LLPS-Aon-2213
HDAC9
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Histone deacetylase |
| Gene Name: | HDAC9 |
| Ensembl Gene: | ENSANAG00000036895.1 |
| Ensembl Protein: | ENSANAP00000038948.1 |
| Organism: | Aotus nancymaae |
| Taxa ID: | 37293 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| PML nuclear body | Predicted from orthologs | (View) |
▼ FUNCTION
| Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSANAT00000057044.1 | ENSANAP00000038948.1 |
| Ensembl | ENSANAT00000057024.1 | ENSANAP00000038928.1 |
| Ensembl | ENSANAT00000057051.1 | ENSANAP00000038955.1 |
| Ensembl | ENSANAT00000057018.1 | ENSANAP00000038922.1 |
| Ensembl | ENSANAT00000057032.1 | ENSANAP00000038936.1 |
| Ensembl | ENSANAT00000057042.1 | ENSANAP00000038946.1 |
| Ensembl | ENSANAT00000057059.1 | ENSANAP00000038963.1 |
| UniProt | A0A2K5F0A8, A0A2K5F0A8_AOTNA |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MLQTIYESDS CFSSDGVAGR EQLLAQQRMH SMISSVDVKS EVPVGLEPIS PLDLRTDLRM 60 61 MMPVVDPVVR EKQLQQELLL IQQQQQIQKQ LLIAEFQKQH ENLTRQHQAQ LQEHIKLQQE 120 121 LLAIKQQQEL LEKEQKLEQQ RQEQEVERHR REQQLPPLRG KDRGRERAVA STEVKQKLQE 180 181 FLLSKSATKD TPTNGKNHSV SRHPKLWYTA AHHTSLDQSS PPLSGTSPSY KYTLPGAQDA 240 241 KDDFPLRKTA SEPNLKVRSR LKQKVAERRS SPLLRRKDGN VVTSFKKRMF EVTESSVSSS 300 301 SPGSGPSSPN NGPTGSVTEN ETSVLPPTPH AEQMVSQQRI LIHEDSMNLL SLYTSPSLPN 360 361 ITLGLPAVPS QLNASNSLKE KPKCDTQTLR QGVALPGQYG GSISASSSHP HVTLEGKPPN 420 421 SSHQALLQHL LLKEQMRQQK LLVAGGVPLH PQSPLATKER ISPGIRGTHK LPRHRPLNRT 480 481 QSAPLPQSTL AQLVIQQQHQ QFLEKQKQYQ QQIHMNKLLS KSIEQLKQPG SHLEEAEEEL 540 541 QGDQAMQEDR APSSGNSTRS DSSACVDDTV GQVGAVKVKE EPVDSDEDAQ IQEMESGEQA 600 601 AFMQQPFLEP PRTHALSVHQ APLAAVGTDG LDKHRLVSRT HSSPAASVLP HPAMDRPLQP 660 661 GSATGIAYDP LMLKHQCVCG NSTTHPEHAG RIQSIWSRLQ ETGLLNKCER IQGRKASLEE 720 721 IQLVHSEHHS LLYGTNPLDG QKLDPRILLG DDSQKFFSSL PCGGLGVDSD TIWNELHSSG 780 781 AARMAVGCVI ELASKVASGE LKNGFAVVRP PGHHAEESTA MGFCFFNSVA ITAKYLRDQL 840 841 NISKILIVDL DVHHGNGTQQ AFYADPSILY ISLHRYDEGN FFPGSGAPNE VGTGLGEGYN 900 901 INIAWTGGLD PPMGDVEYLE AFRTIVKPVA KEFDPDMVLV SAGFDALEGH TPPLGGYKVT 960 961 AKCFGHLTKQ LMTLADGRVV LALEGGHDLT AICDASEACV NALLGNELEP LAEEVLHQSP 1020 1021 NMNAVISLQK IIEIQSKYWK SLRMVATPRG CALAGAQLQE ETETVSALAS LTVDVEQPFA 1080 1081 QEDSRYIPDY FL 1092 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCACAGTA TGATCAGCTC AGTGGATGTG AAGTCAGAAG TTCCTGTGGG CCTGGAGCCC 60 61 ATTTCGCCTT TAGACCTAAG GACAGACCTC AGGATGATGA TGCCTGTGGT GGACCCTGTT 120 121 GTCCGTGAGA AGCAATTGCA GCAGGAACTA CTTCTTATCC AGCAGCAGCA ACAAATCCAG 180 181 AAGCAGCTCC TGATAGCAGA GTTTCAGAAA CAGCATGAGA ACTTGACACG GCAGCACCAG 240 241 GCTCAGCTTC AGGAACATAT CAAGTTGCAA CAGGAACTTC TAGCCATAAA ACAGCAACAA 300 301 GAACTCCTAG AAAAGGAGCA GAAACTGGAG CAGCAGAGGC AAGAACAGGA AGTAGAGAGG 360 361 CATCGCAGAG AGCAGCAGCT TCCTCCTCTC AGAGGCAAAG ATAGAGGACG AGAAAGGGCA 420 421 GTGGCAAGTA CAGAAGTAAA GCAGAAGCTT CAAGAATTCC TATTGAGTAA ATCGGCAACG 480 481 AAAGACACTC CAACTAATGG AAAAAATCAT TCCGTGAGCC GCCATCCCAA GCTCTGGTAC 540 541 ACGGCTGCCC ACCACACATC ACTGGATCAA AGCTCTCCAC CCCTTAGTGG AACATCTCCA 600 601 TCCTACAAGT ACACGTTACC AGGAGCACAA GATGCAAAGG ATGATTTCCC TCTTCGAAAA 660 661 ACTGCCTCTG AGCCCAACTT GAAGGTGCGG TCCAGGTTAA AACAGAAAGT GGCAGAGAGG 720 721 AGAAGCAGCC CCTTACTCAG GCGGAAGGAT GGAAATGTTG TCACTTCATT CAAGAAGCGA 780 781 ATGTTTGAGG TGACAGAATC CTCAGTCAGT AGCAGTTCTC CAGGCTCGGG TCCCAGTTCA 840 841 CCAAACAACG GGCCAACTGG AAGTGTTACT GAAAATGAGA CTTCGGTTTT GCCCCCGACC 900 901 CCTCATGCTG AGCAAATGGT TTCACAGCAA CGCATTTTAA TTCATGAAGA TTCCATGAAC 960 961 CTGCTAAGTC TTTATACCTC TCCTTCTTTG CCCAACATTA CGTTGGGGCT TCCTGCAGTG 1020 1021 CCATCCCAGC TCAATGCTTC GAATTCACTC AAAGAAAAGC CGAAGTGTGA CACACAGACG 1080 1081 CTTAGGCAAG GTGTTGCTCT GCCTGGGCAG TATGGGGGCA GCATCTCGGC ATCTTCCAGC 1140 1141 CACCCTCACG TCACTTTAGA GGGAAAGCCA CCCAACAGCA GCCACCAGGC TCTCCTGCAG 1200 1201 CATTTATTAT TGAAAGAACA AATGCGACAG CAAAAGCTTC TTGTGGCTGG TGGAGTTCCC 1260 1261 TTACATCCTC AGTCTCCCTT GGCAACTAAA GAGAGAATTT CACCTGGCAT TAGAGGTACA 1320 1321 CACAAATTGC CCCGTCACAG ACCTCTGAAC CGAACCCAGT CTGCACCTTT GCCTCAGAGT 1380 1381 ACATTGGCTC AGCTTGTCAT TCAACAGCAA CACCAGCAAT TCTTGGAGAA GCAGAAGCAA 1440 1441 TACCAGCAGC AGATCCACAT GAACAAACTG CTTTCGAAAT CTATTGAACA ACTGAAGCAA 1500 1501 CCAGGCAGTC ACCTTGAGGA AGCAGAGGAA GAGCTTCAGG GGGACCAGGC GATGCAGGAA 1560 1561 GACAGAGCGC CCTCTAGTGG CAACAGCACT AGGAGCGACA GCAGTGCTTG TGTGGATGAC 1620 1621 ACAGTGGGAC AAGTTGGGGC TGTGAAGGTC AAGGAGGAAC CAGTGGACAG TGATGAAGAT 1680 1681 GCTCAGATCC AGGAAATGGA ATCTGGGGAG CAGGCTGCTT TTATGCAACA GCCCTTCCTG 1740 1741 GAGCCCCCGC GCACACATGC ACTCTCTGTG CACCAAGCTC CACTGGCTGC GGTTGGCACG 1800 1801 GATGGACTAG ACAAACACCG TCTTGTCTCC AGGACTCACT CTTCCCCTGC TGCCTCCGTT 1860 1861 TTACCTCACC CAGCAATGGA CCGCCCCCTC CAGCCGGGCT CTGCAACTGG AATTGCCTAC 1920 1921 GACCCCTTGA TGCTGAAACA TCAGTGCGTT TGTGGCAATT CCACTACCCA CCCTGAGCAT 1980 1981 GCTGGACGAA TACAGAGTAT CTGGTCACGA CTGCAAGAAA CTGGCCTGCT AAATAAATGT 2040 2041 GAGCGAATTC AAGGTCGAAA AGCCAGCCTG GAGGAAATAC AGCTTGTTCA TTCTGAACAT 2100 2101 CACTCACTGT TGTATGGCAC CAACCCCCTG GACGGACAGA AGCTGGACCC CAGGATACTC 2160 2161 CTAGGTGATG ACTCTCAAAA GTTTTTTTCC TCATTACCCT GTGGTGGACT TGGGGTGGAC 2220 2221 AGTGACACCA TTTGGAATGA ACTGCATTCG TCCGGTGCTG CACGCATGGC TGTTGGCTGT 2280 2281 GTCATCGAGC TGGCTTCCAA AGTGGCCTCA GGAGAGCTGA AGAATGGGTT TGCCGTTGTG 2340 2341 AGGCCCCCTG GCCATCATGC TGAAGAATCC ACAGCCATGG GGTTCTGCTT TTTTAATTCA 2400 2401 GTTGCAATTA CCGCCAAATA CTTGAGAGAC CAACTAAATA TAAGCAAGAT ATTGATTGTA 2460 2461 GATCTGGATG TTCACCATGG AAACGGTACC CAGCAGGCCT TTTATGCTGA CCCCAGCATC 2520 2521 CTGTACATTT CACTCCATCG CTATGATGAA GGGAACTTTT TCCCTGGCAG TGGAGCCCCA 2580 2581 AATGAGGTCG GAACAGGCCT CGGAGAAGGT TACAATATAA ATATTGCCTG GACAGGTGGC 2640 2641 CTTGATCCTC CGATGGGAGA TGTTGAGTAC CTGGAAGCAT TCAGGACCAT CGTGAAGCCT 2700 2701 GTGGCAAAAG AGTTTGATCC AGACATGGTC TTAGTATCCG CTGGATTTGA TGCATTGGAA 2760 2761 GGCCACACCC CTCCTCTAGG GGGTTACAAA GTGACAGCAA AATGTTTTGG TCATTTGACG 2820 2821 AAGCAATTGA TGACATTGGC TGATGGACGT GTCGTGTTGG CTCTAGAAGG AGGACATGAT 2880 2881 CTCACAGCCA TCTGTGATGC GTCAGAAGCC TGTGTAAATG CCCTTCTAGG AAATGAGCTG 2940 2941 GAGCCACTTG CAGAAGAAGT TCTCCACCAA AGCCCGAATA TGAATGCTGT TATTTCTTTA 3000 3001 CAGAAGATCA TTGAAATTCA AAGCAAGTAT TGGAAGTCAT TAAGGATGGT GGCTACGCCA 3060 3061 AGGGGCTGTG CTCTGGCTGG TGCTCAGTTG CAAGAGGAGA CAGAGACCGT TTCTGCCCTG 3120 3121 GCCTCCCTAA CAGTGGATGT GGAACAGCCC TTTGCTCAGG AAGACAGCAG AACTGCTGGT 3180 3181 GAGCCTATGG AAGAGGAGCC AGCCTTGTGA 3210 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Histone deacetylase complex | |
Cellular Component | Transcription factor complex | |
Molecular Function | Histone deacetylase activity (H4-K16 specific) | |
Molecular Function | Histone deacetylase binding | |
Molecular Function | Metal ion binding | |
Molecular Function | NAD-dependent histone deacetylase activity (H3-K14 specific) | |
Molecular Function | Protein kinase C binding | |
Molecular Function | Repressing transcription factor binding | |
Biological Process | Cellular response to insulin stimulus | |
Biological Process | Cholesterol homeostasis | |
Biological Process | Histone H4-K16 deacetylation | |
Biological Process | Negative regulation of cytokine secretion | |
Biological Process | Negative regulation of lipoprotein lipase activity | |
Biological Process | Negative regulation of transcription by RNA polymerase II | |
Biological Process | Peptidyl-lysine deacetylation | |
Biological Process | Positive regulation of cell migration involved in sprouting angiogenesis |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Urm-0413 | Ursus maritimus | 99.58 | 3e-89 | 309 |
| LLPS-Otg-1740 | Otolemur garnettii | 99.54 | 1e-76 | 273 |
| LLPS-Caj-3889 | Callithrix jacchus | 99.24 | 0.0 | 1855 |
| LLPS-Hos-1173 | Homo sapiens | 98.58 | 0.0 | 1840 |
| LLPS-Paa-4208 | Papio anubis | 98.58 | 0.0 | 1843 |
| LLPS-Maf-3043 | Macaca fascicularis | 98.58 | 0.0 | 1843 |
| LLPS-Cea-0406 | Cercocebus atys | 98.58 | 0.0 | 1843 |
| LLPS-Man-0901 | Macaca nemestrina | 98.49 | 0.0 | 1842 |
| LLPS-Chs-0601 | Chlorocebus sabaeus | 98.45 | 0.0 | 1247 |
| LLPS-Mam-3880 | Macaca mulatta | 97.93 | 0.0 | 1545 |
| LLPS-Poa-2228 | Pongo abelii | 97.63 | 0.0 | 1808 |
| LLPS-Caf-1595 | Canis familiaris | 96.69 | 0.0 | 1799 |
| LLPS-Cas-3947 | Carlito syrichta | 96.69 | 0.0 | 1778 |
| LLPS-Fec-0752 | Felis catus | 96.41 | 0.0 | 1796 |
| LLPS-Mup-3150 | Mustela putorius furo | 96.12 | 0.0 | 1793 |
| LLPS-Aim-1347 | Ailuropoda melanoleuca | 95.93 | 0.0 | 1791 |
| LLPS-Ict-2982 | Ictidomys tridecemlineatus | 95.75 | 0.0 | 1757 |
| LLPS-Sus-1427 | Sus scrofa | 95.66 | 0.0 | 1832 |
| LLPS-Bot-3202 | Bos taurus | 95.46 | 0.0 | 1774 |
| LLPS-Nol-2285 | Nomascus leucogenys | 95.36 | 0.0 | 1839 |
| LLPS-Rhb-0333 | Rhinopithecus bieti | 95.27 | 0.0 | 1839 |
| LLPS-Mal-1562 | Mandrillus leucophaeus | 95.18 | 0.0 | 1839 |
| LLPS-Gog-1236 | Gorilla gorilla | 95.18 | 0.0 | 1833 |
| LLPS-Loa-2892 | Loxodonta africana | 95.09 | 0.0 | 1771 |
| LLPS-Pat-3972 | Pan troglodytes | 95.08 | 0.0 | 1832 |
| LLPS-Pap-2868 | Pan paniscus | 95.04 | 0.0 | 1815 |
| LLPS-Orc-4361 | Oryctolagus cuniculus | 94.61 | 0.0 | 1752 |
| LLPS-Eqc-0883 | Equus caballus | 94.32 | 0.0 | 1774 |
| LLPS-Mum-4255 | Mus musculus | 91.59 | 0.0 | 1682 |
| LLPS-Ran-4625 | Rattus norvegicus | 91.49 | 0.0 | 1680 |
| LLPS-Ova-2744 | Ovis aries | 91.18 | 0.0 | 1441 |
| LLPS-Cap-0707 | Cavia porcellus | 91.06 | 0.0 | 1633 |
| LLPS-Myl-0056 | Myotis lucifugus | 89.17 | 0.0 | 1328 |
| LLPS-Pes-2896 | Pelodiscus sinensis | 85.73 | 0.0 | 1553 |
| LLPS-Fia-2482 | Ficedula albicollis | 82.86 | 0.0 | 1495 |
| LLPS-Mod-3794 | Monodelphis domestica | 82.79 | 0.0 | 1505 |
| LLPS-Meg-2429 | Meleagris gallopavo | 79.83 | 0.0 | 1505 |
| LLPS-Tag-1961 | Taeniopygia guttata | 75.91 | 0.0 | 1035 |
| LLPS-Leo-3542 | Lepisosteus oculatus | 70.89 | 0.0 | 1219 |
| LLPS-Scf-0886 | Scleropages formosus | 69.56 | 0.0 | 687 |
| LLPS-Ora-0871 | Ornithorhynchus anatinus | 69.13 | 2e-149 | 460 |
| LLPS-Orn-1616 | Oreochromis niloticus | 67.9 | 0.0 | 650 |
| LLPS-Anc-2211 | Anolis carolinensis | 67.42 | 0.0 | 702 |
| LLPS-Ten-3618 | Tetraodon nigroviridis | 66.89 | 0.0 | 632 |
| LLPS-Xet-1453 | Xenopus tropicalis | 65.94 | 0.0 | 633 |
| LLPS-Sah-1057 | Sarcophilus harrisii | 64.69 | 0.0 | 613 |
| LLPS-Tar-3225 | Takifugu rubripes | 64.55 | 0.0 | 659 |
| LLPS-Asm-0143 | Astyanax mexicanus | 64.46 | 0.0 | 587 |
| LLPS-Mea-4295 | Mesocricetus auratus | 64.43 | 0.0 | 599 |
| LLPS-Fud-2596 | Fukomys damarensis | 64.03 | 0.0 | 603 |
| LLPS-Pof-0372 | Poecilia formosa | 63.62 | 0.0 | 659 |
| LLPS-Gaa-1354 | Gasterosteus aculeatus | 62.5 | 0.0 | 589 |
| LLPS-Dar-3905 | Danio rerio | 56.88 | 0.0 | 963 |
| LLPS-Lac-0469 | Latimeria chalumnae | 56.63 | 0.0 | 917 |
| LLPS-Tut-0359 | Tursiops truncatus | 56.53 | 0.0 | 912 |
| LLPS-Dio-0554 | Dipodomys ordii | 56.04 | 0.0 | 902 |
| LLPS-Gaga-3850 | Gallus gallus | 55.93 | 0.0 | 954 |
| LLPS-Drm-2310 | Drosophila melanogaster | 54.71 | 2e-163 | 524 |
| LLPS-Xim-4021 | Xiphophorus maculatus | 54.12 | 0.0 | 852 |
| LLPS-Orl-1784 | Oryzias latipes | 54.05 | 0.0 | 630 |
| LLPS-Scm-1573 | Scophthalmus maximus | 53.14 | 0.0 | 871 |
| LLPS-Icp-2804 | Ictalurus punctatus | 52.64 | 9e-138 | 449 |
| LLPS-Cis-0244 | Ciona savignyi | 52.38 | 6e-98 | 318 |
| LLPS-Bro-1176 | Brassica oleracea | 44.19 | 1e-85 | 297 |
| LLPS-Brr-1585 | Brassica rapa | 43.81 | 5e-83 | 289 |
| LLPS-Brn-2227 | Brassica napus | 43.81 | 6e-83 | 289 |
| LLPS-Thc-2469 | Theobroma cacao | 43.64 | 1e-78 | 277 |
| LLPS-Cus-2033 | Cucumis sativus | 43.19 | 7e-78 | 275 |
| LLPS-Usm-0116 | Ustilago maydis | 42.6 | 7e-77 | 273 |
| LLPS-Gor-2789 | Gossypium raimondii | 42.19 | 1e-80 | 283 |
| LLPS-Mae-1065 | Manihot esculenta | 42.12 | 1e-78 | 277 |
| LLPS-Via-0255 | Vigna angularis | 41.93 | 5e-79 | 278 |
| LLPS-Miv-0122 | Microbotryum violaceum | 41.61 | 7e-81 | 291 |
| LLPS-Abg-0974 | Absidia glauca | 41.19 | 3e-79 | 278 |
| LLPS-Mel-0391 | Melampsora laricipopulina | 40.99 | 9e-78 | 275 |
| LLPS-Sem-1923 | Selaginella moellendorffii | 39.53 | 8e-79 | 276 |
| LLPS-Crn-1166 | Cryptococcus neoformans | 39.36 | 3e-78 | 277 |
| LLPS-Lem-1290 | Leptosphaeria maculans | 38.95 | 5e-78 | 280 |
| LLPS-Tum-1364 | Tuber melanosporum | 38.93 | 7e-78 | 268 |
| LLPS-Asn-1628 | Aspergillus nidulans | 38.73 | 3e-77 | 275 |
| LLPS-Cii-0108 | Ciona intestinalis | 37.71 | 2e-159 | 506 |