LLPS-Pap-1983
MTAP
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase |
| Gene Name: | MTAP |
| Ensembl Gene: | ENSPPAG00000038109.1 |
| Ensembl Protein: | ENSPPAP00000030237.1 |
| Organism: | Pan paniscus |
| Taxa ID: | 9597 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSPPAT00000053096.1 | ENSPPAP00000030237.1 |
| Ensembl | ENSPPAT00000053101.1 | ENSPPAP00000030242.1 |
| UniProt | A0A2R9BP85, A0A2R9BP85_PANPA | |
| GeneBank | AJFE02108008, AJFE02108011, AJFE02108009, AJFE02108010 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 IGIIGGTGLD DPEILEGRTE KYVDTPFGKP SDALILGKIK NVDCVLLARH GRQHTIMPSK 60 61 VNYQANIWAL KEEGCTHVIV TTACGSLREE IQPGDIVIID QFIDRTTMRP QSFYDGSHSC 120 121 ARGVCHIPMA EPFCPKTREV LIETAKKLGL RCHSKGTMVT IEGPRFSSRA ESFMFRTWGA 180 181 DVINMTTVPE VVLAKEAGIC YASIAMATDY DCWKEHEEAV SVDRVLKTLK ENANKAKSLL 240 241 LTTIPQIGST EWSETLHNLK MIKFQMILSE GYHPFNIQES PFYRGLLDFP SVGHGRGEIL 300 301 PLSPLDLAGY CFQQPMQPPC PDS 323 |
| Nucleotide CDS Sequence (FASTA) |
1 ATTGGAATAA TTGGTGGAAC AGGCCTGGAT GATCCAGAAA TTTTAGAAGG AAGAACTGAA 60 61 AAATATGTGG ATACTCCATT TGGCAAGCCA TCTGATGCCT TAATTTTGGG GAAGATAAAA 120 121 AATGTTGATT GCGTCCTCCT TGCAAGGCAT GGAAGGCAGC ACACCATCAT GCCTTCAAAG 180 181 GTCAACTACC AGGCGAACAT CTGGGCTTTG AAGGAAGAGG GCTGTACACA TGTCATAGTG 240 241 ACCACAGCTT GTGGCTCCTT GAGGGAGGAG ATTCAGCCCG GCGATATTGT CATTATTGAT 300 301 CAGTTCATTG ACAGGACCAC TATGAGACCT CAGTCCTTCT ATGATGGAAG TCATTCTTGT 360 361 GCCAGAGGAG TGTGCCATAT TCCAATGGCT GAGCCGTTTT GCCCCAAAAC GAGAGAGGTT 420 421 CTTATAGAGA CTGCTAAGAA GCTAGGACTC CGGTGCCACT CAAAGGGGAC AATGGTCACA 480 481 ATCGAGGGAC CTCGTTTTAG CTCCCGGGCA GAAAGCTTCA TGTTCCGCAC CTGGGGGGCG 540 541 GATGTTATCA ACATGACCAC AGTTCCAGAG GTGGTTCTTG CTAAGGAGGC TGGAATTTGT 600 601 TACGCAAGTA TCGCCATGGC GACAGATTAT GACTGCTGGA AGGAGCACGA GGAAGCAGTT 660 661 TCGGTGGACC GGGTCTTAAA GACCCTGAAA GAAAATGCTA ATAAAGCCAA AAGCTTACTG 720 721 CTCACTACCA TACCTCAGAT AGGGTCCACA GAATGGTCAG AAACCCTCCA TAACCTGAAG 780 781 ATGATCAAGT TCCAGATGAT CCTCAGTGAG GGATACCATC CTTTCAATAT TCAAGAGTCA 840 841 CCCTTCTACA GAGGACTCCT AGACTTCCCA TCAGTGGGAC ATGGCAGAGG TGAAATCCTG 900 901 CCCCTGTCTC CCTTAGACCT GGCTGGATAC TGCTTCCAAC AACCCATGCA ACCACCCTGC 960 961 CCTGACAGCT AG 972 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleus | |
Molecular Function | S-methyl-5-thioadenosine phosphorylase activity | |
Biological Process | L-methionine salvage from methylthioadenosine | |
Biological Process | Purine ribonucleoside salvage |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pat-3130 | Pan troglodytes | 100.0 | 0.0 | 677 |
| LLPS-Hos-3407 | Homo sapiens | 100.0 | 0.0 | 677 |
| LLPS-Gog-3299 | Gorilla gorilla | 99.69 | 0.0 | 674 |
| LLPS-Nol-3407 | Nomascus leucogenys | 99.07 | 0.0 | 665 |
| LLPS-Cea-4686 | Cercocebus atys | 98.14 | 0.0 | 657 |
| LLPS-Mal-3793 | Mandrillus leucophaeus | 98.14 | 0.0 | 657 |
| LLPS-Paa-0595 | Papio anubis | 98.14 | 0.0 | 657 |
| LLPS-Rhb-1681 | Rhinopithecus bieti | 98.14 | 0.0 | 657 |
| LLPS-Chs-3976 | Chlorocebus sabaeus | 97.77 | 0.0 | 545 |
| LLPS-Maf-4626 | Macaca fascicularis | 97.52 | 0.0 | 654 |
| LLPS-Man-1323 | Macaca nemestrina | 97.52 | 0.0 | 654 |
| LLPS-Dio-0948 | Dipodomys ordii | 97.32 | 0.0 | 533 |
| LLPS-Aon-2477 | Aotus nancymaae | 96.9 | 0.0 | 654 |
| LLPS-Caj-3266 | Callithrix jacchus | 96.65 | 0.0 | 536 |
| LLPS-Orc-3945 | Oryctolagus cuniculus | 96.65 | 0.0 | 539 |
| LLPS-Cas-1420 | Carlito syrichta | 96.28 | 0.0 | 535 |
| LLPS-Aim-4222 | Ailuropoda melanoleuca | 95.91 | 0.0 | 533 |
| LLPS-Urm-1614 | Ursus maritimus | 95.91 | 0.0 | 534 |
| LLPS-Mup-2019 | Mustela putorius furo | 95.54 | 0.0 | 535 |
| LLPS-Fec-4485 | Felis catus | 95.54 | 0.0 | 533 |
| LLPS-Mam-0917 | Macaca mulatta | 95.05 | 0.0 | 635 |
| LLPS-Myl-4368 | Myotis lucifugus | 94.8 | 0.0 | 529 |
| LLPS-Caf-4441 | Canis familiaris | 94.8 | 0.0 | 531 |
| LLPS-Otg-2263 | Otolemur garnettii | 94.42 | 0.0 | 530 |
| LLPS-Loa-1451 | Loxodonta africana | 94.42 | 0.0 | 528 |
| LLPS-Ict-4284 | Ictidomys tridecemlineatus | 94.42 | 0.0 | 530 |
| LLPS-Cap-4683 | Cavia porcellus | 94.05 | 0.0 | 528 |
| LLPS-Fud-3969 | Fukomys damarensis | 93.68 | 0.0 | 526 |
| LLPS-Poa-4355 | Pongo abelii | 93.57 | 9e-172 | 484 |
| LLPS-Bot-1894 | Bos taurus | 93.31 | 2e-178 | 502 |
| LLPS-Sus-2946 | Sus scrofa | 92.94 | 0.0 | 524 |
| LLPS-Ora-2300 | Ornithorhynchus anatinus | 92.78 | 2e-59 | 193 |
| LLPS-Mum-4606 | Mus musculus | 92.54 | 0.0 | 517 |
| LLPS-Ova-3289 | Ovis aries | 92.34 | 3e-171 | 484 |
| LLPS-Sah-2553 | Sarcophilus harrisii | 88.17 | 8e-174 | 491 |
| LLPS-Eqc-0399 | Equus caballus | 87.97 | 1e-173 | 491 |
| LLPS-Ten-3369 | Tetraodon nigroviridis | 87.67 | 5e-41 | 144 |
| LLPS-Mod-3597 | Monodelphis domestica | 86.99 | 6e-177 | 499 |
| LLPS-Tag-2633 | Taeniopygia guttata | 86.15 | 2e-166 | 471 |
| LLPS-Gaga-2450 | Gallus gallus | 85.0 | 4e-165 | 469 |
| LLPS-Fia-3178 | Ficedula albicollis | 83.96 | 8e-166 | 471 |
| LLPS-Anc-3294 | Anolis carolinensis | 83.27 | 7e-170 | 481 |
| LLPS-Xet-2262 | Xenopus tropicalis | 82.76 | 1e-162 | 462 |
| LLPS-Xim-3006 | Xiphophorus maculatus | 82.69 | 1e-163 | 465 |
| LLPS-Pof-3930 | Poecilia formosa | 82.31 | 8e-163 | 462 |
| LLPS-Pes-2626 | Pelodiscus sinensis | 81.86 | 9e-124 | 361 |
| LLPS-Scf-3614 | Scleropages formosus | 81.23 | 1e-160 | 457 |
| LLPS-Orn-1812 | Oreochromis niloticus | 80.71 | 2e-156 | 446 |
| LLPS-Orl-2852 | Oryzias latipes | 80.6 | 3e-139 | 402 |
| LLPS-Tar-3378 | Takifugu rubripes | 80.08 | 6e-161 | 457 |
| LLPS-Gaa-4003 | Gasterosteus aculeatus | 79.62 | 6e-158 | 450 |
| LLPS-Meg-1652 | Meleagris gallopavo | 79.11 | 1e-87 | 267 |
| LLPS-Dar-3401 | Danio rerio | 79.1 | 6e-159 | 453 |
| LLPS-Leo-2701 | Lepisosteus oculatus | 78.97 | 6e-151 | 432 |
| LLPS-Lac-3724 | Latimeria chalumnae | 78.16 | 1e-43 | 151 |
| LLPS-Asm-3078 | Astyanax mexicanus | 77.73 | 1e-145 | 422 |
| LLPS-Mea-3663 | Mesocricetus auratus | 75.57 | 5e-130 | 379 |
| LLPS-Icp-1883 | Ictalurus punctatus | 73.13 | 3e-148 | 426 |
| LLPS-Scm-3366 | Scophthalmus maximus | 72.63 | 4e-152 | 439 |
| LLPS-Ran-2516 | Rattus norvegicus | 64.1 | 5e-127 | 376 |
| LLPS-Cii-1304 | Ciona intestinalis | 55.87 | 2e-100 | 304 |
| LLPS-Cae-1172 | Caenorhabditis elegans | 50.77 | 1e-89 | 276 |
| LLPS-Cis-1859 | Ciona savignyi | 46.79 | 2e-87 | 271 |
| LLPS-Drm-2170 | Drosophila melanogaster | 45.04 | 1e-82 | 259 |
| LLPS-Map-0636 | Magnaporthe poae | 43.4 | 6e-24 | 100 |
| LLPS-Nec-1386 | Neurospora crassa | 42.46 | 9e-55 | 187 |
| LLPS-Usm-1556 | Ustilago maydis | 42.4 | 2e-55 | 189 |
| LLPS-Abg-1547 | Absidia glauca | 42.37 | 9e-42 | 151 |
| LLPS-Fuo-0945 | Fusarium oxysporum | 42.31 | 3e-57 | 194 |
| LLPS-Beb-0851 | Beauveria bassiana | 41.98 | 1e-58 | 197 |
| LLPS-Fus-0795 | Fusarium solani | 41.92 | 1e-56 | 192 |
| LLPS-Fuv-0171 | Fusarium verticillioides | 41.76 | 2e-56 | 191 |
| LLPS-Yal-0986 | Yarrowia lipolytica | 41.67 | 8e-53 | 182 |
| LLPS-Cogr-0688 | Colletotrichum graminicola | 41.54 | 6e-55 | 187 |
| LLPS-Spr-1524 | Sporisorium reilianum | 41.52 | 2e-60 | 202 |
| LLPS-Mel-0465 | Melampsora laricipopulina | 41.47 | 2e-51 | 178 |
| LLPS-Trv-0829 | Trichoderma virens | 41.38 | 3e-55 | 188 |
| LLPS-Pug-0790 | Puccinia graminis | 40.86 | 2e-54 | 186 |
| LLPS-Zyt-1077 | Zymoseptoria tritici | 40.82 | 9e-56 | 190 |
| LLPS-Trr-0150 | Trichoderma reesei | 40.77 | 6e-56 | 190 |
| LLPS-Ved-0915 | Verticillium dahliae | 40.77 | 2e-54 | 186 |
| LLPS-Ast-0398 | Aspergillus terreus | 40.53 | 2e-47 | 166 |
| LLPS-Coo-0412 | Colletotrichum orbiculare | 40.46 | 8e-53 | 182 |
| LLPS-Scc-1289 | Schizosaccharomyces cryophilus | 40.23 | 1e-49 | 173 |
| LLPS-Put-0592 | Puccinia triticina | 40.08 | 3e-53 | 183 |
| LLPS-Miv-0033 | Microbotryum violaceum | 40.0 | 1e-54 | 187 |
| LLPS-Gag-0773 | Gaeumannomyces graminis | 39.85 | 6e-54 | 185 |
| LLPS-Crn-0614 | Cryptococcus neoformans | 39.76 | 2e-50 | 176 |
| LLPS-Phn-1446 | Phaeosphaeria nodorum | 39.71 | 2e-53 | 184 |
| LLPS-Mao-0844 | Magnaporthe oryzae | 39.46 | 1e-55 | 189 |
| LLPS-Asc-1006 | Aspergillus clavatus | 39.43 | 8e-56 | 190 |
| LLPS-Blg-1183 | Blumeria graminis | 39.06 | 1e-51 | 179 |
| LLPS-Scj-1299 | Schizosaccharomyces japonicus | 39.03 | 2e-50 | 176 |
| LLPS-Pytr-1328 | Pyrenophora triticirepentis | 38.93 | 9e-54 | 184 |
| LLPS-Asn-0759 | Aspergillus nidulans | 38.87 | 2e-55 | 190 |
| LLPS-Aso-0933 | Aspergillus oryzae | 38.71 | 4e-55 | 188 |
| LLPS-Dos-0728 | Dothistroma septosporum | 38.64 | 9e-53 | 182 |
| LLPS-Lem-1451 | Leptosphaeria maculans | 38.58 | 7e-54 | 186 |
| LLPS-Pyt-1395 | Pyrenophora teres | 38.58 | 3e-54 | 186 |
| LLPS-Asni-1190 | Aspergillus niger | 38.52 | 6e-55 | 187 |
| LLPS-Asg-1376 | Ashbya gossypii | 38.43 | 7e-42 | 153 |
| LLPS-Nef-1621 | Neosartorya fischeri | 38.35 | 8e-55 | 187 |
| LLPS-Asfu-0163 | Aspergillus fumigatus | 38.35 | 2e-54 | 187 |
| LLPS-Tum-1228 | Tuber melanosporum | 38.31 | 6e-52 | 182 |
| LLPS-Scp-1554 | Schizosaccharomyces pombe | 38.28 | 3e-49 | 172 |
| LLPS-Scs-0078 | Sclerotinia sclerotiorum | 37.93 | 2e-51 | 178 |
| LLPS-Cog-1244 | Colletotrichum gloeosporioides | 36.86 | 6e-40 | 148 |
| LLPS-Asf-0267 | Aspergillus flavus | 36.21 | 1e-49 | 176 |
| LLPS-Sac-0392 | Saccharomyces cerevisiae | 35.29 | 4e-39 | 146 |
| LLPS-Kop-0889 | Komagataella pastoris | 29.61 | 3e-13 | 72.8 |
| LLPS-Ere-0755 | Erinaceus europaeus | 28.04 | 7e-17 | 82.8 |
| LLPS-Anp-1451 | Anas platyrhynchos | 27.99 | 4e-16 | 80.9 |
| LLPS-Tut-2156 | Tursiops truncatus | 27.55 | 1e-15 | 79.3 |
| LLPS-Cym-0604 | Cyanidioschyzon merolae | 27.14 | 7e-14 | 74.3 |