LLPS-Urm-3658
AK3
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | GTP:AMP phosphotransferase AK3, mitochondrial; Adenylate kinase 3; AK 3; Adenylate kinase 3 alpha-like 1 |
| Gene Name: | AK3 |
| Ensembl Gene: | ENSUMAG00000017904.1 |
| Ensembl Protein: | ENSUMAP00000024637.1 |
| Organism: | Ursus maritimus |
| Taxa ID: | 29073 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSUMAT00000029178.1 | ENSUMAP00000024637.1 |
| UniProt | A0A384C2P0, A0A384C2P0_URSMA | |
| RefSeq | , XM_008690919.1 | , XP_008689141.1, XP_008689141.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGPPGSGKGT VSSRITKHFA LKHLSSGDLL RDNMLRGTEI GVLAKTFIDQ GKLIPDDVMT 60 61 RLALHELKNL TQHSWLLDGF PRTLPQAEAL DRAYQIDTVI NLNVPFEVIK QRLTARWIHP 120 121 ASGRVYNIEF NPPKAVGIDD LTGEPLIQRD DDKPETVVKR LKAYEVQTQP VLEYYQRKGV 180 181 LETFSGTETD KIWPHVYDFL QTKVLQISGK ASVTP 215 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGGCCGC CGGGCTCGGG CAAGGGCACC GTGTCGTCGC GCATCACCAA ACACTTCGCG 60 61 CTGAAGCACC TCTCCAGCGG GGACCTGCTC CGAGACAACA TGCTTCGGGG CACAGAAATT 120 121 GGTGTGTTAG CCAAGACTTT CATTGACCAA GGGAAGCTCA TCCCAGATGA TGTCATGACT 180 181 CGGCTGGCCC TTCATGAGCT GAAAAACCTC ACCCAACATA GCTGGCTATT GGATGGTTTT 240 241 CCAAGGACAC TTCCACAGGC AGAAGCCCTG GATAGAGCTT ATCAGATAGA CACAGTGATT 300 301 AATCTGAACG TGCCCTTTGA GGTCATTAAG CAGCGTCTCA CTGCTCGCTG GATTCATCCA 360 361 GCCAGCGGCC GAGTCTACAA CATCGAATTC AACCCTCCCA AAGCTGTGGG CATTGACGAC 420 421 CTGACTGGGG AGCCTCTCAT TCAGCGTGAT GATGATAAGC CAGAGACAGT GGTCAAGAGA 480 481 CTGAAGGCTT ATGAAGTCCA AACACAGCCG GTCCTGGAAT ATTACCAGAG AAAGGGGGTG 540 541 TTGGAAACCT TCTCCGGAAC AGAAACCGAC AAGATCTGGC CCCATGTCTA TGATTTCCTA 600 601 CAAACAAAAG TTCTACAGAT AAGCGGGAAA GCATCAGTTA CTCCATGA 648 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrial matrix | |
Molecular Function | Adenylate kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | GTP binding | |
Molecular Function | Nucleoside triphosphate adenylate kinase activity | |
Biological Process | ADP biosynthetic process | |
Biological Process | AMP metabolic process | |
Biological Process | GTP metabolic process | |
Biological Process | ITP metabolic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Aim-3521 | Ailuropoda melanoleuca | 98.13 | 6e-152 | 428 |
| LLPS-Mup-1498 | Mustela putorius furo | 95.81 | 5e-150 | 424 |
| LLPS-Caf-0197 | Canis familiaris | 94.88 | 6e-148 | 418 |
| LLPS-Fec-2857 | Felis catus | 93.02 | 3e-146 | 414 |
| LLPS-Fud-4128 | Fukomys damarensis | 92.66 | 4e-117 | 339 |
| LLPS-Dio-0241 | Dipodomys ordii | 92.61 | 8e-118 | 340 |
| LLPS-Gog-2340 | Gorilla gorilla | 92.09 | 8e-144 | 408 |
| LLPS-Caj-4220 | Callithrix jacchus | 92.09 | 2e-144 | 409 |
| LLPS-Poa-3305 | Pongo abelii | 92.09 | 3e-144 | 409 |
| LLPS-Nol-3890 | Nomascus leucogenys | 92.09 | 7e-143 | 405 |
| LLPS-Hos-1278 | Homo sapiens | 92.09 | 8e-144 | 408 |
| LLPS-Cas-3791 | Carlito syrichta | 91.72 | 2e-103 | 303 |
| LLPS-Paa-3663 | Papio anubis | 91.63 | 2e-143 | 407 |
| LLPS-Mal-1706 | Mandrillus leucophaeus | 91.63 | 2e-143 | 407 |
| LLPS-Maf-4062 | Macaca fascicularis | 91.63 | 2e-143 | 407 |
| LLPS-Chs-1846 | Chlorocebus sabaeus | 91.63 | 2e-143 | 407 |
| LLPS-Aon-3970 | Aotus nancymaae | 91.63 | 9e-144 | 407 |
| LLPS-Cea-4707 | Cercocebus atys | 91.63 | 2e-143 | 407 |
| LLPS-Mam-3079 | Macaca mulatta | 91.63 | 2e-143 | 407 |
| LLPS-Rhb-2771 | Rhinopithecus bieti | 91.63 | 2e-143 | 407 |
| LLPS-Pat-4933 | Pan troglodytes | 91.16 | 1e-141 | 402 |
| LLPS-Otg-4576 | Otolemur garnettii | 90.7 | 4e-143 | 406 |
| LLPS-Pap-1941 | Pan paniscus | 90.56 | 1e-115 | 336 |
| LLPS-Mea-3170 | Mesocricetus auratus | 90.23 | 1e-142 | 405 |
| LLPS-Cap-3561 | Cavia porcellus | 90.23 | 1e-142 | 405 |
| LLPS-Ran-1148 | Rattus norvegicus | 89.77 | 1e-140 | 400 |
| LLPS-Mum-4427 | Mus musculus | 89.77 | 1e-141 | 402 |
| LLPS-Orc-2157 | Oryctolagus cuniculus | 89.77 | 2e-141 | 402 |
| LLPS-Bot-1076 | Bos taurus | 89.3 | 1e-141 | 402 |
| LLPS-Sus-3963 | Sus scrofa | 89.3 | 2e-140 | 399 |
| LLPS-Ict-4296 | Ictidomys tridecemlineatus | 89.3 | 4e-141 | 401 |
| LLPS-Ova-2825 | Ovis aries | 88.84 | 5e-141 | 400 |
| LLPS-Eqc-3895 | Equus caballus | 88.84 | 6e-143 | 405 |
| LLPS-Myl-1581 | Myotis lucifugus | 86.44 | 2e-111 | 323 |
| LLPS-Ere-0898 | Erinaceus europaeus | 84.66 | 6e-110 | 320 |
| LLPS-Loa-0381 | Loxodonta africana | 84.24 | 2e-111 | 324 |
| LLPS-Mod-2884 | Monodelphis domestica | 84.19 | 2e-133 | 382 |
| LLPS-Sah-3547 | Sarcophilus harrisii | 82.27 | 5e-131 | 375 |
| LLPS-Man-4693 | Macaca nemestrina | 78.4 | 1e-114 | 333 |
| LLPS-Pes-0746 | Pelodiscus sinensis | 73.95 | 2e-115 | 336 |
| LLPS-Anc-3590 | Anolis carolinensis | 73.91 | 5e-114 | 332 |
| LLPS-Xet-0374 | Xenopus tropicalis | 73.56 | 8e-113 | 329 |
| LLPS-Lac-0818 | Latimeria chalumnae | 72.6 | 7e-111 | 324 |
| LLPS-Gaga-2281 | Gallus gallus | 72.56 | 5e-118 | 343 |
| LLPS-Leo-3702 | Lepisosteus oculatus | 72.17 | 3e-112 | 328 |
| LLPS-Tag-1355 | Taeniopygia guttata | 72.09 | 2e-117 | 341 |
| LLPS-Fia-3500 | Ficedula albicollis | 72.09 | 2e-117 | 341 |
| LLPS-Meg-2901 | Meleagris gallopavo | 71.35 | 4e-94 | 280 |
| LLPS-Ora-3207 | Ornithorhynchus anatinus | 69.63 | 8e-104 | 306 |
| LLPS-Orn-3212 | Oreochromis niloticus | 69.52 | 1e-104 | 308 |
| LLPS-Scm-3995 | Scophthalmus maximus | 68.87 | 2e-106 | 313 |
| LLPS-Asm-3798 | Astyanax mexicanus | 68.69 | 5e-105 | 309 |
| LLPS-Scf-3033 | Scleropages formosus | 68.63 | 1e-103 | 306 |
| LLPS-Icp-2366 | Ictalurus punctatus | 68.14 | 5e-103 | 304 |
| LLPS-Dar-0586 | Danio rerio | 67.29 | 4e-103 | 305 |
| LLPS-Tar-3627 | Takifugu rubripes | 67.15 | 2e-102 | 302 |
| LLPS-Gaa-2067 | Gasterosteus aculeatus | 65.09 | 7e-102 | 301 |
| LLPS-Orl-1150 | Oryzias latipes | 65.09 | 1e-103 | 305 |
| LLPS-Xim-3858 | Xiphophorus maculatus | 64.62 | 3e-103 | 305 |
| LLPS-Pof-3756 | Poecilia formosa | 63.68 | 3e-102 | 302 |
| LLPS-Ten-1399 | Tetraodon nigroviridis | 63.59 | 4e-89 | 268 |
| LLPS-Cii-1777 | Ciona intestinalis | 58.25 | 1e-85 | 260 |
| LLPS-Cis-0940 | Ciona savignyi | 54.46 | 2e-80 | 247 |
| LLPS-Drm-1003 | Drosophila melanogaster | 49.51 | 3e-69 | 218 |
| LLPS-Sot-0077 | Solanum tuberosum | 47.57 | 9e-55 | 181 |
| LLPS-Osl-0221 | Ostreococcus lucimarinus | 47.51 | 4e-52 | 174 |
| LLPS-Brn-2977 | Brassica napus | 47.06 | 3e-54 | 180 |
| LLPS-Bro-1971 | Brassica oleracea | 47.06 | 3e-54 | 180 |
| LLPS-Brr-1705 | Brassica rapa | 47.06 | 3e-54 | 180 |
| LLPS-Viv-1785 | Vitis vinifera | 46.52 | 8e-55 | 181 |
| LLPS-Art-2486 | Arabidopsis thaliana | 46.52 | 1e-54 | 181 |
| LLPS-Nia-1810 | Nicotiana attenuata | 46.32 | 7e-56 | 184 |
| LLPS-Arl-1016 | Arabidopsis lyrata | 45.99 | 4e-54 | 180 |
| LLPS-Sem-2390 | Selaginella moellendorffii | 45.99 | 6e-53 | 176 |
| LLPS-Coc-2071 | Corchorus capsularis | 45.99 | 5e-54 | 179 |
| LLPS-Mae-1823 | Manihot esculenta | 45.99 | 5e-55 | 182 |
| LLPS-Gas-0935 | Galdieria sulphuraria | 45.74 | 2e-52 | 176 |
| LLPS-Amt-1607 | Amborella trichopoda | 45.5 | 4e-55 | 182 |
| LLPS-Sol-1626 | Solanum lycopersicum | 45.26 | 3e-53 | 177 |
| LLPS-Orbr-2188 | Oryza brachyantha | 45.26 | 2e-54 | 180 |
| LLPS-Sac-0959 | Saccharomyces cerevisiae | 45.05 | 9e-52 | 173 |
| LLPS-Pot-1410 | Populus trichocarpa | 44.92 | 4e-52 | 175 |
| LLPS-Sei-2131 | Setaria italica | 44.74 | 2e-53 | 179 |
| LLPS-Gor-2584 | Gossypium raimondii | 44.74 | 6e-54 | 179 |
| LLPS-Yal-0201 | Yarrowia lipolytica | 44.6 | 7e-60 | 194 |
| LLPS-Crn-1273 | Cryptococcus neoformans | 44.55 | 4e-56 | 186 |
| LLPS-Cym-0813 | Cyanidioschyzon merolae | 44.39 | 3e-54 | 181 |
| LLPS-Zem-1836 | Zea mays | 44.39 | 2e-52 | 175 |
| LLPS-Spr-1550 | Sporisorium reilianum | 44.35 | 2e-59 | 195 |
| LLPS-Php-2000 | Physcomitrella patens | 44.33 | 2e-52 | 175 |
| LLPS-Glm-1627 | Glycine max | 44.21 | 6e-54 | 179 |
| LLPS-Hea-0536 | Helianthus annuus | 44.21 | 5e-52 | 174 |
| LLPS-Orp-1205 | Oryza punctata | 44.21 | 1e-53 | 179 |
| LLPS-Sob-1462 | Sorghum bicolor | 44.21 | 4e-53 | 177 |
| LLPS-Phv-1102 | Phaseolus vulgaris | 44.21 | 2e-53 | 178 |
| LLPS-Orm-1071 | Oryza meridionalis | 43.75 | 3e-54 | 180 |
| LLPS-Orgl-0879 | Oryza glumaepatula | 43.68 | 8e-53 | 176 |
| LLPS-Orb-0077 | Oryza barthii | 43.68 | 8e-53 | 176 |
| LLPS-Ori-1133 | Oryza indica | 43.68 | 8e-53 | 176 |
| LLPS-Orni-1021 | Oryza nivara | 43.68 | 8e-53 | 176 |
| LLPS-Orr-0252 | Oryza rufipogon | 43.68 | 8e-53 | 176 |
| LLPS-Prp-1204 | Prunus persica | 43.68 | 3e-52 | 175 |
| LLPS-Org-0580 | Oryza glaberrima | 43.68 | 8e-53 | 176 |
| LLPS-Ors-0513 | Oryza sativa | 43.68 | 8e-53 | 176 |
| LLPS-Tum-0311 | Tuber melanosporum | 43.67 | 5e-55 | 182 |
| LLPS-Mua-1517 | Musa acuminata | 43.65 | 6e-53 | 177 |
| LLPS-Zyt-1373 | Zymoseptoria tritici | 43.19 | 6e-54 | 179 |
| LLPS-Lep-2363 | Leersia perrieri | 43.16 | 7e-53 | 176 |
| LLPS-Met-1477 | Medicago truncatula | 43.16 | 9e-53 | 176 |
| LLPS-Usm-1146 | Ustilago maydis | 43.16 | 2e-59 | 194 |
| LLPS-Kop-1236 | Komagataella pastoris | 42.86 | 5e-53 | 176 |
| LLPS-Hov-1716 | Hordeum vulgare | 42.78 | 2e-50 | 172 |
| LLPS-Trv-0307 | Trichoderma virens | 42.65 | 2e-54 | 181 |
| LLPS-Trr-1570 | Trichoderma reesei | 42.65 | 4e-54 | 181 |
| LLPS-Cus-0610 | Cucumis sativus | 42.64 | 2e-52 | 175 |
| LLPS-Brd-1286 | Brachypodium distachyon | 42.63 | 2e-52 | 175 |
| LLPS-Tra-2488 | Triticum aestivum | 42.63 | 6e-53 | 177 |
| LLPS-Ast-0054 | Aspergillus terreus | 42.58 | 1e-53 | 179 |
| LLPS-Nef-0344 | Neosartorya fischeri | 42.58 | 3e-53 | 177 |
| LLPS-Mel-1114 | Melampsora laricipopulina | 42.38 | 1e-52 | 178 |
| LLPS-Asni-0903 | Aspergillus niger | 42.29 | 3e-51 | 173 |
| LLPS-Fus-0783 | Fusarium solani | 42.18 | 6e-54 | 179 |
| LLPS-Scp-0879 | Schizosaccharomyces pombe | 42.11 | 8e-53 | 176 |
| LLPS-Asfu-1253 | Aspergillus fumigatus | 42.11 | 6e-53 | 177 |
| LLPS-Tru-0420 | Triticum urartu | 42.11 | 2e-51 | 173 |
| LLPS-Fuv-0733 | Fusarium verticillioides | 41.71 | 1e-52 | 176 |
| LLPS-Fuo-1051 | Fusarium oxysporum | 41.71 | 1e-52 | 176 |
| LLPS-Scj-0014 | Schizosaccharomyces japonicus | 41.63 | 6e-53 | 176 |
| LLPS-Thc-2053 | Theobroma cacao | 41.59 | 3e-53 | 178 |
| LLPS-Cog-0477 | Colletotrichum gloeosporioides | 41.23 | 3e-53 | 178 |
| LLPS-Aso-1040 | Aspergillus oryzae | 41.15 | 4e-52 | 174 |
| LLPS-Asf-1041 | Aspergillus flavus | 41.15 | 9e-52 | 174 |
| LLPS-Asc-1349 | Aspergillus clavatus | 41.15 | 7e-53 | 177 |
| LLPS-Pyt-0219 | Pyrenophora teres | 41.1 | 1e-50 | 172 |
| LLPS-Coo-0474 | Colletotrichum orbiculare | 40.76 | 1e-52 | 177 |
| LLPS-Cogr-0943 | Colletotrichum graminicola | 40.76 | 2e-52 | 176 |
| LLPS-Beb-1240 | Beauveria bassiana | 40.76 | 6e-51 | 172 |
| LLPS-Pug-1384 | Puccinia graminis | 40.54 | 2e-51 | 174 |
| LLPS-Asn-0756 | Aspergillus nidulans | 40.28 | 1e-51 | 174 |
| LLPS-Put-0435 | Puccinia triticina | 40.27 | 5e-52 | 176 |
| LLPS-Nec-0794 | Neurospora crassa | 40.0 | 7e-51 | 172 |
| LLPS-Asg-1224 | Ashbya gossypii | 38.94 | 2e-51 | 173 |