LLPS-Ran-4613
Idh2

▼ OVERVIEW

Status: Unreviewed
Protein Name: Isocitrate dehydrogenase [NADP], mitochondrial
Gene Name: Idh2
Ensembl Gene: ENSRNOG00000013949.7
Ensembl Protein: ENSRNOP00000069080.1
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAGYLRAVSS  LCRASGSTRT  WAPAALNVPS  WPEQPRRHYA  EKRIKVEKPV  VEMDGDEMTR  60
61    IIWQFIKEKL  ILPHVDVQLK  YFDLGLPNRD  QTNDQVTIDS  ALATQKYSVA  VKCATITPDE  120
121   ARVEEFKLKK  MWKSPNGTIR  NILGGTVFRE  PIICKNIPRL  VPGWTKPITI  GRHAHGDQYK  180
181   ATDFVVDRAG  MFKLVFTPKD  GSGAKEWEVY  NFPAGGVGMG  MYNTDESISG  FAHSCFQYSI  240
241   QKKWPLYLST  KNTIMKAYDG  RFKDIFQEIF  DKHYKTDFDK  NKIWYEHRLI  DDMVAQVLKS  300
301   SGGFVWACKN  YDGDVQSDIL  AQGFGSLGLM  TSVLVCPDGK  TIEAEAAHGT  VTRHYREHQK  360
361   GRPTSTNPIA  SIFAWTRGLE  HRGKLDGNQD  LIRFAQTLEK  VCVQTVESGA  MTKDLAGCIH  420
421   GLSNVKLNEH  FLNTTDFLDT  IKSNLDRALG  KQ  452
Nucleotide CDS Sequence (FASTA)
1     ATGGCCGGCT  ATCTGCGGGC  CGTGAGCTCG  CTCTGCAGAG  CCTCGGGCTC  AACACGGACC  60
61    TGGGCACCGG  CTGCACTGAA  TGTCCCCAGC  TGGCCGGAGC  AGCCGCGGCG  CCACTATGCT  120
121   GAGAAGAGAA  TCAAGGTGGA  GAAGCCGGTG  GTGGAGATGG  ATGGCGATGA  GATGACCCGG  180
181   ATCATCTGGC  AGTTCATCAA  GGAGAAGCTC  ATCCTGCCTC  ACGTGGATGT  CCAGCTCAAG  240
241   TATTTTGACC  TTGGGCTTCC  AAACCGTGAC  CAGACCAATG  ACCAGGTCAC  CATCGACTCT  300
301   GCGCTGGCCA  CTCAGAAGTA  CAGTGTGGCT  GTTAAGTGTG  CTACAATCAC  CCCCGATGAG  360
361   GCCCGTGTGG  AAGAGTTCAA  GCTGAAGAAA  ATGTGGAAGA  GCCCTAACGG  AACTATCCGT  420
421   AACATCCTTG  GGGGAACGGT  CTTCAGAGAG  CCAATTATCT  GCAAAAATAT  CCCCCGCCTT  480
481   GTCCCTGGCT  GGACCAAGCC  CATCACCATT  GGCAGACACG  CCCATGGCGA  CCAGTACAAG  540
541   GCCACAGATT  TTGTGGTAGA  TCGAGCTGGC  ATGTTCAAGT  TGGTCTTCAC  CCCAAAGGAT  600
601   GGCAGTGGTG  CCAAGGAGTG  GGAGGTGTAT  AACTTCCCTG  CCGGAGGCGT  TGGTATGGGG  660
661   ATGTACAACA  CCGACGAGTC  CATTTCGGGC  TTCGCGCACA  GCTGCTTCCA  GTACTCTATC  720
721   CAGAAGAAAT  GGCCGCTCTA  CTTGAGCACC  AAGAACACCA  TTATGAAGGC  CTATGACGGG  780
781   CGTTTCAAGG  ACATCTTCCA  GGAGATCTTT  GACAAGCACT  ATAAGACTGA  CTTTGACAAG  840
841   AATAAGATCT  GGTACGAGCA  TCGGCTCATT  GACGACATGG  TGGCTCAGGT  GCTCAAGTCT  900
901   TCCGGTGGCT  TTGTGTGGGC  CTGCAAGAAC  TATGACGGAG  ATGTACAGTC  TGACATCCTG  960
961   GCTCAAGGAT  TTGGCTCCCT  TGGCCTGATG  ACATCTGTGC  TGGTCTGCCC  TGACGGGAAG  1020
1021  ACCATTGAAG  CTGAGGCTGC  TCACGGGACA  GTCACCCGCC  ACTACCGAGA  ACACCAGAAG  1080
1081  GGCCGGCCCA  CCAGTACCAA  CCCTATTGCC  AGCATCTTTG  CCTGGACACG  GGGTCTGGAG  1140
1141  CATCGAGGGA  AGCTGGATGG  GAACCAGGAC  CTCATCAGGT  TTGCACAGAC  TCTGGAGAAG  1200
1201  GTGTGCGTGC  AGACTGTGGA  GAGCGGAGCT  ATGACCAAGG  ACCTGGCTGG  CTGCATCCAT  1260
1261  GGCCTCAGCA  ATGTGAAGCT  GAATGAGCAC  TTCCTGAACA  CCACAGACTT  CCTGGACACC  1320
1321  ATTAAGAGCA  ACCTGGACAG  AGCTCTGGGC  AAGCAGTAG  1359

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Direct protein sequencing
Glyoxylate bypass
Magnesium
Manganese
Metal-binding
Mitochondrion
NADP
Oxidoreductase
Reference proteome
Transit peptide
Tricarboxylic acid cycle

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Mitochondrion
Cellular Component
Peroxisome
Molecular Function
Isocitrate dehydrogenase (NADP+) activity
Molecular Function
Magnesium ion binding
Molecular Function
NAD binding
Molecular Function
Protein homodimerization activity
Biological Process
2-oxoglutarate metabolic process
Biological Process
Glyoxylate cycle
Biological Process
Isocitrate metabolic process
Biological Process
NADP biosynthetic process
Biological Process
NADP metabolic process
Biological Process
Negative regulation of glial cell migration
Biological Process
Negative regulation of glial cell proliferation
Biological Process
Negative regulation of matrix metallopeptidase secretion
Biological Process
Tricarboxylic acid cycle

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-4480Mus musculus98.890.0 939
LLPS-Mam-3410Macaca mulatta97.250.0 824
LLPS-Fud-2394Fukomys damarensis97.090.0 845
LLPS-Mea-2525Mesocricetus auratus96.90.0 924
LLPS-Urm-3144Ursus maritimus96.890.0 725
LLPS-Caf-2123Canis familiaris96.370.0 844
LLPS-Loa-1811Loxodonta africana95.880.0 837
LLPS-Tut-1848Tursiops truncatus95.880.0 841
LLPS-Aim-4259Ailuropoda melanoleuca95.870.0 837
LLPS-Sah-0715Sarcophilus harrisii95.640.0 838
LLPS-Pap-1106Pan paniscus95.360.0 866
LLPS-Cas-2948Carlito syrichta95.350.0 908
LLPS-Orc-2336Oryctolagus cuniculus95.130.0 906
LLPS-Ict-0540Ictidomys tridecemlineatus95.130.0 907
LLPS-Pat-2155Pan troglodytes94.910.0 907
LLPS-Rhb-4312Rhinopithecus bieti94.910.0 907
LLPS-Gog-3800Gorilla gorilla94.910.0 907
LLPS-Man-1676Macaca nemestrina94.690.0 905
LLPS-Hos-0643Homo sapiens94.690.0 905
LLPS-Cea-1367Cercocebus atys94.690.0 905
LLPS-Chs-1107Chlorocebus sabaeus94.690.0 905
LLPS-Paa-1273Papio anubis94.690.0 905
LLPS-Fec-3358Felis catus94.680.0 899
LLPS-Poa-0590Pongo abelii94.470.0 906
LLPS-Eqc-4335Equus caballus94.470.0 901
LLPS-Sus-4632Sus scrofa94.470.0 902
LLPS-Maf-1727Macaca fascicularis94.470.0 904
LLPS-Bot-4096Bos taurus94.470.0 902
LLPS-Nol-3714Nomascus leucogenys94.250.0 902
LLPS-Mup-0441Mustela putorius furo94.220.0 893
LLPS-Otg-2869Otolemur garnettii94.030.0 898
LLPS-Caj-1238Callithrix jacchus94.030.0 898
LLPS-Cap-4581Cavia porcellus93.580.0 890
LLPS-Fia-0857Ficedula albicollis93.00.0 790
LLPS-Mal-3639Mandrillus leucophaeus92.920.0 846
LLPS-Anc-0766Anolis carolinensis91.760.0 829
LLPS-Meg-0508Meleagris gallopavo91.540.0 652
LLPS-Dio-3628Dipodomys ordii91.350.0 845
LLPS-Lac-0308Latimeria chalumnae89.640.0 678
LLPS-Aon-3269Aotus nancymaae89.550.0 874
LLPS-Mod-2712Monodelphis domestica88.320.0 846
LLPS-Gaga-0569Gallus gallus88.170.0 833
LLPS-Myl-3809Myotis lucifugus87.280.0 827
LLPS-Xet-2971Xenopus tropicalis85.490.0 813
LLPS-Leo-1022Lepisosteus oculatus85.180.0 811
LLPS-Orn-0156Oreochromis niloticus84.330.0 802
LLPS-Ten-3075Tetraodon nigroviridis84.260.0 807
LLPS-Tar-0733Takifugu rubripes84.260.0 803
LLPS-Scf-3927Scleropages formosus84.110.0 803
LLPS-Pof-0365Poecilia formosa83.890.0 801
LLPS-Xim-1387Xiphophorus maculatus83.440.0 796
LLPS-Asm-3271Astyanax mexicanus83.070.0 789
LLPS-Gaa-2351Gasterosteus aculeatus82.960.0 787
LLPS-Orl-2856Oryzias latipes82.780.0 795
LLPS-Ora-3461Ornithorhynchus anatinus81.540.0 749
LLPS-Scm-2244Scophthalmus maximus80.440.0 778
LLPS-Icp-0242Ictalurus punctatus77.180.0 771
LLPS-Cis-0102Ciona savignyi77.160.0 687
LLPS-Cii-0411Ciona intestinalis76.630.0 681
LLPS-Mua-1677Musa acuminata71.50.0 597
LLPS-Asf-1316Aspergillus flavus70.670.0 558
LLPS-Sol-2369Solanum lycopersicum70.30.0 599
LLPS-Abg-1928Absidia glauca70.120.0 605
LLPS-Sem-2460Selaginella moellendorffii70.020.0 599
LLPS-Zem-2436Zea mays69.90.0 592
LLPS-Pot-1248Populus trichocarpa69.830.0 598
LLPS-Nia-0951Nicotiana attenuata69.830.0 601
LLPS-Hea-0996Helianthus annuus69.730.0 600
LLPS-Php-0116Physcomitrella patens69.510.0 589
LLPS-Aso-1278Aspergillus oryzae69.50.0 546
LLPS-Cae-2008Caenorhabditis elegans69.430.0 613
LLPS-Sob-0922Sorghum bicolor69.420.0 591
LLPS-Sei-0654Setaria italica69.420.0 592
LLPS-Bro-1492Brassica oleracea69.360.0 585
LLPS-Orgl-0801Oryza glumaepatula69.340.0 593
LLPS-Prp-0869Prunus persica69.310.0 598
LLPS-Brn-1369Brassica napus69.290.0 598
LLPS-Dac-0559Daucus carota69.250.0 597
LLPS-Met-0759Medicago truncatula69.210.0 594
LLPS-Ors-1098Oryza sativa69.170.0 593
LLPS-Orr-0068Oryza rufipogon69.170.0 593
LLPS-Orb-1355Oryza barthii69.10.0 592
LLPS-Sot-0130Solanum tuberosum69.080.0 602
LLPS-Orm-1255Oryza meridionalis69.020.0 585
LLPS-Orbr-0429Oryza brachyantha68.930.0 592
LLPS-Org-1330Oryza glaberrima68.930.0 587
LLPS-Ori-0994Oryza indica68.930.0 587
LLPS-Orni-1202Oryza nivara68.930.0 587
LLPS-Gor-0915Gossypium raimondii68.860.0 590
LLPS-Lep-2108Leersia perrieri68.860.0 585
LLPS-Coc-0574Corchorus capsularis68.840.0 598
LLPS-Amt-0771Amborella trichopoda68.80.0 584
LLPS-Thc-2314Theobroma cacao68.80.0 590
LLPS-Orp-0216Oryza punctata68.780.0 586
LLPS-Via-0664Vigna angularis68.690.0 601
LLPS-Art-2459Arabidopsis thaliana68.630.0 598
LLPS-Phv-1039Phaseolus vulgaris68.630.0 589
LLPS-Arl-1135Arabidopsis lyrata68.630.0 597
LLPS-Mae-1858Manihot esculenta68.450.0 597
LLPS-Glm-2375Glycine max68.450.0 595
LLPS-Vir-0897Vigna radiata68.450.0 590
LLPS-Brr-1548Brassica rapa68.280.0 583
LLPS-Cus-0461Cucumis sativus68.240.0 590
LLPS-Viv-2447Vitis vinifera68.120.0 598
LLPS-Chr-1711Chlamydomonas reinhardtii67.890.0 607
LLPS-Hov-0561Hordeum vulgare67.880.0 584
LLPS-Tra-2939Triticum aestivum67.880.0 581
LLPS-Dar-3474Danio rerio67.820.0 590
LLPS-Asn-0762Aspergillus nidulans67.240.0 561
LLPS-Blg-1556Blumeria graminis67.00.0 568
LLPS-Brd-0694Brachypodium distachyon66.830.0 571
LLPS-Cogr-0254Colletotrichum graminicola66.340.0 566
LLPS-Yal-0857Yarrowia lipolytica66.340.0 563
LLPS-Asfu-1413Aspergillus fumigatus66.010.0 560
LLPS-Miv-0522Microbotryum violaceum65.850.0 560
LLPS-Trv-0903Trichoderma virens65.850.0 565
LLPS-Tru-0011Triticum urartu65.80.0 572
LLPS-Scs-0130Sclerotinia sclerotiorum65.550.0 563
LLPS-Coo-1113Colletotrichum orbiculare65.540.0 565
LLPS-Asc-1674Aspergillus clavatus65.530.0 551
LLPS-Ved-0383Verticillium dahliae65.390.0 561
LLPS-Gag-0022Gaeumannomyces graminis65.370.0 558
LLPS-Drm-2041Drosophila melanogaster65.350.0 565
LLPS-Pytr-0904Pyrenophora triticirepentis65.120.0 551
LLPS-Pyt-0249Pyrenophora teres65.120.0 551
LLPS-Nef-1424Neosartorya fischeri65.040.0 548
LLPS-Ast-1386Aspergillus terreus64.954e-168 489
LLPS-Mel-0810Melampsora laricipopulina64.830.0 521
LLPS-Usm-0378Ustilago maydis64.480.0 573
LLPS-Kop-0353Komagataella pastoris64.390.0 555
LLPS-Scp-1427Schizosaccharomyces pombe64.30.0 564
LLPS-Asg-1267Ashbya gossypii64.160.0 559
LLPS-Sac-1510Saccharomyces cerevisiae64.130.0 546
LLPS-Fuo-0792Fusarium oxysporum63.950.0 573
LLPS-Fuv-1123Fusarium verticillioides63.950.0 573
LLPS-Spr-0350Sporisorium reilianum63.530.0 570
LLPS-Dos-0038Dothistroma septosporum63.440.0 558
LLPS-Tum-1230Tuber melanosporum63.410.0 546
LLPS-Zyt-0366Zymoseptoria tritici63.210.0 552
LLPS-Mao-0355Magnaporthe oryzae62.980.0 549
LLPS-Put-1186Puccinia triticina62.650.0 525
LLPS-Scj-1583Schizosaccharomyces japonicus62.440.0 569
LLPS-Map-1037Magnaporthe poae62.410.0 561
LLPS-Scc-0485Schizosaccharomyces cryophilus62.290.0 537
LLPS-Fus-0022Fusarium solani62.110.0 561
LLPS-Lem-1010Leptosphaeria maculans60.930.0 553
LLPS-Gas-0858Galdieria sulphuraria60.470.0 541
LLPS-Chc-0474Chondrus crispus60.16e-178 513
LLPS-Phn-1175Phaeosphaeria nodorum59.313e-164 475
LLPS-Cym-0162Cyanidioschyzon merolae58.640.0 529