• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Anp-1973
EIF3E

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit E
Gene Name: EIF3E, EIF3S6
Ensembl Gene: ENSAPLG00000006091.1
Ensembl Protein: ENSAPLP00000005727.1
Organism: Anas platyrhynchos
Taxa ID: 8839
LLPS Type: LLPS regulator


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION


Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

▼ CROSS REFERENCE


DatabaseNucleotide IDProtein ID
EnsemblENSAPLT00000006359.1ENSAPLP00000005727.1
UniProtU3IEQ5, U3IEQ5_ANAPL
GeneBankADON01093473, ADON01093472

▼ SEQUENCE


Protein Sequence (FASTA)
1     MAEYDLTTRI  AHFLDRHHEC  ISCILVFVNQ  LQIYNEKELL  QGKLDLLSDT  NMVDFAMDVY  60
61    KNLYSDEIPH  ALREKRTTVV  AQLKQLQAET  EPIVKMFEDP  ETTRQMQSTR  DGRMLFDYLA  120
121   EKHGFRQEYL  DTLYRYAKFQ  YECGNYSGAA  EYLYFFRVLV  PATDRNALSS  LWGKLASEIL  180
181   MQNWDAAMED  LTRLKETIDN  NSVSSPLQSL  QQRTWLIHWS  LFVFFNHPKG  RDNIIDLFLY  240
241   QPQYLNAIQT  MCPRLLRYLT  TAVITNKDVR  KRGQVLKDLV  KVIQQESYTY  RDPITEFVEC  300
301   LYVNFDFDGA  QKKLRECETV  LVNDFFLVAC  LEDFIENARL  FIFETFCRIH  QCISIGMLAD  360
361   KLNMTPEEAE  RWIVNLIRNA  RLDAKLDSKL  GHVVMGNNAV  SPYQQVIEKT  KSLSFRSQML  420
421   AMNIEKKLNQ  SGRSEAPNWA  TQDSGFY  447
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGAGT  ACGACCTGAC  CACCCGCATC  GCGCACTTCT  TGGACCGCCA  CCATGAGTGC  60
61    ATTAGTTGTA  TTTTGGTGTT  TGTAAACCAG  CTCCAGATAT  ACAATGAAAA  AGAACTCCTT  120
121   CAAGGAAAGC  TGGATCTCCT  CAGTGATACC  AACATGGTGG  ATTTTGCTAT  GGATGTGTAC  180
181   AAAAACCTGT  ATTCTGATGA  AATTCCACAT  GCTCTGCGTG  AGAAGAGAAC  AACTGTTGTT  240
241   GCACAGCTGA  AACAACTTCA  GGCTGAAACT  GAACCTATTG  TCAAGATGTT  TGAGGATCCA  300
301   GAGACTACGA  GGCAAATGCA  GTCCACTAGG  GATGGTCGAA  TGCTGTTTGA  CTACTTAGCT  360
361   GAGAAGCATG  GTTTTAGGCA  GGAGTACCTA  GATACACTCT  ACAGGTATGC  AAAATTCCAG  420
421   TATGAATGTG  GCAATTACTC  TGGAGCTGCA  GAATATCTAT  ACTTCTTTAG  GGTTCTGGTT  480
481   CCAGCTACAG  ACAGAAATGC  TCTGAGTTCT  CTGTGGGGGA  AACTTGCATC  TGAAATTCTG  540
541   ATGCAGAATT  GGGATGCAGC  CATGGAAGAT  CTCACAAGAC  TGAAGGAGAC  AATAGATAAT  600
601   AATTCAGTAA  GCTCTCCGCT  GCAGTCGCTT  CAACAAAGAA  CATGGCTCAT  CCACTGGTCT  660
661   CTGTTTGTGT  TTTTTAATCA  TCCTAAAGGG  AGAGACAATA  TCATTGATCT  CTTTCTCTAT  720
721   CAACCACAGT  ATCTCAATGC  AATTCAGACA  ATGTGCCCAC  GTCTCCTCCG  ATACCTCACT  780
781   ACTGCAGTCA  TAACAAATAA  GGATGTTCGA  AAACGTGGAC  AAGTGCTGAA  AGATCTAGTC  840
841   AAGGTTATTC  AACAGGAGTC  CTACACGTAC  AGGGACCCCA  TCACAGAATT  TGTGGAATGC  900
901   CTGTATGTTA  ATTTTGATTT  TGATGGTGCA  CAGAAGAAGC  TGAGAGAGTG  TGAAACAGTG  960
961   CTTGTGAATG  ATTTTTTCTT  AGTGGCATGC  CTTGAAGACT  TCATTGAGAA  TGCCCGTCTC  1020
1021  TTTATATTTG  AGACTTTCTG  TCGCATCCAT  CAATGTATCA  GCATTGGTAT  GTTAGCAGAT  1080
1081  AAACTAAACA  TGACTCCTGA  GGAAGCAGAA  AGATGGATTG  TCAATCTAAT  CCGAAATGCA  1140
1141  CGATTAGATG  CCAAGTTGGA  TTCAAAGCTG  GGCCATGTAG  TTATGGGCAA  CAACGCAGTG  1200
1201  TCACCCTATC  AACAGGTGAT  TGAAAAAACC  AAAAGCCTGT  CTTTTCGTAG  TCAAATGTTG  1260
1261  GCTATGAACA  TTGAGAAGAA  ACTGAATCAG  AGTGGTAGAT  CTGAGGCACC  TAACTGGGCT  1320
1321  ACTCAAGACT  CTGGCTTCTA  CTGA  1344

▼ KEYWORD


ID
Family
Complete proteome
Cytoplasm
Initiation factor
Nucleus
Protein biosynthesis
Reference proteome

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex, eIF3e
Cellular Component
PML body
Molecular Function
Protein N-terminus binding
Molecular Function
Translation initiation factor activity
Biological Process
Formation of cytoplasmic translation initiation complex
Biological Process
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Biological Process
Positive regulation of mRNA binding
Biological Process
Positive regulation of translation

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Tag-0123Taeniopygia guttata99.280.0 863
LLPS-Ora-2314Ornithorhynchus anatinus97.220.0 811
LLPS-Fia-1025Ficedula albicollis96.420.0 895
LLPS-Meg-1489Meleagris gallopavo96.20.0 894
LLPS-Man-3648Macaca nemestrina94.630.0 881
LLPS-Pat-0851Pan troglodytes94.630.0 881
LLPS-Urm-2276Ursus maritimus94.630.0 882
LLPS-Hos-0975Homo sapiens94.630.0 882
LLPS-Orc-0560Oryctolagus cuniculus94.630.0 882
LLPS-Otg-0113Otolemur garnettii94.630.0 882
LLPS-Poa-2585Pongo abelii94.630.0 882
LLPS-Caf-2977Canis familiaris94.630.0 882
LLPS-Eqc-3206Equus caballus94.630.0 882
LLPS-Cap-1000Cavia porcellus94.630.0 882
LLPS-Ict-2861Ictidomys tridecemlineatus94.630.0 882
LLPS-Cas-0337Carlito syrichta94.630.0 882
LLPS-Cea-0656Cercocebus atys94.630.0 881
LLPS-Aon-3178Aotus nancymaae94.630.0 884
LLPS-Sus-1884Sus scrofa94.630.0 882
LLPS-Mea-1193Mesocricetus auratus94.630.0 882
LLPS-Mum-3244Mus musculus94.630.0 882
LLPS-Chs-2306Chlorocebus sabaeus94.630.0 882
LLPS-Caj-1851Callithrix jacchus94.630.0 880
LLPS-Gog-1470Gorilla gorilla94.630.0 881
LLPS-Dio-3881Dipodomys ordii94.630.0 882
LLPS-Tut-1262Tursiops truncatus94.630.0 882
LLPS-Mal-2391Mandrillus leucophaeus94.630.0 882
LLPS-Paa-2566Papio anubis94.630.0 880
LLPS-Mup-0832Mustela putorius furo94.630.0 882
LLPS-Aim-4127Ailuropoda melanoleuca94.630.0 882
LLPS-Ran-0642Rattus norvegicus94.630.0 882
LLPS-Nol-0308Nomascus leucogenys94.410.0 879
LLPS-Fud-1996Fukomys damarensis94.410.0 880
LLPS-Ova-1735Ovis aries94.410.0 880
LLPS-Myl-1257Myotis lucifugus94.410.0 880
LLPS-Bot-2536Bos taurus94.270.0 854
LLPS-Pes-1943Pelodiscus sinensis94.180.0 874
LLPS-Sah-0761Sarcophilus harrisii94.180.0 880
LLPS-Lac-3327Latimeria chalumnae93.30.0 870
LLPS-Loa-0336Loxodonta africana93.290.0 870
LLPS-Rhb-2534Rhinopithecus bieti93.060.0 861
LLPS-Gaga-3007Gallus gallus92.670.0 883
LLPS-Leo-0285Lepisosteus oculatus92.630.0 864
LLPS-Anc-0178Anolis carolinensis91.50.0 855
LLPS-Asm-0076Astyanax mexicanus91.290.0 852
LLPS-Mod-0686Monodelphis domestica91.050.0 856
LLPS-Orn-2279Oreochromis niloticus90.850.0 852
LLPS-Ten-2233Tetraodon nigroviridis90.850.0 852
LLPS-Icp-1034Ictalurus punctatus90.620.0 850
LLPS-Mam-3956Macaca mulatta90.380.0 868
LLPS-Maf-3049Macaca fascicularis90.380.0 868
LLPS-Xet-2289Xenopus tropicalis90.20.0 840
LLPS-Pof-0940Poecilia formosa90.180.0 849
LLPS-Xim-1166Xiphophorus maculatus90.180.0 848
LLPS-Dar-3547Danio rerio89.960.0 847
LLPS-Scm-4001Scophthalmus maximus89.960.0 847
LLPS-Orl-2298Oryzias latipes89.490.0 835
LLPS-Fec-0170Felis catus89.050.0 867
LLPS-Gaa-3010Gasterosteus aculeatus89.040.0 837
LLPS-Pap-0921Pan paniscus88.891e-97 297
LLPS-Scf-2756Scleropages formosus87.990.0 830
LLPS-Tar-2697Takifugu rubripes87.70.0 821
LLPS-Cii-0261Ciona intestinalis70.660.0 630
LLPS-Cis-1860Ciona savignyi62.010.0 558
LLPS-Drm-0276Drosophila melanogaster57.373e-177 510
LLPS-Amt-0389Amborella trichopoda55.054e-166 483
LLPS-Php-0216Physcomitrella patens54.824e-168 488
LLPS-Thc-1850Theobroma cacao52.985e-155 454
LLPS-Orp-1552Oryza punctata52.756e-156 456
LLPS-Orbr-1555Oryza brachyantha52.754e-156 457
LLPS-Ori-1726Oryza indica52.752e-155 455
LLPS-Orni-0395Oryza nivara52.753e-155 455
LLPS-Viv-1090Vitis vinifera52.691e-158 463
LLPS-Arl-1172Arabidopsis lyrata52.564e-150 442
LLPS-Glm-0251Glycine max52.555e-155 454
LLPS-Ors-1131Oryza sativa52.528e-155 453
LLPS-Orr-0331Oryza rufipogon52.528e-155 453
LLPS-Org-0590Oryza glaberrima52.521e-154 453
LLPS-Orb-0408Oryza barthii52.521e-154 453
LLPS-Orgl-0784Oryza glumaepatula52.528e-155 453
LLPS-Art-0514Arabidopsis thaliana52.331e-149 440
LLPS-Prp-0610Prunus persica52.249e-156 456
LLPS-Via-1571Vigna angularis52.028e-157 459
LLPS-Gor-1561Gossypium raimondii51.962e-152 447
LLPS-Gas-0689Galdieria sulphuraria51.891e-154 454
LLPS-Sob-2292Sorghum bicolor51.837e-157 459
LLPS-Lep-1643Leersia perrieri51.831e-152 448
LLPS-Cus-1444Cucumis sativus51.832e-152 447
LLPS-Phv-1685Phaseolus vulgaris51.795e-157 459
LLPS-Mae-0118Manihot esculenta51.798e-154 451
LLPS-Coc-1431Corchorus capsularis51.792e-156 457
LLPS-Mua-1130Musa acuminata51.61e-150 443
LLPS-Pot-1422Populus trichocarpa51.577e-154 451
LLPS-Met-2253Medicago truncatula51.572e-155 455
LLPS-Sei-1634Setaria italica51.385e-155 454
LLPS-Tum-0108Tuber melanosporum51.352e-29 117
LLPS-Sot-0524Solanum tuberosum51.283e-146 432
LLPS-Chr-1697Chlamydomonas reinhardtii50.822e-148 437
LLPS-Zem-1630Zea mays50.794e-157 459
LLPS-Tru-1299Triticum urartu50.728e-144 425
LLPS-Brr-1984Brassica rapa50.562e-150 442
LLPS-Nia-1167Nicotiana attenuata50.563e-151 444
LLPS-Bro-2638Brassica oleracea50.562e-150 442
LLPS-Brn-0213Brassica napus50.562e-150 442
LLPS-Dac-0605Daucus carota50.452e-148 437
LLPS-Sol-1322Solanum lycopersicum50.356e-145 428
LLPS-Orm-1128Oryza meridionalis50.235e-143 422
LLPS-Brd-2276Brachypodium distachyon50.228e-153 448
LLPS-Hov-0330Hordeum vulgare50.119e-149 439
LLPS-Tra-3043Triticum aestivum50.115e-149 439
LLPS-Abg-0278Absidia glauca49.773e-150 441
LLPS-Hea-1754Helianthus annuus49.552e-148 437
LLPS-Cae-0889Caenorhabditis elegans49.073e-142 421
LLPS-Sem-0787Selaginella moellendorffii48.524e-142 421
LLPS-Chc-0625Chondrus crispus48.513e-136 407
LLPS-Vir-1245Vigna radiata47.762e-135 402
LLPS-Put-1004Puccinia triticina46.773e-74 241
LLPS-Nef-0374Neosartorya fischeri46.466e-125 377
LLPS-Asn-0787Aspergillus nidulans46.234e-124 375
LLPS-Asfu-1365Aspergillus fumigatus45.816e-126 380
LLPS-Blg-0126Blumeria graminis45.812e-116 355
LLPS-Asni-0403Aspergillus niger45.584e-125 378
LLPS-Aso-0014Aspergillus oryzae45.358e-125 377
LLPS-Asf-0391Aspergillus flavus45.358e-125 377
LLPS-Ast-0414Aspergillus terreus45.281e-122 371
LLPS-Asc-0093Aspergillus clavatus45.286e-125 377
LLPS-Phn-0171Phaeosphaeria nodorum45.059e-106 327
LLPS-Zyt-0642Zymoseptoria tritici44.427e-105 325
LLPS-Dos-0819Dothistroma septosporum43.581e-115 353
LLPS-Scj-0810Schizosaccharomyces japonicus43.095e-92 295
LLPS-Ved-1234Verticillium dahliae43.045e-104 323
LLPS-Trr-1214Trichoderma reesei42.538e-103 320
LLPS-Trv-0839Trichoderma virens42.531e-102 320
LLPS-Lem-0677Leptosphaeria maculans42.425e-113 347
LLPS-Pytr-0122Pyrenophora triticirepentis42.362e-111 342
LLPS-Pyt-0116Pyrenophora teres42.361e-111 343
LLPS-Cog-0331Colletotrichum gloeosporioides42.286e-107 331
LLPS-Cogr-0308Colletotrichum graminicola42.282e-106 329
LLPS-Pug-0386Puccinia graminis42.244e-108 335
LLPS-Yal-0722Yarrowia lipolytica42.081e-110 340
LLPS-Coo-0310Colletotrichum orbiculare42.032e-106 330
LLPS-Map-0890Magnaporthe poae41.532e-112 345
LLPS-Mel-0452Melampsora laricipopulina41.392e-97 305
LLPS-Nec-1322Neurospora crassa41.387e-108 333
LLPS-Miv-0178Microbotryum violaceum41.235e-110 341
LLPS-Beb-1068Beauveria bassiana41.133e-101 317
LLPS-Fuo-1477Fusarium oxysporum40.941e-100 315
LLPS-Fuv-1049Fusarium verticillioides40.948e-101 315
LLPS-Fus-1507Fusarium solani40.911e-100 315
LLPS-Gag-0583Gaeumannomyces graminis40.637e-110 338
LLPS-Mao-0125Magnaporthe oryzae39.733e-107 332
LLPS-Crn-0627Cryptococcus neoformans38.552e-100 315
LLPS-Scp-1264Schizosaccharomyces pombe38.161e-99 314
LLPS-Scc-0582Schizosaccharomyces cryophilus37.61e-95 303
LLPS-Kop-0645Komagataella pastoris36.872e-78 256
LLPS-Osl-0632Ostreococcus lucimarinus36.781e-88 283
LLPS-Spr-0564Sporisorium reilianum35.361e-92 297
LLPS-Usm-0565Ustilago maydis35.236e-94 300
LLPS-Cym-0734Cyanidioschyzon merolae31.972e-69 236