• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Trv-0839
INT6

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit E
Gene Name: INT6, TRIVIDRAFT_74050
Ensembl Gene: TRIVIDRAFT_74050
Ensembl Protein: EHK23492
Organism: Trichoderma virens
Taxa ID: 413071
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblEHK23492EHK23492
UniProtG9MNN7, G9MNN7_HYPVG
GeneBankABDF02000005EHK23492.1
RefSeqXM_014102238.1XP_013957713.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEDILKALPA  DGASIMPKVA  PHLSRHLLFP  LIQFEGDQAE  EKGDAELAKK  ILSGKIQLLD  60
61    DTNMTDYVAS  LYCELHGVAE  APAEYTKKRQ  DVLAQLDKYE  KATEQIANLL  TQDEVVNGLR  120
121   SDKVANLEFL  KNQHGVTIEM  VNALYDFGQF  QFRCGQYGPA  ADMLYQFRVL  STDNDKVAAA  180
181   TWGKLASEIL  STNWESAVDE  LKNVREGIDT  RLFNNPRAQL  DHRTMLIHWS  LFPLFNFEGA  240
241   REPILDMFFS  ASYINTIQTS  CPWILRYLIA  AVITGRTRAR  NSSVQQKQLK  DIVRYVRQEA  300
301   YEYADPITQF  VNALYIAHDF  NAAREALRMA  EEVCRGDFFL  AASTDAFVNA  ARHLICESYC  360
361   KIFSRMNIRD  LSAKLGLNPD  DGEKWIVNLI  RETRLDAKID  SQDGTVIMNH  PPNNVYQQVI  420
421   EKTKGGFFRT  QVLNAAVSK  439
Nucleotide CDS Sequence (FASTA)
1     ATGGAGGATA  TTCTGAAGGC  CCTGCCAGCC  GATGGCGCGT  CAATCATGCC  CAAGGTTGCG  60
61    CCGCACCTGA  GCCGTCACCT  GCTCTTCCCG  CTTATCCAGT  TCGAGGGCGA  CCAGGCTGAG  120
121   GAGAAGGGCG  ATGCCGAGCT  GGCCAAGAAG  ATTCTGTCAG  GCAAGATTCA  GCTGCTGGAC  180
181   GACACCAACA  TGACGGACTA  CGTGGCGTCG  CTATACTGCG  AGCTGCACGG  AGTGGCCGAG  240
241   GCCCCGGCCG  AGTACACCAA  GAAGAGACAG  GATGTGCTGG  CACAGCTGGA  CAAGTACGAG  300
301   AAGGCGACGG  AGCAGATTGC  AAACCTCTTG  ACCCAGGACG  AGGTCGTCAA  CGGACTGAGA  360
361   AGCGACAAGG  TGGCCAACTT  GGAGTTTCTC  AAGAACCAGC  ACGGAGTTAC  TATTGAGATG  420
421   GTGAATGCTC  TGTATGACTT  TGGACAGTTC  CAGTTCCGAT  GCGGCCAGTA  TGGACCTGCT  480
481   GCCGATATGC  TCTACCAATT  CCGAGTTCTC  TCCACCGACA  ATGACAAGGT  GGCCGCTGCC  540
541   ACATGGGGAA  AGCTTGCTTC  CGAAATCCTC  TCCACAAACT  GGGAGTCTGC  CGTTGATGAG  600
601   CTTAAGAACG  TCCGAGAGGG  CATCGACACC  AGACTCTTCA  ACAACCCCCG  AGCTCAGCTC  660
661   GACCACCGGA  CTATGCTTAT  CCACTGGTCT  CTCTTCCCCC  TGTTCAACTT  CGAGGGTGCC  720
721   CGGGAACCCA  TCCTGGACAT  GTTCTTCTCT  GCTTCCTACA  TCAACACCAT  CCAGACTTCT  780
781   TGCCCCTGGA  TTCTGCGGTA  CTTGATTGCC  GCCGTTATCA  CCGGCCGCAC  ACGTGCCCGC  840
841   AACAGCTCTG  TCCAGCAAAA  GCAGCTCAAG  GACATCGTTC  GCTATGTTCG  ACAGGAGGCC  900
901   TACGAGTATG  CTGACCCCAT  TACCCAGTTT  GTCAACGCCC  TCTACATTGC  CCACGACTTC  960
961   AACGCTGCTC  GTGAGGCTCT  CCGCATGGCC  GAGGAGGTGT  GCCGTGGCGA  TTTCTTCCTG  1020
1021  GCTGCCTCTA  CTGACGCATT  CGTCAACGCT  GCTCGACACC  TCATTTGCGA  AAGCTACTGC  1080
1081  AAGATCTTCA  GCCGAATGAA  CATCCGGGAT  CTGAGCGCCA  AGCTTGGCTT  GAACCCCGAC  1140
1141  GATGGCGAGA  AGTGGATCGT  GAACCTGATC  CGCGAGACTC  GCCTGGATGC  CAAGATTGAC  1200
1201  AGCCAGGATG  GCACTGTCAT  TATGAACCAC  CCTCCCAACA  ACGTTTACCA  GCAGGTCATT  1260
1261  GAGAAGACCA  AGGGTGGATT  CTTCAGGACA  CAAGTCCTCA  ACGCGGCTGT  CTCTAAATAA  1320

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Initiation factor
Protein biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex, eIF3e
Molecular Function
Translation initiation factor activity
Biological Process
Formation of cytoplasmic translation initiation complex

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Trr-1214Trichoderma reesei98.410.0 903
LLPS-Fuv-1049Fusarium verticillioides88.150.0 829
LLPS-Fuo-1477Fusarium oxysporum87.930.0 828
LLPS-Fus-1507Fusarium solani87.020.0 822
LLPS-Beb-1068Beauveria bassiana84.040.0 799
LLPS-Coo-0310Colletotrichum orbiculare79.270.0 751
LLPS-Ved-1234Verticillium dahliae79.040.0 723
LLPS-Cog-0331Colletotrichum gloeosporioides77.90.0 743
LLPS-Cogr-0308Colletotrichum graminicola77.90.0 738
LLPS-Tum-0108Tuber melanosporum72.734e-50 173
LLPS-Nec-1322Neurospora crassa65.410.0 599
LLPS-Gag-0583Gaeumannomyces graminis65.350.0 597
LLPS-Map-0890Magnaporthe poae65.120.0 594
LLPS-Mao-0125Magnaporthe oryzae63.950.0 582
LLPS-Blg-0126Blumeria graminis63.740.0 588
LLPS-Asfu-1365Aspergillus fumigatus63.110.0 580
LLPS-Asn-0787Aspergillus nidulans63.020.0 572
LLPS-Nef-0374Neosartorya fischeri62.820.0 568
LLPS-Ast-0414Aspergillus terreus62.350.0 568
LLPS-Asf-0391Aspergillus flavus62.180.0 567
LLPS-Aso-0014Aspergillus oryzae62.180.0 567
LLPS-Asni-0403Aspergillus niger61.720.0 568
LLPS-Dos-0819Dothistroma septosporum61.520.0 555
LLPS-Asc-0093Aspergillus clavatus61.410.0 558
LLPS-Lem-0677Leptosphaeria maculans60.470.0 545
LLPS-Pytr-0122Pyrenophora triticirepentis59.770.0 540
LLPS-Pyt-0116Pyrenophora teres59.530.0 538
LLPS-Zyt-0642Zymoseptoria tritici59.310.0 521
LLPS-Phn-0171Phaeosphaeria nodorum59.022e-173 500
LLPS-Abg-1819Absidia glauca48.16e-147 433
LLPS-Yal-0722Yarrowia lipolytica47.429e-132 394
LLPS-Scj-0810Schizosaccharomyces japonicus45.85e-105 328
LLPS-Php-0216Physcomitrella patens43.711e-117 358
LLPS-Miv-0178Microbotryum violaceum43.683e-121 370
LLPS-Icp-1034Ictalurus punctatus42.897e-112 343
LLPS-Tag-0123Taeniopygia guttata42.782e-103 321
LLPS-Anp-1973Anas platyrhynchos42.531e-102 320
LLPS-Orl-2298Oryzias latipes42.422e-110 340
LLPS-Cii-0261Ciona intestinalis42.429e-111 340
LLPS-Xim-2832Xiphophorus maculatus42.425e-111 341
LLPS-Orn-0109Oreochromis niloticus42.422e-110 340
LLPS-Scm-2845Scophthalmus maximus42.421e-108 335
LLPS-Gaa-3010Gasterosteus aculeatus42.199e-110 338
LLPS-Asm-0076Astyanax mexicanus42.123e-110 339
LLPS-Ora-2314Ornithorhynchus anatinus42.115e-97 303
LLPS-Put-1004Puccinia triticina42.111e-78 252
LLPS-Leo-0285Lepisosteus oculatus41.961e-110 340
LLPS-Pof-0940Poecilia formosa41.964e-111 342
LLPS-Ten-2233Tetraodon nigroviridis41.963e-110 339
LLPS-Cea-0656Cercocebus atys41.782e-107 334
LLPS-Paa-2566Papio anubis41.782e-107 334
LLPS-Bot-2536Bos taurus41.784e-108 335
LLPS-Man-3648Macaca nemestrina41.782e-107 334
LLPS-Pat-0851Pan troglodytes41.782e-107 333
LLPS-Lac-3327Latimeria chalumnae41.724e-110 339
LLPS-Meg-1489Meleagris gallopavo41.724e-108 334
LLPS-Dar-3547Danio rerio41.723e-109 337
LLPS-Caj-1851Callithrix jacchus41.495e-108 334
LLPS-Fud-1996Fukomys damarensis41.492e-108 334
LLPS-Gog-1470Gorilla gorilla41.494e-108 334
LLPS-Sus-1884Sus scrofa41.494e-108 334
LLPS-Aon-3178Aotus nancymaae41.493e-108 335
LLPS-Sah-0761Sarcophilus harrisii41.495e-108 333
LLPS-Chs-2306Chlorocebus sabaeus41.494e-108 334
LLPS-Mum-3244Mus musculus41.494e-108 334
LLPS-Mea-1193Mesocricetus auratus41.494e-108 334
LLPS-Ova-1735Ovis aries41.493e-108 334
LLPS-Aim-4127Ailuropoda melanoleuca41.494e-108 334
LLPS-Mup-0832Mustela putorius furo41.494e-108 334
LLPS-Mal-2391Mandrillus leucophaeus41.494e-108 334
LLPS-Ran-0642Rattus norvegicus41.494e-108 334
LLPS-Dio-3881Dipodomys ordii41.494e-108 334
LLPS-Tut-1262Tursiops truncatus41.494e-108 334
LLPS-Orc-0560Oryctolagus cuniculus41.495e-108 334
LLPS-Fia-1025Ficedula albicollis41.499e-108 333
LLPS-Pes-1943Pelodiscus sinensis41.492e-106 331
LLPS-Otg-0113Otolemur garnettii41.494e-108 334
LLPS-Hos-0975Homo sapiens41.494e-108 334
LLPS-Urm-2276Ursus maritimus41.494e-108 334
LLPS-Ict-2861Ictidomys tridecemlineatus41.494e-108 334
LLPS-Cas-0337Carlito syrichta41.494e-108 334
LLPS-Cap-1000Cavia porcellus41.494e-108 334
LLPS-Eqc-3206Equus caballus41.494e-108 334
LLPS-Caf-2977Canis familiaris41.494e-108 334
LLPS-Poa-2585Pongo abelii41.494e-108 334
LLPS-Mel-0452Melampsora laricipopulina41.354e-116 353
LLPS-Tar-2697Takifugu rubripes41.321e-107 333
LLPS-Xet-2289Xenopus tropicalis41.31e-105 327
LLPS-Myl-1257Myotis lucifugus41.262e-107 332
LLPS-Nol-0308Nomascus leucogenys41.156e-108 334
LLPS-Rhb-2534Rhinopithecus bieti41.122e-105 327
LLPS-Anc-0178Anolis carolinensis41.083e-106 329
LLPS-Via-1571Vigna angularis41.034e-109 336
LLPS-Scf-2756Scleropages formosus40.912e-106 330
LLPS-Loa-0336Loxodonta africana40.799e-106 328
LLPS-Mod-0686Monodelphis domestica40.791e-106 330
LLPS-Amt-0389Amborella trichopoda40.76e-111 341
LLPS-Gas-0689Galdieria sulphuraria40.625e-106 328
LLPS-Phv-1685Phaseolus vulgaris40.512e-109 337
LLPS-Met-2253Medicago truncatula40.336e-108 333
LLPS-Prp-0610Prunus persica40.331e-110 340
LLPS-Gaga-3007Gallus gallus40.221e-104 325
LLPS-Coc-1431Corchorus capsularis40.096e-109 336
LLPS-Nia-1167Nicotiana attenuata40.055e-111 341
LLPS-Usm-0565Ustilago maydis40.06e-107 334
LLPS-Maf-3049Macaca fascicularis39.828e-103 322
LLPS-Mam-3956Macaca mulatta39.828e-103 322
LLPS-Glm-0251Glycine max39.812e-107 332
LLPS-Pug-0386Puccinia graminis39.811e-114 352
LLPS-Fec-0170Felis catus39.699e-104 323
LLPS-Sob-2292Sorghum bicolor39.672e-104 324
LLPS-Viv-1090Vitis vinifera39.643e-110 339
LLPS-Mae-0118Manihot esculenta39.586e-107 330
LLPS-Art-0514Arabidopsis thaliana39.583e-108 334
LLPS-Spr-0564Sporisorium reilianum39.483e-105 330
LLPS-Dac-0605Daucus carota39.456e-105 325
LLPS-Pot-1422Populus trichocarpa39.454e-110 338
LLPS-Hea-1754Helianthus annuus39.392e-107 332
LLPS-Mua-1130Musa acuminata39.355e-101 315
LLPS-Ors-1131Oryza sativa39.342e-104 324
LLPS-Orr-0331Oryza rufipogon39.342e-104 324
LLPS-Cis-1860Ciona savignyi39.253e-95 300
LLPS-Sei-1634Setaria italica39.29e-104 322
LLPS-Ori-1726Oryza indica39.118e-104 322
LLPS-Sem-0787Selaginella moellendorffii39.114e-103 320
LLPS-Cus-1444Cucumis sativus39.111e-106 329
LLPS-Bro-2638Brassica oleracea39.111e-106 330
LLPS-Arl-1172Arabidopsis lyrata39.08e-108 333
LLPS-Sol-1322Solanum lycopersicum38.892e-105 327
LLPS-Sot-0524Solanum tuberosum38.891e-105 327
LLPS-Orni-0395Oryza nivara38.885e-103 320
LLPS-Orb-0408Oryza barthii38.885e-103 320
LLPS-Brd-2276Brachypodium distachyon38.889e-102 317
LLPS-Lep-1643Leersia perrieri38.887e-99 310
LLPS-Orgl-0784Oryza glumaepatula38.883e-103 321
LLPS-Brr-1984Brassica rapa38.884e-106 328
LLPS-Gor-2005Gossypium raimondii38.885e-105 325
LLPS-Org-0590Oryza glaberrima38.885e-103 320
LLPS-Brn-0213Brassica napus38.757e-107 330
LLPS-Orp-1552Oryza punctata38.648e-103 320
LLPS-Thc-1850Theobroma cacao38.488e-105 325
LLPS-Chc-0625Chondrus crispus38.486e-91 290
LLPS-Tru-1299Triticum urartu38.443e-97 305
LLPS-Tra-3043Triticum aestivum38.282e-97 306
LLPS-Hov-0330Hordeum vulgare38.285e-97 306
LLPS-Scc-0582Schizosaccharomyces cryophilus38.272e-104 326
LLPS-Zem-1630Zea mays38.262e-101 316
LLPS-Orbr-1555Oryza brachyantha38.175e-101 315
LLPS-Vir-1245Vigna radiata38.06e-92 291
LLPS-Chr-1697Chlamydomonas reinhardtii37.885e-103 320
LLPS-Kop-0645Komagataella pastoris37.799e-92 291
LLPS-Scp-1264Schizosaccharomyces pombe37.714e-100 315
LLPS-Crn-0627Cryptococcus neoformans37.591e-93 296
LLPS-Drm-0276Drosophila melanogaster36.13e-81 264
LLPS-Orm-1128Oryza meridionalis35.587e-89 283
LLPS-Cae-0889Caenorhabditis elegans35.427e-78 255
LLPS-Pap-0921Pan paniscus33.545e-2194.4
LLPS-Osl-0632Ostreococcus lucimarinus33.334e-74 245
LLPS-Cym-0734Cyanidioschyzon merolae26.995e-48 178