• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Scm-1675
SMAX5B_005935

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Serine hydroxymethyltransferase
Gene Name: SMAX5B_005935
Ensembl Gene: ENSSMAG00000006361.1
Ensembl Protein: ENSSMAP00000010342.1
Organism: Scophthalmus maximus
Taxa ID: 52904
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Interconversion of serine and glycine.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSSANGHGVS  KETWDSHNKM  MLEPLVINDS  EVFSIIKKEK  HRQTYGLELI  ASENFASRAV  60
61    LEALGSCMNN  KYSEGYPGQR  YYGGTEHVDE  LERLCQKRAL  EAYGLDSEKW  GVNVQPYSGS  120
121   PANFAVYTAI  VEPHGRIMGL  DLPDGGHLTH  GFMTEKKKIS  ATSMFFESMP  YKVNPDTGYI  180
181   DYDRLQENAR  LFHPKLIIAG  ASCYSRNLDY  ARLRQIANEN  GAYLMADMAH  ISGLVAAGVV  240
241   PSPFEHSDIV  TSTTHKTLRG  CRSGVIFFRK  GLRSVDAKGK  ETLYNLESLI  NQAVFPGLQG  300
301   GPHNHAIAGV  AVALKQAMTP  EFKAYQMQVL  DNCKALSSSL  IDFGYKIVTG  GSDNHLILLD  360
361   LRNKGTDGGR  AEKVLEACAI  ACNKNTCPGD  KSALRPSGLR  FGSPALTSRG  MEQDDFKKVA  420
421   EFIHRGIELT  LEVQRSLDPK  ATLKEFIQAL  SKEEKFQQRV  ADIRAEVEAF  AGQFPMPGLP  480
481   EL  482
Nucleotide CDS Sequence (FASTA)
1     ATGTCTTCAG  CAAACGGCCA  CGGTGTGAGC  AAAGAGACGT  GGGACTCGCA  CAACAAGATG  60
61    ATGCTGGAGC  CGCTGGTCAT  CAACGACTCA  GAGGTGTTCT  CCATCATAAA  GAAAGAGAAG  120
121   CACAGGCAGA  CGTACGGTCT  GGAGCTGATT  GCGTCAGAGA  ACTTCGCCAG  CAGAGCTGTG  180
181   CTCGAGGCTC  TGGGTTCCTG  CATGAACAAC  AAGTACTCTG  AGGGATATCC  TGGTCAGAGG  240
241   TATTATGGTG  GGACGGAGCA  TGTTGACGAG  CTGGAGAGAC  TTTGTCAGAA  GAGGGCGCTG  300
301   GAGGCCTACG  GTCTGGACTC  AGAGAAATGG  GGGGTGAACG  TGCAGCCATA  CTCGGGCTCG  360
361   CCCGCTAACT  TTGCTGTGTA  CACGGCCATT  GTGGAGCCCC  ACGGCAGGAT  CATGGGACTA  420
421   GACCTTCCCG  ACGGAGGTCA  CCTGACACAT  GGCTTCATGA  CGGAGAAGAA  AAAAATCTCT  480
481   GCAACGTCCA  TGTTCTTTGA  GTCCATGCCG  TATAAGGTGA  ATCCAGACAC  TGGCTACATT  540
541   GACTATGACA  GACTGCAAGA  AAACGCACGG  CTGTTCCACC  CCAAACTCAT  CATTGCAGGA  600
601   GCAAGTTGCT  ATTCCCGCAA  CCTTGACTAC  GCCCGTCTGA  GGCAGATTGC  CAACGAGAAC  660
661   GGTGCATATC  TGATGGCAGA  CATGGCTCAC  ATCAGTGGTT  TGGTGGCTGC  TGGTGTGGTG  720
721   CCCTCACCTT  TTGAGCACAG  TGACATTGTT  ACCTCGACAA  CGCACAAGAC  GCTCCGTGGC  780
781   TGCCGCTCTG  GAGTCATCTT  CTTCAGGAAA  GGTCTGCGGA  GTGTCGATGC  TAAGGGGAAG  840
841   GAGACTTTGT  ACAACTTGGA  GTCTCTGATC  AATCAGGCTG  TGTTTCCTGG  GCTGCAGGGA  900
901   GGACCACACA  ACCACGCTAT  TGCGGGTGTC  GCTGTAGCTC  TCAAACAAGC  CATGACCCCG  960
961   GAGTTCAAGG  CCTACCAGAT  GCAGGTTCTT  GATAACTGCA  AAGCTCTGTC  CAGTTCTCTT  1020
1021  ATTGACTTCG  GCTACAAGAT  CGTAACTGGC  GGCTCTGACA  ACCATCTGAT  CCTGCTGGAC  1080
1081  CTGCGCAACA  AGGGAACTGA  TGGAGGACGA  GCTGAGAAGG  TTCTGGAAGC  CTGTGCCATC  1140
1141  GCTTGTAATA  AGAACACCTG  CCCAGGGGAT  AAAAGTGCTT  TGCGTCCTAG  TGGTTTAAGG  1200
1201  TTCGGTTCTC  CAGCTCTGAC  CTCCAGAGGC  ATGGAGCAGG  ATGACTTCAA  GAAGGTGGCT  1260
1261  GAATTCATTC  ACAGAGGTAT  TGAGCTGACA  TTGGAGGTGC  AAAGAAGCCT  GGATCCCAAG  1320
1321  GCCACTCTGA  AGGAGTTTAT  TCAGGCACTG  TCTAAGGAGG  AGAAGTTCCA  GCAGCGGGTA  1380
1381  GCAGACATCA  GGGCTGAGGT  GGAGGCTTTC  GCTGGTCAGT  TCCCCATGCC  TGGCCTACCT  1440
1441  GAGCTGTAG  1449

▼ KEYWORD

ID
Family
Complete proteome
Methyltransferase
One-carbon metabolism
Pyridoxal phosphate
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Nucleus
Molecular Function
Glycine hydroxymethyltransferase activity
Molecular Function
Methyltransferase activity
Molecular Function
Pyridoxal phosphate binding
Biological Process
Glycine biosynthetic process from serine
Biological Process
Tetrahydrofolate interconversion

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Orn-3549Oreochromis niloticus91.080.0 936
LLPS-Tar-2991Takifugu rubripes91.050.0 861
LLPS-Pof-0025Poecilia formosa90.870.0 935
LLPS-Gaa-1845Gasterosteus aculeatus90.50.0 924
LLPS-Ten-0133Tetraodon nigroviridis89.880.0 915
LLPS-Orl-1966Oryzias latipes88.80.0 914
LLPS-Xim-2070Xiphophorus maculatus86.510.0 919
LLPS-Dar-0710Danio rerio83.640.0 863
LLPS-Asm-1891Astyanax mexicanus83.640.0 861
LLPS-Icp-3939Ictalurus punctatus82.880.0 851
LLPS-Fia-3442Ficedula albicollis82.280.0 822
LLPS-Scf-1719Scleropages formosus81.570.0 848
LLPS-Nol-0841Nomascus leucogenys81.520.0 714
LLPS-Xet-2851Xenopus tropicalis80.760.0 817
LLPS-Tag-2072Taeniopygia guttata80.750.0 822
LLPS-Meg-0026Meleagris gallopavo80.210.0 792
LLPS-Anc-3279Anolis carolinensis80.130.0 811
LLPS-Ora-3550Ornithorhynchus anatinus79.750.0 816
LLPS-Mum-4731Mus musculus79.570.0 775
LLPS-Bot-4450Bos taurus79.490.0 800
LLPS-Ran-1760Rattus norvegicus79.190.0 775
LLPS-Gog-1227Gorilla gorilla79.040.0 745
LLPS-Mea-4118Mesocricetus auratus78.940.0 769
LLPS-Loa-4305Loxodonta africana78.810.0 792
LLPS-Sus-1953Sus scrofa78.810.0 800
LLPS-Pes-1713Pelodiscus sinensis78.760.0 810
LLPS-Orc-2179Oryctolagus cuniculus78.750.0 788
LLPS-Gaga-1352Gallus gallus78.460.0 751
LLPS-Cap-2972Cavia porcellus78.220.0 782
LLPS-Poa-3432Pongo abelii78.080.0 769
LLPS-Hos-0773Homo sapiens78.080.0 770
LLPS-Pap-4685Pan paniscus78.080.0 769
LLPS-Pat-0850Pan troglodytes78.080.0 770
LLPS-Paa-0726Papio anubis78.080.0 772
LLPS-Man-4759Macaca nemestrina78.060.0 751
LLPS-Ict-3696Ictidomys tridecemlineatus78.010.0 777
LLPS-Rhb-3293Rhinopithecus bieti77.870.0 772
LLPS-Mup-1989Mustela putorius furo77.850.0 806
LLPS-Tut-0673Tursiops truncatus77.80.0 800
LLPS-Cea-1738Cercocebus atys77.80.0 774
LLPS-Mod-0460Monodelphis domestica77.710.0 799
LLPS-Fec-1836Felis catus77.710.0 798
LLPS-Myl-3641Myotis lucifugus77.660.0 784
LLPS-Eqc-2968Equus caballus77.50.0 795
LLPS-Cas-2133Carlito syrichta77.450.0 773
LLPS-Caj-1121Callithrix jacchus77.450.0 765
LLPS-Mam-3670Macaca mulatta77.390.0 771
LLPS-Maf-4336Macaca fascicularis77.390.0 771
LLPS-Aon-0400Aotus nancymaae77.240.0 761
LLPS-Ova-2371Ovis aries77.120.0 772
LLPS-Caf-3683Canis familiaris76.810.0 802
LLPS-Otg-1848Otolemur garnettii76.760.0 767
LLPS-Fud-0008Fukomys damarensis76.560.0 760
LLPS-Aim-2884Ailuropoda melanoleuca76.490.0 790
LLPS-Leo-1077Lepisosteus oculatus76.340.0 780
LLPS-Lac-0040Latimeria chalumnae75.270.0 740
LLPS-Chs-2181Chlorocebus sabaeus72.870.0 641
LLPS-Urm-3704Ursus maritimus72.340.0 782
LLPS-Dio-4283Dipodomys ordii69.040.0 598
LLPS-Cii-2148Ciona intestinalis67.650.0 674
LLPS-Cis-0607Ciona savignyi66.160.0 640
LLPS-Mal-4235Mandrillus leucophaeus63.910.0 629
LLPS-Sem-0555Selaginella moellendorffii61.370.0 591
LLPS-Cae-0855Caenorhabditis elegans61.280.0 614
LLPS-Viv-1480Vitis vinifera61.060.0 577
LLPS-Cus-0921Cucumis sativus61.010.0 588
LLPS-Coc-0058Corchorus capsularis60.930.0 578
LLPS-Php-0312Physcomitrella patens60.920.0 588
LLPS-Chr-0068Chlamydomonas reinhardtii60.750.0 575
LLPS-Hea-1228Helianthus annuus60.620.0 574
LLPS-Gor-0776Gossypium raimondii60.530.0 600
LLPS-Mae-2311Manihot esculenta60.490.0 578
LLPS-Art-0113Arabidopsis thaliana60.490.0 583
LLPS-Glm-2860Glycine max60.090.0 602
LLPS-Vir-0976Vigna radiata60.040.0 575
LLPS-Osl-1249Ostreococcus lucimarinus59.960.0 562
LLPS-Prp-0623Prunus persica59.960.0 593
LLPS-Thc-0212Theobroma cacao59.830.0 588
LLPS-Via-1929Vigna angularis59.820.0 571
LLPS-Pot-1901Populus trichocarpa59.780.0 584
LLPS-Bro-2529Brassica oleracea59.730.0 570
LLPS-Brr-2981Brassica rapa59.730.0 569
LLPS-Brn-2859Brassica napus59.730.0 570
LLPS-Arl-2343Arabidopsis lyrata59.690.0 571
LLPS-Phv-1564Phaseolus vulgaris59.60.0 568
LLPS-Met-1827Medicago truncatula59.520.0 601
LLPS-Pyt-1337Pyrenophora teres59.480.0 551
LLPS-Nia-2398Nicotiana attenuata59.310.0 592
LLPS-Ved-0846Verticillium dahliae59.050.0 573
LLPS-Abg-1072Absidia glauca58.970.0 545
LLPS-Pytr-1510Pyrenophora triticirepentis58.920.0 563
LLPS-Trv-1328Trichoderma virens58.920.0 568
LLPS-Dac-1581Daucus carota58.730.0 562
LLPS-Cym-0095Cyanidioschyzon merolae58.570.0 539
LLPS-Phn-1290Phaeosphaeria nodorum58.490.0 563
LLPS-Cogr-1236Colletotrichum graminicola58.490.0 569
LLPS-Sot-0061Solanum tuberosum58.350.0 582
LLPS-Sol-0670Solanum lycopersicum58.350.0 583
LLPS-Mua-2113Musa acuminata58.330.0 595
LLPS-Trr-1528Trichoderma reesei58.030.0 559
LLPS-Cog-0571Colletotrichum gloeosporioides57.970.0 562
LLPS-Coo-1335Colletotrichum orbiculare57.760.0 564
LLPS-Gas-0721Galdieria sulphuraria57.480.0 556
LLPS-Lem-0852Leptosphaeria maculans56.90.0 553
LLPS-Beb-0504Beauveria bassiana56.680.0 549
LLPS-Sac-1215Saccharomyces cerevisiae56.560.0 541
LLPS-Scp-1241Schizosaccharomyces pombe56.030.0 548
LLPS-Fuo-1489Fusarium oxysporum55.720.0 571
LLPS-Fuv-0412Fusarium verticillioides55.720.0 571
LLPS-Aso-1178Aspergillus oryzae55.480.0 532
LLPS-Ast-1349Aspergillus terreus55.340.0 533
LLPS-Nef-0921Neosartorya fischeri54.960.0 551
LLPS-Asni-0523Aspergillus niger54.830.0 562
LLPS-Asfu-1415Aspergillus fumigatus54.750.0 550
LLPS-Scj-1324Schizosaccharomyces japonicus54.640.0 541
LLPS-Nec-0140Neurospora crassa54.60.0 552
LLPS-Asn-1265Aspergillus nidulans54.60.0 553
LLPS-Asc-0919Aspergillus clavatus54.580.0 550
LLPS-Asf-0455Aspergillus flavus53.970.0 542
LLPS-Zyt-0219Zymoseptoria tritici53.910.0 553
LLPS-Dos-0925Dothistroma septosporum53.810.0 540
LLPS-Mao-1124Magnaporthe oryzae53.090.0 539