LLPS-Tag-1961
HDAC9
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Histone deacetylase |
| Gene Name: | HDAC9 |
| Ensembl Gene: | ENSTGUG00000002613.1 |
| Ensembl Protein: | ENSTGUP00000002713.1 |
| Organism: | Taeniopygia guttata |
| Taxa ID: | 59729 |
| LLPS Type: | Regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| PML nuclear body | Predicted from orthologs | (View) |
▼ FUNCTION
| Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSTGUT00000002741.1 | ENSTGUP00000002713.1 |
| UniProt | H0YWN9, H0YWN9_TAEGU | |
| GeneBank | ABQF01013515, ABQF01013514, ABQF01013516, ABQF01013517, ABQF01013519, ABQF01013520, ABQF01013518, ABQF01013521 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MVDPIMREKQ LQQELLLIQQ QQQIHKQLLI AEFQKQHENL TRQHQAQLQE HIKLQQELLA 60 61 IKQQQELLEK EQKLEQQRQE QELERHRREQ QLPPLRGKER GRERAVASTE VKQKLQEFLL 120 121 SKSATKDSPA NGKNHSMSRH PKLWAAHHTS LDQSSPPLSG ASPPYKYTLP GAQDAKDDFP 180 181 LRKTASEPNL KVRSRLKQKV TERRSKMEDE SRDFNIMCTF QSGIHVCLIC FSESSVSSSS 240 241 PGSGPSSPSN GPTSSTTETE TSILPSNIQA EHLVSQQRLL IQDESVNLLS LYTSPLPNIT 300 301 LGLPAIQPQI SHFGTQAIQS RNQKKQKGET PSLRQGVALA GQYGGNIPPS STHPHIALEG 360 361 KPNSSHQALL QHLLLKEQMR QQKLLVTAVP LHPQSPLAAK ERVSPGIRAA HKLPRHRPLN 420 421 RTQSAPLPQS TLAQLVIQQQ HQQFLEKQKQ YQQQIHMNKM LSKSIEQLKQ PGSHLEEAEE 480 481 ELHGDHSMQE ERAPSSSASV RAESSSAEEP LDSDEDVQTQ QMESGEQAAF MQQVIGKDLA 540 541 PGFFLAHRHV HQLQIYQAQM ATVGMAGSDK HRPLSRTPSS PTDSTLPHPD MDQPSQHVYT 600 601 TGVVYDSLML KHQCMCGNYT NHPEHAGRIQ SIWSRLQETG LLNKCERIRG RKASLEEIQL 660 661 VHSEHHSLLY GTSPLNRQKL DPRKLLGLVS QKLFSLLPCG GLGVKRDIKW SEMAFSTSGR 720 721 ICVIIPYLKK KFKSSEAKTN GFAVVRPPGH HAEESTAMGF CFFNSIAITA KYLRDKLNIG 780 781 KILIVDLDVH HGNGTQQAFY ADPSILYVSL HRYDEGNFFP GSGAPNEVGS GPGEGYNINI 840 841 AWTGGLDPPM GDVEYLTAFR LV 862 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGTGGACC CAATTATGCG CGAAAAGCAG CTCCAGCAGG AGCTGCTCCT GATCCAGCAG 60 61 CAACAGCAGA TTCACAAACA ACTGCTCATT GCAGAGTTCC AGAAGCAGCA TGAAAATCTG 120 121 ACCCGCCAGC ATCAGGCCCA GCTCCAGGAG CACATTAAGT TACAACAGGA ACTACTAGCC 180 181 ATTAAACAAC AGCAAGAACT CCTTGAAAAA GAGCAGAAAC TGGAGCAGCA AAGACAAGAG 240 241 CAGGAACTGG AGAGGCATCG CAGGGAGCAA CAGCTTCCTC CCCTCCGAGG CAAAGAAAGA 300 301 GGACGAGAAA GGGCAGTGGC CAGTACAGAA GTGAAGCAGA AACTTCAAGA GTTCCTGTTA 360 361 AGTAAATCAG CTACAAAAGA CTCTCCAGCA AATGGGAAGA ATCATTCCAT GAGCCGTCAC 420 421 CCCAAGCTCT GGGCTGCCCA CCATACCTCA CTGGATCAAA GCTCTCCACC CCTGAGTGGG 480 481 GCCTCGCCAC CATACAAATA TACTTTACCA GGAGCACAGG ATGCTAAGGA TGATTTTCCA 540 541 CTTCGTAAAA CGGCTTCAGA GCCCAATTTG AAGGTACGTT CAAGATTAAA ACAAAAGGTG 600 601 ACAGAAAGGA GAAGCAAAAT GGAAGATGAA TCAAGAGACT TTAATATTAT GTGTACCTTT 660 661 CAGAGTGGAA TTCATGTATG TTTAATCTGT TTTTCAGAAT CCTCAGTCAG TAGCAGCTCC 720 721 CCTGGATCAG GTCCCAGTTC CCCAAGCAAT GGTCCGACCA GCAGTACAAC AGAAACTGAA 780 781 ACTTCAATTT TGCCATCTAA TATTCAAGCT GAGCACCTGG TTTCCCAGCA ACGCCTCTTA 840 841 ATACAGGATG AATCAGTGAA CTTGTTGAGT CTGTACACAT CTCCTCTGCC CAACATTACC 900 901 TTGGGCCTTC CAGCAATACA ACCTCAAATC AGTCATTTTG GTACACAAGC AATTCAGAGT 960 961 AGGAACCAGA AAAAGCAGAA GGGGGAGACC CCATCACTAA GACAAGGAGT GGCCTTGGCC 1020 1021 GGACAGTATG GAGGAAACAT TCCTCCATCA TCAACTCATC CTCACATTGC TTTGGAAGGA 1080 1081 AAGCCAAACA GCAGCCACCA AGCTCTCTTG CAGCATCTGT TACTGAAAGA ACAAATGAGA 1140 1141 CAGCAAAAAC TTCTTGTGAC TGCGGTTCCT CTTCATCCAC AGTCTCCTTT AGCAGCAAAG 1200 1201 GAGAGAGTCT CACCTGGCAT AAGAGCTGCC CACAAACTGC CTCGTCACAG GCCACTGAAC 1260 1261 AGAACCCAGT CAGCTCCTCT TCCTCAGAGT ACCTTGGCCC AGCTGGTCAT CCAGCAGCAA 1320 1321 CATCAGCAAT TTTTGGAGAA GCAGAAGCAG TACCAGCAGC AGATCCACAT GAATAAGATG 1380 1381 CTCTCTAAGT CCATTGAGCA GCTCAAGCAG CCTGGCAGTC ACCTGGAGGA AGCTGAAGAA 1440 1441 GAGCTTCATG GAGATCACTC AATGCAGGAA GAGCGAGCTC CCTCCAGCAG TGCCAGCGTT 1500 1501 AGGGCTGAGA GCAGCAGTGC TGAGGAGCCA CTGGACAGTG ATGAGGATGT TCAAACCCAG 1560 1561 CAAATGGAAT CTGGGGAGCA AGCTGCTTTT ATGCAACAGG TAATAGGCAA AGATTTAGCT 1620 1621 CCAGGATTTT TCCTGGCACA TCGGCATGTC CACCAGTTGC AAATCTACCA GGCTCAGATG 1680 1681 GCTACAGTTG GCATGGCAGG ATCAGATAAA CATCGACCAC TTTCCAGGAC CCCATCTTCC 1740 1741 CCCACTGACT CCACATTACC TCACCCAGAC ATGGACCAGC CCAGCCAGCA TGTCTACACA 1800 1801 ACTGGTGTCG TGTATGACAG TCTGATGCTG AAGCACCAGT GCATGTGTGG GAACTACACT 1860 1861 AATCACCCCG AACACGCTGG AAGAATCCAA AGCATCTGGT CAAGGCTGCA AGAAACTGGG 1920 1921 TTGCTAAACA AGTGCGAGCG AATTCGAGGT CGAAAAGCCA GTCTGGAGGA AATACAGCTG 1980 1981 GTTCACTCTG AACATCATTC ACTGCTGTAT GGCACCAGCC CACTGAACAG ACAGAAGCTG 2040 2041 GACCCCAGGA AACTCCTAGG TCTCGTGTCT CAAAAACTCT TTTCCTTGTT GCCTTGTGGG 2100 2101 GGACTTGGGG TAAAAAGAGA TATAAAATGG AGTGAAATGG CATTTTCTAC TTCTGGTAGA 2160 2161 ATTTGTGTGA TTATTCCCTA CTTAAAAAAA AAGTTTAAAT CAAGTGAAGC AAAAACTAAT 2220 2221 GGCTTTGCTG TTGTAAGGCC CCCAGGCCAT CATGCTGAAG AATCAACAGC CATGGGGTTC 2280 2281 TGCTTTTTTA ATTCGATTGC AATTACTGCC AAATACTTGA GAGACAAGCT AAATATAGGC 2340 2341 AAGATATTGA TTGTAGATCT GGATGTTCAC CATGGCAACG GTACACAGCA GGCTTTTTAT 2400 2401 GCTGACCCCA GCATCCTGTA TGTTTCCCTC CATCGCTATG ATGAAGGCAA CTTCTTCCCC 2460 2461 GGCAGTGGAG CCCCAAATGA GGTTGGAAGT GGCCCTGGTG AAGGGTATAA CATAAATATT 2520 2521 GCTTGGACAG GTGGCTTGGA TCCTCCTATG GGTGATGTTG AGTATCTCAC AGCATTCAGG 2580 2581 TTGGTA 2586 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Histone deacetylase complex | |
Cellular Component | Transcription factor complex | |
Molecular Function | Histone deacetylase activity (H4-K16 specific) | |
Molecular Function | Histone deacetylase binding | |
Molecular Function | Metal ion binding | |
Molecular Function | NAD-dependent histone deacetylase activity (H3-K14 specific) | |
Molecular Function | Protein kinase C binding | |
Molecular Function | Repressing transcription factor binding | |
Biological Process | Cellular response to insulin stimulus | |
Biological Process | Cholesterol homeostasis | |
Biological Process | Histone H4-K16 deacetylation | |
Biological Process | Negative regulation of cytokine secretion | |
Biological Process | Negative regulation of lipoprotein lipase activity | |
Biological Process | Negative regulation of transcription by RNA polymerase II | |
Biological Process | Peptidyl-lysine deacetylation | |
Biological Process | Positive regulation of cell migration involved in sprouting angiogenesis |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Urm-0413 | Ursus maritimus | 93.01 | 2e-56 | 211 |
| LLPS-Otg-1740 | Otolemur garnettii | 92.47 | 9e-56 | 209 |
| LLPS-Fia-2482 | Ficedula albicollis | 86.67 | 0.0 | 1162 |
| LLPS-Pes-2896 | Pelodiscus sinensis | 81.81 | 0.0 | 1100 |
| LLPS-Meg-2429 | Meleagris gallopavo | 80.11 | 0.0 | 1131 |
| LLPS-Caf-1595 | Canis familiaris | 76.78 | 0.0 | 1028 |
| LLPS-Fec-0752 | Felis catus | 76.78 | 0.0 | 1026 |
| LLPS-Mam-3880 | Macaca mulatta | 76.7 | 0.0 | 1015 |
| LLPS-Man-0901 | Macaca nemestrina | 76.47 | 0.0 | 1013 |
| LLPS-Hos-1173 | Homo sapiens | 76.47 | 0.0 | 1014 |
| LLPS-Paa-4208 | Papio anubis | 76.47 | 0.0 | 1014 |
| LLPS-Cea-0406 | Cercocebus atys | 76.47 | 0.0 | 1014 |
| LLPS-Maf-3043 | Macaca fascicularis | 76.47 | 0.0 | 1014 |
| LLPS-Aim-1347 | Ailuropoda melanoleuca | 76.33 | 0.0 | 1021 |
| LLPS-Caj-3889 | Callithrix jacchus | 76.24 | 0.0 | 1012 |
| LLPS-Aon-2213 | Aotus nancymaae | 76.24 | 0.0 | 1008 |
| LLPS-Mup-3150 | Mustela putorius furo | 76.22 | 0.0 | 1021 |
| LLPS-Loa-2892 | Loxodonta africana | 76.1 | 0.0 | 1025 |
| LLPS-Poa-2228 | Pongo abelii | 76.0 | 0.0 | 1006 |
| LLPS-Sus-1427 | Sus scrofa | 75.88 | 0.0 | 1019 |
| LLPS-Ict-2982 | Ictidomys tridecemlineatus | 75.82 | 0.0 | 1011 |
| LLPS-Cas-3947 | Carlito syrichta | 75.76 | 0.0 | 990 |
| LLPS-Orc-4361 | Oryctolagus cuniculus | 75.4 | 0.0 | 999 |
| LLPS-Bot-3202 | Bos taurus | 75.08 | 0.0 | 1013 |
| LLPS-Eqc-0883 | Equus caballus | 74.39 | 0.0 | 1001 |
| LLPS-Chs-0601 | Chlorocebus sabaeus | 73.85 | 0.0 | 762 |
| LLPS-Ran-4625 | Rattus norvegicus | 73.81 | 0.0 | 988 |
| LLPS-Myl-0056 | Myotis lucifugus | 73.64 | 0.0 | 961 |
| LLPS-Mum-4255 | Mus musculus | 73.24 | 0.0 | 971 |
| LLPS-Pap-2868 | Pan paniscus | 72.74 | 0.0 | 1009 |
| LLPS-Mod-3794 | Monodelphis domestica | 72.69 | 0.0 | 968 |
| LLPS-Nol-2285 | Nomascus leucogenys | 72.62 | 0.0 | 1009 |
| LLPS-Rhb-0333 | Rhinopithecus bieti | 72.62 | 0.0 | 1009 |
| LLPS-Mal-1562 | Mandrillus leucophaeus | 72.62 | 0.0 | 1009 |
| LLPS-Gog-1236 | Gorilla gorilla | 72.62 | 0.0 | 1007 |
| LLPS-Pat-3972 | Pan troglodytes | 72.51 | 0.0 | 1006 |
| LLPS-Cap-0707 | Cavia porcellus | 72.14 | 0.0 | 914 |
| LLPS-Ova-2744 | Ovis aries | 71.8 | 0.0 | 1001 |
| LLPS-Tar-3834 | Takifugu rubripes | 69.62 | 3e-137 | 444 |
| LLPS-Xim-4021 | Xiphophorus maculatus | 69.62 | 4e-135 | 437 |
| LLPS-Scf-0886 | Scleropages formosus | 69.55 | 6e-146 | 465 |
| LLPS-Leo-0006 | Lepisosteus oculatus | 68.11 | 7e-149 | 471 |
| LLPS-Dio-0554 | Dipodomys ordii | 67.18 | 1e-136 | 442 |
| LLPS-Tut-0359 | Tursiops truncatus | 66.87 | 5e-135 | 439 |
| LLPS-Ora-0871 | Ornithorhynchus anatinus | 66.67 | 7e-119 | 374 |
| LLPS-Orn-1616 | Oreochromis niloticus | 66.56 | 8e-139 | 447 |
| LLPS-Sah-3583 | Sarcophilus harrisii | 66.36 | 1e-136 | 439 |
| LLPS-Ten-3699 | Tetraodon nigroviridis | 66.35 | 2e-129 | 421 |
| LLPS-Scm-1573 | Scophthalmus maximus | 66.24 | 3e-137 | 444 |
| LLPS-Fud-3818 | Fukomys damarensis | 64.8 | 6e-141 | 451 |
| LLPS-Orl-1256 | Oryzias latipes | 64.63 | 4e-137 | 443 |
| LLPS-Gaa-1553 | Gasterosteus aculeatus | 64.49 | 3e-135 | 437 |
| LLPS-Mea-4505 | Mesocricetus auratus | 64.41 | 8e-35 | 147 |
| LLPS-Xet-0796 | Xenopus tropicalis | 64.36 | 2e-128 | 414 |
| LLPS-Icp-2804 | Ictalurus punctatus | 64.14 | 9e-115 | 381 |
| LLPS-Pof-1837 | Poecilia formosa | 63.33 | 7e-125 | 406 |
| LLPS-Asm-2480 | Astyanax mexicanus | 63.01 | 8e-30 | 131 |
| LLPS-Cis-0244 | Ciona savignyi | 61.98 | 2e-48 | 178 |
| LLPS-Drm-2310 | Drosophila melanogaster | 56.3 | 5e-94 | 327 |
| LLPS-Lac-0469 | Latimeria chalumnae | 52.88 | 0.0 | 640 |
| LLPS-Dar-3905 | Danio rerio | 50.83 | 0.0 | 675 |
| LLPS-Gaga-3863 | Gallus gallus | 50.11 | 6e-126 | 416 |
| LLPS-Anc-3833 | Anolis carolinensis | 49.42 | 0.0 | 588 |
| LLPS-Cii-0108 | Ciona intestinalis | 45.25 | 4e-79 | 282 |
| LLPS-Bro-1176 | Brassica oleracea | 41.67 | 6e-51 | 194 |
| LLPS-Brr-1585 | Brassica rapa | 41.67 | 1e-49 | 190 |
| LLPS-Brn-0220 | Brassica napus | 41.29 | 2e-48 | 186 |
| LLPS-Art-2824 | Arabidopsis thaliana | 40.38 | 2e-48 | 186 |
| LLPS-Gor-2789 | Gossypium raimondii | 39.62 | 9e-46 | 179 |
| LLPS-Cus-2033 | Cucumis sativus | 39.54 | 3e-48 | 186 |
| LLPS-Thc-2469 | Theobroma cacao | 39.39 | 4e-47 | 182 |
| LLPS-Via-0255 | Vigna angularis | 39.02 | 3e-44 | 174 |
| LLPS-Arl-2719 | Arabidopsis lyrata | 38.91 | 3e-44 | 173 |
| LLPS-Mae-1065 | Manihot esculenta | 37.88 | 2e-44 | 174 |
| LLPS-Miv-0122 | Microbotryum violaceum | 37.62 | 2e-43 | 174 |
| LLPS-Pot-0706 | Populus trichocarpa | 37.5 | 3e-44 | 174 |
| LLPS-Glm-2269 | Glycine max | 37.5 | 2e-44 | 174 |
| LLPS-Viv-1297 | Vitis vinifera | 37.02 | 2e-43 | 171 |