• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Scp-1241
shm2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Serine hydroxymethyltransferase, mitochondrial
Gene Name: shm2, SPAC18G6.04c
Ensembl Gene: SPAC18G6.04c
Ensembl Protein: SPAC18G6.04c.1
Organism: Schizosaccharomyces pombe
Taxa ID: 284812
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, OthersPredicted from orthologs(View)

▼ FUNCTION

Interconversion of serine and glycine.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblSPAC18G6.04c.1SPAC18G6.04c.1
UniProtQ10104, GLYM_SCHPO
GeneBankCU329670CAA92384.2
RefSeqNM_001019100.2NP_593668.2

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAVLRQFVKN  SYSSIPKRFY  ALSANQKKLL  KAPLAECDPT  VYKILESEKS  RQKESIALIA  60
61    SENFTSRAVM  DALGSIMQNK  YSEGYPGARY  YGGNEFIDQA  ERLCQTRALE  AFHLDGEKWG  120
121   VNVQPHSGSP  ANLQAYQAVM  KPHDRLMGLD  LPHGGHLSHG  FSTPQKAISA  VSTYFSTMPY  180
181   NVNKETGIID  YDSLEKAAIQ  FRPKVIVAGA  SAYARLVDYK  RMRKITEMCN  AYLLCDMAHI  240
241   SGLVAAGVIP  SPFEYADIVT  TTTHKSLRGP  RGAMIFYRKG  TRSHDKRGNP  ILYELEDKIN  300
301   FSVFPGHQGG  PHNHTITALA  VALGQAKTPE  FYQYQKDVLS  NAKAMANAFI  TRGYKLVSGG  360
361   TDTHLVLVDL  TDKGVDGARV  ERILELVNIS  ANKNTVPGDK  SALIPRGLRL  GTPACTTRGF  420
421   DEKDFERVVE  LIDEVVSLTK  KINEAALKEG  KSKFRDFKAY  VGDGSKFSEI  AKLKKEVITW  480
481   AGKFDFPV  488
Nucleotide CDS Sequence (FASTA)
1     ATGGCAGTTC  TTCGTCAATT  CGTCAAGAAC  TCTTACTCTT  CAATTCCCAA  GCGCTTTTAT  60
61    GCGCTTTCTG  CTAATCAAAA  AAAGTTACTC  AAAGCACCAT  TGGCAGAATG  TGATCCGACA  120
121   GTGTATAAGA  TTTTGGAATC  TGAGAAAAGC  CGTCAGAAAG  AGTCGATAGC  TTTAATTGCT  180
181   AGCGAAAACT  TTACTTCAAG  AGCTGTGATG  GATGCACTCG  GAAGTATTAT  GCAAAACAAA  240
241   TATAGTGAAG  GCTATCCTGG  TGCAAGATAT  TATGGTGGTA  ATGAATTTAT  AGATCAAGCT  300
301   GAAAGACTAT  GTCAAACGAG  AGCTTTAGAA  GCTTTTCATT  TGGATGGGGA  AAAATGGGGA  360
361   GTAAATGTAC  AACCCCATTC  TGGGTCTCCG  GCCAACTTAC  AGGCTTATCA  AGCAGTAATG  420
421   AAGCCACACG  ATCGCCTAAT  GGGTTTAGAT  TTACCCCATG  GCGGTCATTT  ATCTCATGGT  480
481   TTCTCTACTC  CCCAGAAAGC  TATTTCAGCT  GTCTCGACTT  ATTTTTCCAC  CATGCCATAT  540
541   AACGTAAATA  AGGAAACTGG  TATTATTGAC  TATGATAGTT  TGGAAAAGGC  TGCGATACAA  600
601   TTTCGTCCTA  AAGTTATAGT  TGCAGGCGCT  AGTGCTTATG  CACGACTCGT  TGATTACAAG  660
661   CGTATGCGTA  AAATTACGGA  AATGTGCAAT  GCCTATTTGC  TTTGTGATAT  GGCTCACATA  720
721   TCCGGTTTAG  TAGCTGCCGG  TGTAATTCCT  TCTCCGTTTG  AATACGCCGA  TATTGTTACT  780
781   ACGACGACTC  ATAAGTCTTT  ACGTGGACCG  AGAGGAGCTA  TGATATTTTA  TCGAAAAGGT  840
841   ACTCGTTCTC  ACGATAAACG  TGGTAATCCA  ATTTTATATG  AATTAGAGGA  TAAAATCAAT  900
901   TTCTCAGTTT  TTCCTGGACA  TCAAGGCGGC  CCCCATAATC  ATACAATTAC  TGCGTTAGCT  960
961   GTCGCCCTTG  GACAAGCAAA  AACTCCTGAA  TTCTATCAAT  ACCAAAAGGA  CGTTCTAAGT  1020
1021  AACGCCAAGG  CAATGGCCAA  TGCATTTATT  ACTCGTGGCT  ATAAGTTAGT  TTCAGGTGGC  1080
1081  ACGGATACTC  ACTTGGTTCT  TGTTGATTTG  ACCGACAAAG  GTGTAGATGG  TGCCCGTGTC  1140
1141  GAACGTATTT  TAGAGCTTGT  AAATATTTCT  GCCAACAAGA  ATACTGTGCC  CGGAGATAAG  1200
1201  TCTGCTTTAA  TTCCACGTGG  ATTACGTCTG  GGAACTCCAG  CTTGCACTAC  TCGCGGTTTT  1260
1261  GATGAGAAGG  ATTTTGAGAG  AGTGGTAGAG  CTAATTGATG  AAGTTGTATC  TTTGACCAAG  1320
1321  AAAATAAATG  AAGCTGCTTT  GAAGGAAGGA  AAATCGAAGT  TTAGAGACTT  CAAAGCATAT  1380
1381  GTGGGTGATG  GTTCTAAATT  CTCTGAAATC  GCCAAACTGA  AGAAAGAAGT  TATAACTTGG  1440
1441  GCTGGAAAAT  TTGATTTCCC  CGTTTAA  1467

▼ KEYWORD

ID
Family
Complete proteome
Mitochondrion
One-carbon metabolism
Pyridoxal phosphate
Reference proteome
Transferase
Transit peptide

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrion
Molecular Function
Amino acid binding
Molecular Function
Cobalt ion binding
Molecular Function
Glycine hydroxymethyltransferase activity
Molecular Function
Pyridoxal phosphate binding
Molecular Function
Serine binding
Molecular Function
Zinc ion binding
Biological Process
Cellular response to tetrahydrofolate
Biological Process
Folic acid metabolic process
Biological Process
Glycine biosynthetic process from serine
Biological Process
Glycine metabolic process
Biological Process
L-serine catabolic process
Biological Process
L-serine metabolic process
Biological Process
One-carbon metabolic process
Biological Process
Serine family amino acid biosynthetic process
Biological Process
Tetrahydrofolate interconversion
Biological Process
Tetrahydrofolate metabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Scc-1511Schizosaccharomyces cryophilus78.730.0 814
LLPS-Trv-1328Trichoderma virens67.020.0 649
LLPS-Scj-1324Schizosaccharomyces japonicus66.960.0 655
LLPS-Abg-1072Absidia glauca66.590.0 610
LLPS-Trr-1528Trichoderma reesei66.380.0 642
LLPS-Cogr-1236Colletotrichum graminicola66.170.0 636
LLPS-Ved-0846Verticillium dahliae65.880.0 644
LLPS-Coo-1335Colletotrichum orbiculare65.740.0 642
LLPS-Cog-0571Colletotrichum gloeosporioides65.740.0 637
LLPS-Prp-1906Prunus persica65.070.0 613
LLPS-Nef-0921Neosartorya fischeri65.050.0 637
LLPS-Asfu-1415Aspergillus fumigatus65.050.0 637
LLPS-Fus-0988Fusarium solani64.90.0 609
LLPS-Pytr-1368Pyrenophora triticirepentis64.90.0 581
LLPS-Beb-0504Beauveria bassiana64.890.0 634
LLPS-Chr-1685Chlamydomonas reinhardtii64.630.0 614
LLPS-Asc-0919Aspergillus clavatus64.50.0 641
LLPS-Gor-0776Gossypium raimondii64.470.0 612
LLPS-Pyt-1354Pyrenophora teres64.260.0 613
LLPS-Asn-1265Aspergillus nidulans64.210.0 641
LLPS-Phv-0465Phaseolus vulgaris64.190.0 599
LLPS-Aso-1178Aspergillus oryzae64.180.0 611
LLPS-Fuo-1485Fusarium oxysporum64.150.0 629
LLPS-Asni-0523Aspergillus niger64.00.0 636
LLPS-Asf-0455Aspergillus flavus64.00.0 634
LLPS-Mua-2113Musa acuminata63.970.0 607
LLPS-Glm-2556Glycine max63.970.0 603
LLPS-Nia-2632Nicotiana attenuata63.970.0 602
LLPS-Coc-0892Corchorus capsularis63.970.0 604
LLPS-Lem-0852Leptosphaeria maculans63.830.0 612
LLPS-Phn-1290Phaeosphaeria nodorum63.830.0 612
LLPS-Php-0058Physcomitrella patens63.760.0 606
LLPS-Thc-0481Theobroma cacao63.680.0 600
LLPS-Ast-1349Aspergillus terreus63.540.0 627
LLPS-Viv-0937Vitis vinifera63.540.0 596
LLPS-Mae-0851Manihot esculenta63.460.0 596
LLPS-Dac-0425Daucus carota63.320.0 601
LLPS-Brn-0898Brassica napus63.320.0 601
LLPS-Sot-0061Solanum tuberosum63.320.0 599
LLPS-Bro-1574Brassica oleracea63.320.0 602
LLPS-Fuv-0779Fusarium verticillioides63.310.0 624
LLPS-Pot-1901Populus trichocarpa63.240.0 593
LLPS-Blg-1491Blumeria graminis63.180.0 607
LLPS-Dos-0925Dothistroma septosporum63.180.0 618
LLPS-Arl-2349Arabidopsis lyrata63.10.0 602
LLPS-Met-0857Medicago truncatula63.10.0 593
LLPS-Art-0987Arabidopsis thaliana63.10.0 602
LLPS-Hea-2602Helianthus annuus63.080.0 612
LLPS-Sol-0670Solanum lycopersicum62.880.0 597
LLPS-Cus-1961Cucumis sativus62.880.0 590
LLPS-Zyt-0219Zymoseptoria tritici62.810.0 628
LLPS-Yal-0033Yarrowia lipolytica62.790.0 613
LLPS-Brr-0246Brassica rapa62.660.0 598
LLPS-Mao-1124Magnaporthe oryzae62.550.0 611
LLPS-Sem-0783Selaginella moellendorffii62.550.0 594
LLPS-Kop-1003Komagataella pastoris62.550.0 622
LLPS-Osl-0955Ostreococcus lucimarinus61.930.0 590
LLPS-Map-1159Magnaporthe poae61.750.0 623
LLPS-Gag-0749Gaeumannomyces graminis61.750.0 619
LLPS-Via-0418Vigna angularis61.640.0 590
LLPS-Leo-0252Lepisosteus oculatus61.10.0 575
LLPS-Scf-2491Scleropages formosus61.10.0 575
LLPS-Nec-0140Neurospora crassa61.090.0 622
LLPS-Caf-0064Canis familiaris60.780.0 554
LLPS-Asg-0172Ashbya gossypii60.720.0 585
LLPS-Asm-1638Astyanax mexicanus60.660.0 571
LLPS-Mea-0700Mesocricetus auratus60.530.0 570
LLPS-Ict-4352Ictidomys tridecemlineatus60.530.0 570
LLPS-Ten-1134Tetraodon nigroviridis60.530.0 565
LLPS-Xim-1691Xiphophorus maculatus60.440.0 570
LLPS-Pof-3853Poecilia formosa60.440.0 572
LLPS-Tar-2590Takifugu rubripes60.220.0 573
LLPS-Ran-3826Rattus norvegicus60.090.0 569
LLPS-Anc-2771Anolis carolinensis60.090.0 573
LLPS-Cap-2472Cavia porcellus60.090.0 569
LLPS-Xet-3438Xenopus tropicalis60.080.0 577
LLPS-Icp-0434Ictalurus punctatus60.00.0 565
LLPS-Orl-1539Oryzias latipes60.00.0 568
LLPS-Mum-3405Mus musculus59.870.0 568
LLPS-Mup-3762Mustela putorius furo59.870.0 564
LLPS-Loa-0219Loxodonta africana59.870.0 565
LLPS-Orn-3675Oreochromis niloticus59.780.0 573
LLPS-Scm-2054Scophthalmus maximus59.780.0 563
LLPS-Fud-2617Fukomys damarensis59.650.0 565
LLPS-Dio-3021Dipodomys ordii59.650.0 566
LLPS-Urm-1529Ursus maritimus59.650.0 563
LLPS-Gaa-1164Gasterosteus aculeatus59.560.0 560
LLPS-Cym-0095Cyanidioschyzon merolae59.440.0 571
LLPS-Myl-2997Myotis lucifugus59.430.0 560
LLPS-Aim-3168Ailuropoda melanoleuca59.430.0 561
LLPS-Eqc-3485Equus caballus59.430.0 563
LLPS-Sac-1215Saccharomyces cerevisiae59.410.0 583
LLPS-Dar-1628Danio rerio59.340.0 562
LLPS-Cae-0855Caenorhabditis elegans59.270.0 564
LLPS-Bot-2589Bos taurus59.210.0 559
LLPS-Fec-3953Felis catus59.210.0 559
LLPS-Rhb-2692Rhinopithecus bieti58.80.0 562
LLPS-Otg-2294Otolemur garnettii58.770.0 558
LLPS-Tag-2072Taeniopygia guttata58.690.0 562
LLPS-Caj-4755Callithrix jacchus58.580.0 560
LLPS-Gog-2559Gorilla gorilla58.580.0 561
LLPS-Cea-1768Cercocebus atys58.580.0 560
LLPS-Aon-2076Aotus nancymaae58.580.0 561
LLPS-Maf-4287Macaca fascicularis58.580.0 560
LLPS-Paa-3552Papio anubis58.580.0 560
LLPS-Mal-4235Mandrillus leucophaeus58.580.0 560
LLPS-Man-4703Macaca nemestrina58.580.0 560
LLPS-Pap-3850Pan paniscus58.580.0 561
LLPS-Pat-0610Pan troglodytes58.580.0 561
LLPS-Cas-1407Carlito syrichta58.550.0 547
LLPS-Chs-2450Chlorocebus sabaeus58.370.0 558
LLPS-Hos-0008Homo sapiens58.370.0 560
LLPS-Poa-3846Pongo abelii58.370.0 561
LLPS-Orc-2507Oryctolagus cuniculus58.330.0 548
LLPS-Lac-1839Latimeria chalumnae58.330.0 561
LLPS-Cis-1282Ciona savignyi57.990.0 553
LLPS-Sus-0009Sus scrofa57.680.0 531
LLPS-Sob-1412Sorghum bicolor56.862e-179 521
LLPS-Mam-2281Macaca mulatta56.640.0 550
LLPS-Mod-0460Monodelphis domestica56.570.0 545
LLPS-Fia-3442Ficedula albicollis56.380.0 556
LLPS-Pes-1713Pelodiscus sinensis56.380.0 543
LLPS-Meg-0026Meleagris gallopavo56.360.0 538
LLPS-Vir-0976Vigna radiata56.290.0 545
LLPS-Gaga-1352Gallus gallus56.189e-180 520
LLPS-Ora-3550Ornithorhynchus anatinus55.770.0 535
LLPS-Cii-2148Ciona intestinalis55.650.0 545
LLPS-Tut-0673Tursiops truncatus55.30.0 530
LLPS-Nol-1402Nomascus leucogenys54.955e-179 520