LLPS-Aim-3521
AK3
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | GTP:AMP phosphotransferase AK3, mitochondrial; Adenylate kinase 3; AK 3; Adenylate kinase 3 alpha-like 1 |
| Gene Name: | AK3 |
| Ensembl Gene: | ENSAMEG00000002640.1 |
| Ensembl Protein: | ENSAMEP00000002778.1 |
| Organism: | Ailuropoda melanoleuca |
| Taxa ID: | 9646 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSAMET00000002897.1 | ENSAMEP00000002778.1 |
| UniProt | G1L7B2, G1L7B2_AILME | |
| GeneBank | ACTA01010279, ACTA01026279, ACTA01002279, ACTA01018279 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 LGSGERERLG ARGAPGSGKG TVSSRITKHF ALKHLSSGDL LRDNMLRGTE IGVLAKTFID 60 61 QGKLIPDDVM TRLALHELKN LTQHSWLLDG FPRTLPQAEA LDRAYQIDTV INLNVPFEVI 120 121 KQRLTARWIH PASGRVYNIE FNPPKAVGID DLTGEPLIQR DDDKPETVVK RLKAYEVQTQ 180 181 PVLEYYQRKG VLETFSGTET DKIWPHVYAF LQTKVPQISR KASVTP 226 |
| Nucleotide CDS Sequence (FASTA) |
1 CTCGGGAGCG GCGAGAGGGA GCGCCTGGGC GCGCGGGGGG CGCCGGGCTC GGGCAAGGGC 60 61 ACCGTGTCGT CGCGCATCAC CAAACACTTC GCGCTGAAGC ACCTCTCCAG CGGGGACCTG 120 121 CTCCGAGACA ACATGCTTCG GGGCACAGAA ATTGGTGTGT TAGCCAAGAC TTTCATTGAC 180 181 CAAGGGAAGC TCATCCCAGA TGATGTCATG ACTCGGCTGG CCCTTCATGA GCTGAAAAAC 240 241 CTCACCCAGC ATAGCTGGCT ATTGGATGGT TTTCCAAGGA CACTTCCACA GGCAGAAGCC 300 301 CTGGATAGAG CTTATCAGAT AGACACAGTG ATTAATCTGA ACGTGCCCTT TGAGGTCATT 360 361 AAGCAGCGTC TCACTGCTCG CTGGATTCAT CCCGCCAGCG GCCGAGTCTA TAACATAGAA 420 421 TTCAACCCTC CCAAAGCTGT GGGCATTGAC GACCTGACTG GGGAGCCTCT CATTCAGCGT 480 481 GATGATGATA AGCCAGAGAC AGTGGTCAAG AGACTGAAGG CTTATGAAGT CCAAACACAG 540 541 CCGGTCCTGG AATATTACCA GAGAAAGGGG GTGTTGGAAA CCTTCTCCGG AACAGAAACT 600 601 GACAAGATCT GGCCCCATGT CTATGCTTTC CTACAAACAA AAGTTCCACA GATAAGCAGG 660 661 AAAGCATCAG TTACTCCATG A 681 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrial matrix | |
Molecular Function | Adenylate kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | GTP binding | |
Molecular Function | Nucleoside triphosphate adenylate kinase activity | |
Biological Process | ADP biosynthetic process | |
Biological Process | AMP metabolic process | |
Biological Process | GTP metabolic process | |
Biological Process | ITP metabolic process | |
Biological Process | UTP metabolic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Urm-3658 | Ursus maritimus | 98.13 | 7e-152 | 428 |
| LLPS-Mup-1498 | Mustela putorius furo | 97.2 | 6e-153 | 431 |
| LLPS-Caf-0197 | Canis familiaris | 96.26 | 8e-151 | 426 |
| LLPS-Fec-2857 | Felis catus | 94.39 | 5e-149 | 421 |
| LLPS-Fud-4128 | Fukomys damarensis | 93.79 | 8e-120 | 347 |
| LLPS-Gog-2340 | Gorilla gorilla | 93.46 | 9e-147 | 416 |
| LLPS-Caj-4220 | Callithrix jacchus | 93.46 | 2e-147 | 417 |
| LLPS-Hos-1278 | Homo sapiens | 93.46 | 9e-147 | 416 |
| LLPS-Poa-3305 | Pongo abelii | 93.46 | 3e-147 | 417 |
| LLPS-Nol-3890 | Nomascus leucogenys | 93.46 | 1e-145 | 413 |
| LLPS-Dio-0241 | Dipodomys ordii | 93.14 | 7e-118 | 341 |
| LLPS-Chs-1846 | Chlorocebus sabaeus | 92.99 | 3e-146 | 414 |
| LLPS-Maf-4062 | Macaca fascicularis | 92.99 | 3e-146 | 414 |
| LLPS-Cea-4707 | Cercocebus atys | 92.99 | 3e-146 | 414 |
| LLPS-Aon-3970 | Aotus nancymaae | 92.99 | 9e-147 | 416 |
| LLPS-Paa-3663 | Papio anubis | 92.99 | 3e-146 | 414 |
| LLPS-Mal-1706 | Mandrillus leucophaeus | 92.99 | 3e-146 | 414 |
| LLPS-Rhb-2771 | Rhinopithecus bieti | 92.99 | 3e-146 | 414 |
| LLPS-Mam-3079 | Macaca mulatta | 92.99 | 3e-146 | 414 |
| LLPS-Cas-3791 | Carlito syrichta | 92.99 | 3e-106 | 310 |
| LLPS-Pat-4933 | Pan troglodytes | 92.52 | 1e-144 | 410 |
| LLPS-Otg-4576 | Otolemur garnettii | 92.06 | 6e-146 | 414 |
| LLPS-Cap-3561 | Cavia porcellus | 91.59 | 8e-146 | 413 |
| LLPS-Orc-2157 | Oryctolagus cuniculus | 91.12 | 4e-144 | 409 |
| LLPS-Ict-4296 | Ictidomys tridecemlineatus | 90.65 | 4e-144 | 409 |
| LLPS-Eqc-3895 | Equus caballus | 90.19 | 8e-146 | 413 |
| LLPS-Sus-3963 | Sus scrofa | 89.04 | 8e-144 | 408 |
| LLPS-Bot-1076 | Bos taurus | 89.04 | 1e-144 | 410 |
| LLPS-Ova-2825 | Ovis aries | 88.58 | 4e-144 | 409 |
| LLPS-Mea-3170 | Mesocricetus auratus | 88.0 | 1e-145 | 413 |
| LLPS-Myl-1581 | Myotis lucifugus | 87.57 | 3e-114 | 331 |
| LLPS-Mum-4427 | Mus musculus | 87.56 | 9e-145 | 410 |
| LLPS-Ran-1148 | Rattus norvegicus | 87.56 | 1e-143 | 408 |
| LLPS-Loa-0381 | Loxodonta africana | 85.33 | 4e-114 | 331 |
| LLPS-Ere-0898 | Erinaceus europaeus | 85.23 | 8e-112 | 325 |
| LLPS-Sah-3547 | Sarcophilus harrisii | 82.65 | 5e-132 | 379 |
| LLPS-Mod-2884 | Monodelphis domestica | 81.58 | 7e-135 | 385 |
| LLPS-Man-4693 | Macaca nemestrina | 79.62 | 5e-117 | 340 |
| LLPS-Pap-1941 | Pan paniscus | 77.68 | 7e-119 | 345 |
| LLPS-Pes-0746 | Pelodiscus sinensis | 74.3 | 4e-116 | 338 |
| LLPS-Anc-3590 | Anolis carolinensis | 73.79 | 1e-113 | 332 |
| LLPS-Leo-3702 | Lepisosteus oculatus | 73.4 | 5e-110 | 322 |
| LLPS-Xet-0374 | Xenopus tropicalis | 72.51 | 2e-113 | 331 |
| LLPS-Fia-3500 | Ficedula albicollis | 72.43 | 2e-118 | 343 |
| LLPS-Gaga-2281 | Gallus gallus | 72.43 | 2e-118 | 344 |
| LLPS-Tag-1355 | Taeniopygia guttata | 72.43 | 2e-118 | 344 |
| LLPS-Lac-0818 | Latimeria chalumnae | 72.04 | 2e-112 | 328 |
| LLPS-Meg-2901 | Meleagris gallopavo | 71.91 | 2e-96 | 286 |
| LLPS-Dar-0586 | Danio rerio | 69.12 | 4e-104 | 307 |
| LLPS-Orn-3212 | Oreochromis niloticus | 68.87 | 8e-106 | 311 |
| LLPS-Scm-3995 | Scophthalmus maximus | 68.72 | 7e-106 | 311 |
| LLPS-Scf-3033 | Scleropages formosus | 68.47 | 2e-102 | 303 |
| LLPS-Ora-3207 | Ornithorhynchus anatinus | 68.0 | 4e-106 | 313 |
| LLPS-Icp-2366 | Ictalurus punctatus | 67.8 | 6e-103 | 304 |
| LLPS-Asm-3798 | Astyanax mexicanus | 67.79 | 8e-104 | 306 |
| LLPS-Tar-3627 | Takifugu rubripes | 65.73 | 6e-103 | 304 |
| LLPS-Gaa-2067 | Gasterosteus aculeatus | 64.93 | 3e-101 | 300 |
| LLPS-Orl-1150 | Oryzias latipes | 64.45 | 9e-102 | 301 |
| LLPS-Pof-3756 | Poecilia formosa | 63.51 | 1e-101 | 301 |
| LLPS-Ten-1399 | Tetraodon nigroviridis | 63.33 | 5e-90 | 271 |
| LLPS-Xim-3858 | Xiphophorus maculatus | 61.88 | 1e-102 | 304 |
| LLPS-Cii-1777 | Ciona intestinalis | 57.14 | 2e-83 | 255 |
| LLPS-Cis-0940 | Ciona savignyi | 53.42 | 1e-79 | 246 |
| LLPS-Drm-1003 | Drosophila melanogaster | 50.25 | 6e-70 | 220 |
| LLPS-Sot-0077 | Solanum tuberosum | 46.84 | 3e-53 | 178 |
| LLPS-Brn-2977 | Brassica napus | 46.35 | 8e-53 | 177 |
| LLPS-Brr-1705 | Brassica rapa | 46.35 | 8e-53 | 177 |
| LLPS-Bro-1971 | Brassica oleracea | 46.35 | 9e-53 | 176 |
| LLPS-Art-2486 | Arabidopsis thaliana | 45.83 | 3e-53 | 178 |
| LLPS-Viv-1785 | Vitis vinifera | 45.83 | 1e-53 | 179 |
| LLPS-Nia-1810 | Nicotiana attenuata | 45.64 | 2e-54 | 181 |
| LLPS-Sac-0959 | Saccharomyces cerevisiae | 45.54 | 2e-52 | 175 |
| LLPS-Sem-2390 | Selaginella moellendorffii | 45.31 | 9e-52 | 174 |
| LLPS-Arl-1016 | Arabidopsis lyrata | 45.31 | 1e-52 | 176 |
| LLPS-Mae-1823 | Manihot esculenta | 45.31 | 6e-54 | 179 |
| LLPS-Coc-2071 | Corchorus capsularis | 45.31 | 1e-52 | 176 |
| LLPS-Yal-0201 | Yarrowia lipolytica | 45.16 | 2e-60 | 196 |
| LLPS-Zyt-1373 | Zymoseptoria tritici | 45.15 | 6e-54 | 179 |
| LLPS-Orbr-2188 | Oryza brachyantha | 44.97 | 6e-53 | 177 |
| LLPS-Amt-1607 | Amborella trichopoda | 44.97 | 1e-53 | 179 |
| LLPS-Gas-0935 | Galdieria sulphuraria | 44.72 | 6e-53 | 178 |
| LLPS-Sol-1626 | Solanum lycopersicum | 44.62 | 5e-52 | 175 |
| LLPS-Pot-1410 | Populus trichocarpa | 44.27 | 8e-51 | 172 |
| LLPS-Sei-2131 | Setaria italica | 44.1 | 4e-52 | 176 |
| LLPS-Gor-2584 | Gossypium raimondii | 44.1 | 1e-52 | 176 |
| LLPS-Sob-1462 | Sorghum bicolor | 43.92 | 2e-51 | 173 |
| LLPS-Spr-1550 | Sporisorium reilianum | 43.83 | 8e-61 | 199 |
| LLPS-Zem-1836 | Zea mays | 43.75 | 3e-51 | 172 |
| LLPS-Crn-1273 | Cryptococcus neoformans | 43.72 | 1e-54 | 182 |
| LLPS-Glm-1627 | Glycine max | 43.59 | 1e-52 | 176 |
| LLPS-Hea-0536 | Helianthus annuus | 43.59 | 8e-51 | 172 |
| LLPS-Orp-1205 | Oryza punctata | 43.59 | 2e-52 | 176 |
| LLPS-Phv-1102 | Phaseolus vulgaris | 43.59 | 6e-52 | 174 |
| LLPS-Tum-0311 | Tuber melanosporum | 43.48 | 5e-54 | 180 |
| LLPS-Kop-1236 | Komagataella pastoris | 43.46 | 2e-53 | 177 |
| LLPS-Usm-1146 | Ustilago maydis | 43.4 | 5e-61 | 199 |
| LLPS-Cym-0813 | Cyanidioschyzon merolae | 43.35 | 5e-53 | 178 |
| LLPS-Php-2000 | Physcomitrella patens | 43.28 | 3e-51 | 172 |
| LLPS-Osl-0221 | Ostreococcus lucimarinus | 43.19 | 4e-51 | 172 |
| LLPS-Orm-1071 | Oryza meridionalis | 43.15 | 4e-53 | 177 |
| LLPS-Ori-1133 | Oryza indica | 43.08 | 1e-51 | 173 |
| LLPS-Orb-0077 | Oryza barthii | 43.08 | 1e-51 | 173 |
| LLPS-Orni-1021 | Oryza nivara | 43.08 | 1e-51 | 173 |
| LLPS-Orgl-0879 | Oryza glumaepatula | 43.08 | 1e-51 | 173 |
| LLPS-Ors-0513 | Oryza sativa | 43.08 | 1e-51 | 173 |
| LLPS-Orr-0252 | Oryza rufipogon | 43.08 | 1e-51 | 173 |
| LLPS-Prp-1204 | Prunus persica | 43.08 | 7e-51 | 172 |
| LLPS-Org-0580 | Oryza glaberrima | 43.08 | 1e-51 | 173 |
| LLPS-Mua-1517 | Musa acuminata | 43.07 | 8e-52 | 174 |
| LLPS-Lep-2363 | Leersia perrieri | 42.56 | 1e-51 | 174 |
| LLPS-Met-1477 | Medicago truncatula | 42.56 | 2e-51 | 173 |
| LLPS-Trr-1570 | Trichoderma reesei | 42.38 | 4e-52 | 176 |
| LLPS-Brd-1286 | Brachypodium distachyon | 42.33 | 7e-51 | 172 |
| LLPS-Tra-2488 | Triticum aestivum | 42.33 | 2e-51 | 173 |
| LLPS-Asni-0834 | Aspergillus niger | 42.25 | 2e-50 | 170 |
| LLPS-Scp-0879 | Schizosaccharomyces pombe | 42.25 | 2e-52 | 175 |
| LLPS-Cus-0610 | Cucumis sativus | 42.08 | 6e-51 | 172 |
| LLPS-Scj-0014 | Schizosaccharomyces japonicus | 41.78 | 2e-52 | 175 |
| LLPS-Fuv-0733 | Fusarium verticillioides | 41.43 | 7e-51 | 172 |
| LLPS-Fus-0783 | Fusarium solani | 41.36 | 3e-52 | 176 |
| LLPS-Trv-0307 | Trichoderma virens | 41.36 | 2e-51 | 174 |
| LLPS-Ast-0054 | Aspergillus terreus | 41.2 | 7e-52 | 175 |
| LLPS-Mel-1114 | Melampsora laricipopulina | 41.15 | 4e-51 | 174 |
| LLPS-Thc-2053 | Theobroma cacao | 41.1 | 3e-52 | 175 |
| LLPS-Nef-0344 | Neosartorya fischeri | 41.01 | 1e-51 | 174 |
| LLPS-Tru-0420 | Triticum urartu | 40.93 | 5e-50 | 170 |
| LLPS-Fuo-1051 | Fusarium oxysporum | 40.91 | 3e-51 | 173 |
| LLPS-Asfu-1253 | Aspergillus fumigatus | 40.55 | 3e-51 | 173 |
| LLPS-Aso-0797 | Aspergillus oryzae | 40.47 | 3e-50 | 170 |
| LLPS-Asf-1519 | Aspergillus flavus | 40.47 | 3e-50 | 170 |
| LLPS-Cog-0477 | Colletotrichum gloeosporioides | 40.45 | 1e-51 | 174 |
| LLPS-Pug-1384 | Puccinia graminis | 40.43 | 1e-53 | 181 |
| LLPS-Asc-1270 | Aspergillus clavatus | 40.35 | 1e-49 | 169 |
| LLPS-Put-0435 | Puccinia triticina | 40.26 | 2e-54 | 182 |
| LLPS-Pytr-1490 | Pyrenophora triticirepentis | 40.08 | 2e-51 | 174 |
| LLPS-Coo-0474 | Colletotrichum orbiculare | 40.0 | 8e-51 | 172 |
| LLPS-Cogr-0943 | Colletotrichum graminicola | 39.09 | 1e-49 | 169 |
| LLPS-Nec-0794 | Neurospora crassa | 38.86 | 5e-50 | 171 |
| LLPS-Asn-0756 | Aspergillus nidulans | 38.81 | 1e-49 | 169 |
| LLPS-Asg-1224 | Ashbya gossypii | 38.14 | 8e-50 | 170 |