• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Cis-0607

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Serine hydroxymethyltransferase
Ensembl Gene: ENSCSAVG00000006938.1
Ensembl Protein: ENSCSAVP00000011827.1
Organism: Ciona savignyi
Taxa ID: 51511
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Interconversion of serine and glycine.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     LKPLETKESL  WLEESLEVND  PEIYKIIRNE  KERQRDGLEL  IASENFTSGA  VLEALGSCLN  60
61    NKYSEGYPGV  RYYGGTENID  ELELLCQKRA  LEVFKLNPAE  WGVNVQPYSG  SPANFAVLTA  120
121   VVEPHGRIMG  LDLPDGGHLT  HGFMTEKKKI  SATSIFFESM  PYKVNPETGL  IDYDQLAQNA  180
181   KLFKPKLIIA  GMSCYSRVID  YERMRKITDD  NKAILMADMA  HVSGLVAANV  IPSPFEHCHI  240
241   VTSTTHKTLR  GPRAGIIFYR  RGVKVPAANG  KPAEMYNFEK  PINEAVFPGL  QGGPHNHAYW  300
301   RGRLPVYILF  TQKTSIKTYL  FSQVVVNAQT  LGRVLMDKGY  DVVTGGTDTH  LILVNLKSKG  360
361   LNGTDGNRAD  KVLEAIGVAC  NKNTCPGDKA  ALRPSGLRLG  SPALTSRGLN  AKDFERVADF  420
421   IDRGVQLAVD  IQKSLDPKAT  FKDFRTKLNN  DQEIVAKVAA  IKSEVASFAR  TFPIPGL  477
Nucleotide CDS Sequence (FASTA)
1     GAGTCGCTCG  AAGTTAATGA  CCCAGAAATC  TACAAAATCA  TCAGAAATGA  GAAAGAACGC  60
61    CAAAGGGACG  GTTTAGAATT  AATTGCATCA  GAAAATTTTA  CTAGTGGTGC  CGTCTTAGAA  120
121   GCTCTTGGGT  CTTGTTTGAA  CAACAAATAT  TCCGAAGGAT  ATCCAGGCGT  AAGATACTAT  180
181   GGAGGAACCG  AAAACATTGA  CGAACTTGAG  TTACTCTGTC  AAAAACGAGC  TTTGGAAGTT  240
241   TTTAAACTTA  ATCCTGCAGA  ATGGGGAGTC  AATGTCCAAC  CATACTCTGG  TTCACCTGCC  300
301   AATTTTGCCG  TCTTAACAGC  GGTGGTAGAA  CCACACGGCC  GAATAATGGG  ATTAGATCTT  360
361   CCGGACGGTG  GCCATCTCAC  ACATGGATTC  ATGACCGAAA  AGAAAAAAAT  ATCAGCAACA  420
421   TCCATATTTT  TCGAATCGAT  GCCATACAAG  GTCAATCCAG  AAACTGGGCT  GATTGATTAC  480
481   GACCAACTCG  CTCAAAATGC  AAAACTTTTC  AAGCCCAAGT  TGATCATCGC  AGGCATGAGC  540
541   TGTTATTCAA  GAGTCATCGA  TTACGAGCGT  ATGAGAAAAA  TCACAGACGA  CAACAAGGCA  600
601   ATATTAATGG  CGGATATGGC  TCACGTCAGT  GGACTAGTTG  CTGCAAATGT  CATACCATCG  660
661   CCATTTGAAC  ACTGCCATAT  CGTCACCAGT  ACCACCCACA  AAACCTTAAG  GGGTCCCAGG  720
721   GCTGGTATCA  TCTTCTACAG  ACGTGGGGTC  AAACCGATAA  ACGAGGCCGT  TTTCCCTGGT  780
781   TTGCAAGGTG  GTCCACACAA  CCACGCCTAT  TGGCGGGACA  TATTGTTTAC  ACAGAAAACT  840
841   TCAATAAAAA  CATATCTTTT  CTCACAGGTT  GTGGTAAATG  CACAAACACT  GGGCCGAGTG  900
901   CTGATGGACA  AGGGTTATGA  CGTTGTCACC  GGTGGCACGG  ATACCCATCT  TATTCTTGTC  960
961   AACCTCAAAA  GCAAGGGTTT  AAATGGTACC  GATGGAAATC  GTGCCGACAA  AGTATTAGAA  1020
1021  GCCATTGGGG  TAGCATGTAA  CAAGAACACC  TGTCCCGGTG  ATAAAGCTGC  TCTCAGACCC  1080
1081  AGTGGGTTAC  GTTTAGGATC  ACCTGCTCTC  ACTTCACGGG  GACTCAATGC  CAAAGACTTT  1140
1141  GAAAGGGTTG  CAGACTTTAT  TGACAGGGGA  GTACAACTTG  CAGTTGATAT  TCAAAAAAGT  1200
1201  CTCGATCCGA  AAGCCACGTT  CAAGGATTTC  AGAACCAAGC  TCAACAACGA  CCAAGAAATT  1260
1261  GTCGCCAAGG  TTGCAGCCAT  AAAAAGCGAG  GTCGCAAGCT  TCGCTCGCAC  A  1311

▼ KEYWORD

ID
Family
Complete proteome
One-carbon metabolism
Pyridoxal phosphate
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Nucleus
Molecular Function
Glycine hydroxymethyltransferase activity
Molecular Function
Pyridoxal phosphate binding
Biological Process
Glycine biosynthetic process from serine
Biological Process
Tetrahydrofolate interconversion

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cii-2148Ciona intestinalis84.680.0 837
LLPS-Nol-0841Nomascus leucogenys69.670.0 574
LLPS-Tar-2991Takifugu rubripes67.990.0 629
LLPS-Gog-1227Gorilla gorilla67.90.0 610
LLPS-Orn-3549Oreochromis niloticus67.810.0 650
LLPS-Caf-3683Canis familiaris67.790.0 657
LLPS-Fia-3442Ficedula albicollis67.460.0 651
LLPS-Eqc-2968Equus caballus67.440.0 647
LLPS-Otg-1848Otolemur garnettii67.370.0 620
LLPS-Ict-3696Ictidomys tridecemlineatus67.240.0 616
LLPS-Man-4759Macaca nemestrina67.170.0 615
LLPS-Orl-1966Oryzias latipes67.030.0 641
LLPS-Sus-1953Sus scrofa67.020.0 635
LLPS-Orc-2179Oryctolagus cuniculus67.020.0 619
LLPS-Scf-1719Scleropages formosus66.950.0 645
LLPS-Bot-4450Bos taurus66.950.0 640
LLPS-Paa-0726Papio anubis66.810.0 618
LLPS-Icp-3939Ictalurus punctatus66.810.0 644
LLPS-Maf-4336Macaca fascicularis66.810.0 618
LLPS-Cea-1738Cercocebus atys66.810.0 620
LLPS-Mam-3670Macaca mulatta66.810.0 618
LLPS-Asm-1891Astyanax mexicanus66.740.0 649
LLPS-Aim-2884Ailuropoda melanoleuca66.670.0 642
LLPS-Xet-2851Xenopus tropicalis66.670.0 645
LLPS-Rhb-3293Rhinopithecus bieti66.60.0 617
LLPS-Hos-0773Homo sapiens66.60.0 616
LLPS-Pat-0850Pan troglodytes66.60.0 615
LLPS-Loa-4305Loxodonta africana66.60.0 643
LLPS-Tag-2072Taeniopygia guttata66.590.0 646
LLPS-Mup-1989Mustela putorius furo66.530.0 649
LLPS-Poa-3432Pongo abelii66.390.0 613
LLPS-Pap-4685Pan paniscus66.390.0 613
LLPS-Cap-2972Cavia porcellus66.320.0 620
LLPS-Ten-0133Tetraodon nigroviridis66.310.0 635
LLPS-Tut-0673Tursiops truncatus66.180.0 637
LLPS-Aon-0400Aotus nancymaae66.180.0 612
LLPS-Scm-1675Scophthalmus maximus66.160.0 640
LLPS-Ora-3550Ornithorhynchus anatinus66.110.0 639
LLPS-Fec-1836Felis catus66.110.0 644
LLPS-Caj-1121Callithrix jacchus65.970.0 609
LLPS-Dar-0710Danio rerio65.970.0 649
LLPS-Pof-0025Poecilia formosa65.950.0 639
LLPS-Fud-0008Fukomys damarensis65.890.0 614
LLPS-Mum-4731Mus musculus65.890.0 620
LLPS-Cas-2133Carlito syrichta65.890.0 608
LLPS-Ran-1760Rattus norvegicus65.880.0 612
LLPS-Anc-3279Anolis carolinensis65.810.0 632
LLPS-Gaa-1845Gasterosteus aculeatus65.730.0 639
LLPS-Mea-4118Mesocricetus auratus65.550.0 612
LLPS-Myl-3641Myotis lucifugus65.260.0 635
LLPS-Mod-0460Monodelphis domestica65.050.0 634
LLPS-Ova-2371Ovis aries64.990.0 611
LLPS-Pes-1713Pelodiscus sinensis64.990.0 634
LLPS-Chs-2181Chlorocebus sabaeus64.30.0 528
LLPS-Xim-2070Xiphophorus maculatus64.20.0 628
LLPS-Meg-0026Meleagris gallopavo64.00.0 623
LLPS-Lac-0040Latimeria chalumnae63.540.0 599
LLPS-Urm-3704Ursus maritimus63.370.0 635
LLPS-Gaga-1352Gallus gallus63.360.0 596
LLPS-Leo-1077Lepisosteus oculatus61.830.0 583
LLPS-Mal-4235Mandrillus leucophaeus59.660.0 579
LLPS-Cae-0855Caenorhabditis elegans58.370.0 549
LLPS-Dio-3021Dipodomys ordii58.280.0 573
LLPS-Ast-1349Aspergillus terreus58.242e-171 501
LLPS-Dac-0425Daucus carota56.650.0 540
LLPS-Nia-2632Nicotiana attenuata56.440.0 537
LLPS-Sem-1030Selaginella moellendorffii56.330.0 529
LLPS-Mua-2113Musa acuminata56.220.0 537
LLPS-Brn-0374Brassica napus56.220.0 544
LLPS-Prp-0623Prunus persica56.220.0 526
LLPS-Mae-1119Manihot esculenta56.220.0 525
LLPS-Bro-1574Brassica oleracea56.010.0 543
LLPS-Coc-1068Corchorus capsularis56.010.0 524
LLPS-Gor-0776Gossypium raimondii56.010.0 531
LLPS-Glm-2556Glycine max55.890.0 537
LLPS-Arl-2349Arabidopsis lyrata55.790.0 540
LLPS-Osl-1249Ostreococcus lucimarinus55.744e-180 520
LLPS-Cym-0219Cyanidioschyzon merolae55.723e-177 515
LLPS-Php-0058Physcomitrella patens55.680.0 533
LLPS-Sot-0061Solanum tuberosum55.670.0 537
LLPS-Hea-0430Helianthus annuus55.671e-179 521
LLPS-Sol-0670Solanum lycopersicum55.670.0 538
LLPS-Thc-0481Theobroma cacao55.636e-179 519
LLPS-Viv-0937Vitis vinifera55.580.0 527
LLPS-Chr-1685Chlamydomonas reinhardtii55.466e-177 514
LLPS-Cus-1961Cucumis sativus55.360.0 526
LLPS-Brr-0246Brassica rapa55.360.0 537
LLPS-Art-0987Arabidopsis thaliana55.360.0 538
LLPS-Abg-1072Absidia glauca55.356e-170 495
LLPS-Gas-0784Galdieria sulphuraria55.141e-171 499
LLPS-Met-0857Medicago truncatula54.940.0 527
LLPS-Phv-0465Phaseolus vulgaris54.820.0 524
LLPS-Pot-0564Populus trichocarpa54.71e-171 499
LLPS-Via-2243Vigna angularis54.683e-170 495
LLPS-Trr-1528Trichoderma reesei54.193e-180 521
LLPS-Vir-0976Vigna radiata54.041e-175 511
LLPS-Fuv-0412Fusarium verticillioides53.963e-176 512
LLPS-Fuo-1489Fusarium oxysporum53.968e-176 511
LLPS-Scj-1324Schizosaccharomyces japonicus53.833e-177 513
LLPS-Asf-0455Aspergillus flavus53.625e-173 504
LLPS-Trv-1328Trichoderma virens53.591e-179 520
LLPS-Lep-0000Leersia perrieri53.46e-168 489
LLPS-Ved-0846Verticillium dahliae53.331e-172 502
LLPS-Asn-1265Aspergillus nidulans53.244e-173 507
LLPS-Asni-0523Aspergillus niger53.061e-171 501
LLPS-Cogr-1236Colletotrichum graminicola52.741e-174 507
LLPS-Lem-0852Leptosphaeria maculans52.695e-172 500
LLPS-Nec-0140Neurospora crassa52.595e-169 495
LLPS-Pytr-1510Pyrenophora triticirepentis52.587e-169 492
LLPS-Pyt-1354Pyrenophora teres52.367e-168 489
LLPS-Phn-1290Phaeosphaeria nodorum52.362e-169 493
LLPS-Cog-0571Colletotrichum gloeosporioides51.91e-171 499
LLPS-Beb-0504Beauveria bassiana51.839e-171 497
LLPS-Asc-0919Aspergillus clavatus51.755e-169 495
LLPS-Scp-1241Schizosaccharomyces pombe51.374e-171 498
LLPS-Coo-1335Colletotrichum orbiculare51.052e-169 493
LLPS-Gag-0749Gaeumannomyces graminis50.939e-168 491
LLPS-Map-1159Magnaporthe poae50.721e-168 493