• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Hea-1588
PFK3

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: ATP-dependent 6-phosphofructokinase
Gene Name: PFK3, PFK, HannXRQ_Chr06g0172111
Ensembl Gene: HannXRQ_Chr06g0172111
Ensembl Protein: OTG22493
Organism: Helianthus annuus
Taxa ID: 4232
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblOTG22493OTG22493
UniProtA0A251UHG5, A0A251UHG5_HELAN
GeneBankCM007895OTG22493.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MHSVCNSGSI  VGFYKVSGDN  NSGRKTGNCN  GRKALVKVTH  RSRVMGSVPV  KVLGQPKVVR  60
61    GDHGYVLEDV  PHLTDYISDL  PTYPNPLQDH  PAYAVVKQYF  VDTDDTIAQK  IVVHANGPRG  120
121   THFRRAGPRQ  KVYFKSDDVH  ACIVTCGGLC  PGLNTVIREI  VGSLHDMYGV  TRIEGIEGGY  180
181   RGFYSRNTIS  LTPKVVNGIH  KRGGTIIGTS  RGGYDNKKIV  NSIEDRGINQ  VYIIGGDGTQ  240
241   KGASAIYEEV  RRRGLNVAVV  GIPKTIDNDI  PVIDQSFGFD  TAVEEAQRAI  NAAHVEAESN  300
301   ENCIGLVKLM  GRNSGFIAMH  ATLASRDVDC  CLIPESSFYL  EGPGGLFEYI  EKRIKENGHM  360
361   VIVVAEGAGQ  DLVAESLRTN  DDKDASGNKL  LNDVGLWLSQ  KIKGHFKKQT  EMEINLKYID  420
421   PTYMIRAVPS  NASDNVYCTL  LAQSAVHGAM  AGYTGFTVGP  VHGRECYLPF  YRITEKQNKV  480
481   VITDRMWARM  LSSTNQPSFL  NTKDIIESDM  DEAPPTQLLD  DRVVDNGFVT  KETTVC  536
Nucleotide CDS Sequence (FASTA)
1     ATGCATTCTG  TATGTAACAG  TGGTTCGATC  GTTGGTTTTT  ATAAGGTAAG  TGGTGATAAT  60
61    AATTCTGGTC  GGAAAACGGG  TAACTGTAAC  GGGAGAAAAG  CGTTGGTGAA  AGTGACACAT  120
121   CGGAGTAGAG  TTATGGGTTC  AGTGCCGGTT  AAAGTGTTGG  GTCAACCGAA  GGTTGTTAGG  180
181   GGGGATCATG  GTTATGTTCT  TGAAGATGTT  CCTCATTTGA  CTGATTATAT  CTCTGATCTT  240
241   CCGACTTATC  CTAATCCACT  GCAAGATCAT  CCTGCATACG  CAGTTGTTAA  GCAGTATTTC  300
301   GTTGATACGG  ATGACACTAT  TGCTCAAAAG  ATTGTTGTTC  ATGCTAATGG  TCCTAGAGGC  360
361   ACCCATTTTC  GACGAGCAGG  ACCACGTCAA  AAGGTGTATT  TCAAATCAGA  CGACGTTCAC  420
421   GCTTGTATTG  TGACATGTGG  GGGCCTATGC  CCCGGTCTCA  ACACTGTGAT  TAGAGAAATC  480
481   GTTGGTAGTT  TACACGATAT  GTATGGCGTT  ACAAGAATCG  AAGGGATTGA  AGGAGGTTAC  540
541   CGAGGTTTTT  ACTCACGAAA  TACAATATCA  TTAACACCTA  AAGTGGTTAA  CGGTATTCAT  600
601   AAACGAGGTG  GCACCATAAT  CGGGACTTCA  CGAGGTGGTT  ATGATAACAA  AAAGATAGTC  660
661   AATAGTATTG  AAGATCGCGG  AATCAATCAG  GTGTATATAA  TAGGAGGTGA  CGGAACACAA  720
721   AAGGGGGCGT  CCGCTATCTA  TGAGGAAGTT  AGAAGGCGGG  GTCTTAACGT  TGCAGTTGTC  780
781   GGGATTCCAA  AAACTATAGA  TAATGACATT  CCGGTTATCG  ATCAATCATT  CGGCTTTGAT  840
841   ACTGCTGTCG  AGGAGGCTCA  ACGTGCTATT  AATGCAGCAC  ATGTTGAGGC  AGAGAGTAAC  900
901   GAGAACTGTA  TCGGCCTTGT  GAAGTTAATG  GGACGAAATA  GTGGGTTTAT  TGCAATGCAT  960
961   GCAACACTAG  CAAGCCGAGA  TGTTGATTGT  TGTTTGATTC  CCGAGTCATC  TTTCTATCTT  1020
1021  GAAGGACCCG  GAGGTCTTTT  CGAATATATA  GAAAAAAGAA  TCAAAGAAAA  CGGGCATATG  1080
1081  GTAATCGTTG  TAGCAGAAGG  TGCGGGCCAG  GATCTTGTTG  CCGAGAGCTT  ACGAACTAAT  1140
1141  GATGACAAGG  ATGCCTCTGG  AAACAAGCTC  TTAAATGATG  TTGGTTTGTG  GTTATCTCAA  1200
1201  AAAATCAAGG  GTCATTTCAA  GAAACAAACA  GAAATGGAGA  TCAACCTTAA  ATACATAGAT  1260
1261  CCTACGTACA  TGATTCGAGC  TGTTCCAAGT  AATGCATCGG  ATAATGTTTA  CTGCACTCTT  1320
1321  CTGGCTCAAA  GTGCGGTTCA  CGGAGCTATG  GCTGGCTACA  CTGGCTTCAC  TGTTGGCCCG  1380
1381  GTCCATGGTC  GAGAATGTTA  CCTACCGTTT  TACAGAATAA  CTGAGAAACA  AAACAAGGTT  1440
1441  GTAATTACTG  ATAGGATGTG  GGCAAGAATG  TTATCTTCAA  CGAATCAACC  GAGTTTTTTG  1500
1501  AATACGAAAG  ATATCATTGA  GTCAGACATG  GATGAAGCAC  CACCAACTCA  GTTGCTAGAT  1560
1561  GACCGGGTGG  TGGATAACGG  GTTTGTGACC  AAGGAAACTA  CTGTTTGCTG  A  1611

▼ KEYWORD

ID
Family
Allosteric enzyme
ATP-binding
Complete proteome
Cytoplasm
Glycolysis
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Molecular Function
6-phosphofructokinase activity
Molecular Function
ATP binding
Molecular Function
Metal ion binding
Biological Process
Fructose 6-phosphate metabolic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Viv-0705Vitis vinifera82.010.0 779
LLPS-Prp-2415Prunus persica80.170.0 771
LLPS-Brr-2009Brassica rapa80.090.0 745
LLPS-Amt-0078Amborella trichopoda80.00.0 722
LLPS-Mua-1967Musa acuminata79.780.0 754
LLPS-Brn-2034Brassica napus79.780.0 712
LLPS-Bro-1325Brassica oleracea79.640.0 713
LLPS-Arl-1096Arabidopsis lyrata79.550.0 711
LLPS-Sol-1883Solanum lycopersicum79.440.0 743
LLPS-Phv-2540Phaseolus vulgaris79.430.0 738
LLPS-Nia-1787Nicotiana attenuata79.230.0 740
LLPS-Via-2380Vigna angularis79.180.0 753
LLPS-Glm-1088Glycine max79.090.0 746
LLPS-Met-2270Medicago truncatula78.540.0 738
LLPS-Art-1339Arabidopsis thaliana78.30.0 702
LLPS-Gor-2030Gossypium raimondii78.250.0 744
LLPS-Sob-1961Sorghum bicolor78.230.0 728
LLPS-Sei-1924Setaria italica78.020.0 721
LLPS-Zem-2480Zea mays77.80.0 730
LLPS-Lep-1767Leersia perrieri77.660.0 727
LLPS-Orni-0591Oryza nivara77.620.0 736
LLPS-Orb-1034Oryza barthii77.620.0 736
LLPS-Ori-0655Oryza indica77.620.0 736
LLPS-Org-1039Oryza glaberrima77.620.0 736
LLPS-Orr-0831Oryza rufipogon77.620.0 736
LLPS-Ors-1378Oryza sativa77.620.0 736
LLPS-Tra-1810Triticum aestivum77.570.0 733
LLPS-Pot-2480Populus trichocarpa77.570.0 750
LLPS-Tru-0487Triticum urartu77.360.0 732
LLPS-Coc-2271Corchorus capsularis77.320.0 751
LLPS-Brd-0195Brachypodium distachyon77.250.0 719
LLPS-Mae-2519Manihot esculenta77.160.0 755
LLPS-Hov-2159Hordeum vulgare77.150.0 730
LLPS-Thc-2290Theobroma cacao76.970.0 759
LLPS-Sot-0352Solanum tuberosum76.020.0 708
LLPS-Dac-2369Daucus carota75.840.0 715
LLPS-Orgl-0692Oryza glumaepatula75.050.0 736
LLPS-Orbr-0719Oryza brachyantha75.00.0 719
LLPS-Orm-1308Oryza meridionalis73.860.0 686
LLPS-Orp-1193Oryza punctata73.860.0 686
LLPS-Cus-1362Cucumis sativus72.070.0 644
LLPS-Vir-0185Vigna radiata71.760.0 725
LLPS-Sem-0561Selaginella moellendorffii69.210.0 642
LLPS-Gas-1104Galdieria sulphuraria54.828e-145 434
LLPS-Chc-1089Chondrus crispus53.813e-141 426
LLPS-Cym-0836Cyanidioschyzon merolae51.156e-137 412
LLPS-Php-0236Physcomitrella patens49.881e-122 378
LLPS-Osl-1292Ostreococcus lucimarinus45.244e-104 326
LLPS-Dar-1019Danio rerio31.011e-0758.5
LLPS-Man-4011Macaca nemestrina30.682e-0861.6
LLPS-Eqc-3401Equus caballus30.595e-0963.2
LLPS-Anc-2842Anolis carolinensis30.129e-0962.4
LLPS-Paa-4204Papio anubis30.116e-0859.7
LLPS-Pat-3613Pan troglodytes30.113e-0860.8
LLPS-Hos-3107Homo sapiens30.113e-0860.5
LLPS-Mal-2659Mandrillus leucophaeus30.03e-0860.8
LLPS-Chs-4099Chlorocebus sabaeus29.892e-0861.6
LLPS-Mam-0948Macaca mulatta29.892e-0861.6
LLPS-Dio-4205Dipodomys ordii29.814e-0757.0
LLPS-Cas-1179Carlito syrichta29.766e-0859.7
LLPS-Tag-2200Taeniopygia guttata29.692e-0755.5
LLPS-Mel-1375Melampsora laricipopulina29.634e-0653.9
LLPS-Put-0611Puccinia triticina29.635e-0653.5
LLPS-Myl-3619Myotis lucifugus29.458e-0859.3
LLPS-Loa-1417Loxodonta africana29.417e-0859.7
LLPS-Pap-2887Pan paniscus29.313e-0860.8
LLPS-Ora-0863Ornithorhynchus anatinus29.279e-0859.3
LLPS-Gaga-2424Gallus gallus29.271e-0758.9
LLPS-Fud-4456Fukomys damarensis29.177e-0962.8
LLPS-Caf-0713Canis familiaris29.172e-0861.6
LLPS-Fec-0079Felis catus29.173e-0860.5
LLPS-Meg-1133Meleagris gallopavo28.991e-0862.0
LLPS-Bot-3173Bos taurus28.571e-0758.9
LLPS-Pes-2933Pelodiscus sinensis28.491e-0758.9
LLPS-Xet-2537Xenopus tropicalis28.44e-0757.0
LLPS-Orn-2342Oreochromis niloticus28.41e-0758.9
LLPS-Scf-2914Scleropages formosus28.322e-0861.2
LLPS-Leo-1200Lepisosteus oculatus28.165e-0756.6
LLPS-Cae-0984Caenorhabditis elegans28.027e-0962.8
LLPS-Xim-4111Xiphophorus maculatus28.04e-0757.0
LLPS-Ten-2750Tetraodon nigroviridis27.756e-0859.7
LLPS-Ict-3662Ictidomys tridecemlineatus27.685e-0653.5
LLPS-Gaa-2758Gasterosteus aculeatus27.651e-0758.9
LLPS-Urm-3158Ursus maritimus27.416e-0653.1
LLPS-Icp-2024Ictalurus punctatus27.325e-0757.0
LLPS-Maf-1952Macaca fascicularis26.863e-0654.3
LLPS-Cea-1426Cercocebus atys26.863e-0654.3
LLPS-Nol-1703Nomascus leucogenys26.861e-0655.5
LLPS-Otg-4170Otolemur garnettii26.861e-0655.5
LLPS-Scm-0523Scophthalmus maximus26.697e-0962.8
LLPS-Rhb-4328Rhinopithecus bieti26.671e-0655.5
LLPS-Asg-1356Ashbya gossypii26.273e-0757.8
LLPS-Sac-0201Saccharomyces cerevisiae26.265e-0963.5
LLPS-Ran-2738Rattus norvegicus26.233e-0654.3
LLPS-Aim-0056Ailuropoda melanoleuca26.232e-0654.7
LLPS-Mup-0465Mustela putorius furo26.232e-0654.7
LLPS-Mum-4455Mus musculus26.233e-0654.3
LLPS-Orl-3989Oryzias latipes26.227e-0653.1
LLPS-Tar-3767Takifugu rubripes26.071e-0758.5
LLPS-Orc-3475Oryctolagus cuniculus26.062e-0654.7
LLPS-Lem-1131Leptosphaeria maculans25.943e-0654.7
LLPS-Sah-2879Sarcophilus harrisii25.871e-0862.0
LLPS-Pof-3822Poecilia formosa25.792e-0861.2
LLPS-Caj-3275Callithrix jacchus25.777e-0962.8
LLPS-Cap-2401Cavia porcellus25.683e-0654.3
LLPS-Spr-0794Sporisorium reilianum25.396e-0653.1
LLPS-Map-0973Magnaporthe poae25.375e-0756.6
LLPS-Usm-1259Ustilago maydis25.332e-0655.1
LLPS-Nef-1245Neosartorya fischeri25.264e-0757.0
LLPS-Gog-2307Gorilla gorilla25.172e-0861.6
LLPS-Pytr-1140Pyrenophora triticirepentis24.816e-0653.1
LLPS-Abg-0709Absidia glauca24.415e-0757.0
LLPS-Sus-4399Sus scrofa24.266e-0756.6
LLPS-Kop-0294Komagataella pastoris23.913e-0860.8
LLPS-Ova-1289Ovis aries23.92e-0654.7
LLPS-Fia-1639Ficedula albicollis23.883e-0963.9