LLPS-Gaa-1044
MCM7
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | DNA replication licensing factor MCM7 |
| Gene Name: | MCM7 |
| Ensembl Gene: | ENSGACG00000016398.1 |
| Ensembl Protein: | ENSGACP00000021654.1 |
| Organism: | Gasterosteus aculeatus |
| Taxa ID: | 69293 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Chromatin, Nucleolus, Centrosome/Spindle pole body, P-body, Stress granule, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSGACT00000021695.1 | ENSGACP00000021654.1 |
| UniProt | G3PVL5, G3PVL5_GASAC |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MARKDYAAEK EKCKRFLQEF YSEDDNGKKV FKYGAQLVAL AHREQVSIFV DLDDVAEEDP 60 61 ELVESICENA KRYTGLFADA IHELLPEYKE RDIVAKDSLD VYIEHRLMME QRGRDPADTR 120 121 DARNQYPPEL MRRFELYFKP PTTAKPKVVR DVRAESIGNL VNVRGIVTRA TEVKPMMAVA 180 181 TYTCDQCGAE TYQPIQSPTF MPLVMCPSQE CVTNKSGGRL YLQTRGSKFV KFQELRIQEH 240 241 SDQVPVGNIP RSMSIYARGE NTRLAQPGDH VAVTGVFLPL LRTGFKQATL QGLLSETYLE 300 301 AHNITLMNKS EDDELGNDDL TEEELRGITE EGFYEKLAGS IAPEIYGHED VKKALLLLLV 360 361 GGVQQAPKGM KIRGNINICL MGDPGVAKSQ LLSYIDRLAP RSQYTTGRGS SGVGLTAAVM 420 421 RDSVTGEMTL EGGALVLADQ GVCCIDEFDK MADADRTAIH EVMEQQTISI AKAGIMTSLN 480 481 ARCSILAAAN PAYGRYNPRK TIEQNIQLPA ALLSRFDLLW LIQDKPDADA DLRLAQHITY 540 541 VHQHCRQPPT HFTPIDMKLM RCGSKSSDSF ESQMWDVNPA GVTSPCVARL RHDGDGGEVN 600 601 EAMRMMEMSK DSLQADKSSA TRTQRPADVI FSLVRELSTV VRMAEAEQRC VSRGFTPAQF 660 661 QEALEEYEEL NVWQVNQART RVTFV 685 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCTCGTA AGGATTATGC GGCGGAGAAA GAGAAATGCA AACGGTTCCT GCAGGAGTTT 60 61 TACTCTGAGG ACGACAACGG GAAGAAAGTG TTCAAATATG GAGCTCAACT TGTGGCCTTG 120 121 GCCCACCGGG AGCAGGTGTC CATCTTTGTG GATCTCGACG ATGTGGCTGA AGAAGACCCG 180 181 GAGCTGGTCG AGAGCATCTG TGAGAACGCC AAGCGCTACA CGGGCCTGTT CGCCGACGCC 240 241 ATCCACGAGC TGCTGCCAGA GTACAAAGAA AGAGACATTG TTGCCAAGGA TTCTTTGGAC 300 301 GTGTACATTG AGCACAGGCT GATGATGGAG CAGAGAGGTC GTGACCCCGC AGACACCAGA 360 361 GACGCTCGTA ACCAGTACCC GCCTGAGCTC ATGAGGAGAT TTGAGCTGTA CTTCAAGCCT 420 421 CCCACGACGG CTAAACCCAA AGTGGTGCGA GACGTGCGGG CGGAGAGCAT CGGGAATCTG 480 481 GTGAACGTTC GAGGAATCGT GACCCGCGCC ACCGAGGTCA AGCCGATGAT GGCGGTCGCC 540 541 ACGTACACGT GTGACCAGTG TGGTGCAGAA ACCTATCAGC CGATCCAGTC TCCCACCTTC 600 601 ATGCCCCTCG TCATGTGTCC CAGCCAGGAG TGTGTCACCA ACAAATCCGG CGGTCGACTC 660 661 TACCTGCAGA CCAGAGGCTC CAAGTTCGTC AAGTTCCAGG AGCTGCGTAT CCAGGAGCAC 720 721 AGCGACCAGG TGCCCGTCGG GAACATTCCA CGCAGCATGT CCATCTATGC CCGCGGAGAA 780 781 AACACGCGCC TCGCCCAGCC GGGGGACCAC GTGGCCGTCA CTGGGGTCTT CCTCCCTCTC 840 841 CTGCGCACAG GCTTCAAGCA GGCCACCCTT CAGGGTCTTC TGTCAGAAAC GTACCTGGAG 900 901 GCTCATAACA TCACACTCAT GAACAAGTCG GAGGATGATG AGCTCGGCAA TGACGATCTA 960 961 ACTGAAGAGG AGCTTCGCGG CATCACAGAG GAAGGCTTCT ACGAGAAGCT GGCTGGCTCC 1020 1021 ATAGCACCAG AGATCTATGG CCATGAAGAC GTCAAGAAGG CTCTGCTGCT GCTGCTGGTC 1080 1081 GGGGGGGTCC AACAAGCCCC CAAAGGCATG AAAATCCGAG GCAACATAAA CATCTGCCTG 1140 1141 ATGGGGGACC CCGGAGTGGC CAAGTCCCAG CTGCTGTCCT ACATCGACCG CCTGGCTCCT 1200 1201 CGCAGTCAGT ACACAACGGG CCGCGGCTCA TCTGGCGTCG GCCTGACCGC CGCGGTGATG 1260 1261 CGAGACTCGG TGACCGGGGA AATGACTCTG GAAGGCGGCG CCTTGGTGCT CGCCGACCAG 1320 1321 GGCGTCTGCT GCATCGATGA GTTCGACAAG ATGGCCGACG CCGACCGCAC AGCCATCCAC 1380 1381 GAGGTGATGG AGCAGCAGAC CATCTCCATC GCTAAGGCGG GCATCATGAC CTCCCTCAAC 1440 1441 GCCCGCTGCT CCATCCTAGC AGCGGCCAAC CCCGCCTACG GCCGCTACAA CCCCCGCAAG 1500 1501 ACCATCGAGC AGAACATCCA GCTGCCCGCC GCCCTGCTGT CCCGCTTCGA CCTGCTGTGG 1560 1561 CTGATCCAGG ACAAGCCGGA CGCCGACGCC GACCTGCGTC TGGCGCAGCA CATCACCTAC 1620 1621 GTCCACCAGC ACTGCCGCCA GCCCCCCACC CACTTCACCC CCATCGACAT GAAGCTGATG 1680 1681 AGATGTGGGT CCAAAAGTAG CGACTCGTTT GAAAGCCAGA TGTGGGATGT GAACCCCGCA 1740 1741 GGCGTTACAT CGCCGTGTGT AGCTCGCCTG CGGCATGATG GAGACGGTGG AGAAGTGAAC 1800 1801 GAGGCCATGA GGATGATGGA GATGTCCAAG GATTCGCTAC AAGCCGACAA GTCCAGCGCC 1860 1861 ACGAGGACTC AGCGCCCGGC CGACGTCATC TTCTCCCTGG TGCGCGAGCT CTCCACGGTG 1920 1921 GTCCGCATGG CCGAAGCGGA GCAGCGCTGC GTCTCTCGGG GCTTCACGCC CGCCCAGTTC 1980 1981 CAGGAGGCGC TGGAGGAGTA CGAGGAGCTC AACGTGTGGC AGGTGAACCA GGCCCGCACG 2040 2041 CGCGTCACCT TCGTCTGA 2058 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | MCM complex | |
Cellular Component | Nucleus | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA helicase activity | |
Biological Process | Cell cycle | |
Biological Process | DNA replication initiation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Asm-0402 | Astyanax mexicanus | 90.55 | 0.0 | 1041 |
| LLPS-Scm-0687 | Scophthalmus maximus | 84.62 | 0.0 | 1219 |
| LLPS-Orn-1852 | Oreochromis niloticus | 84.53 | 0.0 | 1220 |
| LLPS-Tar-1272 | Takifugu rubripes | 84.07 | 0.0 | 1204 |
| LLPS-Pof-0090 | Poecilia formosa | 83.86 | 0.0 | 1216 |
| LLPS-Ten-0068 | Tetraodon nigroviridis | 83.42 | 0.0 | 1210 |
| LLPS-Xim-0956 | Xiphophorus maculatus | 83.17 | 0.0 | 1211 |
| LLPS-Orl-0074 | Oryzias latipes | 83.1 | 0.0 | 1199 |
| LLPS-Scf-1283 | Scleropages formosus | 80.55 | 0.0 | 1162 |
| LLPS-Icp-0471 | Ictalurus punctatus | 78.42 | 0.0 | 1139 |
| LLPS-Leo-2618 | Lepisosteus oculatus | 77.01 | 0.0 | 1126 |
| LLPS-Lac-0987 | Latimeria chalumnae | 75.77 | 0.0 | 910 |
| LLPS-Mup-0469 | Mustela putorius furo | 74.59 | 0.0 | 1004 |
| LLPS-Pat-1350 | Pan troglodytes | 74.58 | 0.0 | 1075 |
| LLPS-Pap-0600 | Pan paniscus | 74.58 | 0.0 | 1075 |
| LLPS-Fud-0420 | Fukomys damarensis | 74.44 | 0.0 | 1075 |
| LLPS-Cap-0510 | Cavia porcellus | 74.44 | 0.0 | 1077 |
| LLPS-Hos-1113 | Homo sapiens | 74.44 | 0.0 | 1073 |
| LLPS-Caj-1589 | Callithrix jacchus | 74.37 | 0.0 | 1060 |
| LLPS-Aon-2388 | Aotus nancymaae | 74.31 | 0.0 | 1075 |
| LLPS-Poa-1362 | Pongo abelii | 74.31 | 0.0 | 1073 |
| LLPS-Eqc-1664 | Equus caballus | 74.31 | 0.0 | 1076 |
| LLPS-Loa-0128 | Loxodonta africana | 74.31 | 0.0 | 1086 |
| LLPS-Aim-0110 | Ailuropoda melanoleuca | 74.17 | 0.0 | 1070 |
| LLPS-Myl-1003 | Myotis lucifugus | 74.17 | 0.0 | 1078 |
| LLPS-Bot-0778 | Bos taurus | 74.17 | 0.0 | 1075 |
| LLPS-Gog-2030 | Gorilla gorilla | 74.17 | 0.0 | 1071 |
| LLPS-Sus-0950 | Sus scrofa | 74.17 | 0.0 | 1075 |
| LLPS-Nol-1428 | Nomascus leucogenys | 74.17 | 0.0 | 1074 |
| LLPS-Caf-0177 | Canis familiaris | 74.17 | 0.0 | 1076 |
| LLPS-Chs-0360 | Chlorocebus sabaeus | 74.03 | 0.0 | 1073 |
| LLPS-Otg-1868 | Otolemur garnettii | 74.03 | 0.0 | 1073 |
| LLPS-Paa-0631 | Papio anubis | 73.89 | 0.0 | 1073 |
| LLPS-Cea-0607 | Cercocebus atys | 73.89 | 0.0 | 1073 |
| LLPS-Ict-0114 | Ictidomys tridecemlineatus | 73.89 | 0.0 | 1074 |
| LLPS-Rhb-0826 | Rhinopithecus bieti | 73.89 | 0.0 | 1071 |
| LLPS-Mal-2610 | Mandrillus leucophaeus | 73.75 | 0.0 | 1069 |
| LLPS-Maf-0261 | Macaca fascicularis | 73.75 | 0.0 | 1070 |
| LLPS-Cas-0994 | Carlito syrichta | 73.75 | 0.0 | 1062 |
| LLPS-Fec-1644 | Felis catus | 73.75 | 0.0 | 1069 |
| LLPS-Man-1394 | Macaca nemestrina | 73.75 | 0.0 | 1070 |
| LLPS-Mod-2290 | Monodelphis domestica | 73.59 | 0.0 | 1067 |
| LLPS-Orc-0284 | Oryctolagus cuniculus | 73.51 | 0.0 | 1057 |
| LLPS-Mam-1978 | Macaca mulatta | 73.48 | 0.0 | 1050 |
| LLPS-Ran-1358 | Rattus norvegicus | 73.06 | 0.0 | 1057 |
| LLPS-Mea-2244 | Mesocricetus auratus | 73.05 | 0.0 | 1034 |
| LLPS-Sah-1054 | Sarcophilus harrisii | 73.03 | 0.0 | 1056 |
| LLPS-Mum-1489 | Mus musculus | 72.64 | 0.0 | 1052 |
| LLPS-Ova-0334 | Ovis aries | 72.36 | 0.0 | 1034 |
| LLPS-Pes-0904 | Pelodiscus sinensis | 72.08 | 0.0 | 878 |
| LLPS-Dio-1502 | Dipodomys ordii | 71.23 | 4e-168 | 493 |
| LLPS-Dar-1180 | Danio rerio | 70.24 | 0.0 | 805 |
| LLPS-Xet-2353 | Xenopus tropicalis | 64.56 | 0.0 | 629 |
| LLPS-Cis-0181 | Ciona savignyi | 63.55 | 0.0 | 777 |
| LLPS-Cii-1377 | Ciona intestinalis | 63.16 | 0.0 | 877 |
| LLPS-Drm-1371 | Drosophila melanogaster | 62.85 | 0.0 | 869 |
| LLPS-Asc-0781 | Aspergillus clavatus | 48.97 | 0.0 | 597 |
| LLPS-Cae-0175 | Caenorhabditis elegans | 48.87 | 0.0 | 627 |
| LLPS-Anc-0281 | Anolis carolinensis | 48.71 | 0.0 | 571 |
| LLPS-Coc-1470 | Corchorus capsularis | 48.53 | 6e-175 | 560 |
| LLPS-Asfu-0062 | Aspergillus fumigatus | 47.99 | 0.0 | 573 |
| LLPS-Nef-0323 | Neosartorya fischeri | 47.95 | 0.0 | 587 |
| LLPS-Cus-0285 | Cucumis sativus | 47.94 | 0.0 | 595 |
| LLPS-Php-0604 | Physcomitrella patens | 47.8 | 0.0 | 602 |
| LLPS-Brn-1232 | Brassica napus | 47.55 | 0.0 | 595 |
| LLPS-Prp-0681 | Prunus persica | 47.54 | 0.0 | 592 |
| LLPS-Abg-0453 | Absidia glauca | 47.41 | 0.0 | 560 |
| LLPS-Bro-0700 | Brassica oleracea | 47.41 | 0.0 | 593 |
| LLPS-Trr-0880 | Trichoderma reesei | 47.39 | 4e-176 | 525 |
| LLPS-Orgl-1284 | Oryza glumaepatula | 47.28 | 0.0 | 574 |
| LLPS-Sot-0357 | Solanum tuberosum | 47.25 | 0.0 | 592 |
| LLPS-Hea-1096 | Helianthus annuus | 47.25 | 0.0 | 593 |
| LLPS-Amt-1936 | Amborella trichopoda | 47.2 | 0.0 | 592 |
| LLPS-Nia-1476 | Nicotiana attenuata | 47.17 | 0.0 | 585 |
| LLPS-Orni-0603 | Oryza nivara | 47.14 | 0.0 | 573 |
| LLPS-Orb-0135 | Oryza barthii | 47.14 | 0.0 | 573 |
| LLPS-Orr-0417 | Oryza rufipogon | 47.14 | 0.0 | 573 |
| LLPS-Art-0744 | Arabidopsis thaliana | 47.13 | 0.0 | 590 |
| LLPS-Sem-1236 | Selaginella moellendorffii | 47.08 | 0.0 | 564 |
| LLPS-Spr-0390 | Sporisorium reilianum | 47.05 | 0.0 | 573 |
| LLPS-Brr-0710 | Brassica rapa | 47.0 | 0.0 | 588 |
| LLPS-Lep-0317 | Leersia perrieri | 46.99 | 0.0 | 569 |
| LLPS-Asni-0253 | Aspergillus niger | 46.99 | 0.0 | 577 |
| LLPS-Thc-0260 | Theobroma cacao | 46.99 | 0.0 | 586 |
| LLPS-Viv-0356 | Vitis vinifera | 46.99 | 0.0 | 587 |
| LLPS-Sol-0375 | Solanum lycopersicum | 46.98 | 0.0 | 588 |
| LLPS-Brd-0828 | Brachypodium distachyon | 46.9 | 0.0 | 586 |
| LLPS-Asn-0241 | Aspergillus nidulans | 46.88 | 0.0 | 578 |
| LLPS-Arl-0638 | Arabidopsis lyrata | 46.86 | 0.0 | 586 |
| LLPS-Gor-1001 | Gossypium raimondii | 46.86 | 0.0 | 590 |
| LLPS-Orp-0050 | Oryza punctata | 46.85 | 0.0 | 565 |
| LLPS-Met-1535 | Medicago truncatula | 46.84 | 0.0 | 589 |
| LLPS-Orm-1216 | Oryza meridionalis | 46.81 | 0.0 | 563 |
| LLPS-Ori-0565 | Oryza indica | 46.76 | 0.0 | 581 |
| LLPS-Org-0639 | Oryza glaberrima | 46.76 | 0.0 | 581 |
| LLPS-Orbr-0476 | Oryza brachyantha | 46.76 | 0.0 | 582 |
| LLPS-Ors-0299 | Oryza sativa | 46.76 | 0.0 | 581 |
| LLPS-Mua-0804 | Musa acuminata | 46.7 | 0.0 | 578 |
| LLPS-Mae-0228 | Manihot esculenta | 46.57 | 0.0 | 584 |
| LLPS-Dac-0092 | Daucus carota | 46.51 | 0.0 | 575 |
| LLPS-Aso-0187 | Aspergillus oryzae | 46.4 | 0.0 | 584 |
| LLPS-Vir-0823 | Vigna radiata | 46.39 | 0.0 | 578 |
| LLPS-Hov-0021 | Hordeum vulgare | 46.34 | 0.0 | 573 |
| LLPS-Tra-0534 | Triticum aestivum | 46.34 | 0.0 | 573 |
| LLPS-Tru-1912 | Triticum urartu | 46.34 | 0.0 | 571 |
| LLPS-Via-0304 | Vigna angularis | 46.29 | 0.0 | 582 |
| LLPS-Crn-0189 | Cryptococcus neoformans | 46.27 | 0.0 | 568 |
| LLPS-Sob-0464 | Sorghum bicolor | 46.23 | 0.0 | 582 |
| LLPS-Blg-0288 | Blumeria graminis | 46.19 | 0.0 | 555 |
| LLPS-Asf-0806 | Aspergillus flavus | 46.09 | 0.0 | 566 |
| LLPS-Pot-0200 | Populus trichocarpa | 46.08 | 0.0 | 584 |
| LLPS-Ast-1043 | Aspergillus terreus | 46.06 | 0.0 | 567 |
| LLPS-Miv-0752 | Microbotryum violaceum | 46.03 | 0.0 | 567 |
| LLPS-Sei-0391 | Setaria italica | 45.95 | 0.0 | 578 |
| LLPS-Phn-0681 | Phaeosphaeria nodorum | 45.93 | 0.0 | 563 |
| LLPS-Phv-0349 | Phaseolus vulgaris | 45.91 | 0.0 | 576 |
| LLPS-Scp-0701 | Schizosaccharomyces pombe | 45.9 | 0.0 | 561 |
| LLPS-Zem-0832 | Zea mays | 45.82 | 0.0 | 578 |
| LLPS-Coo-0200 | Colletotrichum orbiculare | 45.79 | 0.0 | 564 |
| LLPS-Glm-2462 | Glycine max | 45.64 | 0.0 | 571 |
| LLPS-Usm-0478 | Ustilago maydis | 45.61 | 0.0 | 562 |
| LLPS-Scc-0192 | Schizosaccharomyces cryophilus | 45.53 | 0.0 | 555 |
| LLPS-Beb-0877 | Beauveria bassiana | 45.45 | 0.0 | 553 |
| LLPS-Pyt-0117 | Pyrenophora teres | 45.42 | 0.0 | 558 |
| LLPS-Mao-0779 | Magnaporthe oryzae | 45.42 | 0.0 | 559 |
| LLPS-Pytr-0050 | Pyrenophora triticirepentis | 45.37 | 0.0 | 558 |
| LLPS-Tum-0440 | Tuber melanosporum | 45.3 | 0.0 | 558 |
| LLPS-Lem-0592 | Leptosphaeria maculans | 45.23 | 0.0 | 551 |
| LLPS-Cogr-0622 | Colletotrichum graminicola | 45.22 | 0.0 | 563 |
| LLPS-Scj-0023 | Schizosaccharomyces japonicus | 45.21 | 0.0 | 568 |
| LLPS-Trv-0158 | Trichoderma virens | 45.18 | 0.0 | 557 |
| LLPS-Fus-0248 | Fusarium solani | 45.12 | 0.0 | 543 |
| LLPS-Nec-0824 | Neurospora crassa | 44.99 | 0.0 | 548 |
| LLPS-Ved-0080 | Verticillium dahliae | 44.88 | 0.0 | 556 |
| LLPS-Gag-0266 | Gaeumannomyces graminis | 44.7 | 0.0 | 552 |
| LLPS-Dos-0376 | Dothistroma septosporum | 44.7 | 0.0 | 543 |
| LLPS-Zyt-0009 | Zymoseptoria tritici | 44.55 | 0.0 | 553 |
| LLPS-Fuv-0684 | Fusarium verticillioides | 44.31 | 0.0 | 551 |
| LLPS-Fuo-0025 | Fusarium oxysporum | 44.31 | 0.0 | 549 |
| LLPS-Sac-0488 | Saccharomyces cerevisiae | 44.19 | 4e-180 | 541 |
| LLPS-Pug-0144 | Puccinia graminis | 44.11 | 0.0 | 555 |
| LLPS-Cym-0052 | Cyanidioschyzon merolae | 44.03 | 3e-160 | 490 |
| LLPS-Cog-0510 | Colletotrichum gloeosporioides | 43.98 | 0.0 | 565 |
| LLPS-Kop-0209 | Komagataella pastoris | 43.97 | 4e-180 | 540 |
| LLPS-Asg-0209 | Ashbya gossypii | 43.91 | 0.0 | 550 |
| LLPS-Yal-0763 | Yarrowia lipolytica | 43.32 | 0.0 | 558 |
| LLPS-Mel-0180 | Melampsora laricipopulina | 43.1 | 4e-176 | 530 |
| LLPS-Osl-0040 | Ostreococcus lucimarinus | 42.68 | 5e-165 | 498 |
| LLPS-Put-0063 | Puccinia triticina | 42.31 | 2e-168 | 509 |
| LLPS-Gas-0055 | Galdieria sulphuraria | 42.3 | 8e-172 | 519 |
| LLPS-Chr-0378 | Chlamydomonas reinhardtii | 41.92 | 8e-157 | 479 |
| LLPS-Chc-0200 | Chondrus crispus | 39.87 | 5e-88 | 299 |
| LLPS-Scs-0830 | Sclerotinia sclerotiorum | 34.86 | 1e-88 | 303 |