LLPS-Aso-0933
AO090001000546
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase |
| Gene Name: | AO090001000546 |
| Ensembl Gene: | AO090001000546 |
| Ensembl Protein: | BAE57055 |
| Organism: | Aspergillus oryzae |
| Taxa ID: | 510516 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | BAE57055 | BAE57055 |
| UniProt | Q2UN10, Q2UN10_ASPOR | |
| GeneBank | AP007154 | BAE57055.1 |
| RefSeq | XM_001819005.2 | XP_001819057.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MASLPNTYAD PVRIAVIGGT GLRELPGFTQ VASLNISTPW GTPSSPITIL HHQCSHNKQT 60 61 VAVAFLSRHG LHHQIAPHEV PARANIAALR SIGVRTIIAF SAVGSLQEEI KPRDFVIPDQ 120 121 VIDRTKGIRP FTFFEGGVVA HVPFGDPFDE GVAKVVRACG HSLEGEGVVL HDRGTLVCME 180 181 GPQFSTRAES KLYRSWGGSV INMSCLPEAK LAREAEIAYQ MICMSTDYDC WHEATADVTV 240 241 EMVMGNMKAN AENAKHFVTA VLDELASDKN SELVQAKHVE GSVKFGLSTA QPNWSPEARE 300 301 RMNWLFPGYF N 311 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleus | |
Molecular Function | S-methyl-5-thioadenosine phosphorylase activity | |
Biological Process | L-methionine salvage from methylthioadenosine | |
Biological Process | Purine ribonucleoside salvage |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ast-0398 | Aspergillus terreus | 94.61 | 4e-171 | 481 |
| LLPS-Asni-1190 | Aspergillus niger | 93.57 | 0.0 | 620 |
| LLPS-Asf-0267 | Aspergillus flavus | 93.11 | 0.0 | 638 |
| LLPS-Asn-0759 | Aspergillus nidulans | 91.94 | 0.0 | 598 |
| LLPS-Asc-1006 | Aspergillus clavatus | 91.32 | 0.0 | 605 |
| LLPS-Nef-1621 | Neosartorya fischeri | 90.35 | 0.0 | 597 |
| LLPS-Asfu-0163 | Aspergillus fumigatus | 90.03 | 0.0 | 597 |
| LLPS-Scs-0078 | Sclerotinia sclerotiorum | 74.52 | 1e-140 | 407 |
| LLPS-Zyt-1077 | Zymoseptoria tritici | 72.99 | 2e-171 | 486 |
| LLPS-Dos-0728 | Dothistroma septosporum | 71.47 | 1e-167 | 476 |
| LLPS-Phn-1446 | Phaeosphaeria nodorum | 68.69 | 7e-159 | 454 |
| LLPS-Cogr-0688 | Colletotrichum graminicola | 68.57 | 2e-150 | 432 |
| LLPS-Lem-1451 | Leptosphaeria maculans | 67.99 | 3e-153 | 441 |
| LLPS-Nec-1386 | Neurospora crassa | 67.94 | 9e-149 | 427 |
| LLPS-Coo-0412 | Colletotrichum orbiculare | 67.83 | 9e-149 | 427 |
| LLPS-Pytr-1328 | Pyrenophora triticirepentis | 67.73 | 2e-157 | 450 |
| LLPS-Pyt-1395 | Pyrenophora teres | 67.73 | 1e-157 | 450 |
| LLPS-Fus-0795 | Fusarium solani | 66.56 | 5e-144 | 416 |
| LLPS-Fuo-0945 | Fusarium oxysporum | 66.56 | 1e-145 | 419 |
| LLPS-Trv-0829 | Trichoderma virens | 66.56 | 8e-144 | 415 |
| LLPS-Fuv-0171 | Fusarium verticillioides | 66.56 | 6e-146 | 421 |
| LLPS-Gag-0773 | Gaeumannomyces graminis | 66.46 | 4e-145 | 419 |
| LLPS-Ved-0915 | Verticillium dahliae | 65.92 | 5e-146 | 421 |
| LLPS-Trr-0150 | Trichoderma reesei | 65.71 | 3e-145 | 419 |
| LLPS-Beb-0851 | Beauveria bassiana | 65.29 | 2e-146 | 422 |
| LLPS-Mao-0844 | Magnaporthe oryzae | 64.86 | 4e-143 | 414 |
| LLPS-Map-0636 | Magnaporthe poae | 62.75 | 9e-57 | 187 |
| LLPS-Blg-1183 | Blumeria graminis | 62.26 | 4e-136 | 395 |
| LLPS-Tum-1228 | Tuber melanosporum | 62.18 | 2e-133 | 392 |
| LLPS-Ten-3369 | Tetraodon nigroviridis | 56.72 | 1e-20 | 89.0 |
| LLPS-Cog-1244 | Colletotrichum gloeosporioides | 56.51 | 5e-110 | 329 |
| LLPS-Yal-0986 | Yarrowia lipolytica | 53.33 | 2e-111 | 333 |
| LLPS-Scj-1299 | Schizosaccharomyces japonicus | 53.16 | 3e-103 | 311 |
| LLPS-Abg-1547 | Absidia glauca | 52.16 | 1e-79 | 249 |
| LLPS-Scp-1554 | Schizosaccharomyces pombe | 51.94 | 2e-104 | 315 |
| LLPS-Asg-1376 | Ashbya gossypii | 51.77 | 5e-94 | 288 |
| LLPS-Scc-1289 | Schizosaccharomyces cryophilus | 51.66 | 5e-102 | 308 |
| LLPS-Crn-0614 | Cryptococcus neoformans | 50.0 | 4e-88 | 274 |
| LLPS-Usm-1556 | Ustilago maydis | 49.84 | 2e-93 | 286 |
| LLPS-Pug-0790 | Puccinia graminis | 49.02 | 1e-92 | 284 |
| LLPS-Mel-0465 | Melampsora laricipopulina | 49.02 | 1e-90 | 279 |
| LLPS-Spr-1524 | Sporisorium reilianum | 48.87 | 2e-91 | 281 |
| LLPS-Lac-3724 | Latimeria chalumnae | 48.48 | 2e-11 | 63.9 |
| LLPS-Put-0592 | Puccinia triticina | 48.37 | 1e-90 | 279 |
| LLPS-Sac-0392 | Saccharomyces cerevisiae | 46.69 | 5e-90 | 279 |
| LLPS-Miv-0033 | Microbotryum violaceum | 46.42 | 2e-90 | 280 |
| LLPS-Cii-1304 | Ciona intestinalis | 44.53 | 5e-62 | 205 |
| LLPS-Orl-2852 | Oryzias latipes | 42.72 | 4e-48 | 168 |
| LLPS-Ora-2300 | Ornithorhynchus anatinus | 41.57 | 3e-12 | 67.0 |
| LLPS-Pes-2626 | Pelodiscus sinensis | 41.33 | 3e-42 | 151 |
| LLPS-Orn-1812 | Oreochromis niloticus | 41.1 | 1e-50 | 175 |
| LLPS-Sah-2553 | Sarcophilus harrisii | 40.61 | 6e-57 | 192 |
| LLPS-Tar-3378 | Takifugu rubripes | 40.55 | 2e-52 | 180 |
| LLPS-Dio-0948 | Dipodomys ordii | 40.53 | 3e-56 | 189 |
| LLPS-Fec-4485 | Felis catus | 40.52 | 2e-58 | 195 |
| LLPS-Cap-4683 | Cavia porcellus | 40.52 | 3e-58 | 195 |
| LLPS-Poa-4355 | Pongo abelii | 40.5 | 1e-51 | 177 |
| LLPS-Scm-3366 | Scophthalmus maximus | 40.08 | 7e-48 | 171 |
| LLPS-Ict-4284 | Ictidomys tridecemlineatus | 40.07 | 2e-56 | 190 |
| LLPS-Orc-3945 | Oryctolagus cuniculus | 40.0 | 4e-57 | 192 |
| LLPS-Gaa-4003 | Gasterosteus aculeatus | 40.0 | 5e-55 | 187 |
| LLPS-Pof-3930 | Poecilia formosa | 39.85 | 3e-55 | 187 |
| LLPS-Sus-2946 | Sus scrofa | 39.85 | 2e-56 | 190 |
| LLPS-Xim-3006 | Xiphophorus maculatus | 39.85 | 1e-55 | 188 |
| LLPS-Mum-4606 | Mus musculus | 39.78 | 2e-57 | 193 |
| LLPS-Mup-2019 | Mustela putorius furo | 39.78 | 1e-56 | 191 |
| LLPS-Otg-2263 | Otolemur garnettii | 39.77 | 1e-55 | 188 |
| LLPS-Caf-4441 | Canis familiaris | 39.77 | 1e-54 | 186 |
| LLPS-Cas-1420 | Carlito syrichta | 39.7 | 3e-56 | 189 |
| LLPS-Aim-4222 | Ailuropoda melanoleuca | 39.7 | 6e-56 | 189 |
| LLPS-Chs-3976 | Chlorocebus sabaeus | 39.64 | 3e-57 | 192 |
| LLPS-Fud-3969 | Fukomys damarensis | 39.62 | 1e-55 | 188 |
| LLPS-Myl-4368 | Myotis lucifugus | 39.47 | 1e-55 | 188 |
| LLPS-Urm-1614 | Ursus maritimus | 39.41 | 6e-55 | 187 |
| LLPS-Caj-3266 | Callithrix jacchus | 39.41 | 1e-55 | 189 |
| LLPS-Eqc-0399 | Equus caballus | 39.37 | 3e-58 | 196 |
| LLPS-Mod-3597 | Monodelphis domestica | 39.3 | 1e-57 | 194 |
| LLPS-Xet-2262 | Xenopus tropicalis | 39.26 | 2e-56 | 190 |
| LLPS-Anc-3294 | Anolis carolinensis | 39.26 | 2e-57 | 192 |
| LLPS-Aon-2477 | Aotus nancymaae | 39.15 | 1e-55 | 190 |
| LLPS-Loa-1451 | Loxodonta africana | 39.1 | 2e-55 | 188 |
| LLPS-Hos-3407 | Homo sapiens | 39.04 | 2e-56 | 191 |
| LLPS-Pat-3130 | Pan troglodytes | 39.04 | 2e-56 | 191 |
| LLPS-Man-1323 | Macaca nemestrina | 39.04 | 3e-56 | 191 |
| LLPS-Rhb-1681 | Rhinopithecus bieti | 39.04 | 2e-56 | 192 |
| LLPS-Mam-0917 | Macaca mulatta | 39.04 | 3e-56 | 191 |
| LLPS-Nol-3407 | Nomascus leucogenys | 39.04 | 2e-56 | 191 |
| LLPS-Maf-4626 | Macaca fascicularis | 39.04 | 3e-56 | 191 |
| LLPS-Cea-4686 | Cercocebus atys | 39.04 | 2e-56 | 192 |
| LLPS-Gog-3299 | Gorilla gorilla | 39.04 | 3e-56 | 191 |
| LLPS-Paa-0595 | Papio anubis | 39.04 | 2e-56 | 192 |
| LLPS-Mal-3793 | Mandrillus leucophaeus | 39.04 | 2e-56 | 192 |
| LLPS-Ova-3289 | Ovis aries | 38.84 | 3e-43 | 156 |
| LLPS-Pap-1983 | Pan paniscus | 38.71 | 4e-55 | 188 |
| LLPS-Gaga-2450 | Gallus gallus | 38.7 | 6e-55 | 186 |
| LLPS-Leo-2701 | Lepisosteus oculatus | 38.62 | 8e-51 | 176 |
| LLPS-Dar-3401 | Danio rerio | 38.46 | 3e-52 | 179 |
| LLPS-Fia-3178 | Ficedula albicollis | 38.46 | 4e-53 | 182 |
| LLPS-Tag-2633 | Taeniopygia guttata | 38.46 | 7e-54 | 183 |
| LLPS-Icp-1883 | Ictalurus punctatus | 38.46 | 2e-55 | 187 |
| LLPS-Bot-1894 | Bos taurus | 38.29 | 1e-47 | 167 |
| LLPS-Cae-1172 | Caenorhabditis elegans | 38.24 | 4e-48 | 169 |
| LLPS-Scf-3614 | Scleropages formosus | 38.24 | 3e-54 | 184 |
| LLPS-Meg-1652 | Meleagris gallopavo | 37.5 | 8e-28 | 111 |
| LLPS-Asm-3078 | Astyanax mexicanus | 35.43 | 2e-48 | 171 |
| LLPS-Cis-1859 | Ciona savignyi | 34.24 | 1e-45 | 163 |
| LLPS-Mea-3663 | Mesocricetus auratus | 34.08 | 1e-38 | 143 |
| LLPS-Drm-2170 | Drosophila melanogaster | 31.5 | 5e-37 | 139 |
| LLPS-Ran-2516 | Rattus norvegicus | 29.1 | 3e-31 | 125 |