LLPS-Scj-1299
SJAG_03881
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase |
| Gene Name: | SJAG_03881 |
| Ensembl Gene: | SJAG_03881 |
| Ensembl Protein: | EEB08715 |
| Organism: | Schizosaccharomyces japonicus |
| Taxa ID: | 402676 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | EEB08715 | EEB08715 |
| UniProt | B6K5B1, B6K5B1_SCHJY | |
| GeneBank | KE651167 | EEB08715.1 |
| RefSeq | XM_002174972.1 | XP_002175008.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MVHNVLLGVI GGSGFYELSG FEHVKTVNPE TPWGFPSSPI NIVKSKTGLH VAFLARHGVG 60 61 HRYTPTEIPV RANIAALKSL GVQAILAFSA VGSLREEIPP EDFVLPNQII DRTLCARPNT 120 121 FFPSGCVAHV SFGDPFDADL ARIVAQCAGA LERGAKLHVP TVDHDLTVVC MEGPAFSTRA 180 181 ESKLYRSWGA SVINMSVIPE AKLAREAEIA YQMVCMATDY DCWRKSERPV TVNEVMTHLS 240 241 NNTDNAKQLL TQVIKLLEPE LRKGSIGETL RGAVQHGIQT NHAHRDPAVV GKLRFLFPSL 300 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGTTCACA ACGTTCTTTT AGGTGTCATC GGCGGCAGCG GCTTCTACGA GCTCTCCGGA 60 61 TTTGAACATG TCAAAACAGT CAATCCCGAA ACGCCCTGGG GGTTCCCCTC TTCACCAATC 120 121 AACATTGTGA AATCCAAAAC TGGCCTCCAC GTGGCATTTT TAGCACGACA CGGTGTTGGT 180 181 CACCGCTATA CGCCGACGGA AATCCCTGTT CGGGCAAATA TTGCTGCGTT GAAGAGCCTG 240 241 GGTGTTCAGG CCATTCTTGC CTTTAGCGCT GTTGGTTCGC TACGCGAGGA AATCCCGCCC 300 301 GAAGACTTTG TTTTGCCGAA TCAGATCATC GATCGTACTT TGTGTGCTCG ACCCAACACC 360 361 TTCTTCCCTT CAGGATGTGT TGCACATGTG AGTTTCGGTG ACCCTTTTGA TGCAGACTTG 420 421 GCACGCATTG TCGCTCAATG TGCAGGCGCT CTTGAACGCG GGGCAAAGTT GCACGTGCCC 480 481 ACCGTGGATC ATGACCTCAC CGTTGTGTGT ATGGAGGGCC CCGCATTTAG TACACGTGCT 540 541 GAAAGCAAAC TTTACCGAAG CTGGGGAGCA AGTGTCATTA ACATGTCCGT CATTCCCGAG 600 601 GCAAAGCTTG CTCGGGAGGC TGAGATTGCC TACCAAATGG TTTGTATGGC TACGGACTAC 660 661 GATTGCTGGC GCAAGTCCGA GCGCCCCGTC ACCGTGAACG AGGTCATGAC GCATCTGTCT 720 721 AACAACACGG ACAACGCGAA GCAGCTCTTG ACGCAAGTCA TTAAGCTTCT CGAACCCGAG 780 781 CTGCGCAAGG GCTCCATCGG CGAGACCCTG CGTGGTGCCG TCCAGCATGG CATCCAAACC 840 841 AACCATGCTC ATCGTGATCC TGCCGTGGTC GGCAAATTGC GTTTCCTGTT CCCAAGTCTG 900 901 TAA 903 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleus | |
Molecular Function | MRNA binding | |
Molecular Function | S-methyl-5-thioadenosine phosphorylase activity | |
Biological Process | Glutamate biosynthetic process | |
Biological Process | L-methionine salvage from methylthioadenosine | |
Biological Process | Purine ribonucleoside salvage |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Scc-1289 | Schizosaccharomyces cryophilus | 72.64 | 2e-159 | 454 |
| LLPS-Scp-1554 | Schizosaccharomyces pombe | 71.96 | 9e-160 | 455 |
| LLPS-Yal-0986 | Yarrowia lipolytica | 54.88 | 9e-113 | 336 |
| LLPS-Ten-3369 | Tetraodon nigroviridis | 54.69 | 8e-19 | 83.6 |
| LLPS-Asn-0759 | Aspergillus nidulans | 54.67 | 2e-104 | 316 |
| LLPS-Ast-0398 | Aspergillus terreus | 54.58 | 4e-84 | 260 |
| LLPS-Pyt-1395 | Pyrenophora teres | 53.8 | 2e-98 | 299 |
| LLPS-Pytr-1328 | Pyrenophora triticirepentis | 53.8 | 2e-98 | 299 |
| LLPS-Scs-0078 | Sclerotinia sclerotiorum | 53.63 | 2e-97 | 296 |
| LLPS-Nec-1386 | Neurospora crassa | 53.49 | 2e-103 | 311 |
| LLPS-Fuo-0945 | Fusarium oxysporum | 53.49 | 2e-100 | 304 |
| LLPS-Fuv-0171 | Fusarium verticillioides | 53.33 | 3e-99 | 301 |
| LLPS-Aso-0933 | Aspergillus oryzae | 53.16 | 3e-103 | 311 |
| LLPS-Asni-1190 | Aspergillus niger | 53.16 | 7e-103 | 310 |
| LLPS-Asfu-0163 | Aspergillus fumigatus | 53.16 | 1e-103 | 313 |
| LLPS-Trv-0829 | Trichoderma virens | 53.14 | 2e-99 | 301 |
| LLPS-Nef-1621 | Neosartorya fischeri | 52.82 | 5e-103 | 311 |
| LLPS-Lem-1451 | Leptosphaeria maculans | 52.77 | 2e-97 | 298 |
| LLPS-Asc-1006 | Aspergillus clavatus | 52.49 | 2e-102 | 309 |
| LLPS-Cogr-0688 | Colletotrichum graminicola | 52.33 | 1e-100 | 304 |
| LLPS-Zyt-1077 | Zymoseptoria tritici | 52.32 | 2e-98 | 300 |
| LLPS-Trr-0150 | Trichoderma reesei | 52.32 | 5e-100 | 303 |
| LLPS-Ved-0915 | Verticillium dahliae | 52.0 | 1e-99 | 302 |
| LLPS-Phn-1446 | Phaeosphaeria nodorum | 51.82 | 3e-94 | 289 |
| LLPS-Blg-1183 | Blumeria graminis | 51.8 | 5e-100 | 303 |
| LLPS-Coo-0412 | Colletotrichum orbiculare | 51.67 | 2e-97 | 296 |
| LLPS-Gag-0773 | Gaeumannomyces graminis | 51.67 | 5e-93 | 285 |
| LLPS-Fus-0795 | Fusarium solani | 51.67 | 9e-98 | 297 |
| LLPS-Tum-1228 | Tuber melanosporum | 51.16 | 3e-94 | 291 |
| LLPS-Map-0636 | Magnaporthe poae | 51.09 | 2e-35 | 131 |
| LLPS-Usm-1556 | Ustilago maydis | 50.67 | 5e-88 | 272 |
| LLPS-Mao-0844 | Magnaporthe oryzae | 50.34 | 3e-89 | 276 |
| LLPS-Dos-0728 | Dothistroma septosporum | 50.33 | 6e-93 | 285 |
| LLPS-Asg-1376 | Ashbya gossypii | 50.32 | 1e-83 | 261 |
| LLPS-Beb-0851 | Beauveria bassiana | 50.0 | 1e-96 | 294 |
| LLPS-Asf-0267 | Aspergillus flavus | 49.69 | 1e-97 | 299 |
| LLPS-Spr-1524 | Sporisorium reilianum | 49.5 | 1e-87 | 271 |
| LLPS-Crn-0614 | Cryptococcus neoformans | 49.49 | 2e-88 | 274 |
| LLPS-Pug-0790 | Puccinia graminis | 49.33 | 5e-96 | 293 |
| LLPS-Sac-0392 | Saccharomyces cerevisiae | 49.02 | 3e-92 | 284 |
| LLPS-Mel-0465 | Melampsora laricipopulina | 48.99 | 6e-94 | 287 |
| LLPS-Abg-1547 | Absidia glauca | 48.65 | 8e-88 | 270 |
| LLPS-Put-0592 | Puccinia triticina | 48.5 | 2e-93 | 286 |
| LLPS-Lac-3724 | Latimeria chalumnae | 48.05 | 3e-12 | 66.2 |
| LLPS-Miv-0033 | Microbotryum violaceum | 47.21 | 5e-88 | 274 |
| LLPS-Ora-2300 | Ornithorhynchus anatinus | 46.99 | 2e-13 | 70.1 |
| LLPS-Cog-1244 | Colletotrichum gloeosporioides | 44.71 | 8e-74 | 236 |
| LLPS-Pes-2626 | Pelodiscus sinensis | 42.45 | 7e-44 | 155 |
| LLPS-Anc-3294 | Anolis carolinensis | 41.54 | 5e-54 | 184 |
| LLPS-Leo-2701 | Lepisosteus oculatus | 41.13 | 4e-50 | 173 |
| LLPS-Xet-2262 | Xenopus tropicalis | 41.09 | 7e-52 | 178 |
| LLPS-Mod-3597 | Monodelphis domestica | 40.21 | 2e-55 | 187 |
| LLPS-Icp-1883 | Ictalurus punctatus | 40.15 | 8e-53 | 180 |
| LLPS-Dar-3401 | Danio rerio | 40.08 | 4e-50 | 173 |
| LLPS-Dio-0948 | Dipodomys ordii | 40.0 | 6e-53 | 181 |
| LLPS-Orl-2852 | Oryzias latipes | 40.0 | 5e-44 | 157 |
| LLPS-Poa-4355 | Pongo abelii | 39.92 | 1e-47 | 166 |
| LLPS-Mup-2019 | Mustela putorius furo | 39.85 | 3e-52 | 179 |
| LLPS-Otg-2263 | Otolemur garnettii | 39.78 | 5e-52 | 179 |
| LLPS-Eqc-0399 | Equus caballus | 39.72 | 1e-54 | 186 |
| LLPS-Ict-4284 | Ictidomys tridecemlineatus | 39.71 | 7e-53 | 181 |
| LLPS-Cas-1420 | Carlito syrichta | 39.63 | 2e-52 | 180 |
| LLPS-Maf-4626 | Macaca fascicularis | 39.48 | 4e-51 | 177 |
| LLPS-Mam-0917 | Macaca mulatta | 39.48 | 3e-51 | 177 |
| LLPS-Orc-3945 | Oryctolagus cuniculus | 39.48 | 7e-53 | 181 |
| LLPS-Man-1323 | Macaca nemestrina | 39.48 | 4e-51 | 177 |
| LLPS-Aim-4222 | Ailuropoda melanoleuca | 39.41 | 4e-52 | 179 |
| LLPS-Fud-3969 | Fukomys damarensis | 39.41 | 2e-51 | 177 |
| LLPS-Urm-1614 | Ursus maritimus | 39.41 | 5e-51 | 177 |
| LLPS-Ran-2516 | Rattus norvegicus | 39.38 | 1e-26 | 111 |
| LLPS-Mum-4606 | Mus musculus | 39.34 | 2e-52 | 180 |
| LLPS-Fec-4485 | Felis catus | 39.34 | 3e-52 | 179 |
| LLPS-Sah-2553 | Sarcophilus harrisii | 39.27 | 3e-53 | 182 |
| LLPS-Orn-1812 | Oreochromis niloticus | 39.27 | 5e-47 | 165 |
| LLPS-Mal-3793 | Mandrillus leucophaeus | 39.11 | 1e-50 | 176 |
| LLPS-Paa-0595 | Papio anubis | 39.11 | 1e-50 | 176 |
| LLPS-Gog-3299 | Gorilla gorilla | 39.11 | 1e-50 | 176 |
| LLPS-Chs-3976 | Chlorocebus sabaeus | 39.11 | 8e-52 | 178 |
| LLPS-Cea-4686 | Cercocebus atys | 39.11 | 1e-50 | 176 |
| LLPS-Aon-2477 | Aotus nancymaae | 39.11 | 3e-50 | 175 |
| LLPS-Nol-3407 | Nomascus leucogenys | 39.11 | 1e-50 | 176 |
| LLPS-Cap-4683 | Cavia porcellus | 39.11 | 1e-51 | 177 |
| LLPS-Rhb-1681 | Rhinopithecus bieti | 39.11 | 1e-50 | 176 |
| LLPS-Pat-3130 | Pan troglodytes | 39.11 | 9e-51 | 176 |
| LLPS-Hos-3407 | Homo sapiens | 39.11 | 9e-51 | 176 |
| LLPS-Xim-3006 | Xiphophorus maculatus | 39.06 | 4e-50 | 173 |
| LLPS-Pof-3930 | Poecilia formosa | 39.06 | 2e-49 | 172 |
| LLPS-Meg-1652 | Meleagris gallopavo | 39.06 | 8e-25 | 103 |
| LLPS-Caj-3266 | Callithrix jacchus | 39.03 | 2e-50 | 175 |
| LLPS-Pap-1983 | Pan paniscus | 39.03 | 2e-50 | 176 |
| LLPS-Ova-3289 | Ovis aries | 39.02 | 8e-41 | 149 |
| LLPS-Fia-3178 | Ficedula albicollis | 38.98 | 1e-47 | 167 |
| LLPS-Caf-4441 | Canis familiaris | 38.89 | 5e-51 | 176 |
| LLPS-Scf-3614 | Scleropages formosus | 38.77 | 6e-53 | 181 |
| LLPS-Sus-2946 | Sus scrofa | 38.75 | 2e-51 | 177 |
| LLPS-Myl-4368 | Myotis lucifugus | 38.69 | 1e-51 | 177 |
| LLPS-Gaa-4003 | Gasterosteus aculeatus | 38.41 | 2e-52 | 179 |
| LLPS-Gaga-2450 | Gallus gallus | 38.19 | 7e-50 | 173 |
| LLPS-Tag-2633 | Taeniopygia guttata | 38.18 | 2e-49 | 171 |
| LLPS-Asm-3078 | Astyanax mexicanus | 38.04 | 3e-45 | 163 |
| LLPS-Loa-1451 | Loxodonta africana | 38.01 | 1e-50 | 175 |
| LLPS-Scm-3366 | Scophthalmus maximus | 37.9 | 3e-44 | 160 |
| LLPS-Bot-1894 | Bos taurus | 37.64 | 1e-43 | 156 |
| LLPS-Cii-1304 | Ciona intestinalis | 37.64 | 4e-51 | 176 |
| LLPS-Cae-1172 | Caenorhabditis elegans | 37.25 | 2e-43 | 156 |
| LLPS-Tar-3378 | Takifugu rubripes | 36.16 | 1e-48 | 169 |
| LLPS-Cis-1859 | Ciona savignyi | 34.64 | 2e-42 | 154 |
| LLPS-Mea-3663 | Mesocricetus auratus | 33.96 | 1e-37 | 140 |
| LLPS-Drm-2170 | Drosophila melanogaster | 33.47 | 7e-30 | 120 |