LLPS-Bot-1076
AK3
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | GTP:AMP phosphotransferase AK3, mitochondrial; Adenylate kinase 3; AK 3; Adenylate kinase 3 alpha-like 1 |
| Gene Name: | AK3, AK3L1 |
| Ensembl Gene: | ENSBTAG00000017147.4 |
| Ensembl Protein: | ENSBTAP00000022789.3 |
| Organism: | Bos taurus |
| Taxa ID: | 9913 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSBTAT00000022789.4 | ENSBTAP00000022789.3 |
| UniProt | P08760, KAD3_BOVIN, Q29RI4 | |
| GeneBank | M25757, D10376, BC114157 | BAA01210.1, AAA30705.1, AAI14158.1 |
| RefSeq | NM_174237.2 | NP_776662.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGASARLLRA AIMGAPGSGK GTVSSRITKH FELKHLSSGD LLRDNMLRGT EIGVLAKTFI 60 61 DQGKLIPDDV MTRLVLHELK NLTQYNWLLD GFPRTLPQAE ALDRAYQIDT VINLNVPFEV 120 121 IKQRLTARWI HPGSGRVYNI EFNPPKTMGI DDLTGEPLVQ REDDRPETVV KRLKAYEAQT 180 181 EPVLEYYRKK GVLETFSGTE TNKIWPHVYA FLQTKLPQRS QETSVTP 227 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGGGCGT CTGCGCGGCT ACTGCGCGCA GCGATCATGG GGGCGCCGGG CTCTGGCAAA 60 61 GGCACCGTGT CCTCGCGCAT CACCAAACAC TTCGAGCTGA AGCACCTCTC CAGCGGGGAC 120 121 CTGCTCAGAG ATAATATGCT TCGGGGCACA GAAATTGGTG TTTTAGCCAA GACTTTCATT 180 181 GACCAAGGGA AGCTCATCCC AGACGATGTC ATGACTCGGT TGGTCCTTCA TGAGCTGAAA 240 241 AATCTCACCC AATATAACTG GCTGTTGGAT GGCTTTCCAA GGACACTTCC GCAGGCAGAA 300 301 GCCCTGGATA GAGCCTATCA GATAGACACA GTGATTAACC TGAACGTGCC CTTTGAGGTC 360 361 ATCAAGCAAC GCCTTACTGC TCGCTGGATC CATCCAGGCA GCGGCCGTGT CTACAACATC 420 421 GAGTTCAACC CTCCCAAAAC CATGGGAATT GATGATCTGA CTGGGGAGCC TCTTGTTCAG 480 481 CGTGAGGATG ATAGACCAGA GACAGTTGTC AAGAGACTGA AAGCTTATGA AGCCCAAACA 540 541 GAGCCTGTCC TGGAGTACTA CAGGAAAAAA GGGGTGTTGG AAACATTCTC TGGAACAGAA 600 601 ACCAACAAGA TCTGGCCACA TGTATATGCT TTCCTACAAA CAAAACTTCC ACAAAGAAGC 660 661 CAGGAAACAT CAGTTACTCC ATGA 684 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrial matrix | |
Cellular Component | Mitochondrion | |
Molecular Function | Adenylate kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | GTP binding | |
Molecular Function | Nucleoside triphosphate adenylate kinase activity | |
Biological Process | ADP biosynthetic process | |
Biological Process | AMP metabolic process | |
Biological Process | GTP metabolic process | |
Biological Process | ITP metabolic process | |
Biological Process | UTP metabolic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ova-2825 | Ovis aries | 99.56 | 8e-167 | 466 |
| LLPS-Sus-3963 | Sus scrofa | 94.71 | 1e-158 | 446 |
| LLPS-Dio-0241 | Dipodomys ordii | 93.62 | 1e-128 | 369 |
| LLPS-Caj-4220 | Callithrix jacchus | 92.95 | 2e-157 | 442 |
| LLPS-Aon-3970 | Aotus nancymaae | 92.95 | 6e-157 | 442 |
| LLPS-Gog-2340 | Gorilla gorilla | 92.51 | 1e-156 | 441 |
| LLPS-Hos-1278 | Homo sapiens | 92.51 | 1e-156 | 441 |
| LLPS-Fec-2857 | Felis catus | 92.51 | 3e-156 | 440 |
| LLPS-Poa-3305 | Pongo abelii | 92.07 | 1e-155 | 438 |
| LLPS-Nol-3890 | Nomascus leucogenys | 91.82 | 6e-149 | 421 |
| LLPS-Caf-0197 | Canis familiaris | 91.63 | 4e-154 | 434 |
| LLPS-Orc-2157 | Oryctolagus cuniculus | 91.63 | 8e-155 | 436 |
| LLPS-Pat-4933 | Pan troglodytes | 91.63 | 2e-154 | 435 |
| LLPS-Mal-1706 | Mandrillus leucophaeus | 91.19 | 2e-154 | 435 |
| LLPS-Paa-3663 | Papio anubis | 91.19 | 2e-154 | 435 |
| LLPS-Maf-4062 | Macaca fascicularis | 91.19 | 2e-154 | 435 |
| LLPS-Chs-1846 | Chlorocebus sabaeus | 91.19 | 2e-154 | 435 |
| LLPS-Cea-4707 | Cercocebus atys | 91.19 | 2e-154 | 435 |
| LLPS-Ict-4296 | Ictidomys tridecemlineatus | 91.19 | 1e-154 | 436 |
| LLPS-Mam-3079 | Macaca mulatta | 91.19 | 2e-154 | 435 |
| LLPS-Rhb-2771 | Rhinopithecus bieti | 91.19 | 2e-154 | 435 |
| LLPS-Cas-3791 | Carlito syrichta | 91.08 | 4e-104 | 305 |
| LLPS-Eqc-3895 | Equus caballus | 90.75 | 7e-155 | 436 |
| LLPS-Otg-4576 | Otolemur garnettii | 90.75 | 2e-154 | 435 |
| LLPS-Mup-1498 | Mustela putorius furo | 90.31 | 9e-153 | 431 |
| LLPS-Cap-3561 | Cavia porcellus | 90.13 | 3e-150 | 424 |
| LLPS-Mea-3170 | Mesocricetus auratus | 89.87 | 2e-153 | 432 |
| LLPS-Ran-1148 | Rattus norvegicus | 89.43 | 4e-151 | 427 |
| LLPS-Mum-4427 | Mus musculus | 89.43 | 1e-152 | 431 |
| LLPS-Urm-3658 | Ursus maritimus | 89.3 | 2e-141 | 402 |
| LLPS-Aim-3521 | Ailuropoda melanoleuca | 89.04 | 1e-144 | 410 |
| LLPS-Ere-0898 | Erinaceus europaeus | 88.07 | 6e-114 | 330 |
| LLPS-Myl-1581 | Myotis lucifugus | 87.57 | 5e-114 | 331 |
| LLPS-Loa-0381 | Loxodonta africana | 86.41 | 4e-115 | 333 |
| LLPS-Fud-4128 | Fukomys damarensis | 84.26 | 4e-117 | 340 |
| LLPS-Mod-2884 | Monodelphis domestica | 83.33 | 5e-141 | 401 |
| LLPS-Sah-3547 | Sarcophilus harrisii | 81.97 | 2e-137 | 392 |
| LLPS-Man-4693 | Macaca nemestrina | 77.73 | 2e-115 | 336 |
| LLPS-Pap-1941 | Pan paniscus | 75.77 | 1e-119 | 347 |
| LLPS-Pes-0746 | Pelodiscus sinensis | 75.11 | 4e-121 | 351 |
| LLPS-Fia-3500 | Ficedula albicollis | 75.11 | 6e-126 | 363 |
| LLPS-Gaga-2281 | Gallus gallus | 74.67 | 2e-126 | 365 |
| LLPS-Tag-1355 | Taeniopygia guttata | 74.21 | 3e-124 | 358 |
| LLPS-Meg-2901 | Meleagris gallopavo | 74.16 | 2e-99 | 293 |
| LLPS-Anc-3590 | Anolis carolinensis | 74.04 | 4e-116 | 338 |
| LLPS-Xet-0374 | Xenopus tropicalis | 73.85 | 3e-118 | 343 |
| LLPS-Leo-3702 | Lepisosteus oculatus | 72.86 | 3e-114 | 333 |
| LLPS-Lac-0818 | Latimeria chalumnae | 71.56 | 2e-115 | 337 |
| LLPS-Scm-3995 | Scophthalmus maximus | 69.86 | 2e-112 | 328 |
| LLPS-Orn-3212 | Oreochromis niloticus | 69.55 | 8e-111 | 325 |
| LLPS-Ora-3207 | Ornithorhynchus anatinus | 69.06 | 1e-107 | 316 |
| LLPS-Scf-3033 | Scleropages formosus | 68.35 | 2e-108 | 318 |
| LLPS-Gaa-2067 | Gasterosteus aculeatus | 68.25 | 2e-106 | 313 |
| LLPS-Asm-3798 | Astyanax mexicanus | 68.06 | 2e-108 | 318 |
| LLPS-Dar-0586 | Danio rerio | 67.91 | 3e-108 | 318 |
| LLPS-Icp-2366 | Ictalurus punctatus | 67.44 | 9e-108 | 317 |
| LLPS-Tar-3627 | Takifugu rubripes | 66.67 | 9e-107 | 314 |
| LLPS-Xim-3858 | Xiphophorus maculatus | 65.62 | 1e-108 | 319 |
| LLPS-Pof-3756 | Poecilia formosa | 65.3 | 2e-107 | 316 |
| LLPS-Orl-1150 | Oryzias latipes | 64.57 | 8e-109 | 319 |
| LLPS-Ten-1399 | Tetraodon nigroviridis | 64.32 | 4e-94 | 281 |
| LLPS-Cii-1777 | Ciona intestinalis | 56.6 | 6e-85 | 258 |
| LLPS-Cis-0940 | Ciona savignyi | 53.12 | 2e-81 | 250 |
| LLPS-Drm-1003 | Drosophila melanogaster | 49.76 | 1e-72 | 226 |
| LLPS-Brn-2977 | Brassica napus | 47.12 | 8e-55 | 182 |
| LLPS-Bro-1971 | Brassica oleracea | 47.12 | 8e-55 | 182 |
| LLPS-Brr-1705 | Brassica rapa | 47.12 | 8e-55 | 182 |
| LLPS-Yal-0201 | Yarrowia lipolytica | 46.4 | 1e-62 | 201 |
| LLPS-Usm-1146 | Ustilago maydis | 46.22 | 2e-66 | 213 |
| LLPS-Arl-1016 | Arabidopsis lyrata | 46.07 | 4e-55 | 183 |
| LLPS-Viv-1785 | Vitis vinifera | 46.07 | 3e-55 | 183 |
| LLPS-Spr-1550 | Sporisorium reilianum | 46.06 | 5e-67 | 215 |
| LLPS-Sac-0959 | Saccharomyces cerevisiae | 46.04 | 1e-53 | 179 |
| LLPS-Sot-0077 | Solanum tuberosum | 46.03 | 5e-54 | 180 |
| LLPS-Nia-1810 | Nicotiana attenuata | 45.88 | 3e-56 | 185 |
| LLPS-Sem-2390 | Selaginella moellendorffii | 45.55 | 9e-54 | 179 |
| LLPS-Coc-2071 | Corchorus capsularis | 45.55 | 2e-54 | 181 |
| LLPS-Art-2486 | Arabidopsis thaliana | 45.55 | 1e-54 | 181 |
| LLPS-Cym-0813 | Cyanidioschyzon merolae | 45.5 | 8e-54 | 180 |
| LLPS-Mel-1114 | Melampsora laricipopulina | 45.13 | 2e-53 | 180 |
| LLPS-Amt-1607 | Amborella trichopoda | 44.85 | 1e-55 | 184 |
| LLPS-Sol-1626 | Solanum lycopersicum | 44.33 | 3e-53 | 177 |
| LLPS-Orbr-2188 | Oryza brachyantha | 44.33 | 2e-54 | 181 |
| LLPS-Phv-1102 | Phaseolus vulgaris | 43.98 | 5e-53 | 177 |
| LLPS-Pot-1410 | Populus trichocarpa | 43.98 | 3e-52 | 175 |
| LLPS-Hea-0536 | Helianthus annuus | 43.81 | 2e-52 | 176 |
| LLPS-Glm-1627 | Glycine max | 43.81 | 2e-54 | 181 |
| LLPS-Gor-2584 | Gossypium raimondii | 43.81 | 4e-54 | 180 |
| LLPS-Orp-1205 | Oryza punctata | 43.81 | 4e-54 | 180 |
| LLPS-Mae-1823 | Manihot esculenta | 43.78 | 4e-56 | 185 |
| LLPS-Crn-1273 | Cryptococcus neoformans | 43.72 | 4e-56 | 186 |
| LLPS-Zem-1836 | Zea mays | 43.46 | 2e-52 | 176 |
| LLPS-Sob-1462 | Sorghum bicolor | 43.46 | 1e-52 | 176 |
| LLPS-Php-2000 | Physcomitrella patens | 43.43 | 6e-52 | 174 |
| LLPS-Orgl-0879 | Oryza glumaepatula | 43.3 | 3e-53 | 178 |
| LLPS-Orni-1021 | Oryza nivara | 43.3 | 3e-53 | 178 |
| LLPS-Orb-0077 | Oryza barthii | 43.3 | 3e-53 | 178 |
| LLPS-Ori-1133 | Oryza indica | 43.3 | 3e-53 | 178 |
| LLPS-Org-0580 | Oryza glaberrima | 43.3 | 3e-53 | 178 |
| LLPS-Orr-0252 | Oryza rufipogon | 43.3 | 3e-53 | 178 |
| LLPS-Ors-0513 | Oryza sativa | 43.3 | 3e-53 | 178 |
| LLPS-Sei-2131 | Setaria italica | 43.28 | 1e-53 | 180 |
| LLPS-Mua-1517 | Musa acuminata | 43.28 | 2e-53 | 178 |
| LLPS-Cus-0610 | Cucumis sativus | 42.79 | 1e-53 | 179 |
| LLPS-Orm-1071 | Oryza meridionalis | 42.79 | 7e-55 | 182 |
| LLPS-Met-1477 | Medicago truncatula | 42.78 | 5e-53 | 177 |
| LLPS-Brd-1286 | Brachypodium distachyon | 42.78 | 5e-53 | 177 |
| LLPS-Tra-2488 | Triticum aestivum | 42.78 | 3e-53 | 178 |
| LLPS-Lep-2363 | Leersia perrieri | 42.78 | 4e-53 | 177 |
| LLPS-Tum-0311 | Tuber melanosporum | 42.55 | 9e-55 | 182 |
| LLPS-Prp-1204 | Prunus persica | 42.29 | 5e-53 | 177 |
| LLPS-Kop-1236 | Komagataella pastoris | 42.13 | 2e-55 | 182 |
| LLPS-Scp-0879 | Schizosaccharomyces pombe | 42.06 | 2e-54 | 180 |
| LLPS-Osl-0221 | Ostreococcus lucimarinus | 41.98 | 2e-51 | 173 |
| LLPS-Nef-0344 | Neosartorya fischeri | 41.47 | 4e-54 | 181 |
| LLPS-Ast-0054 | Aspergillus terreus | 41.47 | 3e-54 | 181 |
| LLPS-Put-0435 | Puccinia triticina | 41.23 | 2e-56 | 188 |
| LLPS-Trr-1570 | Trichoderma reesei | 41.2 | 2e-53 | 179 |
| LLPS-Asni-0903 | Aspergillus niger | 41.15 | 1e-51 | 174 |
| LLPS-Scj-0014 | Schizosaccharomyces japonicus | 41.12 | 4e-53 | 177 |
| LLPS-Asfu-1253 | Aspergillus fumigatus | 41.01 | 1e-53 | 179 |
| LLPS-Thc-2053 | Theobroma cacao | 40.83 | 7e-54 | 180 |
| LLPS-Pug-1384 | Puccinia graminis | 40.69 | 1e-55 | 186 |
| LLPS-Fus-0783 | Fusarium solani | 40.45 | 2e-53 | 179 |
| LLPS-Fuv-0733 | Fusarium verticillioides | 40.28 | 1e-52 | 177 |
| LLPS-Aso-1040 | Aspergillus oryzae | 40.19 | 7e-53 | 176 |
| LLPS-Asn-0756 | Aspergillus nidulans | 40.18 | 3e-52 | 176 |
| LLPS-Asf-1041 | Aspergillus flavus | 40.09 | 1e-52 | 177 |
| LLPS-Fuo-1051 | Fusarium oxysporum | 40.0 | 1e-52 | 177 |
| LLPS-Zyt-1373 | Zymoseptoria tritici | 39.91 | 1e-51 | 173 |
| LLPS-Asc-1349 | Aspergillus clavatus | 39.73 | 5e-54 | 180 |
| LLPS-Trv-0307 | Trichoderma virens | 39.57 | 2e-52 | 177 |
| LLPS-Map-0357 | Magnaporthe poae | 39.45 | 1e-52 | 177 |
| LLPS-Asg-1224 | Ashbya gossypii | 39.44 | 1e-52 | 177 |
| LLPS-Nec-0794 | Neurospora crassa | 39.3 | 2e-52 | 177 |
| LLPS-Pytr-1490 | Pyrenophora triticirepentis | 39.22 | 1e-53 | 180 |
| LLPS-Coo-0474 | Colletotrichum orbiculare | 38.64 | 1e-52 | 177 |
| LLPS-Cog-0477 | Colletotrichum gloeosporioides | 38.5 | 2e-52 | 177 |
| LLPS-Cogr-0943 | Colletotrichum graminicola | 38.18 | 4e-52 | 176 |