• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Fud-0420
MCM7

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: DNA replication licensing factor MCM7
Gene Name: MCM7, H920_01724
Ensembl Gene: ENSFDAG00000011387.1
Ensembl Protein: ENSFDAP00000001393.1
Organism: Fukomys damarensis
Taxa ID: 885580
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Chromatin, Nucleolus, Centrosome/Spindle pole body, P-body, Stress granule, OthersPredicted from orthologs(View)

▼ FUNCTION


Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MALKDYALEK  EKVKKFLQEF  YQDDEFGKKQ  FKYESQLVHL  AHREQVAMYV  DLDDVAEDDP  60
61    ELVDSICENA  KRYARLFADA  IQELLPQYKE  REVVNKDVLD  VYIEHRLMME  QRSRDPGATR  120
121   SPQNQYPPEL  MRRFELYFQG  PGSNKPRVIR  EVRADSVGKL  VTVRGIVTRV  SEVKPRMVVA  180
181   TYTCDQCGAE  TYQPIQAPTF  MPLIMCPSQE  CQTNRSGGRL  YLQTRGSKFI  KFQEMKMQEH  240
241   SDQVPVGNIP  RSITVMVEGE  NTRIAQPGDH  VSVTGIFLPV  LRTGFRQVVQ  GLLSETYLEA  300
301   HRIVKMNKSE  DDEAGAGELS  REELRQIAEE  DFYEKLAASI  APEIYGHEDV  KKALLLLLVG  360
361   GVDQSPRGMK  IRGNINICLM  GDPGVAKSQL  LSYIDRLAPR  SQYTTGRGSS  GVGLTAAVLR  420
421   DSVSGELTLE  GGALVLADQG  VCCIDEFDKM  AEADRTAIHE  VMEQQTISIA  KAGILTTLNA  480
481   RCSILAAANP  AYGRYNPRRS  LEQNIQLPAA  LLSRFDLLWL  IQDRPDRDND  LRLAQHITYV  540
541   HQHSRQPPAK  FEPLNMKLMR  RYIAMCREKQ  PTVPESLADY  ITAAYVEMRR  EAWASKDATY  600
601   TSARTLLAIL  RLSTALARLR  MVDTVEKEDV  NEAIRLMEMS  KDSLLGDKGQ  TARTQRPADV  660
661   IFATVRELVS  GSRSVRFSEA  EQRCISRGFT  PAQFQAALDE  YEELNVWQIN  VSRTRITFV  719
Nucleotide CDS Sequence (FASTA)
1     ATGGCATTGA  AGGACTACGC  ACTTGAGAAA  GAAAAGGTTA  AGAAGTTTCT  TCAAGAGTTT  60
61    TACCAGGATG  ATGAATTTGG  AAAGAAGCAG  TTCAAGTATG  AGAGTCAGTT  GGTTCATCTG  120
121   GCTCATCGGG  AACAAGTGGC  GATGTATGTC  GACCTGGATG  ACGTAGCTGA  GGATGACCCT  180
181   GAGTTGGTAG  ACTCGATTTG  TGAGAACGCC  AAGCGCTATG  CGAGGCTCTT  TGCTGATGCC  240
241   ATACAAGAGC  TCCTGCCTCA  GTACAAGGAG  AGGGAGGTAG  TAAATAAAGA  TGTTTTGGAT  300
301   GTTTATATTG  AGCACCGGCT  GATGATGGAA  CAGCGGAGCC  GGGACCCTGG  GGCAACCCGA  360
361   AGCCCCCAGA  ATCAGTACCC  TCCTGAGCTC  ATGCGCAGAT  TTGAGCTGTA  TTTTCAAGGT  420
421   CCAGGCAGCA  ACAAGCCTCG  TGTGATCCGG  GAAGTACGAG  CTGACTCTGT  GGGAAAGTTG  480
481   GTAACTGTGC  GTGGAATCGT  CACTCGTGTC  TCTGAAGTCA  AACCCAGGAT  GGTGGTGGCC  540
541   ACTTACACTT  GTGACCAGTG  TGGGGCAGAG  ACTTACCAAC  CGATCCAGGC  TCCCACATTC  600
601   ATGCCTCTGA  TCATGTGCCC  AAGCCAGGAG  TGCCAAACCA  ACCGCTCCGG  AGGGCGGCTG  660
661   TATCTGCAGA  CACGTGGCTC  CAAGTTCATC  AAATTCCAGG  AGATGAAAAT  GCAAGAACAT  720
721   AGTGACCAAG  TGCCTGTGGG  AAACATCCCT  CGAAGTATCA  CAGTGATGGT  AGAAGGAGAG  780
781   AACACAAGGA  TTGCCCAGCC  CGGGGACCAT  GTCAGTGTCA  CTGGTATCTT  CTTGCCAGTC  840
841   CTGCGCACAG  GGTTCCGACA  GGTAGTCCAG  GGCCTACTCT  CAGAAACTTA  CCTGGAAGCC  900
901   CACCGAATTG  TGAAGATGAA  TAAGAGTGAG  GATGATGAGG  CTGGGGCTGG  AGAGCTCAGC  960
961   AGGGAGGAAC  TGAGGCAAAT  TGCAGAGGAA  GATTTCTATG  AAAAGCTGGC  CGCTTCTATT  1020
1021  GCCCCAGAGA  TATATGGACA  TGAAGATGTG  AAGAAGGCAC  TATTGCTGCT  GCTGGTGGGT  1080
1081  GGCGTGGACC  AGTCTCCTCG  CGGCATGAAA  ATCAGAGGCA  ACATCAATAT  CTGCCTGATG  1140
1141  GGTGATCCTG  GTGTGGCCAA  GTCTCAGCTG  CTGTCTTACA  TTGATCGTCT  AGCACCCCGC  1200
1201  AGCCAGTATA  CAACCGGCCG  GGGCTCCTCT  GGAGTAGGGC  TCACAGCAGC  TGTTCTAAGG  1260
1261  GACTCTGTGA  GTGGAGAGCT  GACCTTAGAG  GGTGGGGCCC  TGGTGCTAGC  TGACCAGGGC  1320
1321  GTGTGCTGCA  TCGATGAGTT  TGACAAGATG  GCAGAAGCTG  ACCGCACAGC  CATCCATGAG  1380
1381  GTCATGGAGC  AGCAGACCAT  CTCCATAGCC  AAGGCTGGCA  TTCTTACCAC  ACTCAACGCC  1440
1441  CGCTGTTCCA  TCCTGGCTGC  TGCCAATCCT  GCCTATGGGC  GCTACAACCC  CCGCCGCAGC  1500
1501  CTGGAGCAAA  ACATACAGCT  TCCTGCTGCA  CTGCTGTCTC  GATTTGACCT  CCTCTGGCTG  1560
1561  ATTCAGGACC  GGCCTGACCG  AGACAATGAC  CTCCGGTTGG  CCCAGCACAT  CACCTATGTG  1620
1621  CACCAGCACA  GCCGGCAGCC  CCCTGCCAAG  TTTGAACCTT  TGAACATGAA  GCTTATGAGA  1680
1681  CGGTACATAG  CCATGTGCCG  TGAGAAGCAG  CCCACGGTAC  CCGAGTCCCT  GGCTGACTAT  1740
1741  ATCACAGCAG  CGTATGTGGA  GATGAGGCGA  GAGGCTTGGG  CCAGTAAAGA  TGCCACCTAC  1800
1801  ACCTCTGCCC  GGACCCTGCT  GGCTATTCTC  CGGCTTTCCA  CTGCTCTGGC  GCGCCTGCGA  1860
1861  ATGGTGGACA  CAGTGGAGAA  GGAAGATGTG  AATGAAGCCA  TAAGACTAAT  GGAGATGTCA  1920
1921  AAGGACTCAC  TTCTAGGCGA  CAAGGGGCAA  ACAGCTAGGA  CCCAGAGGCC  AGCAGATGTG  1980
1981  ATATTTGCCA  CTGTCCGTGA  ACTGGTCTCA  GGGAGCCGAA  GTGTCCGGTT  TTCTGAGGCA  2040
2041  GAGCAGCGCT  GTATATCACG  TGGCTTCACA  CCTGCCCAGT  TCCAGGCGGC  TCTAGATGAA  2100
2101  TACGAGGAGT  TAAATGTCTG  GCAGATCAAT  GTTTCCCGGA  CACGGATCAC  CTTTGTCTGA  2160

▼ KEYWORD


ID
Family
ATP-binding
Cell cycle
Complete proteome
DNA replication
DNA-binding
Helicase
Hydrolase
Nucleotide-binding
Nucleus
Reference proteome

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
MCM complex
Cellular Component
Nucleus
Molecular Function
ATP binding
Molecular Function
DNA binding
Molecular Function
DNA helicase activity
Biological Process
Cell cycle
Biological Process
DNA replication initiation

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cap-0510Cavia porcellus97.360.01437
LLPS-Sus-0950Sus scrofa96.80.01429
LLPS-Eqc-1664Equus caballus96.80.01431
LLPS-Ict-0114Ictidomys tridecemlineatus96.660.01431
LLPS-Caj-1589Callithrix jacchus96.470.01407
LLPS-Chs-0360Chlorocebus sabaeus96.380.01427
LLPS-Orc-0284Oryctolagus cuniculus96.260.01414
LLPS-Aon-2388Aotus nancymaae96.240.01424
LLPS-Nol-1428Nomascus leucogenys96.240.01423
LLPS-Mup-0469Mustela putorius furo96.130.01329
LLPS-Myl-1003Myotis lucifugus96.110.01425
LLPS-Paa-0631Papio anubis96.110.01426
LLPS-Cea-0607Cercocebus atys96.110.01426
LLPS-Poa-1362Pongo abelii96.110.01424
LLPS-Hos-1113Homo sapiens96.110.01423
LLPS-Otg-1868Otolemur garnettii96.110.01420
LLPS-Dio-1502Dipodomys ordii96.010.0 702
LLPS-Bot-0778Bos taurus95.970.01420
LLPS-Maf-0261Macaca fascicularis95.970.01424
LLPS-Gog-2030Gorilla gorilla95.970.01422
LLPS-Caf-0177Canis familiaris95.970.01421
LLPS-Man-1394Macaca nemestrina95.970.01424
LLPS-Pat-1350Pan troglodytes95.970.01422
LLPS-Pap-0600Pan paniscus95.970.01422
LLPS-Rhb-0826Rhinopithecus bieti95.970.01423
LLPS-Mal-2610Mandrillus leucophaeus95.830.01420
LLPS-Fec-1644Felis catus95.830.01420
LLPS-Aim-0110Ailuropoda melanoleuca95.690.01417
LLPS-Cas-0994Carlito syrichta95.690.01409
LLPS-Loa-0128Loxodonta africana95.130.01412
LLPS-Mam-1978Macaca mulatta94.850.01401
LLPS-Ova-0334Ovis aries94.30.01379
LLPS-Ran-1358Rattus norvegicus94.160.01394
LLPS-Mea-2244Mesocricetus auratus93.890.01363
LLPS-Mum-1489Mus musculus92.630.01375
LLPS-Mod-2290Monodelphis domestica92.290.01373
LLPS-Sah-1054Sarcophilus harrisii91.830.01361
LLPS-Pes-0904Pelodiscus sinensis85.040.01087
LLPS-Lac-0987Latimeria chalumnae83.060.01071
LLPS-Asm-0402Astyanax mexicanus80.670.0 961
LLPS-Orn-1852Oreochromis niloticus80.640.01223
LLPS-Ten-0068Tetraodon nigroviridis79.840.01205
LLPS-Tar-1272Takifugu rubripes79.780.01196
LLPS-Leo-2618Lepisosteus oculatus79.750.01209
LLPS-Xim-0956Xiphophorus maculatus79.70.01206
LLPS-Scf-1283Scleropages formosus79.420.01193
LLPS-Pof-0090Poecilia formosa79.420.01207
LLPS-Icp-0471Ictalurus punctatus79.360.01193
LLPS-Scm-0687Scophthalmus maximus78.540.01194
LLPS-Orl-0074Oryzias latipes78.270.01182
LLPS-Gaa-1044Gasterosteus aculeatus74.440.01082
LLPS-Dar-1180Danio rerio71.270.0 879
LLPS-Cis-0181Ciona savignyi68.170.0 891
LLPS-Drm-1371Drosophila melanogaster66.940.0 984
LLPS-Cii-1377Ciona intestinalis66.30.0 994
LLPS-Xet-2353Xenopus tropicalis61.590.0 785
LLPS-Anc-0281Anolis carolinensis55.320.0 739
LLPS-Scj-0023Schizosaccharomyces japonicus52.610.0 673
LLPS-Cae-0175Caenorhabditis elegans51.610.0 709
LLPS-Spr-0390Sporisorium reilianum51.140.0 671
LLPS-Trr-0880Trichoderma reesei50.930.0 597
LLPS-Sem-1236Selaginella moellendorffii50.860.0 648
LLPS-Miv-0752Microbotryum violaceum50.820.0 681
LLPS-Prp-0681Prunus persica50.620.0 667
LLPS-Coc-1470Corchorus capsularis50.590.0 624
LLPS-Pot-0200Populus trichocarpa50.480.0 660
LLPS-Crn-0189Cryptococcus neoformans50.420.0 668
LLPS-Mua-0804Musa acuminata50.410.0 665
LLPS-Php-0604Physcomitrella patens50.410.0 672
LLPS-Asc-0781Aspergillus clavatus50.340.0 663
LLPS-Viv-0356Vitis vinifera50.340.0 665
LLPS-Cus-0285Cucumis sativus50.280.0 669
LLPS-Thc-0260Theobroma cacao50.210.0 657
LLPS-Orbr-0476Oryza brachyantha50.210.0 665
LLPS-Gor-1001Gossypium raimondii50.140.0 665
LLPS-Usm-0478Ustilago maydis50.070.0 656
LLPS-Amt-1936Amborella trichopoda50.070.0 666
LLPS-Brn-0069Brassica napus50.00.0 664
LLPS-Arl-0638Arabidopsis lyrata49.930.0 664
LLPS-Sei-0391Setaria italica49.930.0 659
LLPS-Ori-0565Oryza indica49.930.0 661
LLPS-Org-0639Oryza glaberrima49.930.0 660
LLPS-Ors-0299Oryza sativa49.930.0 661
LLPS-Art-0744Arabidopsis thaliana49.860.0 662
LLPS-Bro-0700Brassica oleracea49.80.0 661
LLPS-Vir-0823Vigna radiata49.790.0 660
LLPS-Brd-0828Brachypodium distachyon49.730.0 662
LLPS-Beb-0877Beauveria bassiana49.730.0 642
LLPS-Nef-0323Neosartorya fischeri49.730.0 658
LLPS-Sot-0357Solanum tuberosum49.720.0 661
LLPS-Hea-1096Helianthus annuus49.720.0 675
LLPS-Sob-0464Sorghum bicolor49.660.0 657
LLPS-Asf-0806Aspergillus flavus49.650.0 636
LLPS-Aso-0187Aspergillus oryzae49.590.0 655
LLPS-Lep-0317Leersia perrieri49.520.0 642
LLPS-Orgl-1284Oryza glumaepatula49.520.0 647
LLPS-Zem-0832Zea mays49.520.0 657
LLPS-Asfu-0062Aspergillus fumigatus49.520.0 644
LLPS-Nia-1476Nicotiana attenuata49.450.0 654
LLPS-Mae-0228Manihot esculenta49.450.0 660
LLPS-Tum-0440Tuber melanosporum49.440.0 657
LLPS-Brr-0710Brassica rapa49.390.0 658
LLPS-Orb-0135Oryza barthii49.380.0 646
LLPS-Orni-0603Oryza nivara49.380.0 645
LLPS-Orr-0417Oryza rufipogon49.380.0 646
LLPS-Glm-2621Glycine max49.370.0 655
LLPS-Sol-0375Solanum lycopersicum49.310.0 656
LLPS-Trv-0158Trichoderma virens49.310.0 640
LLPS-Tra-0534Triticum aestivum49.240.0 654
LLPS-Hov-0021Hordeum vulgare49.240.0 654
LLPS-Met-1535Medicago truncatula49.240.0 662
LLPS-Tru-1912Triticum urartu49.240.0 654
LLPS-Asn-0241Aspergillus nidulans49.180.0 649
LLPS-Via-0304Vigna angularis49.170.0 660
LLPS-Scc-0192Schizosaccharomyces cryophilus49.160.0 651
LLPS-Orp-0050Oryza punctata49.110.0 637
LLPS-Pyt-0117Pyrenophora teres49.050.0 652
LLPS-Orm-1216Oryza meridionalis49.040.0 638
LLPS-Asni-0253Aspergillus niger48.980.0 655
LLPS-Pug-0144Puccinia graminis48.980.0 654
LLPS-Blg-0288Blumeria graminis48.920.0 645
LLPS-Pytr-0050Pyrenophora triticirepentis48.910.0 656
LLPS-Phv-0349Phaseolus vulgaris48.840.0 659
LLPS-Ast-1043Aspergillus terreus48.650.0 646
LLPS-Fus-0248Fusarium solani48.630.0 628
LLPS-Abg-0453Absidia glauca48.580.0 638
LLPS-Cym-0052Cyanidioschyzon merolae48.480.0 583
LLPS-Phn-0681Phaeosphaeria nodorum48.440.0 649
LLPS-Fuv-0684Fusarium verticillioides48.430.0 644
LLPS-Dac-0092Daucus carota48.420.0 639
LLPS-Mao-0779Magnaporthe oryzae48.370.0 633
LLPS-Scp-0701Schizosaccharomyces pombe48.280.0 660
LLPS-Lem-0592Leptosphaeria maculans48.230.0 647
LLPS-Nec-0824Neurospora crassa48.180.0 635
LLPS-Cog-0510Colletotrichum gloeosporioides48.170.0 644
LLPS-Cogr-0622Colletotrichum graminicola48.030.0 633
LLPS-Gag-0266Gaeumannomyces graminis47.970.0 635
LLPS-Ved-0080Verticillium dahliae47.960.0 623
LLPS-Fuo-0025Fusarium oxysporum47.950.0 639
LLPS-Coo-0200Colletotrichum orbiculare47.90.0 637
LLPS-Mel-0180Melampsora laricipopulina47.790.0 643
LLPS-Dos-0376Dothistroma septosporum47.550.0 633
LLPS-Zyt-0009Zymoseptoria tritici47.340.0 638
LLPS-Put-0063Puccinia triticina47.00.0 608
LLPS-Gas-0055Galdieria sulphuraria46.670.0 605
LLPS-Asg-0209Ashbya gossypii46.160.0 646
LLPS-Kop-0209Komagataella pastoris45.790.0 624
LLPS-Sac-0488Saccharomyces cerevisiae45.780.0 627
LLPS-Osl-0040Ostreococcus lucimarinus45.730.0 576
LLPS-Chr-0378Chlamydomonas reinhardtii45.070.0 568
LLPS-Yal-0763Yarrowia lipolytica45.060.0 632
LLPS-Chc-0192Chondrus crispus42.620.0 548