DrLLPS - Data resource of LLPS

LLPS-Sac-0336
NIP7

▼ OVERVIEW


Status:	Reviewed
Protein Name:	60S ribosome subunit biogenesis protein NIP7; Nuclear import protein 7
Gene Name:	NIP7, YPL211W
Ensembl Gene:	YPL211W
Ensembl Protein:	YPL211W_mRNA
Organism:	Saccharomyces cerevisiae
Taxa ID:	559292
LLPS Type:	Client

PDB: 6EM5 (2, 6, L, M, N, Q, R, S, T, U, Z, c, d, e, f, g, i, j, k, E, G, O, V, X, Y, h, B, C, H, A, K, m, D, W, l, b, o, n, r, s, t, y, z, p, q, u, v, w, I, J, x, 3, 4, 5, 1, F, P) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Nucleolus	"...Out of the 142 yeast nucleolar proteins that have at least one human homologue, 124 are found in the updated nucleolar proteome."	Saccharomyces cerevisiae	15635413
Stress granule	"...Here we systematically identified proteins sequestered in Saccharomyces cerevisiae at 46 °C by a SG co‐localization screen and proteomic analysis of insoluble protein fractions. We identified novel SG components including essential aminoacyl‐tRNA synthetases."	Saccharomyces cerevisiae	26484595
Stress granule	"...Here we systematically identified proteins sequestered in Saccharomyces cerevisiae at 46 °C by a SG co‐localization screen and proteomic analysis of insoluble protein fractions."	Saccharomyces cerevisiae	26484595

▼ FUNCTION

Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	YPL211W_mRNA	YPL211W_mRNA
UniProt		Q08962, NIP7_YEAST, D6W3F9
GeneBank	Z73567, AY558059, BK006949	DAA11225.1, CAA97926.1, AAS56385.1
RefSeq	NM_001184025.1	NP_015113.1
Entrez	855890

▼ SEQUENCE

Protein Sequence (FASTA)
1 MRQLTEEETK VVFEKLAGYI GRNISFLVDN KELPHVFRLQ KDRVYYVPDH VAKLATSVAR 60 61 PNLMSLGICL GKFTKTGKFR LHITSLTVLA KHAKYKIWIK PNGEMPFLYG NHVLKAHVGK 120 121 MSDDIPEHAG VIVFAMNDVP LGFGVSAKST SESRNMQPTG IVAFRQADIG EYLRDEDTLF 180 181 T 181
Nucleotide CDS Sequence (FASTA)
1 ATGAGACAGC TAACAGAAGA AGAGACCAAG GTTGTTTTCG AAAAACTCGC CGGCTATATT 60 61 GGTAGAAATA TTTCTTTTTT AGTGGATAAT AAAGAACTTC CTCATGTCTT CAGATTACAA 120 121 AAGGATAGAG TATATTACGT ACCCGATCAT GTTGCAAAAT TGGCTACTAG TGTAGCAAGA 180 181 CCTAACTTGA TGTCTCTGGG TATTTGTTTA GGTAAATTCA CGAAAACTGG AAAATTCAGG 240 241 TTACATATTA CTTCTTTGAC AGTATTGGCT AAGCATGCCA AATATAAGAT ATGGATTAAA 300 301 CCTAATGGGG AGATGCCATT CTTATACGGT AATCATGTGT TAAAGGCACA TGTGGGTAAA 360 361 ATGTCTGATG ATATACCAGA ACACGCCGGT GTTATTGTGT TTGCAATGAA TGATGTGCCA 420 421 TTAGGGTTCG GTGTCAGTGC GAAAAGTACT TCTGAGTCAA GAAACATGCA ACCCACTGGT 480 481 ATAGTTGCTT TCAGACAAGC AGATATTGGT GAGTATTTGA GAGATGAAGA CACCTTGTTT 540 541 ACTTAG 546

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0690	Ribosome biogenesis
KW-0694	RNA-binding

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005737	Cellular Component	Cytoplasm
GO:0005730	Cellular Component	Nucleolus
GO:0005634	Cellular Component	Nucleus
GO:0030687	Cellular Component	Preribosome, large subunit precursor
GO:0003723	Molecular Function	RNA binding
GO:1902626	Biological Process	Assembly of large subunit precursor of preribosome
GO:0000463	Biological Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0042273	Biological Process	Ribosomal large subunit biogenesis
GO:0042255	Biological Process	Ribosome assembly

▼ KEGG

sce:YPL211W

▼ ANNOTATION

Disorder
IUPred2A

Domain
SMART	Pfam	InterPro	CDD	PROSITE
Gene3D

PTM
EPSD	PLMD	dbPTM	BioGRID

Interaction
HINT	Mentha	YTRP	PINA	IID
iRefIndex	MIST

Physicochemical
Compute pI/Mw	AAindex

Function
PIRSF

Structure
PDB

Element
RAID

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Asg-0229	Ashbya gossypii	91.16	4e-124	354
LLPS-Kop-0139	Komagataella pastoris	80.11	1e-109	318
LLPS-Yal-0537	Yarrowia lipolytica	75.14	1e-99	293
LLPS-Scc-0309	Schizosaccharomyces cryophilus	72.22	2e-96	284
LLPS-Scp-0415	Schizosaccharomyces pombe	70.56	1e-95	282
LLPS-Scj-0739	Schizosaccharomyces japonicus	69.44	1e-95	282
LLPS-Pytr-0257	Pyrenophora triticirepentis	69.02	7e-90	268
LLPS-Pyt-0287	Pyrenophora teres	69.02	1e-89	267
LLPS-Tum-0731	Tuber melanosporum	68.33	1e-92	275
LLPS-Lem-0367	Leptosphaeria maculans	67.93	4e-89	266
LLPS-Phn-0010	Phaeosphaeria nodorum	67.39	1e-88	265
LLPS-Spr-0691	Sporisorium reilianum	67.22	8e-93	275
LLPS-Zyt-1010	Zymoseptoria tritici	67.02	4e-90	268
LLPS-Usm-0828	Ustilago maydis	66.67	1e-92	275
LLPS-Dos-0268	Dothistroma septosporum	66.49	6e-90	268
LLPS-Crn-0294	Cryptococcus neoformans	65.19	6e-86	258
LLPS-Blg-1127	Blumeria graminis	64.86	2e-83	252
LLPS-Cogr-0183	Colletotrichum graminicola	64.32	8e-86	258
LLPS-Cog-0280	Colletotrichum gloeosporioides	64.32	1e-85	257
LLPS-Coo-0325	Colletotrichum orbiculare	64.32	2e-85	256
LLPS-Miv-0249	Microbotryum violaceum	63.89	2e-85	256
LLPS-Beb-0473	Beauveria bassiana	63.78	1e-83	252
LLPS-Trv-0523	Trichoderma virens	63.74	4e-83	250
LLPS-Trr-0459	Trichoderma reesei	62.64	2e-82	249
LLPS-Nec-0519	Neurospora crassa	62.64	2e-78	238
LLPS-Aso-0127	Aspergillus oryzae	62.5	1e-84	254
LLPS-Map-0095	Magnaporthe poae	62.09	1e-82	249
LLPS-Anp-2182	Anas platyrhynchos	62.0	2e-15	72.4
LLPS-Abg-1377	Absidia glauca	61.67	1e-81	246
LLPS-Fuo-0182	Fusarium oxysporum	61.62	2e-82	249
LLPS-Fus-0002	Fusarium solani	61.62	5e-82	248
LLPS-Fuv-0556	Fusarium verticillioides	61.62	2e-82	249
LLPS-Nef-0549	Neosartorya fischeri	61.45	4e-78	238
LLPS-Ved-0018	Verticillium dahliae	61.41	4e-81	245
LLPS-Asfu-1145	Aspergillus fumigatus	60.89	1e-77	237
LLPS-Mao-0002	Magnaporthe oryzae	60.44	3e-80	243
LLPS-Gag-1123	Gaeumannomyces graminis	60.44	6e-81	245
LLPS-Asn-0595	Aspergillus nidulans	60.0	2e-76	234
LLPS-Anc-0289	Anolis carolinensis	59.78	1e-77	236
LLPS-Lac-0186	Latimeria chalumnae	59.78	9e-77	234
LLPS-Leo-1131	Lepisosteus oculatus	59.78	7e-77	234
LLPS-Mel-0464	Melampsora laricipopulina	59.44	5e-82	248
LLPS-Xet-2171	Xenopus tropicalis	58.66	2e-76	233
LLPS-Ova-2467	Ovis aries	58.66	2e-74	228
LLPS-Ora-0149	Ornithorhynchus anatinus	58.51	1e-30	113
LLPS-Cap-1379	Cavia porcellus	58.1	1e-73	226
LLPS-Mod-1972	Monodelphis domestica	58.1	5e-75	229
LLPS-Fec-1258	Felis catus	58.1	1e-73	226
LLPS-Urm-0706	Ursus maritimus	58.1	7e-74	227
LLPS-Aim-1822	Ailuropoda melanoleuca	58.1	1e-73	226
LLPS-Ere-0297	Erinaceus europaeus	58.1	5e-74	227
LLPS-Scf-1224	Scleropages formosus	58.1	6e-75	229
LLPS-Bot-0035	Bos taurus	58.1	1e-73	226
LLPS-Dio-1796	Dipodomys ordii	58.1	1e-73	226
LLPS-Sus-1387	Sus scrofa	58.1	3e-74	228
LLPS-Cis-0629	Ciona savignyi	58.1	8e-76	232
LLPS-Cii-0391	Ciona intestinalis	58.1	4e-76	233
LLPS-Ict-3673	Ictidomys tridecemlineatus	57.54	2e-73	226
LLPS-Eqc-1993	Equus caballus	57.54	1e-73	226
LLPS-Ten-1808	Tetraodon nigroviridis	57.54	2e-75	231
LLPS-Orn-1011	Oreochromis niloticus	57.54	1e-73	226
LLPS-Myl-0984	Myotis lucifugus	57.54	2e-73	226
LLPS-Ran-1536	Rattus norvegicus	57.54	2e-73	226
LLPS-Tut-0800	Tursiops truncatus	57.54	2e-73	226
LLPS-Xim-0948	Xiphophorus maculatus	57.54	2e-74	228
LLPS-Caj-0438	Callithrix jacchus	57.54	1e-73	226
LLPS-Aon-0118	Aotus nancymaae	57.54	1e-73	226
LLPS-Pes-0367	Pelodiscus sinensis	57.5	2e-64	202
LLPS-Nol-0925	Nomascus leucogenys	56.98	2e-72	223
LLPS-Cas-2151	Carlito syrichta	56.98	4e-73	225
LLPS-Caf-2024	Canis familiaris	56.98	3e-72	223
LLPS-Poa-0050	Pongo abelii	56.98	2e-73	225
LLPS-Orc-1093	Oryctolagus cuniculus	56.98	2e-73	225
LLPS-Hos-0738	Homo sapiens	56.98	2e-73	225
LLPS-Pap-1760	Pan paniscus	56.98	2e-73	225
LLPS-Pat-0442	Pan troglodytes	56.98	2e-73	225
LLPS-Pof-1102	Poecilia formosa	56.98	9e-74	226
LLPS-Tar-1519	Takifugu rubripes	56.98	1e-74	228
LLPS-Gog-0913	Gorilla gorilla	56.98	2e-73	225
LLPS-Orl-0988	Oryzias latipes	56.98	3e-73	225
LLPS-Mea-0751	Mesocricetus auratus	56.98	3e-73	225
LLPS-Gaga-0576	Gallus gallus	56.42	3e-72	223
LLPS-Otg-0146	Otolemur garnettii	56.42	6e-73	224
LLPS-Loa-2047	Loxodonta africana	56.42	1e-72	224
LLPS-Man-2622	Macaca nemestrina	56.42	5e-73	225
LLPS-Paa-1506	Papio anubis	56.42	4e-73	225
LLPS-Mal-2069	Mandrillus leucophaeus	56.42	4e-73	225
LLPS-Icp-1803	Ictalurus punctatus	56.42	3e-74	228
LLPS-Fud-2607	Fukomys damarensis	56.42	1e-72	223
LLPS-Cea-0038	Cercocebus atys	56.42	4e-73	225
LLPS-Mum-0949	Mus musculus	56.42	1e-72	224
LLPS-Maf-1895	Macaca fascicularis	56.42	4e-73	225
LLPS-Sot-1651	Solanum tuberosum	56.15	7e-68	212
LLPS-Scm-1125	Scophthalmus maximus	55.87	1e-72	224
LLPS-Dar-1496	Danio rerio	55.87	2e-73	225
LLPS-Chs-0037	Chlorocebus sabaeus	55.87	6e-73	224
LLPS-Asc-0126	Aspergillus clavatus	55.83	1e-78	240
LLPS-Chc-0252	Chondrus crispus	55.62	1e-66	208
LLPS-Sol-0613	Solanum lycopersicum	55.61	9e-67	209
LLPS-Gas-0236	Galdieria sulphuraria	55.37	8e-69	214
LLPS-Chr-0250	Chlamydomonas reinhardtii	55.31	6e-72	222
LLPS-Nia-0552	Nicotiana attenuata	55.08	2e-66	208
LLPS-Rhb-0348	Rhinopithecus bieti	54.97	9e-67	208
LLPS-Ast-0336	Aspergillus terreus	54.84	8e-67	209
LLPS-Arl-0347	Arabidopsis lyrata	54.55	4e-67	210
LLPS-Fia-0184	Ficedula albicollis	54.37	2e-62	197
LLPS-Meg-1438	Meleagris gallopavo	54.37	4e-63	199
LLPS-Tag-0317	Taeniopygia guttata	54.19	4e-68	212
LLPS-Brr-0502	Brassica rapa	54.01	1e-66	208
LLPS-Art-0069	Arabidopsis thaliana	54.01	5e-66	207
LLPS-Brn-0192	Brassica napus	54.01	5e-66	207
LLPS-Gaa-0113	Gasterosteus aculeatus	53.99	8e-63	199
LLPS-Bro-2281	Brassica oleracea	53.97	2e-66	208
LLPS-Cae-0812	Caenorhabditis elegans	53.63	2e-69	215
LLPS-Sem-0172	Selaginella moellendorffii	53.59	7e-68	211
LLPS-Vir-1732	Vigna radiata	53.48	3e-66	207
LLPS-Mam-0842	Macaca mulatta	53.07	3e-65	205
LLPS-Osl-0715	Ostreococcus lucimarinus	53.04	1e-67	211
LLPS-Phv-0034	Phaseolus vulgaris	52.94	1e-65	206
LLPS-Viv-0618	Vitis vinifera	52.94	1e-64	204
LLPS-Asm-0092	Astyanax mexicanus	52.48	2e-51	172
LLPS-Met-0365	Medicago truncatula	52.41	5e-65	204
LLPS-Via-0872	Vigna angularis	52.41	1e-65	206
LLPS-Glm-0477	Glycine max	52.41	3e-64	202
LLPS-Php-0268	Physcomitrella patens	52.15	5e-64	202
LLPS-Mae-0349	Manihot esculenta	51.87	3e-62	197
LLPS-Cus-0432	Cucumis sativus	51.87	2e-63	201
LLPS-Dac-1327	Daucus carota	51.87	3e-60	192
LLPS-Coc-0479	Corchorus capsularis	50.81	2e-61	195
LLPS-Amt-0038	Amborella trichopoda	50.8	4e-63	199
LLPS-Prp-0736	Prunus persica	50.27	8e-61	194
LLPS-Gor-0469	Gossypium raimondii	50.27	2e-58	188
LLPS-Hea-1757	Helianthus annuus	50.27	4e-61	194
LLPS-Pot-0068	Populus trichocarpa	49.73	7e-60	191
LLPS-Thc-0533	Theobroma cacao	49.19	4e-59	189
LLPS-Cym-0102	Cyanidioschyzon merolae	46.93	4e-56	181
LLPS-Drm-0316	Drosophila melanogaster	46.67	1e-61	196
LLPS-Sei-0088	Setaria italica	41.49	2e-45	156
LLPS-Lep-0746	Leersia perrieri	41.49	2e-46	157
LLPS-Orbr-0174	Oryza brachyantha	41.28	8e-25	103
LLPS-Tru-0160	Triticum urartu	40.51	4e-15	74.3
LLPS-Org-0156	Oryza glaberrima	40.43	3e-47	159
LLPS-Orr-0571	Oryza rufipogon	40.43	3e-47	159
LLPS-Orm-0484	Oryza meridionalis	40.43	3e-47	159
LLPS-Ors-0379	Oryza sativa	40.43	3e-47	159
LLPS-Orni-0332	Oryza nivara	40.43	3e-47	159
LLPS-Ori-0816	Oryza indica	40.43	3e-47	159
LLPS-Hov-0760	Hordeum vulgare	39.89	1e-44	152
LLPS-Sob-0695	Sorghum bicolor	39.36	5e-45	153
LLPS-Orp-0623	Oryza punctata	39.36	5e-46	156
LLPS-Orb-0788	Oryza barthii	38.89	1e-40	141
LLPS-Zem-0049	Zea mays	38.83	1e-44	152
LLPS-Tra-0246	Triticum aestivum	38.83	2e-43	149
LLPS-Brd-0150	Brachypodium distachyon	38.83	2e-43	149
LLPS-Mua-1629	Musa acuminata	34.68	2e-25	101

LLPS-Sac-0336NIP7

Protein Sequence

Nucleotide Sequence

LLPS-Sac-0336
NIP7