• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Aim-1347
HDAC9

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Histone deacetylase
Gene Name: HDAC9
Ensembl Gene: ENSAMEG00000008517.1
Ensembl Protein: ENSAMEP00000008994.1
Organism: Ailuropoda melanoleuca
Taxa ID: 9646
LLPS Type: Regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
PML nuclear bodyPredicted from orthologs(View)

▼ FUNCTION

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MHSMISSVDV  KSEVPVGLEP  ISPLDLRTDL  RMMMPVVDPV  VREKQLQQEL  LLIQQQQQIQ  60
61    KQLLIAEFQK  QHENLTRQHQ  AQLQEHIKLQ  QELLAIKQQQ  ELLEKEQKLE  QQRQEQEVER  120
121   HRREQQLPPL  RGKDRGRERA  VASTEVKQKL  QEFLLSKSAT  KDTPTNGKNH  SVSRHPKLWY  180
181   TAAHHTSLDQ  SSPPLSGTSP  SYKYTLPGAQ  DAKDDFPLRK  TASEPNLKVR  SRLKQKVAER  240
241   RSSPLLRRKD  GNVVTSFKKR  MFEVTESSVS  SSSPGSGPSS  PNNGPTGNVT  ENDTSVLPPT  300
301   PHAEQIVSQQ  RILIHEDSMN  LLSLYTSPSL  PNITLGLPAV  PTQLNASNSL  KEKQKCETQT  360
361   LRQGVPLPGQ  YAGSIPASSS  HPHVALEGKP  NSSHQALLQH  LLLKEQMRQQ  KLLVAGGVPL  420
421   HPQSPLAAKE  RISPGIRGTH  KLPRHRPLNR  TQSAPLPQST  LAQLVIQQQH  QQFLEKQKQY  480
481   QQQIHMNKLL  SKSIEQLKQP  GSHLEEAEEE  LQGDQAMQED  RAPSSGNSTR  SDSSACVDDT  540
541   LGQVGAVKVK  EEPVDSDEDA  QIQEMESGEQ  AAFMQQPFLE  PQHTRALSVH  QTQLAVVGMD  600
601   GLEKHRLVSR  THSSPAASIL  PHPAMDCPLQ  PGSATGIAYD  PLMLKHQCIC  GNSTTHPEHA  660
661   GRIQSIWSRL  QETGLLNKCE  RIQGRKASLE  EIQLVHSEHH  SLLYGTNPLD  GQKLDPRTLL  720
721   GDASQKFFSS  LPCGGLGVDS  DTIWNELHSS  GAARMAVGCV  IELASRVASG  ELKNGFAVVR  780
781   PPGHHAEEST  AMGFCFFNSV  AITAKYLRDQ  LNISKILIVD  LDVHHGNGTQ  QAFYADPSIL  840
841   YISLHRYDEG  NFFPGSGAPN  EVGTGLGEGY  NINIAWTGGL  DPPMGDIEYL  EAFRTVVTPV  900
901   AKEFDPDMVL  VSAGFDALEG  HAPPLGGYKV  TAKCFGHLTK  QLMTLADGHV  VLALEGGHDL  960
961   TAICDASEAC  VNALLGNELE  PLAEDILHQT  PNMNAVVSLQ  KIIEIQSKYW  KSVRMVTVPR  1020
1021  GCSLAGTQLQ  EETETVSALA  SLTVDVEQPF  ASEDNRTAGE  PMEEEPAL  1068
Nucleotide CDS Sequence (FASTA)
1     ATGCACAGTA  TGATCAGCTC  AGTGGATGTG  AAATCAGAAG  TTCCCGTGGG  CCTAGAGCCC  60
61    ATCTCACCTT  TAGACCTAAG  GACAGACCTC  AGGATGATGA  TGCCTGTGGT  GGATCCTGTT  120
121   GTCCGCGAGA  AGCAGCTGCA  GCAAGAATTA  CTCCTCATCC  AGCAACAGCA  GCAAATCCAG  180
181   AAGCAGCTCC  TGATTGCAGA  GTTTCAGAAA  CAGCATGAGA  ACTTGACACG  GCAGCACCAG  240
241   GCTCAGCTCC  AGGAGCACAT  CAAGTTGCAA  CAGGAACTTC  TAGCCATAAA  ACAGCAACAA  300
301   GAACTCCTAG  AAAAGGAGCA  GAAACTGGAG  CAGCAGAGGC  AAGAACAGGA  AGTAGAGAGG  360
361   CACCGCAGAG  AACAGCAGCT  TCCTCCTCTC  AGAGGCAAAG  ATAGAGGACG  AGAAAGGGCA  420
421   GTGGCAAGTA  CAGAAGTAAA  GCAGAAGCTT  CAAGAATTCC  TGTTGAGTAA  ATCAGCAACA  480
481   AAAGACACTC  CAACAAATGG  AAAAAATCAT  TCCGTGAGCC  GCCATCCCAA  GCTCTGGTAC  540
541   ACGGCTGCCC  ACCACACGTC  ACTGGATCAA  AGCTCTCCAC  CCCTGAGTGG  AACGTCGCCA  600
601   TCCTACAAAT  ACACATTACC  AGGAGCACAG  GATGCAAAGG  ATGATTTCCC  CCTTCGAAAA  660
661   ACTGCCTCTG  AGCCCAACTT  GAAGGTGCGG  TCCAGGTTAA  AACAGAAAGT  GGCAGAGAGG  720
721   AGAAGCAGCC  CCTTACTCAG  GCGGAAGGAT  GGAAATGTTG  TCACTTCATT  CAAGAAGAGA  780
781   ATGTTTGAGG  TGACAGAATC  CTCGGTCAGC  AGCAGCTCTC  CAGGGTCTGG  CCCCAGCTCA  840
841   CCAAACAATG  GGCCAACTGG  AAATGTTACT  GAAAATGACA  CTTCCGTTTT  GCCACCTACT  900
901   CCTCATGCTG  AGCAAATTGT  GTCCCAGCAA  CGCATTCTAA  TTCATGAAGA  TTCCATGAAC  960
961   CTGCTAAGTC  TTTATACCTC  TCCTTCTCTG  CCCAACATTA  CCTTGGGACT  TCCAGCAGTG  1020
1021  CCAACGCAGC  TCAACGCTTC  GAATTCACTC  AAAGAAAAAC  AGAAGTGTGA  GACCCAGACG  1080
1081  CTCCGACAAG  GCGTTCCTCT  GCCCGGGCAG  TACGCGGGCA  GCATCCCAGC  ATCTTCAAGC  1140
1141  CACCCCCACG  TTGCTTTAGA  GGGAAAGCCC  AACAGCAGCC  ACCAAGCGCT  CCTGCAGCAT  1200
1201  CTATTATTGA  AAGAACAAAT  GCGACAGCAG  AAGCTCCTCG  TGGCTGGTGG  AGTCCCCTTA  1260
1261  CATCCTCAGT  CTCCGTTGGC  AGCAAAGGAG  AGAATTTCAC  CTGGCATTAG  AGGTACCCAC  1320
1321  AAATTACCCC  GTCACAGACC  CCTGAATCGA  ACGCAGTCTG  CACCTCTGCC  TCAGAGCACG  1380
1381  TTGGCTCAGC  TGGTCATTCA  GCAGCAACAC  CAGCAATTCT  TGGAGAAGCA  GAAGCAATAC  1440
1441  CAGCAGCAGA  TCCACATGAA  CAAACTGCTT  TCGAAATCTA  TTGAACAACT  GAAGCAACCA  1500
1501  GGCAGTCACC  TCGAGGAAGC  GGAGGAAGAG  CTTCAGGGGG  ACCAGGCGAT  GCAGGAAGAC  1560
1561  AGAGCGCCCT  CTAGTGGCAA  CAGCACTAGG  AGCGACAGCA  GTGCTTGTGT  GGATGACACA  1620
1621  CTGGGACAAG  TTGGGGCTGT  GAAGGTCAAG  GAGGAACCAG  TGGACAGTGA  CGAAGATGCT  1680
1681  CAGATCCAGG  AAATGGAATC  TGGGGAGCAG  GCTGCTTTTA  TGCAACAGCC  CTTCTTGGAG  1740
1741  CCCCAGCACA  CACGTGCGCT  CTCAGTGCAC  CAAACTCAGC  TGGCTGTGGT  TGGCATGGAT  1800
1801  GGATTAGAGA  AACATCGTCT  TGTCTCCAGG  ACTCATTCCT  CCCCTGCTGC  CTCCATTTTA  1860
1861  CCTCATCCAG  CAATGGACTG  CCCCCTCCAG  CCTGGCTCTG  CAACTGGAAT  TGCCTACGAC  1920
1921  CCTCTGATGC  TGAAACACCA  GTGCATTTGT  GGCAATTCCA  CCACCCACCC  TGAGCACGCT  1980
1981  GGACGAATAC  AGAGCATCTG  GTCACGACTG  CAAGAAACTG  GGCTGCTAAA  TAAATGTGAG  2040
2041  CGAATTCAAG  GTCGAAAAGC  TAGCCTGGAG  GAAATACAGC  TTGTTCATTC  TGAACATCAC  2100
2101  TCACTGTTGT  ATGGCACCAA  CCCCCTGGAT  GGACAGAAGC  TGGACCCCAG  GACACTCCTA  2160
2161  GGTGATGCCT  CTCAAAAGTT  TTTTTCTTCA  TTACCTTGTG  GTGGACTTGG  GGTGGACAGT  2220
2221  GACACCATTT  GGAATGAACT  GCACTCGTCC  GGTGCTGCAC  GCATGGCTGT  TGGCTGTGTC  2280
2281  ATCGAGCTGG  CTTCCAGAGT  GGCCTCAGGA  GAGCTGAAGA  ATGGGTTTGC  TGTTGTAAGG  2340
2341  CCCCCAGGCC  ATCATGCTGA  AGAATCCACA  GCCATGGGGT  TCTGCTTTTT  TAATTCAGTT  2400
2401  GCAATTACCG  CCAAATACTT  GAGAGACCAA  CTAAATATAA  GCAAGATATT  GATTGTAGAT  2460
2461  CTGGATGTTC  ACCATGGAAA  TGGTACACAG  CAGGCCTTTT  ATGCTGACCC  CAGCATCCTG  2520
2521  TATATTTCAC  TCCATCGCTA  TGATGAAGGG  AACTTTTTCC  CTGGCAGTGG  AGCCCCAAAT  2580
2581  GAGGTTGGAA  CAGGCCTTGG  AGAAGGATAC  AATATAAATA  TTGCCTGGAC  AGGTGGCCTT  2640
2641  GATCCCCCGA  TGGGAGATAT  AGAGTACCTT  GAAGCATTCA  GGACTGTAGT  GACGCCTGTG  2700
2701  GCCAAAGAGT  TTGATCCAGA  CATGGTCCTA  GTCTCCGCTG  GATTTGATGC  ATTAGAAGGC  2760
2761  CATGCCCCTC  CTCTGGGGGG  GTACAAAGTG  ACAGCAAAAT  GCTTTGGTCA  TTTGACGAAG  2820
2821  CAGTTGATGA  CATTGGCTGA  TGGACACGTG  GTGTTGGCTC  TAGAAGGAGG  ACATGATCTC  2880
2881  ACAGCCATCT  GTGATGCATC  AGAAGCCTGT  GTAAATGCCC  TTCTAGGAAA  CGAGCTGGAG  2940
2941  CCACTTGCCG  AAGATATTCT  CCACCAAACC  CCGAATATGA  ATGCTGTTGT  TTCTTTACAG  3000
3001  AAGATCATTG  AAATTCAAAG  CAAGTACTGG  AAGTCAGTAA  GGATGGTGAC  TGTGCCAAGG  3060
3061  GGTTGTTCTT  TGGCTGGGAC  TCAGCTGCAA  GAGGAGACCG  AGACTGTTTC  TGCCCTGGCC  3120
3121  TCCCTGACGG  TAGATGTAGA  ACAGCCCTTT  GCTTCTGAAG  ATAACAGAAC  TGCTGGTGAG  3180
3181  CCTATGGAAG  AGGAGCCAGC  CTTG  3204

▼ KEYWORD

ID
Family
Chromatin regulator
Coiled coil
Complete proteome
Hydrolase
Metal-binding
Reference proteome
Repressor
Transcription
Transcription regulation
Zinc

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Histone deacetylase complex
Cellular Component
Transcription factor complex
Molecular Function
Histone deacetylase activity (H4-K16 specific)
Molecular Function
Histone deacetylase binding
Molecular Function
Metal ion binding
Molecular Function
NAD-dependent histone deacetylase activity (H3-K14 specific)
Molecular Function
Protein kinase C binding
Molecular Function
Repressing transcription factor binding
Biological Process
Cellular response to insulin stimulus
Biological Process
Cholesterol homeostasis
Biological Process
Histone H4-K16 deacetylation
Biological Process
Negative regulation of cytokine secretion
Biological Process
Negative regulation of lipoprotein lipase activity
Biological Process
Negative regulation of transcription by RNA polymerase II
Biological Process
Peptidyl-lysine deacetylation
Biological Process
Positive regulation of cell migration involved in sprouting angiogenesis

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Urm-0413Ursus maritimus100.02e-79 281
LLPS-Otg-1740Otolemur garnettii99.541e-76 273
LLPS-Mup-3150Mustela putorius furo98.780.01876
LLPS-Caf-1595Canis familiaris98.690.01871
LLPS-Fec-0752Felis catus98.30.01841
LLPS-Mam-3880Macaca mulatta97.550.01501
LLPS-Chs-0601Chlorocebus sabaeus97.290.01230
LLPS-Sus-1427Sus scrofa97.280.01847
LLPS-Hos-1173Homo sapiens97.10.01840
LLPS-Cea-0406Cercocebus atys97.10.01839
LLPS-Maf-3043Macaca fascicularis97.10.01839
LLPS-Paa-4208Papio anubis97.10.01839
LLPS-Man-0901Macaca nemestrina97.010.01838
LLPS-Bot-3202Bos taurus96.540.01827
LLPS-Cas-3947Carlito syrichta96.070.01791
LLPS-Poa-2228Pongo abelii96.060.01805
LLPS-Ict-2982Ictidomys tridecemlineatus95.980.01791
LLPS-Aon-2213Aotus nancymaae95.930.01791
LLPS-Caj-3889Callithrix jacchus95.880.01817
LLPS-Eqc-0883Equus caballus95.710.01809
LLPS-Loa-2892Loxodonta africana95.360.01775
LLPS-Orc-4361Oryctolagus cuniculus94.110.01770
LLPS-Mal-1562Mandrillus leucophaeus93.920.01835
LLPS-Rhb-0333Rhinopithecus bieti93.830.01835
LLPS-Nol-2285Nomascus leucogenys93.830.01835
LLPS-Gog-1236Gorilla gorilla93.640.01829
LLPS-Pat-3972Pan troglodytes93.550.01830
LLPS-Pap-2868Pan paniscus93.50.01812
LLPS-Ova-2744Ovis aries92.40.01466
LLPS-Mum-4255Mus musculus91.580.01712
LLPS-Ran-4625Rattus norvegicus91.580.01718
LLPS-Cap-0707Cavia porcellus91.040.01630
LLPS-Myl-0056Myotis lucifugus90.730.01340
LLPS-Pes-2896Pelodiscus sinensis85.780.01584
LLPS-Fia-2482Ficedula albicollis83.320.01533
LLPS-Mod-3794Monodelphis domestica82.990.01506
LLPS-Meg-2429Meleagris gallopavo80.130.01537
LLPS-Tag-1961Taeniopygia guttata76.00.01048
LLPS-Leo-3542Lepisosteus oculatus70.750.01248
LLPS-Ora-0871Ornithorhynchus anatinus69.135e-150 461
LLPS-Xet-0796Xenopus tropicalis67.770.0 634
LLPS-Icp-2804Ictalurus punctatus67.361e-123 410
LLPS-Anc-2211Anolis carolinensis67.140.0 712
LLPS-Orn-1616Oreochromis niloticus66.110.0 660
LLPS-Ten-3618Tetraodon nigroviridis65.690.0 644
LLPS-Tar-3834Takifugu rubripes65.130.0 645
LLPS-Sah-1057Sarcophilus harrisii65.00.0 615
LLPS-Mea-4295Mesocricetus auratus63.540.0 599
LLPS-Fud-2596Fukomys damarensis62.950.0 603
LLPS-Pof-0372Poecilia formosa62.70.0 650
LLPS-Gaa-1354Gasterosteus aculeatus62.060.0 586
LLPS-Asm-0143Astyanax mexicanus61.020.0 582
LLPS-Dar-3905Danio rerio56.190.0 965
LLPS-Lac-0469Latimeria chalumnae55.780.0 930
LLPS-Drm-2310Drosophila melanogaster55.763e-164 525
LLPS-Dio-0554Dipodomys ordii55.60.0 904
LLPS-Tut-0359Tursiops truncatus55.60.0 910
LLPS-Gaga-3863Gallus gallus55.450.0 647
LLPS-Scf-0886Scleropages formosus55.280.0 894
LLPS-Orl-1256Oryzias latipes55.170.0 875
LLPS-Scm-1573Scophthalmus maximus55.160.0 877
LLPS-Xim-4021Xiphophorus maculatus54.80.0 866
LLPS-Cis-0244Ciona savignyi52.044e-97 316
LLPS-Brn-2227Brassica napus43.565e-82 286
LLPS-Bro-1176Brassica oleracea43.151e-84 293
LLPS-Brr-1585Brassica rapa43.075e-83 289
LLPS-Thc-2469Theobroma cacao42.771e-77 274
LLPS-Cus-2033Cucumis sativus42.615e-77 272
LLPS-Gor-2789Gossypium raimondii41.412e-80 282
LLPS-Via-0255Vigna angularis41.257e-79 277
LLPS-Abg-0974Absidia glauca40.933e-78 275
LLPS-Mae-1065Manihot esculenta40.893e-78 276
LLPS-Pot-0706Populus trichocarpa40.684e-76 270
LLPS-Mel-0391Melampsora laricipopulina40.491e-76 271
LLPS-Miv-0122Microbotryum violaceum39.91e-79 287
LLPS-Crn-1166Cryptococcus neoformans39.751e-76 273
LLPS-Sem-1923Selaginella moellendorffii39.537e-79 276
LLPS-Lem-1290Leptosphaeria maculans39.055e-78 279
LLPS-Tum-1364Tuber melanosporum38.792e-76 264
LLPS-Ast-1405Aspergillus terreus38.263e-76 272
LLPS-Cii-0108Ciona intestinalis37.371e-155 495