPS-Nec-0824 | Neurospora crassa | 46.82 | 0.0 | 555 |
| LLPS-Mup-0469 | Mustela putorius furo | 46.66 | 0.0 | 541 |
| LLPS-Fuv-0684 | Fusarium verticillioides | 46.6 | 0.0 | 575 |
| LLPS-Scc-0192 | Schizosaccharomyces cryophilus | 46.54 | 0.0 | 574 |
| LLPS-Scp-0701 | Schizosaccharomyces pombe | 46.54 | 0.0 | 584 |
| LLPS-Tum-0440 | Tuber melanosporum | 46.52 | 0.0 | 598 |
| LLPS-Fus-0248 | Fusarium solani | 46.45 | 0.0 | 572 |
| LLPS-Cis-0181 | Ciona savignyi | 46.3 | 3e-167 | 502 |
| LLPS-Scm-0687 | Scophthalmus maximus | 46.24 | 0.0 | 565 |
| LLPS-Mea-2244 | Mesocricetus auratus | 46.19 | 0.0 | 555 |
| LLPS-Orl-0074 | Oryzias latipes | 46.15 | 0.0 | 563 |
| LLPS-Otg-1868 | Otolemur garnettii | 46.13 | 0.0 | 562 |
| LLPS-Loa-0128 | Loxodonta africana | 46.12 | 0.0 | 560 |
| LLPS-Orn-1852 | Oreochromis niloticus | 46.08 | 0.0 | 563 |
| LLPS-Ran-1358 | Rattus norvegicus | 46.06 | 0.0 | 565 |
| LLPS-Ten-0068 | Tetraodon nigroviridis | 46.04 | 0.0 | 561 |
| LLPS-Myl-1003 | Myotis lucifugus | 46.0 | 0.0 | 562 |
| LLPS-Caj-1589 | Callithrix jacchus | 45.93 | 0.0 | 555 |
| LLPS-Rhb-0826 | Rhinopithecus bieti | 45.85 | 0.0 | 561 |
| LLPS-Cogr-0622 | Colletotrichum graminicola | 45.75 | 0.0 | 572 |
| LLPS-Xim-0956 | Xiphophorus maculatus | 45.75 | 0.0 | 560 |
| LLPS-Fec-1644 | Felis catus | 45.73 | 0.0 | 560 |
| LLPS-Fud-0420 | Fukomys damarensis | 45.73 | 0.0 | 560 |
| LLPS-Sus-0950 | Sus scrofa | 45.73 | 0.0 | 560 |
| LLPS-Chs-0360 | Chlorocebus sabaeus | 45.71 | 0.0 | 560 |
| LLPS-Leo-2618 | Lepisosteus oculatus | 45.66 | 0.0 | 560 |
| LLPS-Mam-1978 | Macaca mulatta | 45.64 | 0.0 | 551 |
| LLPS-Cas-0994 | Carlito syrichta | 45.62 | 0.0 | 553 |
| LLPS-Caf-0177 | Canis familiaris | 45.59 | 0.0 | 558 |
| LLPS-Bot-0778 | Bos taurus | 45.59 | 0.0 | 561 |
| LLPS-Man-1394 | Macaca nemestrina | 45.58 | 0.0 | 558 |
| LLPS-Eqc-1664 | Equus caballus | 45.58 | 0.0 | 556 |
| LLPS-Poa-1362 | Pongo abelii | 45.58 | 0.0 | 559 |
| LLPS-Maf-0261 | Macaca fascicularis | 45.58 | 0.0 | 558 |
| LLPS-Aon-2388 | Aotus nancymaae | 45.58 | 0.0 | 559 |
| LLPS-Cea-0607 | Cercocebus atys | 45.58 | 0.0 | 559 |
| LLPS-Aim-0110 | Ailuropoda melanoleuca | 45.58 | 0.0 | 557 |
| LLPS-Mal-2610 | Mandrillus leucophaeus | 45.58 | 0.0 | 556 |
| LLPS-Paa-0631 | Papio anubis | 45.58 | 0.0 | 559 |
| LLPS-Mod-2290 | Monodelphis domestica | 45.52 | 0.0 | 557 |
| LLPS-Mum-1489 | Mus musculus | 45.52 | 0.0 | 560 |
| LLPS-Pof-0090 | Poecilia formosa | 45.48 | 0.0 | 555 |
| LLPS-Icp-0471 | Ictalurus punctatus | 45.39 | 0.0 | 560 |
| LLPS-Nol-1428 | Nomascus leucogenys | 45.38 | 0.0 | 561 |
| LLPS-Hos-1113 | Homo sapiens | 45.24 | 0.0 | 560 |
| LLPS-Pap-0600 | Pan paniscus | 45.24 | 0.0 | 560 |
| LLPS-Pat-1350 | Pan troglodytes | 45.24 | 0.0 | 560 |
| LLPS-Gog-2030 | Gorilla gorilla | 45.24 | 0.0 | 559 |
| LLPS-Ict-0114 | Ictidomys tridecemlineatus | 45.18 | 0.0 | 553 |
| LLPS-Cap-0510 | Cavia porcellus | 45.18 | 0.0 | 554 |
| LLPS-Scf-1283 | Scleropages formosus | 45.03 | 0.0 | 557 |
| LLPS-Asf-0806 | Aspergillus flavus | 44.99 | 0.0 | 577 |
| LLPS-Pyt-0117 | Pyrenophora teres | 44.99 | 0.0 | 568 |
| LLPS-Pytr-0050 | Pyrenophora triticirepentis | 44.85 | 0.0 | 570 |
| LLPS-Ved-0080 | Verticillium dahliae | 44.84 | 0.0 | 585 |
| LLPS-Beb-0877 | Beauveria bassiana | 44.81 | 0.0 | 565 |
| LLPS-Asc-0781 | Aspergillus clavatus | 44.81 | 0.0 | 591 |
| LLPS-Spr-0390 | Sporisorium reilianum | 44.8 | 0.0 | 567 |
| LLPS-Orc-0284 | Oryctolagus cuniculus | 44.79 | 0.0 | 545 |
| LLPS-Dos-0376 | Dothistroma septosporum | 44.76 | 0.0 | 578 |
| LLPS-Blg-0288 | Blumeria graminis | 44.71 | 1e-180 | 543 |
| LLPS-Sah-1054 | Sarcophilus harrisii | 44.7 | 0.0 | 548 |
| LLPS-Chr-0378 | Chlamydomonas reinhardtii | 44.64 | 0.0 | 560 |
| LLPS-Mel-0180 | Melampsora laricipopulina | 44.61 | 0.0 | 554 |
| LLPS-Phn-0681 | Phaeosphaeria nodorum | 44.6 | 0.0 | 574 |
| LLPS-Lem-0592 | Leptosphaeria maculans | 44.57 | 0.0 | 564 |
| LLPS-Sac-0488 | Saccharomyces cerevisiae | 44.53 | 0.0 | 563 |
| LLPS-Ova-0334 | Ovis aries | 44.5 | 1e-174 | 524 |
| LLPS-Usm-0478 | Ustilago maydis | 44.49 | 0.0 | 562 |
| LLPS-Drm-1371 | Drosophila melanogaster | 44.49 | 8e-180 | 538 |
| LLPS-Zyt-0009 | Zymoseptoria tritici | 44.44 | 0.0 | 579 |
| LLPS-Gag-0266 | Gaeumannomyces graminis | 44.41 | 0.0 | 548 |
| LLPS-Aso-0187 | Aspergillus oryzae | 44.34 | 0.0 | 585 |
| LLPS-Asni-0253 | Aspergillus niger | 44.32 | 0.0 | 590 |
| LLPS-Pug-0144 | Puccinia graminis | 44.3 | 0.0 | 549 |
| LLPS-Trv-0158 | Trichoderma virens | 44.21 | 0.0 | 577 |
| LLPS-Kop-0209 | Komagataella pastoris | 44.21 | 0.0 | 546 |
| LLPS-Asfu-0062 | Aspergillus fumigatus | 44.19 | 0.0 | 575 |
| LLPS-Ast-1043 | Aspergillus terreus | 44.16 | 0.0 | 583 |
| LLPS-Cym-0052 | Cyanidioschyzon merolae | 44.11 | 1e-179 | 541 |
| LLPS-Asn-0241 | Aspergillus nidulans | 44.05 | 0.0 | 583 |
| LLPS-Gas-0055 | Galdieria sulphuraria | 44.04 | 0.0 | 571 |
| LLPS-Mao-0643 | Magnaporthe oryzae | 44.01 | 8e-102 | 335 |
| LLPS-Nef-0323 | Neosartorya fischeri | 43.9 | 0.0 | 582 |
| LLPS-Cii-1377 | Ciona intestinalis | 43.76 | 5e-177 | 531 |
| LLPS-Cog-0510 | Colletotrichum gloeosporioides | 43.37 | 0.0 | 553 |
| LLPS-Put-0063 | Puccinia triticina | 42.99 | 3e-168 | 510 |
| LLPS-Yal-0763 | Yarrowia lipolytica | 42.78 | 0.0 | 557 |
| LLPS-Chc-0192 | Chondrus crispus | 42.38 | 9e-175 | 528 |
| LLPS-Gaa-1044 | Gasterosteus aculeatus | 42.28 | 2e-166 | 503 |
| LLPS-Cae-0175 | Caenorhabditis elegans | 42.23 | 8e-169 | 510 |
| LLPS-Asg-0209 | Ashbya gossypii | 41.63 | 0.0 | 585 |
| LLPS-Dar-1180 | Danio rerio | 41.59 | 7e-127 | 397 |
| LLPS-Anc-0281 | Anolis carolinensis | 35.67 | 4e-99 | 328 |