• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Caf-1595
HDAC9

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Histone deacetylase
Gene Name: HDAC9
Ensembl Gene: ENSCAFG00000002498.3
Ensembl Protein: ENSCAFP00000003650.3
Organism: Canis familiaris
Taxa ID: 9615
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
PML nuclear bodyPredicted from orthologs(View)

▼ FUNCTION

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSCAFT00000003949.3ENSCAFP00000003650.3
UniProtF6X8E7, F6X8E7_CANLF
GeneBankAAEX03009354

▼ SEQUENCE

Protein Sequence (FASTA)
1     MHSMISSVDV  KSEVPVGLEP  ISPLDLRTDL  RMMMPVVDPV  VREKQLQQEL  LLIQQQQQIQ  60
61    KQLLIAEFQK  QHENLTRQHQ  AQLQEHIKLQ  QELLAIKQQQ  ELLEKEQKLE  QQRQEQEVER  120
121   HRREQQLPPL  RGKDRGRERA  VASTEVKQKL  QEFLLSKSAT  KDTPTNGKNH  SVSRHPKLWY  180
181   TAAHHTSLDQ  SSPPLSGTSP  SYKYTLPGAQ  DAKDDFPLRK  TASEPNLKVR  SRLKQKVAER  240
241   RSSPLLRRKD  GNVVTSFKKR  MFEVTESSVS  SSSPGSGPSS  PNNGPTGNVT  ENETSVLPPT  300
301   PHAEQMVSQQ  RILIHEDSMN  LLSLYTSPSL  PNITLGLPAV  PPQLNASNSL  KEKQKCETQT  360
361   LRQGVPLPGQ  YGGSIPASSS  HPHVALEGKP  NSSHQALLQH  LLLKEQMRQQ  KLLVAGGVPL  420
421   HPQSPLATKE  RISPGIRGTH  KLPRHRPLNR  TQSAPLPQST  LAQLVIQQQH  QQFLEKQKQY  480
481   QQQIHMNKLL  SKSIEQLKQP  GSHLEEAEEE  LQGDQAMQED  RAPSSGNSTR  SDSSACVDDT  540
541   LGQVGAVKVK  EEPVDSDEDA  QIQEMESGEQ  AAFMQQPFLE  PQHTRALSVR  QAQLAVVGMD  600
601   GLEKHRLVSR  THSSPAASIL  PHPAMDCPLQ  PGSATGIAYD  PLMLKHQCIC  GNSTTHPEHA  660
661   GRIQSIWSRL  QETGLLNKCE  RIQGRKASLE  EIQLVHSEHH  SLLYGTNPLD  GQKLDPRTLL  720
721   GDTSQKIFSS  LPCGGLGVDS  DTIWNELHSS  GAARMAVGCV  IELASKVASG  ELKNGFAVVR  780
781   PPGHHAEEST  AMGFCFFNSV  AITAKYLRDQ  LNISKILIVD  LDVHHGNGTQ  QAFYADPSIL  840
841   YISLHRYDEG  NFFPGSGAPN  EVGTGLGEGY  NINIAWTGGL  DPPMGDIEYL  EAFRTVVTPV  900
901   AKEFDPDMVL  VSAGFDALEG  HAPPLGGYKV  TAKCFGHLTK  QLMTLADGHV  VLALEGGHDL  960
961   TAICDASEAC  VNALLGNELE  PLAEDILHQT  PNMNAVISLQ  KIIEIQSKYW  KSVRMVAVPR  1020
1021  GCALAGTQLQ  EETETVSALA  SLTVDVEQPF  ASEDSRTAGE  PMEEEPAL  1068
Nucleotide CDS Sequence (FASTA)
1     ATGCACAGTA  TGATCAGCTC  AGTGGATGTG  AAGTCAGAGG  TTCCTGTGGG  CCTAGAGCCC  60
61    ATCTCACCTT  TAGACTTAAG  GACGGACCTC  AGGATGATGA  TGCCTGTGGT  GGATCCTGTT  120
121   GTCCGTGAGA  AGCAACTGCA  GCAAGAATTA  CTTCTTATCC  AGCAACAGCA  GCAAATCCAG  180
181   AAGCAGCTCC  TGATTGCAGA  GTTTCAGAAA  CAGCATGAGA  ACTTGACAAG  GCAGCACCAG  240
241   GCTCAGCTCC  AGGAGCACAT  CAAGTTGCAA  CAGGAACTTC  TAGCCATAAA  ACAGCAACAA  300
301   GAACTCCTAG  AAAAGGAGCA  GAAACTGGAG  CAGCAGAGGC  AAGAACAGGA  AGTAGAGAGG  360
361   CACCGCAGAG  AACAGCAGCT  TCCTCCTCTC  AGAGGCAAAG  ATAGAGGACG  AGAAAGGGCA  420
421   GTGGCAAGTA  CAGAAGTAAA  GCAGAAGCTT  CAAGAATTCC  TGTTGAGTAA  ATCAGCAACA  480
481   AAAGACACTC  CAACCAATGG  AAAAAATCAT  TCCGTGAGCC  GCCATCCCAA  GCTCTGGTAC  540
541   ACGGCTGCCC  ACCACACGTC  ACTGGATCAA  AGCTCTCCAC  CCCTGAGTGG  GACATCTCCG  600
601   TCGTACAAAT  ACACATTACC  AGGAGCACAG  GATGCAAAGG  ATGATTTCCC  CCTTCGAAAA  660
661   ACTGCCTCTG  AGCCCAACTT  GAAGGTGCGG  TCCAGGTTAA  AACAGAAAGT  GGCAGAGAGG  720
721   AGAAGCAGCC  CCTTACTCAG  GCGGAAGGAT  GGAAATGTTG  TCACTTCATT  CAAGAAGCGA  780
781   ATGTTTGAGG  TGACAGAATC  CTCAGTCAGT  AGCAGTTCTC  CAGGGTCTGG  CCCCAGCTCA  840
841   CCAAACAATG  GGCCAACTGG  AAATGTTACT  GAAAATGAGA  CTTCAGTTTT  GCCACCTACT  900
901   CCTCATGCGG  AGCAAATGGT  GTCACAGCAA  CGCATTCTAA  TTCATGAAGA  TTCCATGAAC  960
961   CTGCTAAGTC  TTTATACCTC  TCCCTCTTTG  CCCAACATTA  CCTTGGGACT  TCCAGCAGTG  1020
1021  CCACCCCAGC  TCAATGCTTC  AAATTCACTT  AAAGAGAAAC  AGAAGTGTGA  GACCCAGACG  1080
1081  CTCAGACAAG  GCGTTCCTCT  TCCTGGGCAG  TATGGGGGCA  GCATCCCAGC  ATCTTCAAGC  1140
1141  CATCCCCACG  TTGCTTTAGA  GGGAAAGCCC  AACAGCAGCC  ACCAAGCTCT  CCTACAGCAT  1200
1201  TTATTATTGA  AAGAACAAAT  GCGACAGCAA  AAGCTTCTTG  TGGCTGGTGG  AGTTCCCTTA  1260
1261  CATCCTCAGT  CTCCATTGGC  AACAAAGGAG  AGAATCTCAC  CTGGCATTAG  AGGTACCCAC  1320
1321  AAACTACCCC  GTCACAGACC  CCTGAATCGA  ACCCAGTCTG  CACCTCTGCC  TCAGAGCACG  1380
1381  TTGGCTCAGC  TGGTCATTCA  GCAGCAACAC  CAGCAATTCT  TGGAGAAGCA  GAAGCAATAC  1440
1441  CAGCAGCAGA  TCCACATGAA  CAAACTGCTT  TCGAAATCTA  TTGAACAACT  GAAGCAACCA  1500
1501  GGCAGTCACC  TCGAGGAAGC  GGAGGAAGAG  CTTCAGGGGG  ACCAGGCGAT  GCAGGAAGAC  1560
1561  AGAGCGCCCT  CTAGTGGCAA  CAGCACTAGG  AGCGACAGCA  GTGCTTGTGT  GGATGACACA  1620
1621  CTGGGACAAG  TTGGGGCTGT  GAAGGTCAAG  GAGGAACCAG  TGGACAGTGA  TGAAGATGCT  1680
1681  CAGATCCAGG  AAATGGAATC  TGGGGAGCAG  GCTGCTTTTA  TGCAACAGCC  CTTCCTGGAG  1740
1741  CCCCAGCACA  CACGTGCGCT  CTCAGTGCGC  CAAGCTCAGC  TGGCTGTGGT  TGGCATGGAT  1800
1801  GGATTAGAGA  AACATCGTCT  TGTCTCCAGG  ACACATTCCT  CCCCTGCTGC  CTCCATTTTA  1860
1861  CCTCATCCAG  CAATGGACTG  CCCCCTCCAG  CCTGGCTCTG  CAACTGGAAT  TGCCTATGAC  1920
1921  CCTCTGATGC  TGAAACACCA  GTGCATTTGT  GGCAATTCCA  CCACCCACCC  TGAGCATGCT  1980
1981  GGACGAATAC  AGAGCATCTG  GTCACGGCTG  CAAGAAACTG  GGCTGCTAAA  TAAATGTGAG  2040
2041  CGAATTCAAG  GTCGAAAAGC  CAGCCTGGAG  GAAATACAGC  TTGTTCATTC  TGAACATCAC  2100
2101  TCACTGTTGT  ATGGCACCAA  CCCCCTGGAT  GGACAGAAGC  TGGACCCCAG  GACACTCCTA  2160
2161  GGTGACACCT  CTCAAAAGAT  TTTTTCTTCA  CTACCTTGTG  GTGGACTTGG  GGTGGACAGT  2220
2221  GACACCATTT  GGAATGAGCT  GCACTCGTCC  GGTGCTGCAC  GCATGGCTGT  TGGCTGTGTC  2280
2281  ATCGAACTGG  CTTCCAAAGT  GGCCTCAGGA  GAGCTGAAGA  ATGGGTTTGC  TGTTGTAAGG  2340
2341  CCCCCAGGCC  ATCATGCTGA  AGAATCCACA  GCCATGGGGT  TCTGCTTTTT  TAATTCAGTT  2400
2401  GCAATTACCG  CCAAATACTT  GAGAGACCAA  CTAAATATAA  GCAAGATATT  GATTGTAGAT  2460
2461  CTGGATGTTC  ACCATGGAAA  TGGTACACAG  CAGGCCTTTT  ATGCTGACCC  CAGCATCCTG  2520
2521  TATATTTCAC  TCCATCGCTA  TGATGAAGGG  AACTTTTTCC  CTGGCAGTGG  AGCCCCAAAT  2580
2581  GAGGTTGGAA  CAGGCCTTGG  AGAAGGATAC  AATATAAATA  TTGCATGGAC  AGGTGGCCTT  2640
2641  GATCCCCCAA  TGGGAGATAT  AGAGTACCTT  GAAGCATTCA  GGACTGTAGT  GACGCCTGTG  2700
2701  GCCAAAGAGT  TTGATCCAGA  CATGGTCCTA  GTTTCCGCTG  GATTTGATGC  ATTAGAAGGC  2760
2761  CATGCTCCTC  CTCTGGGGGG  GTACAAAGTG  ACAGCAAAAT  GCTTTGGTCA  TTTGACGAAG  2820
2821  CAATTGATGA  CATTGGCTGA  TGGACACGTG  GTATTGGCCT  TAGAAGGAGG  ACATGATCTG  2880
2881  ACAGCCATCT  GTGATGCATC  AGAAGCCTGC  GTAAATGCTC  TTTTAGGAAA  TGAGCTGGAA  2940
2941  CCCCTTGCCG  AAGATATTCT  CCACCAAACA  CCGAATATGA  ATGCTGTTAT  TTCTTTACAG  3000
3001  AAGATCATTG  AAATTCAAAG  CAAGTACTGG  AAGTCAGTAA  GGATGGTGGC  TGTGCCAAGG  3060
3061  GGCTGTGCTT  TGGCTGGGAC  TCAGTTGCAG  GAGGAGACCG  AGACCGTTTC  TGCCCTGGCC  3120
3121  TCCCTGACAG  TAGATGTAGA  ACAGCCCTTT  GCTTCAGAAG  ATAGCAGAAC  TGCTGGTGAG  3180
3181  CCTATGGAAG  AGGAGCCAGC  CTTGTGA  3207

▼ KEYWORD

ID
Family
Chromatin regulator
Coiled coil
Complete proteome
Hydrolase
Metal-binding
Reference proteome
Repressor
Transcription
Transcription regulation
Zinc

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Histone deacetylase complex
Cellular Component
Transcription factor complex
Molecular Function
Histone deacetylase activity (H4-K16 specific)
Molecular Function
Histone deacetylase binding
Molecular Function
Metal ion binding
Molecular Function
NAD-dependent histone deacetylase activity (H3-K14 specific)
Molecular Function
Protein kinase C binding
Molecular Function
Repressing transcription factor binding
Biological Process
Cellular response to insulin stimulus
Biological Process
Cholesterol homeostasis
Biological Process
Histone H4-K16 deacetylation
Biological Process
Negative regulation of cytokine secretion
Biological Process
Negative regulation of lipoprotein lipase activity
Biological Process
Negative regulation of transcription by RNA polymerase II
Biological Process
Peptidyl-lysine deacetylation
Biological Process
Positive regulation of cell migration involved in sprouting angiogenesis

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Urm-0413Ursus maritimus100.02e-79 281
LLPS-Otg-1740Otolemur garnettii99.541e-76 273
LLPS-Fec-0752Felis catus99.150.01854
LLPS-Aim-1347Ailuropoda melanoleuca98.690.01871
LLPS-Mup-3150Mustela putorius furo98.60.01869
LLPS-Mam-3880Macaca mulatta98.220.01509
LLPS-Sus-1427Sus scrofa98.220.01860
LLPS-Chs-0601Chlorocebus sabaeus98.060.01239
LLPS-Hos-1173Homo sapiens98.040.01853
LLPS-Maf-3043Macaca fascicularis97.940.01850
LLPS-Cea-0406Cercocebus atys97.940.01850
LLPS-Paa-4208Papio anubis97.940.01850
LLPS-Man-0901Macaca nemestrina97.850.01849
LLPS-Bot-3202Bos taurus97.010.01833
LLPS-Poa-2228Pongo abelii97.00.01816
LLPS-Cas-3947Carlito syrichta96.820.01805
LLPS-Caj-3889Callithrix jacchus96.820.01832
LLPS-Aon-2213Aotus nancymaae96.690.01800
LLPS-Ict-2982Ictidomys tridecemlineatus96.540.01799
LLPS-Eqc-0883Equus caballus96.270.01814
LLPS-Loa-2892Loxodonta africana96.120.01784
LLPS-Orc-4361Oryctolagus cuniculus95.040.01783
LLPS-Nol-2285Nomascus leucogenys94.760.01848
LLPS-Mal-1562Mandrillus leucophaeus94.760.01847
LLPS-Rhb-0333Rhinopithecus bieti94.670.01847
LLPS-Gog-1236Gorilla gorilla94.570.01841
LLPS-Pat-3972Pan troglodytes94.480.01842
LLPS-Pap-2868Pan paniscus94.440.01823
LLPS-Ova-2744Ovis aries92.740.01471
LLPS-Ran-4625Rattus norvegicus92.050.01722
LLPS-Mum-4255Mus musculus91.860.01712
LLPS-Cap-0707Cavia porcellus91.520.01633
LLPS-Myl-0056Myotis lucifugus90.840.01339
LLPS-Pes-2896Pelodiscus sinensis86.440.01594
LLPS-Fia-2482Ficedula albicollis83.690.01540
LLPS-Mod-3794Monodelphis domestica83.550.01511
LLPS-Meg-2429Meleagris gallopavo80.320.01536
LLPS-Tag-1961Taeniopygia guttata76.460.01055
LLPS-Leo-3542Lepisosteus oculatus70.660.01243
LLPS-Ora-0871Ornithorhynchus anatinus69.458e-151 463
LLPS-Xet-0796Xenopus tropicalis68.210.0 638
LLPS-Icp-2804Ictalurus punctatus68.061e-124 413
LLPS-Anc-2211Anolis carolinensis67.140.0 711
LLPS-Orn-1616Oreochromis niloticus65.890.0 659
LLPS-Sah-1057Sarcophilus harrisii65.650.0 620
LLPS-Tar-3834Takifugu rubripes64.920.0 644
LLPS-Ten-3618Tetraodon nigroviridis64.20.0 645
LLPS-Mea-4295Mesocricetus auratus63.750.0 601
LLPS-Fud-2596Fukomys damarensis63.580.0 606
LLPS-Xim-3879Xiphophorus maculatus62.70.0 651
LLPS-Gaa-1354Gasterosteus aculeatus62.50.0 589
LLPS-Asm-0143Astyanax mexicanus62.290.0 582
LLPS-Dar-3905Danio rerio56.550.0 968
LLPS-Tut-0359Tursiops truncatus55.890.0 912
LLPS-Dio-0554Dipodomys ordii55.890.0 907
LLPS-Drm-2310Drosophila melanogaster55.865e-165 527
LLPS-Lac-0469Latimeria chalumnae55.780.0 929
LLPS-Gaga-3863Gallus gallus55.610.0 650
LLPS-Scf-0886Scleropages formosus55.410.0 899
LLPS-Orl-1256Oryzias latipes55.280.0 879
LLPS-Scm-1573Scophthalmus maximus55.160.0 875
LLPS-Pof-2491Poecilia formosa55.120.0 861
LLPS-Cis-0244Ciona savignyi52.044e-97 316
LLPS-Bro-1176Brassica oleracea43.933e-85 295
LLPS-Thc-2469Theobroma cacao43.82e-78 276
LLPS-Brn-2227Brassica napus43.568e-83 288
LLPS-Cus-2033Cucumis sativus43.196e-78 275
LLPS-Brr-1125Brassica rapa43.125e-85 295
LLPS-Gor-2789Gossypium raimondii41.671e-80 283
LLPS-Via-0255Vigna angularis41.512e-79 278
LLPS-Miv-0122Microbotryum violaceum41.367e-80 288
LLPS-Pot-0706Populus trichocarpa40.683e-76 270
LLPS-Abg-0974Absidia glauca40.679e-79 276
LLPS-Mae-1065Manihot esculenta40.628e-78 275
LLPS-Mel-0391Melampsora laricipopulina40.496e-76 269
LLPS-Sem-1923Selaginella moellendorffii40.051e-79 279
LLPS-Ast-1405Aspergillus terreus39.91e-76 273
LLPS-Crn-1166Cryptococcus neoformans39.369e-77 273
LLPS-Tum-1364Tuber melanosporum39.291e-76 265
LLPS-Asn-1628Aspergillus nidulans38.992e-76 273
LLPS-Lem-1290Leptosphaeria maculans38.955e-78 279
LLPS-Cii-0108Ciona intestinalis37.263e-156 497