LLPS-Rhb-1681
MTAP
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | S-methyl-5'-thioadenosine phosphorylase; 5'-methylthioadenosine phosphorylase; MTA phosphorylase; MTAP; MTAPase |
| Gene Name: | MTAP |
| Ensembl Gene: | ENSRBIG00000039442.1 |
| Ensembl Protein: | ENSRBIP00000031212.1 |
| Organism: | Rhinopithecus bieti |
| Taxa ID: | 61621 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSRBIT00000055178.1 | ENSRBIP00000031212.1 |
| Ensembl | ENSRBIT00000055181.1 | ENSRBIP00000031215.1 |
| Ensembl | ENSRBIT00000055184.1 | ENSRBIP00000031218.1 |
| Ensembl | ENSRBIT00000055177.1 | ENSRBIP00000031211.1 |
| UniProt | A0A2K6M614, A0A2K6M614_RHIBE |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MASGTTTTAV KIGIIGGTGL DDPEILEGRT EKYVDTPFGK PSDALILGKI KNVDCVLLAR 60 61 HGRQHTIMPS KVNYQANIWA LKEEGCTHVI VTTACGSLRE EIQPGDIVII DQFIDRTTMR 120 121 PQSFYDGSHS CARGVCHIPM AEPFCPKTRE VLIETAKKLG LRCHSKGTMV TIEGPRFSSR 180 181 AESFMFRTWG ADVINMTTVP EVVLAKEAGI CYASIAMATD YDCWKEHEEA VSVDRVLKTL 240 241 KENANKAKSL LLTTIPQIGS TEWSETLHNL KMIKFQMILS EGYHPLNIQE SPFYRGPLDF 300 301 PSVGHGRGEI LPSPLDLAGY YFHQPVQPPC PDS 333 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCTCTG GCACCACCAC CACCGCCGTG AAGATTGGAA TAATTGGTGG AACAGGCCTG 60 61 GATGATCCAG AAATTTTAGA AGGAAGAACT GAAAAATATG TGGATACTCC ATTTGGCAAG 120 121 CCATCCGATG CCCTAATTTT GGGGAAGATA AAAAATGTTG ATTGTGTCCT TCTTGCAAGG 180 181 CATGGAAGGC AGCACACCAT CATGCCTTCA AAGGTCAACT ACCAGGCGAA CATCTGGGCT 240 241 TTGAAGGAAG AGGGCTGTAC ACATGTCATA GTGACCACAG CTTGTGGCTC CTTGAGGGAG 300 301 GAGATTCAGC CCGGTGATAT TGTCATTATT GATCAATTCA TTGACAGGAC CACTATGAGA 360 361 CCTCAGTCCT TCTATGATGG AAGTCATTCT TGTGCCAGAG GAGTGTGCCA TATTCCAATG 420 421 GCTGAGCCGT TTTGCCCCAA AACGAGAGAG GTTCTTATAG AGACTGCTAA GAAGCTAGGA 480 481 CTCCGGTGCC ACTCCAAGGG GACAATGGTC ACAATCGAGG GACCTCGTTT TAGCTCCCGG 540 541 GCAGAAAGCT TCATGTTCCG CACCTGGGGG GCAGATGTTA TCAACATGAC CACAGTTCCA 600 601 GAGGTGGTTC TTGCTAAGGA GGCTGGAATT TGTTATGCAA GTATCGCCAT GGCAACAGAT 660 661 TATGACTGCT GGAAGGAGCA TGAGGAAGCA GTTTCGGTGG ACCGGGTCTT AAAGACCCTG 720 721 AAAGAAAATG CTAATAAAGC CAAAAGCTTA CTGCTGACTA CCATACCTCA GATAGGGTCC 780 781 ACGGAATGGT CAGAAACCCT CCATAACCTG AAGATGATCA AGTTCCAGAT GATCCTCAGT 840 841 GAGGGATACC ATCCTCTCAA TATTCAAGAG TCACCCTTCT ACAGAGGACC CCTAGACTTC 900 901 CCATCAGTGG GACATGGCAG AGGTGAAATC CTGCCCTCTC CCTTAGACCT GGCTGGATAC 960 961 TACTTTCACC AACCCGTGCA GCCACCCTGC CCTGACAGCT AG 1002 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleus | |
Molecular Function | S-methyl-5-thioadenosine phosphorylase activity | |
Biological Process | L-methionine salvage from methylthioadenosine | |
Biological Process | Purine ribonucleoside salvage |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Cea-4686 | Cercocebus atys | 99.4 | 0.0 | 692 |
| LLPS-Mal-3793 | Mandrillus leucophaeus | 99.4 | 0.0 | 692 |
| LLPS-Paa-0595 | Papio anubis | 99.4 | 0.0 | 692 |
| LLPS-Maf-4626 | Macaca fascicularis | 98.8 | 0.0 | 688 |
| LLPS-Man-1323 | Macaca nemestrina | 98.8 | 0.0 | 688 |
| LLPS-Nol-3407 | Nomascus leucogenys | 98.8 | 0.0 | 685 |
| LLPS-Gog-3299 | Gorilla gorilla | 98.5 | 0.0 | 681 |
| LLPS-Hos-3407 | Homo sapiens | 98.2 | 0.0 | 678 |
| LLPS-Pat-3130 | Pan troglodytes | 98.2 | 0.0 | 678 |
| LLPS-Pap-1983 | Pan paniscus | 98.14 | 0.0 | 657 |
| LLPS-Chs-3976 | Chlorocebus sabaeus | 97.86 | 0.0 | 565 |
| LLPS-Aon-2477 | Aotus nancymaae | 96.41 | 0.0 | 666 |
| LLPS-Mam-0917 | Macaca mulatta | 96.4 | 0.0 | 666 |
| LLPS-Caj-3266 | Callithrix jacchus | 96.3 | 0.0 | 539 |
| LLPS-Cas-1420 | Carlito syrichta | 96.28 | 0.0 | 537 |
| LLPS-Dio-0948 | Dipodomys ordii | 96.24 | 0.0 | 536 |
| LLPS-Aim-4222 | Ailuropoda melanoleuca | 95.91 | 0.0 | 535 |
| LLPS-Orc-3945 | Oryctolagus cuniculus | 95.73 | 0.0 | 551 |
| LLPS-Mup-2019 | Mustela putorius furo | 95.0 | 0.0 | 551 |
| LLPS-Fec-4485 | Felis catus | 94.64 | 0.0 | 548 |
| LLPS-Myl-4368 | Myotis lucifugus | 94.14 | 0.0 | 531 |
| LLPS-Ict-4284 | Ictidomys tridecemlineatus | 93.93 | 0.0 | 547 |
| LLPS-Loa-1451 | Loxodonta africana | 93.8 | 0.0 | 536 |
| LLPS-Fud-3969 | Fukomys damarensis | 93.7 | 0.0 | 530 |
| LLPS-Poa-4355 | Pongo abelii | 93.57 | 4e-172 | 486 |
| LLPS-Ora-2300 | Ornithorhynchus anatinus | 92.78 | 1e-59 | 194 |
| LLPS-Caf-4441 | Canis familiaris | 92.55 | 0.0 | 535 |
| LLPS-Urm-1614 | Ursus maritimus | 92.5 | 0.0 | 538 |
| LLPS-Otg-2263 | Otolemur garnettii | 92.5 | 0.0 | 539 |
| LLPS-Cap-4683 | Cavia porcellus | 92.5 | 0.0 | 537 |
| LLPS-Ova-3289 | Ovis aries | 92.34 | 1e-171 | 486 |
| LLPS-Bot-1894 | Bos taurus | 92.14 | 0.0 | 516 |
| LLPS-Mum-4606 | Mus musculus | 91.76 | 0.0 | 532 |
| LLPS-Sus-2946 | Sus scrofa | 91.07 | 0.0 | 530 |
| LLPS-Ten-3369 | Tetraodon nigroviridis | 87.67 | 4e-41 | 144 |
| LLPS-Sah-2553 | Sarcophilus harrisii | 86.67 | 2e-176 | 498 |
| LLPS-Eqc-0399 | Equus caballus | 86.28 | 3e-177 | 500 |
| LLPS-Tag-2633 | Taeniopygia guttata | 86.21 | 2e-167 | 474 |
| LLPS-Mod-3597 | Monodelphis domestica | 85.36 | 4e-180 | 507 |
| LLPS-Gaga-2450 | Gallus gallus | 84.91 | 8e-168 | 476 |
| LLPS-Fia-3178 | Ficedula albicollis | 84.01 | 1e-166 | 474 |
| LLPS-Xet-2262 | Xenopus tropicalis | 82.95 | 5e-165 | 469 |
| LLPS-Pes-2626 | Pelodiscus sinensis | 81.86 | 6e-124 | 362 |
| LLPS-Xim-3006 | Xiphophorus maculatus | 81.58 | 4e-165 | 469 |
| LLPS-Anc-3294 | Anolis carolinensis | 81.43 | 2e-172 | 488 |
| LLPS-Pof-3930 | Poecilia formosa | 81.2 | 2e-164 | 467 |
| LLPS-Scf-3614 | Scleropages formosus | 80.99 | 8e-162 | 461 |
| LLPS-Orn-1812 | Oreochromis niloticus | 80.71 | 1e-156 | 447 |
| LLPS-Orl-2852 | Oryzias latipes | 80.6 | 1e-139 | 404 |
| LLPS-Dar-3401 | Danio rerio | 80.52 | 3e-161 | 459 |
| LLPS-Meg-1652 | Meleagris gallopavo | 79.11 | 7e-88 | 268 |
| LLPS-Leo-2701 | Lepisosteus oculatus | 78.97 | 3e-151 | 434 |
| LLPS-Tar-3378 | Takifugu rubripes | 78.95 | 2e-161 | 459 |
| LLPS-Gaa-4003 | Gasterosteus aculeatus | 78.65 | 8e-160 | 456 |
| LLPS-Lac-3724 | Latimeria chalumnae | 78.16 | 8e-44 | 152 |
| LLPS-Asm-3078 | Astyanax mexicanus | 77.73 | 5e-146 | 424 |
| LLPS-Mea-3663 | Mesocricetus auratus | 75.09 | 2e-130 | 380 |
| LLPS-Icp-1883 | Ictalurus punctatus | 72.63 | 7e-150 | 430 |
| LLPS-Scm-3366 | Scophthalmus maximus | 72.63 | 3e-152 | 440 |
| LLPS-Ran-2516 | Rattus norvegicus | 64.4 | 7e-133 | 391 |
| LLPS-Cii-1304 | Ciona intestinalis | 56.05 | 2e-101 | 307 |
| LLPS-Cae-1172 | Caenorhabditis elegans | 51.15 | 6e-91 | 280 |
| LLPS-Cis-1859 | Ciona savignyi | 47.08 | 2e-89 | 276 |
| LLPS-Drm-2170 | Drosophila melanogaster | 44.94 | 3e-84 | 263 |
| LLPS-Map-0636 | Magnaporthe poae | 43.4 | 7e-24 | 100 |
| LLPS-Nec-1386 | Neurospora crassa | 42.52 | 4e-55 | 188 |
| LLPS-Abg-1547 | Absidia glauca | 42.37 | 1e-41 | 151 |
| LLPS-Beb-0851 | Beauveria bassiana | 42.18 | 2e-59 | 199 |
| LLPS-Usm-1556 | Ustilago maydis | 42.06 | 4e-55 | 189 |
| LLPS-Fuo-0945 | Fusarium oxysporum | 41.79 | 1e-57 | 195 |
| LLPS-Yal-0986 | Yarrowia lipolytica | 41.73 | 4e-53 | 184 |
| LLPS-Cogr-0688 | Colletotrichum graminicola | 41.6 | 3e-55 | 189 |
| LLPS-Fus-0795 | Fusarium solani | 41.57 | 5e-57 | 193 |
| LLPS-Trv-0829 | Trichoderma virens | 41.44 | 1e-55 | 190 |
| LLPS-Spr-1524 | Sporisorium reilianum | 41.43 | 2e-61 | 205 |
| LLPS-Fuv-0171 | Fusarium verticillioides | 41.42 | 9e-57 | 192 |
| LLPS-Mel-0465 | Melampsora laricipopulina | 40.91 | 1e-51 | 179 |
| LLPS-Zyt-1077 | Zymoseptoria tritici | 40.89 | 3e-56 | 192 |
| LLPS-Ved-0915 | Verticillium dahliae | 40.84 | 7e-55 | 187 |
| LLPS-Coo-0412 | Colletotrichum orbiculare | 40.53 | 2e-53 | 184 |
| LLPS-Ast-0398 | Aspergillus terreus | 40.53 | 2e-47 | 166 |
| LLPS-Trr-0150 | Trichoderma reesei | 40.45 | 2e-56 | 191 |
| LLPS-Put-0592 | Puccinia triticina | 40.08 | 3e-53 | 183 |
| LLPS-Miv-0033 | Microbotryum violaceum | 40.0 | 2e-54 | 187 |
| LLPS-Scc-1289 | Schizosaccharomyces cryophilus | 39.92 | 2e-49 | 173 |
| LLPS-Crn-0614 | Cryptococcus neoformans | 39.84 | 1e-50 | 177 |
| LLPS-Gag-0773 | Gaeumannomyces graminis | 39.7 | 4e-55 | 189 |
| LLPS-Asc-1006 | Aspergillus clavatus | 39.5 | 1e-56 | 192 |
| LLPS-Phn-1446 | Phaeosphaeria nodorum | 39.44 | 5e-54 | 186 |
| LLPS-Mao-0844 | Magnaporthe oryzae | 39.33 | 1e-56 | 192 |
| LLPS-Scj-1299 | Schizosaccharomyces japonicus | 39.11 | 1e-50 | 176 |
| LLPS-Aso-0933 | Aspergillus oryzae | 39.04 | 2e-56 | 192 |
| LLPS-Blg-1183 | Blumeria graminis | 39.0 | 4e-52 | 181 |
| LLPS-Lem-1451 | Leptosphaeria maculans | 38.83 | 2e-55 | 191 |
| LLPS-Pytr-1328 | Pyrenophora triticirepentis | 38.66 | 2e-54 | 187 |
| LLPS-Asn-0759 | Aspergillus nidulans | 38.6 | 3e-56 | 192 |
| LLPS-Asni-1190 | Aspergillus niger | 38.6 | 8e-56 | 190 |
| LLPS-Asg-1376 | Ashbya gossypii | 38.52 | 1e-42 | 155 |
| LLPS-Pug-0790 | Puccinia graminis | 38.44 | 2e-54 | 186 |
| LLPS-Asfu-0163 | Aspergillus fumigatus | 38.43 | 2e-55 | 190 |
| LLPS-Pyt-1395 | Pyrenophora teres | 38.32 | 7e-55 | 188 |
| LLPS-Nef-1621 | Neosartorya fischeri | 38.11 | 9e-56 | 190 |
| LLPS-Tum-1228 | Tuber melanosporum | 38.06 | 2e-53 | 186 |
| LLPS-Dos-0728 | Dothistroma septosporum | 38.06 | 5e-53 | 183 |
| LLPS-Scp-1554 | Schizosaccharomyces pombe | 37.98 | 3e-49 | 173 |
| LLPS-Scs-0078 | Sclerotinia sclerotiorum | 37.71 | 2e-52 | 181 |
| LLPS-Cog-1244 | Colletotrichum gloeosporioides | 36.86 | 5e-40 | 148 |
| LLPS-Asf-0267 | Aspergillus flavus | 36.63 | 5e-51 | 179 |
| LLPS-Sac-0392 | Saccharomyces cerevisiae | 35.4 | 2e-39 | 148 |
| LLPS-Kop-0889 | Komagataella pastoris | 29.61 | 3e-13 | 73.2 |
| LLPS-Anp-1451 | Anas platyrhynchos | 28.25 | 1e-16 | 82.8 |
| LLPS-Ere-0755 | Erinaceus europaeus | 27.94 | 4e-17 | 84.0 |
| LLPS-Tut-2156 | Tursiops truncatus | 27.78 | 8e-16 | 80.1 |
| LLPS-Cym-0604 | Cyanidioschyzon merolae | 27.14 | 9e-14 | 73.9 |