• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Eqc-2968
SHMT1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Serine hydroxymethyltransferase
Gene Name: SHMT1
Ensembl Gene: ENSECAG00000015690.2
Ensembl Protein: ENSECAP00000013833.2
Organism: Equus caballus
Taxa ID: 9796
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Interconversion of serine and glycine.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSECAT00000017073.2ENSECAP00000013833.2
UniProtF6TW30, F6TW30_HORSE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MATPVNGAHE  NADLWSSHDK  MMAQPLKDSD  TEVYNIIKKE  SNRQRVGLEL  IASENFASRA  60
61    VLEALGSCLN  NKYSEGYPGQ  RYYGGTEFID  ELELLCQKRA  LQLYDLDPQC  WGVNVQPYSG  120
121   SPANFAVYTA  LVEPHGRIMG  LDLPDGGHLT  HGFMTDKKKI  SATSIFFESM  PYKVNPETGY  180
181   INYDQLEENA  RLFHPKLIIA  GTSCYSRNLD  YARLRKIADD  NGAYLMADMA  HISGLVAAGV  240
241   VPSPFEHCHV  VSTTTHKTLR  GCRAGMIFYR  RGVRSVDPKT  GKESLYNLES  LINAAVFPGL  300
301   QGGPHNHAIA  GVAVALKQAM  TPEFRLYQRQ  VVANCRALAE  SLMALGYTVV  TGGSDNHLIL  360
361   VDLRSKGTDG  GRAEKVLEAC  SIACNKNTCP  GDRSALRPSG  LRLGTPALTS  RGLLEKEFQK  420
421   VAQFIHRGIE  LTLQIQNDVG  IKATLKEFKE  KLAGDEKHQQ  AVRALREEVE  SFASLFPLPG  480
481   LPAF  484
Nucleotide CDS Sequence (FASTA)
1     ATGGCGACTC  CAGTCAATGG  GGCCCACGAG  AATGCTGACC  TGTGGTCCTC  ACATGATAAA  60
61    ATGATGGCAC  AGCCCCTTAA  AGACAGCGAC  ACTGAGGTTT  ATAACATCAT  TAAGAAGGAG  120
121   AGTAACCGGC  AGAGGGTCGG  ATTGGAGCTG  ATCGCGTCCG  AGAACTTTGC  CAGCCGAGCC  180
181   GTTTTAGAGG  CCCTGGGCTC  TTGCTTAAAT  AACAAGTACT  CTGAGGGGTA  CCCAGGCCAG  240
241   AGGTATTACG  GCGGGACTGA  GTTTATCGAT  GAACTGGAGC  TCCTCTGTCA  GAAGCGAGCG  300
301   CTGCAGCTCT  ATGATCTGGA  CCCCCAGTGC  TGGGGGGTCA  ACGTCCAGCC  CTACTCAGGC  360
361   TCCCCTGCAA  ACTTCGCAGT  GTACACCGCC  CTGGTGGAGC  CCCATGGGCG  CATCATGGGC  420
421   CTGGACCTGC  CCGATGGGGG  CCACTTGACC  CATGGGTTCA  TGACAGACAA  GAAGAAAATC  480
481   TCTGCTACAT  CCATCTTTTT  TGAATCTATG  CCCTATAAGG  TGAACCCAGA  GACTGGCTAC  540
541   ATCAACTACG  ACCAGCTGGA  GGAAAATGCT  CGCCTCTTCC  ACCCAAAGCT  CATTATCGCA  600
601   GGAACCAGCT  GCTACTCCCG  AAACCTGGAC  TACGCTCGAT  TGCGGAAGAT  TGCAGATGAC  660
661   AATGGGGCGT  ATCTCATGGC  CGACATGGCA  CACATCAGTG  GGCTGGTGGC  GGCTGGTGTG  720
721   GTGCCCTCCC  CCTTCGAGCA  CTGCCACGTG  GTGTCCACCA  CCACCCACAA  AACCCTGCGA  780
781   GGCTGCCGGG  CTGGCATGAT  CTTCTACAGG  AGAGGAGTGC  GCAGTGTGGA  TCCCAAGACT  840
841   GGCAAAGAAA  GCCTGTACAA  CCTAGAGTCA  CTCATCAACG  CCGCCGTGTT  CCCAGGCCTC  900
901   CAGGGAGGTC  CCCACAACCA  CGCCATCGCT  GGGGTTGCTG  TGGCCCTGAA  GCAAGCCATG  960
961   ACTCCGGAAT  TCAGACTCTA  TCAGCGCCAG  GTGGTGGCCA  ACTGCAGGGC  TCTGGCTGAG  1020
1021  AGCTTGATGG  CACTGGGCTA  CACAGTAGTA  ACAGGTGGTT  CTGACAACCA  TTTGATCCTC  1080
1081  GTGGATCTCC  GTTCCAAAGG  CACAGATGGT  GGCAGGGCTG  AGAAGGTGCT  AGAAGCCTGT  1140
1141  TCTATTGCCT  GCAACAAGAA  CACCTGCCCA  GGTGACAGAA  GTGCACTGCG  GCCCAGCGGA  1200
1201  CTGCGACTGG  GGACCCCAGC  ACTGACCTCC  CGCGGGCTTT  TGGAAAAAGA  GTTCCAAAAA  1260
1261  GTAGCCCAGT  TTATTCATAG  AGGGATAGAA  CTGACTCTGC  AGATTCAGAA  TGATGTGGGC  1320
1321  ATCAAGGCCA  CCCTGAAGGA  GTTCAAGGAG  AAACTGGCAG  GGGACGAGAA  GCACCAACAG  1380
1381  GCTGTCAGGG  CTCTGAGGGA  GGAGGTGGAG  AGCTTCGCCT  CTCTCTTCCC  TCTGCCCGGC  1440
1441  CTGCCTGCCT  TCTAG  1455

▼ KEYWORD

ID
Family
Complete proteome
One-carbon metabolism
Pyridoxal phosphate
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Nucleus
Molecular Function
Amino acid binding
Molecular Function
Cobalt ion binding
Molecular Function
Glycine hydroxymethyltransferase activity
Molecular Function
MRNA 5'-UTR binding
Molecular Function
Protein homodimerization activity
Molecular Function
Pyridoxal phosphate binding
Molecular Function
Serine binding
Molecular Function
Translation repressor activity, mRNA regulatory element binding
Molecular Function
Zinc ion binding
Biological Process
Cellular response to leukemia inhibitory factor
Biological Process
Cellular response to tetrahydrofolate
Biological Process
Folic acid metabolic process
Biological Process
Glycine biosynthetic process from serine
Biological Process
Glycine metabolic process
Biological Process
L-serine catabolic process
Biological Process
One-carbon metabolic process
Biological Process
Protein homotetramerization
Biological Process
Purine nucleobase biosynthetic process
Biological Process
Tetrahydrofolate interconversion
Biological Process
Tetrahydrofolate metabolic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aim-2884Ailuropoda melanoleuca94.240.0 953
LLPS-Fec-1836Felis catus94.010.0 964
LLPS-Caf-3683Canis familiaris93.390.0 958
LLPS-Nol-0841Nomascus leucogenys93.210.0 821
LLPS-Mup-1989Mustela putorius furo93.120.0 947
LLPS-Paa-0726Papio anubis92.560.0 919
LLPS-Mam-3670Macaca mulatta92.360.0 918
LLPS-Maf-4336Macaca fascicularis92.360.0 918
LLPS-Cea-1738Cercocebus atys92.360.0 918
LLPS-Tut-0673Tursiops truncatus92.150.0 936
LLPS-Myl-3641Myotis lucifugus92.150.0 938
LLPS-Cap-2972Cavia porcellus91.940.0 919
LLPS-Hos-0773Homo sapiens91.940.0 913
LLPS-Rhb-3293Rhinopithecus bieti91.940.0 913
LLPS-Gog-1227Gorilla gorilla91.890.0 852
LLPS-Poa-3432Pongo abelii91.740.0 910
LLPS-Pat-0850Pan troglodytes91.740.0 911
LLPS-Pap-4685Pan paniscus91.320.0 909
LLPS-Bot-4450Bos taurus91.320.0 931
LLPS-Aon-0400Aotus nancymaae91.320.0 905
LLPS-Cas-2133Carlito syrichta91.080.0 907
LLPS-Loa-4305Loxodonta africana90.970.0 921
LLPS-Fud-0008Fukomys damarensis90.910.0 904
LLPS-Caj-1121Callithrix jacchus90.910.0 904
LLPS-Otg-1848Otolemur garnettii90.70.0 897
LLPS-Orc-2179Oryctolagus cuniculus90.70.0 900
LLPS-Man-4759Macaca nemestrina90.470.0 866
LLPS-Mea-4118Mesocricetus auratus90.320.0 881
LLPS-Sus-1953Sus scrofa90.290.0 916
LLPS-Ict-3696Ictidomys tridecemlineatus90.080.0 897
LLPS-Mum-4731Mus musculus89.310.0 874
LLPS-Ova-2371Ovis aries89.090.0 902
LLPS-Ere-0497Erinaceus europaeus89.070.0 573
LLPS-Urm-3704Ursus maritimus88.220.0 937
LLPS-Ran-1760Rattus norvegicus87.840.0 865
LLPS-Ora-3550Ornithorhynchus anatinus86.780.0 899
LLPS-Chs-2181Chlorocebus sabaeus84.370.0 738
LLPS-Anc-3279Anolis carolinensis83.470.0 839
LLPS-Mod-0460Monodelphis domestica83.470.0 866
LLPS-Fia-3442Ficedula albicollis82.280.0 835
LLPS-Pes-1713Pelodiscus sinensis82.160.0 847
LLPS-Scf-1719Scleropages formosus81.760.0 823
LLPS-Meg-0026Meleagris gallopavo81.680.0 801
LLPS-Tag-2072Taeniopygia guttata81.610.0 840
LLPS-Gaga-1352Gallus gallus81.520.0 756
LLPS-Xet-2851Xenopus tropicalis81.170.0 822
LLPS-Dar-0710Danio rerio80.960.0 821
LLPS-Asm-1891Astyanax mexicanus79.920.0 817
LLPS-Orl-1966Oryzias latipes79.710.0 810
LLPS-Orn-3549Oreochromis niloticus79.450.0 804
LLPS-Tar-2991Takifugu rubripes79.10.0 752
LLPS-Ten-0133Tetraodon nigroviridis78.980.0 787
LLPS-Pof-0025Poecilia formosa78.660.0 801
LLPS-Icp-3939Ictalurus punctatus78.60.0 803
LLPS-Gaa-1845Gasterosteus aculeatus78.30.0 795
LLPS-Scm-1675Scophthalmus maximus77.50.0 795
LLPS-Lac-0040Latimeria chalumnae76.940.0 747
LLPS-Xim-2070Xiphophorus maculatus75.00.0 788
LLPS-Leo-1077Lepisosteus oculatus75.00.0 754
LLPS-Dio-4283Dipodomys ordii73.80.0 679
LLPS-Mal-2148Mandrillus leucophaeus72.520.0 666
LLPS-Cii-2148Ciona intestinalis71.090.0 686
LLPS-Cis-0607Ciona savignyi67.440.0 647
LLPS-Brn-2859Brassica napus62.780.0 584
LLPS-Sem-0555Selaginella moellendorffii62.670.0 587
LLPS-Pot-1694Populus trichocarpa62.170.0 553
LLPS-Gas-0721Galdieria sulphuraria61.660.0 572
LLPS-Chr-0068Chlamydomonas reinhardtii61.620.0 585
LLPS-Php-0312Physcomitrella patens61.510.0 587
LLPS-Brr-2981Brassica rapa61.490.0 577
LLPS-Cae-0855Caenorhabditis elegans61.280.0 608
LLPS-Viv-1480Vitis vinifera61.270.0 573
LLPS-Bro-2529Brassica oleracea61.180.0 578
LLPS-Sot-1107Solanum tuberosum60.960.0 575
LLPS-Sol-1764Solanum lycopersicum60.960.0 578
LLPS-Coc-0058Corchorus capsularis60.830.0 570
LLPS-Mae-2311Manihot esculenta60.830.0 578
LLPS-Cus-0921Cucumis sativus60.830.0 573
LLPS-Hea-1228Helianthus annuus60.830.0 572
LLPS-Osl-1249Ostreococcus lucimarinus60.660.0 568
LLPS-Gor-0093Gossypium raimondii60.610.0 581
LLPS-Art-0113Arabidopsis thaliana60.390.0 578
LLPS-Arl-2343Arabidopsis lyrata60.390.0 568
LLPS-Cym-0219Cyanidioschyzon merolae60.260.0 559
LLPS-Dac-0425Daucus carota60.260.0 577
LLPS-Glm-2860Glycine max60.210.0 596
LLPS-Prp-0623Prunus persica60.040.0 579
LLPS-Vir-0976Vigna radiata59.960.0 568
LLPS-Thc-0212Theobroma cacao59.910.0 578
LLPS-Phv-1564Phaseolus vulgaris59.740.0 564
LLPS-Via-1929Vigna angularis59.740.0 565
LLPS-Nia-2632Nicotiana attenuata59.40.0 580
LLPS-Mua-2113Musa acuminata59.350.0 582
LLPS-Met-1827Medicago truncatula59.180.0 582
LLPS-Lep-0000Leersia perrieri58.610.0 540
LLPS-Ori-2278Oryza indica58.610.0 543
LLPS-Amt-1026Amborella trichopoda58.440.0 544
LLPS-Orr-1403Oryza rufipogon58.390.0 542
LLPS-Ors-2075Oryza sativa58.390.0 543
LLPS-Orp-2232Oryza punctata58.390.0 542
LLPS-Orni-0789Oryza nivara58.390.0 543
LLPS-Cogr-1236Colletotrichum graminicola58.30.0 576
LLPS-Tra-1518Triticum aestivum58.080.0 541
LLPS-Pytr-1510Pyrenophora triticirepentis57.390.0 563
LLPS-Trv-1328Trichoderma virens57.390.0 564
LLPS-Cog-0571Colletotrichum gloeosporioides57.330.0 562
LLPS-Phn-1290Phaeosphaeria nodorum57.170.0 565
LLPS-Trr-1528Trichoderma reesei57.170.0 561
LLPS-Pyt-1354Pyrenophora teres57.170.0 561
LLPS-Ved-0846Verticillium dahliae56.960.0 554
LLPS-Beb-0504Beauveria bassiana56.750.0 555
LLPS-Coo-1335Colletotrichum orbiculare56.470.0 556
LLPS-Asn-1265Aspergillus nidulans56.120.0 545
LLPS-Asfu-1415Aspergillus fumigatus56.00.0 543
LLPS-Fuo-1489Fusarium oxysporum55.970.0 558
LLPS-Fuv-0412Fusarium verticillioides55.970.0 558
LLPS-Nec-0140Neurospora crassa55.950.0 549
LLPS-Nef-0921Neosartorya fischeri55.910.0 543
LLPS-Lem-0852Leptosphaeria maculans55.890.0 558
LLPS-Asni-0523Aspergillus niger54.180.0 543