• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Tar-2841
arpc1a

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Actin-related protein 2/3 complex subunit
Gene Name: arpc1a
Ensembl Gene: ENSTRUG00000012566.2
Ensembl Protein: ENSTRUP00000031816.2
Organism: Takifugu rubripes
Taxa ID: 31033
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSLHQFLLEP  ITCHAWNRDR  TQIAISPNNH  EVHIYKKSGN  QWLKTHELKE  HNGHITGIDW  60
61    APKSDRIVTC  GADRNAYVWS  QKEGVWKPTL  VILRINRAAT  FVKWSPLENK  FAVGSGARLI  120
121   SVCYFESEND  WWVSKHIKKP  VRSTILSLDW  HPNNILLAAG  SCDFKCRVFS  AYIKEVEEKP  180
181   GPTPWGSKMP  FGAVLAEFGG  AGGGGWVHSV  SFSASGNRLA  WVSHDSTVTV  VDSSKTASPS  240
241   QLKTEFLPLL  SVIFVSENSV  VAAGHDCCPM  LFRCDDGGTL  TFVSKLDLPK  QSIQRNISAM  300
301   ERFRNMDKRA  TTEDRNTALD  TLHQNSITQV  SIYEGDKRDC  RKFCTTGIDG  AMTIWDFKSL  360
361   EASIQGLRIM  370
Nucleotide CDS Sequence (FASTA)
1     ATGTCCCTTC  ATCAGTTTCT  GCTGGAACCC  ATCACCTGCC  ACGCGTGGAA  TCGCGATCGG  60
61    ACACAAATTG  CCATCAGTCC  CAATAACCAC  GAAGTTCATA  TCTACAAGAA  GAGTGGCAAC  120
121   CAGTGGCTAA  AGACCCATGA  GCTGAAAGAG  CACAATGGAC  ACATAACAGG  TATTGACTGG  180
181   GCTCCTAAAA  GTGACCGTAT  AGTGACATGC  GGAGCCGACC  GTAATGCCTA  CGTATGGTCG  240
241   CAGAAGGAGG  GGGTGTGGAA  GCCCACACTG  GTCATCCTCA  GGATCAACCG  AGCTGCCACC  300
301   TTTGTCAAGT  GGTCTCCGCT  GGAGAACAAG  TTCGCGGTTG  GCAGCGGCGC  TCGCCTCATT  360
361   TCTGTCTGCT  ACTTTGAGTC  GGAGAACGAC  TGGTGGGTGA  GCAAGCACAT  CAAGAAGCCT  420
421   GTCCGCTCCA  CCATCCTCAG  TCTGGACTGG  CACCCTAATA  ATATTCTGCT  GGCCGCTGGA  480
481   TCCTGTGACT  TCAAATGCAG  GGTGTTCTCA  GCCTACATTA  AGGAGGTGGA  AGAGAAACCA  540
541   GGTCCCACAC  CCTGGGGCAG  CAAGATGCCA  TTTGGGGCTG  TTCTTGCAGA  ATTTGGAGGA  600
601   GCGGGTGGAG  GGGGCTGGGT  CCATTCAGTC  TCTTTCTCAG  CCTCTGGTAA  TCGCCTGGCC  660
661   TGGGTCAGTC  ACGACAGCAC  TGTTACTGTG  GTGGACAGCT  CTAAGACTGC  CAGTCCCTCA  720
721   CAGCTGAAGA  CGGAGTTTCT  CCCACTCCTC  AGTGTCATTT  TCGTTTCAGA  GAACAGCGTA  780
781   GTAGCCGCAG  GCCACGACTG  TTGCCCCATG  CTTTTCCGTT  GTGATGACGG  CGGAACGCTG  840
841   ACCTTCGTGT  CAAAACTCGA  CCTCCCCAAG  CAGAGTATTC  AGAGGAACAT  CTCTGCCATG  900
901   GAGCGCTTCA  GGAACATGGA  CAAGCGCGCC  ACCACCGAGG  ACCGCAACAC  TGCGCTGGAC  960
961   ACACTGCACC  AGAATAGCAT  CACCCAAGTG  TCTATCTATG  AGGGGGACAA  AAGGGATTGT  1020
1021  CGTAAGTTCT  GCACCACGGG  CATCGATGGA  GCGATGACCA  TCTGGGACTT  CAAGAGTCTA  1080
1081  GAAGCTTCTA  TCCAGGGTCT  CCGCATCATG  TGA  1113

▼ KEYWORD

ID
Family
Actin-binding
Complete proteome
Cytoplasm
Cytoskeleton
Reference proteome
WD repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Arp2/3 protein complex
Cellular Component
Cytoplasm
Molecular Function
Actin binding
Biological Process
Arp2/3 complex-mediated actin nucleation

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ten-3137Tetraodon nigroviridis98.650.0 703
LLPS-Gaa-2111Gasterosteus aculeatus98.650.0 704
LLPS-Orn-2169Oreochromis niloticus98.380.0 703
LLPS-Scm-3051Scophthalmus maximus98.110.0 701
LLPS-Pof-0323Poecilia formosa97.570.0 695
LLPS-Xim-0466Xiphophorus maculatus97.570.0 695
LLPS-Orl-1516Oryzias latipes96.760.0 685
LLPS-Icp-0802Ictalurus punctatus91.620.0 672
LLPS-Asm-0700Astyanax mexicanus91.620.0 674
LLPS-Fia-3549Ficedula albicollis91.350.0 667
LLPS-Dar-0164Danio rerio91.350.0 669
LLPS-Anp-2781Anas platyrhynchos91.350.0 669
LLPS-Tag-2823Taeniopygia guttata91.350.0 667
LLPS-Leo-0449Lepisosteus oculatus91.130.0 665
LLPS-Pes-1033Pelodiscus sinensis91.080.0 668
LLPS-Meg-1505Meleagris gallopavo91.080.0 665
LLPS-Gaga-0493Gallus gallus91.080.0 665
LLPS-Anc-0679Anolis carolinensis91.080.0 666
LLPS-Scf-0768Scleropages formosus91.080.0 667
LLPS-Poa-4598Pongo abelii90.959e-144 414
LLPS-Mod-2375Monodelphis domestica90.00.0 662
LLPS-Ora-0840Ornithorhynchus anatinus89.730.0 661
LLPS-Sah-2146Sarcophilus harrisii89.650.0 656
LLPS-Cas-3647Carlito syrichta89.460.0 657
LLPS-Sus-3844Sus scrofa89.460.0 657
LLPS-Orc-1451Oryctolagus cuniculus89.190.0 655
LLPS-Fec-2367Felis catus89.190.0 655
LLPS-Pat-1273Pan troglodytes89.190.0 655
LLPS-Pap-2201Pan paniscus89.190.0 655
LLPS-Urm-2070Ursus maritimus89.190.0 655
LLPS-Hos-1778Homo sapiens89.190.0 655
LLPS-Man-3292Macaca nemestrina89.190.0 655
LLPS-Nol-4310Nomascus leucogenys89.190.0 655
LLPS-Cap-0184Cavia porcellus89.190.0 655
LLPS-Caf-3663Canis familiaris89.190.0 655
LLPS-Fud-0452Fukomys damarensis89.190.0 655
LLPS-Maf-0057Macaca fascicularis89.190.0 655
LLPS-Cea-1038Cercocebus atys89.190.0 655
LLPS-Aim-3882Ailuropoda melanoleuca89.190.0 655
LLPS-Myl-0369Myotis lucifugus89.190.0 657
LLPS-Bot-0639Bos taurus89.190.0 652
LLPS-Otg-3383Otolemur garnettii88.920.0 654
LLPS-Loa-3501Loxodonta africana88.920.0 654
LLPS-Caj-2367Callithrix jacchus88.920.0 655
LLPS-Mum-0552Mus musculus88.920.0 654
LLPS-Aon-2078Aotus nancymaae88.920.0 655
LLPS-Ova-2711Ovis aries88.920.0 654
LLPS-Tut-1412Tursiops truncatus88.790.0 610
LLPS-Ran-0421Rattus norvegicus88.380.0 570
LLPS-Mam-1468Macaca mulatta88.280.0 634
LLPS-Ict-2724Ictidomys tridecemlineatus88.250.0 637
LLPS-Eqc-1644Equus caballus88.250.0 608
LLPS-Lac-1030Latimeria chalumnae88.140.0 647
LLPS-Dio-3115Dipodomys ordii87.10.0 635
LLPS-Mal-3748Mandrillus leucophaeus86.460.0 611
LLPS-Paa-0239Papio anubis83.290.0 592
LLPS-Xet-2557Xenopus tropicalis81.670.0 593
LLPS-Chs-0908Chlorocebus sabaeus72.920.0 558
LLPS-Gog-2266Gorilla gorilla69.712e-152 440
LLPS-Mea-1286Mesocricetus auratus65.952e-179 510
LLPS-Mup-1341Mustela putorius furo65.422e-178 508
LLPS-Rhb-0043Rhinopithecus bieti64.892e-176 503
LLPS-Cae-1715Caenorhabditis elegans54.93e-127 377
LLPS-Drm-1624Drosophila melanogaster54.777e-135 397
LLPS-Cis-0769Ciona savignyi54.743e-129 383
LLPS-Cii-2329Ciona intestinalis54.059e-132 389
LLPS-Asni-1565Aspergillus niger49.34e-106 323
LLPS-Ast-1398Aspergillus terreus48.615e-107 325
LLPS-Asc-0587Aspergillus clavatus48.066e-105 320
LLPS-Aso-1473Aspergillus oryzae48.062e-101 311
LLPS-Asn-1331Aspergillus nidulans47.913e-104 318
LLPS-Asf-1538Aspergillus flavus47.789e-96 306
LLPS-Brr-3002Brassica rapa47.543e-0857.4
LLPS-Phv-2528Phaseolus vulgaris47.513e-63 209
LLPS-Nef-0952Neosartorya fischeri47.51e-104 320
LLPS-Coo-1452Colletotrichum orbiculare47.51e-101 311
LLPS-Amt-2206Amborella trichopoda47.471e-50 177
LLPS-Sol-0504Solanum lycopersicum47.232e-66 230
LLPS-Asfu-0290Aspergillus fumigatus47.221e-104 320
LLPS-Scj-1410Schizosaccharomyces japonicus46.775e-96 298
LLPS-Cog-0983Colletotrichum gloeosporioides46.671e-98 304
LLPS-Cogr-1658Colletotrichum graminicola46.678e-99 305
LLPS-Abg-0834Absidia glauca46.462e-106 324
LLPS-Scs-1040Sclerotinia sclerotiorum46.261e-99 306
LLPS-Fuv-1401Fusarium verticillioides46.248e-98 302
LLPS-Php-1030Physcomitrella patens46.223e-90 285
LLPS-Trr-0084Trichoderma reesei45.967e-98 302
LLPS-Fus-0415Fusarium solani45.963e-98 303
LLPS-Fuo-0081Fusarium oxysporum45.963e-97 300
LLPS-Ved-0132Verticillium dahliae45.862e-99 306
LLPS-Trv-0229Trichoderma virens45.832e-97 301
LLPS-Tum-1563Tuber melanosporum45.752e-95 295
LLPS-Crn-1480Cryptococcus neoformans45.662e-106 326
LLPS-Pytr-0976Pyrenophora triticirepentis45.583e-97 300
LLPS-Zyt-0493Zymoseptoria tritici45.481e-95 296
LLPS-Pyt-1261Pyrenophora teres45.32e-97 301
LLPS-Miv-0360Microbotryum violaceum45.231e-99 308
LLPS-Beb-1636Beauveria bassiana45.139e-98 302
LLPS-Gag-1297Gaeumannomyces graminis44.727e-96 297
LLPS-Lem-0667Leptosphaeria maculans44.694e-96 298
LLPS-Sem-2445Selaginella moellendorffii44.682e-86 273
LLPS-Mel-0026Melampsora laricipopulina44.675e-99 306
LLPS-Scc-0280Schizosaccharomyces cryophilus44.472e-99 306
LLPS-Dos-1175Dothistroma septosporum44.441e-92 288
LLPS-Pug-0005Puccinia graminis44.333e-100 310
LLPS-Phn-1331Phaeosphaeria nodorum44.239e-93 290
LLPS-Yal-1389Yarrowia lipolytica44.149e-85 269
LLPS-Usm-1163Ustilago maydis44.091e-102 317
LLPS-Nec-1072Neurospora crassa44.081e-95 296
LLPS-Mao-0724Magnaporthe oryzae44.044e-95 295
LLPS-Put-1335Puccinia triticina43.925e-102 315
LLPS-Spr-1200Sporisorium reilianum43.93e-102 315
LLPS-Blg-1376Blumeria graminis43.773e-93 290
LLPS-Scp-0433Schizosaccharomyces pombe43.553e-95 296
LLPS-Hea-2431Helianthus annuus43.092e-87 276
LLPS-Viv-0992Vitis vinifera42.785e-87 275
LLPS-Sob-2167Sorghum bicolor42.666e-89 280
LLPS-Gor-0445Gossypium raimondii42.238e-86 271
LLPS-Thc-1435Theobroma cacao42.22e-85 270
LLPS-Nia-0531Nicotiana attenuata42.099e-84 266
LLPS-Pot-1876Populus trichocarpa42.093e-86 273
LLPS-Met-2364Medicago truncatula41.941e-84 268
LLPS-Via-0017Vigna angularis41.821e-85 271
LLPS-Sei-1261Setaria italica41.735e-86 272
LLPS-Mae-1009Manihot esculenta41.692e-83 266
LLPS-Brd-0826Brachypodium distachyon41.38e-84 266
LLPS-Hov-1473Hordeum vulgare41.292e-77 250
LLPS-Brn-2199Brassica napus41.275e-88 277
LLPS-Dac-1064Daucus carota41.267e-78 251
LLPS-Orm-1729Oryza meridionalis41.214e-82 264
LLPS-Orr-1912Oryza rufipogon41.213e-82 264
LLPS-Orni-0974Oryza nivara41.213e-82 264
LLPS-Orb-0875Oryza barthii41.213e-82 264
LLPS-Orgl-1846Oryza glumaepatula41.214e-82 264
LLPS-Kop-0341Komagataella pastoris41.192e-79 254
LLPS-Prp-0222Prunus persica41.183e-82 262
LLPS-Ors-0129Oryza sativa41.12e-83 265
LLPS-Ori-0691Oryza indica41.12e-83 265
LLPS-Tra-1085Triticum aestivum41.031e-82 263
LLPS-Coc-0388Corchorus capsularis41.022e-83 265
LLPS-Bro-0777Brassica oleracea41.011e-87 276
LLPS-Glm-1553Glycine max40.867e-84 266
LLPS-Orbr-0347Oryza brachyantha40.821e-84 268
LLPS-Lep-0877Leersia perrieri40.661e-82 264
LLPS-Zem-1804Zea mays40.621e-85 271
LLPS-Vir-1099Vigna radiata40.52e-84 267
LLPS-Mua-0378Musa acuminata40.499e-84 266
LLPS-Art-2588Arabidopsis thaliana40.054e-79 254
LLPS-Arl-0923Arabidopsis lyrata39.951e-85 271
LLPS-Cus-1470Cucumis sativus39.841e-80 258
LLPS-Tru-0675Triticum urartu38.674e-71 234
LLPS-Asg-0143Ashbya gossypii37.231e-62 211
LLPS-Sac-1174Saccharomyces cerevisiae35.63e-59 202
LLPS-Chr-1120Chlamydomonas reinhardtii34.458e-32 129
LLPS-Sot-2050Solanum tuberosum32.13e-0756.2
LLPS-Orp-2305Oryza punctata31.413e-42 157
LLPS-Osl-1299Ostreococcus lucimarinus27.987e-0652.0