• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Ora-2314
EIF3E

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Eukaryotic translation initiation factor 3 subunit E
Gene Name: EIF3E, EIF3S6, INT6
Ensembl Gene: ENSOANG00000002269.3
Ensembl Protein: ENSOANP00000003593.3
Organism: Ornithorhynchus anatinus
Taxa ID: 9258
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MVDFAMDVYK  NLYSDDIPHA  LREKRTTVVA  QLKQLQAETE  PIVKMFEDPE  TTRQMQSTRD  60
61    GRMLFDYLAD  KHGFRQEYLD  TLYRYAKFQY  ECGNYSGAAE  YLYFFRVLVP  ATDRNALSSL  120
121   WGKLASEILM  QNWDAAMEDL  TRLKETIDNN  SVSSPLQSLQ  QRTWLIHWSL  FVFFNHPKGR  180
181   DNIIDLFLYQ  PQYLNAIQTM  CPHILRYLTT  AVITNKDVRK  RRQVLKDLVK  VIQQESYTYK  240
241   DPITEFVECL  YVNFDFDGAQ  KKLRECESVL  VNDFFLVACL  EDFIENARLF  IFETFCRIHQ  300
301   CISISMLADK  LNMTPEEAER  WIVNLIRNAR  LDAKIDSKLG  HVVMGNNAVS  PYQQVIEKTK  360
361   SLSFRSQMLA  MNIEKKLNQN  SRSEAPNWAT  QDSGFY  396
Nucleotide CDS Sequence (FASTA)
1     ATGGTGGACT  TCGCTATGGA  TGTATACAAA  AACCTTTATT  CCGATGACAT  TCCTCATGCC  60
61    TTACGAGAAA  AGAGAACCAC  TGTTGTTGCC  CAGCTGAAAC  AGCTGCAGGC  AGAGACCGAA  120
121   CCAATTGTCA  AAATGTTTGA  AGATCCGGAA  ACTACACGGC  AGATGCAGTC  TACCAGGGAT  180
181   GGTAGAATGC  TCTTCGACTA  CCTGGCTGAC  AAGCATGGTT  TTAGGCAGGA  ATATTTAGAT  240
241   ACACTCTACA  GATATGCAAA  ATTCCAGTAT  GAATGTGGGA  ACTATTCAGG  AGCAGCAGAA  300
301   TATCTGTACT  TTTTTAGAGT  ATTGGTTCCA  GCAACAGACA  GAAATGCTTT  GAGCTCCCTT  360
361   TGGGGAAAAT  TGGCATCTGA  AATCTTAATG  CAGAACTGGG  ATGCGGCCAT  GGAAGACCTT  420
421   ACACGATTGA  AAGAGACCAT  AGACAATAAT  TCAGTCAGCT  CCCCACTCCA  GTCTCTTCAG  480
481   CAGAGGACAT  GGCTCATTCA  CTGGTCTCTG  TTTGTTTTCT  TCAACCACCC  TAAAGGCCGA  540
541   GATAATATTA  TTGATCTCTT  CCTTTATCAG  CCACAGTACC  TTAATGCAAT  TCAGACTATG  600
601   TGCCCTCATA  TCCTTCGCTA  TCTGACTACA  GCCGTCATAA  CAAACAAAGA  CGTTAGAAAA  660
661   CGCAGACAAG  TACTGAAAGA  TCTTGTCAAG  GTTATCCAGC  AGGAGTCATA  CACTTACAAA  720
721   GATCCCATTA  CAGAGTTCGT  CGAATGCCTG  TATGTTAACT  TTGACTTTGA  TGGCGCCCAA  780
781   AAAAAATTGA  GGGAGTGTGA  ATCGGTCCTC  GTGAATGACT  TTTTCTTGGT  AGCTTGCCTT  840
841   GAAGATTTCA  TCGAGAATGC  TCGACTCTTC  ATATTTGAGA  CTTTCTGTCG  TATTCACCAA  900
901   TGTATCAGCA  TTAGTATGTT  GGCAGATAAG  CTGAACATGA  CCCCGGAAGA  AGCTGAGAGG  960
961   TGGATAGTAA  ATCTGATCCG  AAATGCAAGG  CTTGATGCCA  AGATAGATTC  CAAATTAGGC  1020
1021  CATGTGGTCA  TGGGTAACAA  CGCAGTCTCA  CCTTATCAGC  AAGTAATTGA  AAAGACCAAA  1080
1081  AGCCTTTCTT  TTCGCAGCCA  GATGTTGGCC  ATGAACATTG  AGAAAAAGCT  TAATCAGAAT  1140
1141  AGTAGGTCGG  AGGCTCCTAA  CTGGGCTACT  CAAGACTCCG  GATTCTACTA  A  1191

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Cytoplasm
Initiation factor
Nucleus
Phosphoprotein
Protein biosynthesis
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Eukaryotic 43S preinitiation complex
Cellular Component
Eukaryotic 48S preinitiation complex
Cellular Component
Eukaryotic translation initiation factor 3 complex
Cellular Component
Eukaryotic translation initiation factor 3 complex, eIF3e
Cellular Component
Nucleus
Cellular Component
PML body
Molecular Function
Protein N-terminus binding
Molecular Function
Translation initiation factor activity
Biological Process
Formation of cytoplasmic translation initiation complex
Biological Process
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Biological Process
Positive regulation of mRNA binding
Biological Process
Positive regulation of translation
Biological Process
Translational initiation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Urm-2276Ursus maritimus99.750.0 829
LLPS-Pat-0851Pan troglodytes99.750.0 829
LLPS-Hos-0975Homo sapiens99.750.0 829
LLPS-Man-3648Macaca nemestrina99.750.0 828
LLPS-Otg-0113Otolemur garnettii99.750.0 829
LLPS-Orc-0560Oryctolagus cuniculus99.750.0 829
LLPS-Caf-2977Canis familiaris99.750.0 829
LLPS-Poa-2585Pongo abelii99.750.0 829
LLPS-Eqc-3206Equus caballus99.750.0 829
LLPS-Cap-1000Cavia porcellus99.750.0 829
LLPS-Cas-0337Carlito syrichta99.750.0 829
LLPS-Ict-2861Ictidomys tridecemlineatus99.750.0 829
LLPS-Mea-1193Mesocricetus auratus99.750.0 829
LLPS-Mum-3244Mus musculus99.750.0 829
LLPS-Chs-2306Chlorocebus sabaeus99.750.0 829
LLPS-Cea-0656Cercocebus atys99.750.0 828
LLPS-Aon-3178Aotus nancymaae99.750.0 831
LLPS-Sus-1884Sus scrofa99.750.0 829
LLPS-Gog-1470Gorilla gorilla99.750.0 829
LLPS-Caj-1851Callithrix jacchus99.750.0 829
LLPS-Tut-1262Tursiops truncatus99.750.0 829
LLPS-Dio-3881Dipodomys ordii99.750.0 829
LLPS-Ran-0642Rattus norvegicus99.750.0 829
LLPS-Mal-2391Mandrillus leucophaeus99.750.0 829
LLPS-Paa-2566Papio anubis99.750.0 828
LLPS-Mup-0832Mustela putorius furo99.750.0 829
LLPS-Aim-4127Ailuropoda melanoleuca99.750.0 829
LLPS-Nol-0308Nomascus leucogenys99.490.0 827
LLPS-Sah-0761Sarcophilus harrisii99.490.0 828
LLPS-Fud-1996Fukomys damarensis99.490.0 828
LLPS-Ova-1735Ovis aries99.490.0 828
LLPS-Myl-1257Myotis lucifugus99.490.0 828
LLPS-Bot-2536Bos taurus99.480.0 803
LLPS-Loa-0336Loxodonta africana98.230.0 817
LLPS-Meg-1489Meleagris gallopavo97.980.0 820
LLPS-Lac-3327Latimeria chalumnae97.980.0 816
LLPS-Fia-1025Ficedula albicollis97.980.0 820
LLPS-Rhb-2534Rhinopithecus bieti97.980.0 810
LLPS-Tag-0123Taeniopygia guttata97.980.0 819
LLPS-Pes-1943Pelodiscus sinensis97.470.0 815
LLPS-Pap-0921Pan paniscus97.31e-72 231
LLPS-Anp-1973Anas platyrhynchos97.220.0 811
LLPS-Leo-0285Lepisosteus oculatus96.730.0 806
LLPS-Anc-0178Anolis carolinensis96.720.0 808
LLPS-Mod-0686Monodelphis domestica96.210.0 807
LLPS-Asm-0076Astyanax mexicanus95.470.0 796
LLPS-Mam-3956Macaca mulatta94.720.0 816
LLPS-Maf-3049Macaca fascicularis94.720.0 816
LLPS-Xet-2289Xenopus tropicalis94.470.0 786
LLPS-Ten-2233Tetraodon nigroviridis94.460.0 791
LLPS-Icp-1034Ictalurus punctatus94.460.0 791
LLPS-Orn-2279Oreochromis niloticus93.950.0 789
LLPS-Gaga-3007Gallus gallus93.950.0 810
LLPS-Dar-3547Danio rerio93.70.0 789
LLPS-Scm-4001Scophthalmus maximus93.70.0 789
LLPS-Pof-0940Poecilia formosa93.450.0 788
LLPS-Xim-1166Xiphophorus maculatus93.450.0 787
LLPS-Orl-2298Oryzias latipes93.430.0 778
LLPS-Fec-0170Felis catus93.160.0 815
LLPS-Gaa-3010Gasterosteus aculeatus92.930.0 781
LLPS-Tar-2697Takifugu rubripes91.920.0 769
LLPS-Scf-2756Scleropages formosus91.150.0 771
LLPS-Cii-0261Ciona intestinalis74.40.0 588
LLPS-Cis-1860Ciona savignyi63.819e-179 513
LLPS-Drm-0276Drosophila melanogaster60.07e-169 487
LLPS-Amt-0389Amborella trichopoda57.142e-154 451
LLPS-Php-0216Physcomitrella patens56.12e-153 448
LLPS-Gas-0689Galdieria sulphuraria55.592e-145 428
LLPS-Orp-1552Oryza punctata54.812e-145 428
LLPS-Orbr-1555Oryza brachyantha54.814e-146 429
LLPS-Thc-1850Theobroma cacao54.817e-143 421
LLPS-Orni-0395Oryza nivara54.812e-145 427
LLPS-Orgl-0784Oryza glumaepatula54.556e-145 426
LLPS-Viv-1090Vitis vinifera54.432e-146 430
LLPS-Mae-0118Manihot esculenta54.336e-141 416
LLPS-Org-0590Oryza glaberrima54.293e-144 424
LLPS-Orb-0408Oryza barthii54.293e-144 424
LLPS-Ori-1726Oryza indica54.293e-144 424
LLPS-Prp-0610Prunus persica54.078e-141 416
LLPS-Ors-1131Oryza sativa54.031e-143 423
LLPS-Orr-0331Oryza rufipogon54.031e-143 423
LLPS-Lep-1643Leersia perrieri53.772e-142 420
LLPS-Sei-1634Setaria italica53.776e-146 429
LLPS-Met-2253Medicago truncatula53.776e-142 419
LLPS-Mua-1130Musa acuminata53.754e-140 414
LLPS-Art-0514Arabidopsis thaliana53.663e-139 412
LLPS-Gor-1561Gossypium raimondii53.661e-140 415
LLPS-Arl-1172Arabidopsis lyrata53.662e-138 410
LLPS-Sob-2292Sorghum bicolor53.518e-146 428
LLPS-Cus-1444Cucumis sativus53.518e-141 416
LLPS-Phv-1685Phaseolus vulgaris53.163e-143 422
LLPS-Chr-1697Chlamydomonas reinhardtii53.056e-140 413
LLPS-Pot-1422Populus trichocarpa52.914e-142 419
LLPS-Coc-1431Corchorus capsularis52.919e-143 421
LLPS-Via-1571Vigna angularis52.912e-142 420
LLPS-Abg-1819Absidia glauca52.797e-141 416
LLPS-Sot-0524Solanum tuberosum52.762e-136 404
LLPS-Brd-2276Brachypodium distachyon52.738e-142 418
LLPS-Zem-1630Zea mays52.541e-146 431
LLPS-Orm-1128Oryza meridionalis52.471e-133 397
LLPS-Glm-0251Glycine max52.412e-141 417
LLPS-Tum-0108Tuber melanosporum52.254e-30 118
LLPS-Hea-1754Helianthus annuus52.233e-136 404
LLPS-Brr-1984Brassica rapa52.216e-138 409
LLPS-Brn-0213Brassica napus52.217e-138 408
LLPS-Sol-1322Solanum lycopersicum52.123e-135 401
LLPS-Tru-1299Triticum urartu52.071e-137 407
LLPS-Tra-3043Triticum aestivum52.071e-137 408
LLPS-Dac-0605Daucus carota51.956e-136 403
LLPS-Nia-1167Nicotiana attenuata51.657e-139 411
LLPS-Hov-0330Hordeum vulgare51.559e-136 404
LLPS-Chc-0625Chondrus crispus51.454e-126 379
LLPS-Bro-2638Brassica oleracea51.395e-138 409
LLPS-Cae-0889Caenorhabditis elegans50.135e-132 393
LLPS-Sem-0787Selaginella moellendorffii49.483e-130 389
LLPS-Vir-1245Vigna radiata49.117e-122 366
LLPS-Nef-0374Neosartorya fischeri48.274e-118 358
LLPS-Asn-0787Aspergillus nidulans48.02e-117 356
LLPS-Asfu-1365Aspergillus fumigatus47.512e-119 362
LLPS-Ast-0414Aspergillus terreus47.473e-115 351
LLPS-Put-1004Puccinia triticina47.311e-76 246
LLPS-Asc-0093Aspergillus clavatus47.27e-118 357
LLPS-Aso-0014Aspergillus oryzae46.986e-117 355
LLPS-Asf-0391Aspergillus flavus46.986e-117 355
LLPS-Asni-0403Aspergillus niger46.728e-117 355
LLPS-Blg-0126Blumeria graminis46.722e-110 338
LLPS-Phn-0171Phaeosphaeria nodorum45.862e-107 329
LLPS-Dos-0819Dothistroma septosporum45.196e-112 342
LLPS-Lem-0677Leptosphaeria maculans44.748e-112 341
LLPS-Mel-0452Melampsora laricipopulina44.239e-93 291
LLPS-Pytr-0122Pyrenophora triticirepentis44.216e-111 339
LLPS-Pyt-0116Pyrenophora teres44.215e-111 339
LLPS-Zyt-0642Zymoseptoria tritici44.192e-103 320
LLPS-Map-0890Magnaporthe poae43.316e-105 324
LLPS-Pug-0386Puccinia graminis42.823e-99 311
LLPS-Cog-0331Colletotrichum gloeosporioides42.781e-101 315
LLPS-Ved-1234Verticillium dahliae42.634e-98 306
LLPS-Cogr-0308Colletotrichum graminicola42.521e-100 313
LLPS-Coo-0310Colletotrichum orbiculare42.529e-101 313
LLPS-Nec-1322Neurospora crassa42.522e-100 312
LLPS-Mao-0125Magnaporthe oryzae42.157e-101 313
LLPS-Trr-1214Trichoderma reesei42.113e-97 304
LLPS-Trv-0839Trichoderma virens42.114e-97 303
LLPS-Miv-0178Microbotryum violaceum42.093e-101 317
LLPS-Gag-0583Gaeumannomyces graminis41.992e-102 318
LLPS-Yal-0722Yarrowia lipolytica41.559e-98 305
LLPS-Scj-0810Schizosaccharomyces japonicus41.282e-76 253
LLPS-Crn-0627Cryptococcus neoformans40.717e-91 288
LLPS-Beb-1068Beauveria bassiana40.571e-96 303
LLPS-Fus-1507Fusarium solani40.423e-95 299
LLPS-Fuo-1477Fusarium oxysporum40.423e-94 296
LLPS-Fuv-1049Fusarium verticillioides40.423e-94 296
LLPS-Osl-0632Ostreococcus lucimarinus38.213e-87 277
LLPS-Kop-0645Komagataella pastoris36.982e-71 236
LLPS-Scp-1264Schizosaccharomyces pombe36.733e-86 277
LLPS-Scc-0582Schizosaccharomyces cryophilus35.912e-82 267
LLPS-Usm-0565Ustilago maydis35.375e-87 281
LLPS-Spr-0564Sporisorium reilianum34.621e-85 277
LLPS-Cym-0734Cyanidioschyzon merolae31.882e-70 238