LLPS-Ran-4353
Pdcd4

▼ OVERVIEW

Status: Unreviewed
Protein Name: Programmed cell death protein 4; Death up-regulated gene protein
Gene Name: Pdcd4, Dug
Ensembl Gene: ENSRNOG00000014779.5
Ensembl Protein: ENSRNOP00000020155.2
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDVENEQILN  VNPTDPDNLS  DSLFSGDEEN  AGTEEIKNEI  NGNWISASTI  NEARINAKAK  60
61    RRLRKNSSRD  SGRGDSVSDN  GSEAVRSGVA  VPTSPKGRLL  DRRSRSGKGR  GLPKKGGAGG  120
121   KGVWGTPGQV  YDVEEVDVKD  PNYDDDQENC  VYETVVLPLD  ETAFEKTLTP  IIQEYFEHGD  180
181   TNEVAEMLRD  LNLGEMKSGV  PVLAVSLALE  GKASHREMTS  KLLSDLCGTV  MSTNDVEKSF  240
241   DKLLKDLPEL  ALDTPRAPQL  VGQFIARAVG  DGILCNTYID  SYKGTVDCVQ  ARAALDKATV  300
301   LLSMSKGGKR  KDSVWGSGGG  QQPVNHLVKE  IDMLLKEYLL  SGDMSEAEHC  LKELEVPHFH  360
361   HELVYEAIVM  VLESTGESAF  KMMLDLLKSL  WKSSTITIDQ  MKRGYERIYN  EIPDINLDVP  420
421   HSYSVLERFV  EECFQAGIIS  KQLRDLCPSR  GRKRFVSEGD  GGRLKPESY  469
Nucleotide CDS Sequence (FASTA)
1     ATGGATGTAG  AAAACGAGCA  GATACTGAAT  GTGAACCCCA  CTGACCCTGA  CAATTTAAGT  60
61    GACTCTCTCT  TTTCTGGAGA  TGAAGAAAAT  GCTGGCACTG  AGGAAATAAA  GAATGAAATA  120
121   AATGGAAATT  GGATCTCCGC  ATCTACTATT  AATGAAGCTA  GAATTAATGC  TAAAGCAAAA  180
181   AGACGACTGC  GGAAAAATTC  ATCCCGGGAC  TCTGGCCGAG  GCGATTCAGT  CAGTGATAAT  240
241   GGAAGTGAAG  CAGTTAGAAG  TGGAGTAGCT  GTGCCCACCA  GTCCAAAAGG  AAGGTTGCTA  300
301   GATAGGCGGT  CCAGATCTGG  GAAAGGAAGG  GGGCTGCCAA  AGAAAGGTGG  TGCAGGAGGC  360
361   AAGGGTGTCT  GGGGCACACC  TGGACAGGTA  TATGATGTGG  AGGAGGTGGA  TGTGAAAGAT  420
421   CCAAACTATG  ATGATGACCA  GGAGAACTGT  GTTTATGAGA  CTGTGGTTCT  GCCCCTGGAT  480
481   GAGACGGCGT  TTGAGAAGAC  GTTAACACCC  ATCATACAGG  AGTACTTTGA  GCACGGAGAT  540
541   ACGAACGAAG  TCGCGGAGAT  GTTAAGGGAT  TTGAACCTTG  GGGAGATGAA  GAGTGGTGTG  600
601   CCCGTGTTGG  CAGTGTCCTT  AGCCTTGGAG  GGGAAAGCCA  GTCACCGGGA  GATGACTTCC  660
661   AAGCTGCTTT  CTGACCTTTG  CGGGACAGTG  ATGAGCACAA  ATGACGTGGA  AAAGTCATTT  720
721   GACAAGTTGT  TGAAGGATCT  CCCCGAGCTA  GCCTTGGACA  CTCCGAGAGC  ACCACAGTTG  780
781   GTGGGCCAGT  TTATTGCTAG  AGCTGTTGGA  GATGGGATCT  TGTGTAACAC  CTACATCGAT  840
841   AGCTACAAAG  GCACTGTGGA  CTGCGTCCAG  GCCAGGGCTG  CTTTGGACAA  GGCTACTGTG  900
901   CTCCTGAGTA  TGTCTAAAGG  TGGAAAGCGT  AAGGATAGTG  TGTGGGGATC  CGGAGGAGGG  960
961   CAGCAGCCTG  TCAATCACCT  TGTTAAAGAG  ATCGATATGC  TGCTTAAAGA  GTATTTGCTC  1020
1021  TCTGGAGATA  TGTCTGAAGC  TGAGCACTGC  CTTAAGGAAC  TGGAAGTACC  GCATTTCCAC  1080
1081  CACGAGCTGG  TATATGAGGC  CATTGTAATG  GTTTTAGAGT  CAACTGGAGA  AAGTGCATTC  1140
1141  AAGATGATGT  TAGATTTATT  AAAATCCTTG  TGGAAGTCTT  CTACTATTAC  CATAGACCAA  1200
1201  ATGAAAAGAG  GTTATGAGAG  AATTTATAAT  GAAATTCCGG  ATATTAATCT  GGATGTCCCA  1260
1261  CACTCATACT  CTGTGCTTGA  GAGATTTGTG  GAGGAATGTT  TTCAGGCTGG  AATCATTTCC  1320
1321  AAACAACTCC  GAGATCTTTG  TCCATCAAGG  GGAAGAAAGC  GTTTTGTAAG  TGAAGGAGAT  1380
1381  GGAGGTCGTC  TTAAACCTGA  GAGCTACTGA  1410

▼ KEYWORD

ID
Family
Acetylation
Alternative splicing
Apoptosis
Complete proteome
Cytoplasm
Nucleus
Phosphoprotein
Reference proteome
Repeat
RNA-binding
Tumor suppressor
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Nucleus
Molecular Function
RNA binding
Biological Process
Apoptotic process
Biological Process
BMP signaling pathway
Biological Process
Cell aging
Biological Process
Cellular response to lipopolysaccharide
Biological Process
Epithelial to mesenchymal transition involved in cardiac fibroblast development
Biological Process
Negative regulation of apoptotic process
Biological Process
Negative regulation of cytokine production involved in inflammatory response
Biological Process
Negative regulation of JUN kinase activity
Biological Process
Negative regulation of myofibroblast differentiation
Biological Process
Negative regulation of transcription, DNA-templated
Biological Process
Negative regulation of vascular smooth muscle cell differentiation
Biological Process
Negative regulation of vascular smooth muscle cell proliferation
Biological Process
Positive regulation of endothelial cell apoptotic process
Biological Process
Positive regulation of inflammatory response
Biological Process
Positive regulation of NIK/NF-kappaB signaling
Biological Process
Positive regulation of smooth muscle cell apoptotic process
Biological Process
Positive regulation of vascular associated smooth muscle cell apoptotic process
Biological Process
Regulation of protein metabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-0801Mus musculus99.150.0 846
LLPS-Dio-1628Dipodomys ordii98.510.0 841
LLPS-Fec-4783Felis catus98.080.0 838
LLPS-Mea-2992Mesocricetus auratus98.080.0 838
LLPS-Mup-0498Mustela putorius furo98.080.0 837
LLPS-Eqc-1141Equus caballus98.020.0 808
LLPS-Ict-3685Ictidomys tridecemlineatus97.870.0 837
LLPS-Cas-3717Carlito syrichta97.870.0 833
LLPS-Caf-4530Canis familiaris97.660.0 832
LLPS-Urm-3282Ursus maritimus97.650.0 833
LLPS-Otg-2442Otolemur garnettii97.440.0 832
LLPS-Pap-3879Pan paniscus97.230.0 830
LLPS-Pat-1489Pan troglodytes97.230.0 830
LLPS-Orc-2343Oryctolagus cuniculus97.230.0 831
LLPS-Gog-0930Gorilla gorilla97.230.0 829
LLPS-Aim-2080Ailuropoda melanoleuca97.020.0 827
LLPS-Bot-3671Bos taurus97.010.0 830
LLPS-Myl-2602Myotis lucifugus97.010.0 829
LLPS-Hos-3828Homo sapiens96.80.0 830
LLPS-Sus-4211Sus scrofa96.80.0 828
LLPS-Ova-3538Ovis aries96.80.0 827
LLPS-Cea-2234Cercocebus atys96.380.0 825
LLPS-Aon-3993Aotus nancymaae96.380.0 825
LLPS-Poa-3723Pongo abelii96.160.0 817
LLPS-Chs-2063Chlorocebus sabaeus96.160.0 822
LLPS-Caj-3019Callithrix jacchus96.160.0 822
LLPS-Fud-0288Fukomys damarensis95.950.0 822
LLPS-Mam-3528Macaca mulatta95.460.0 798
LLPS-Nol-4455Nomascus leucogenys95.460.0 795
LLPS-Paa-3955Papio anubis95.460.0 799
LLPS-Mal-3962Mandrillus leucophaeus95.460.0 799
LLPS-Man-2265Macaca nemestrina95.430.0 795
LLPS-Maf-0837Macaca fascicularis95.430.0 795
LLPS-Cap-1711Cavia porcellus95.310.0 815
LLPS-Mod-3659Monodelphis domestica94.880.0 813
LLPS-Sah-1964Sarcophilus harrisii94.880.0 813
LLPS-Rhb-4554Rhinopithecus bieti94.210.0 792
LLPS-Ora-0937Ornithorhynchus anatinus92.750.0 797
LLPS-Loa-2885Loxodonta africana89.810.0 747
LLPS-Pes-0037Pelodiscus sinensis86.350.0 720
LLPS-Anp-2784Anas platyrhynchos85.50.0 721
LLPS-Fia-1126Ficedula albicollis85.290.0 712
LLPS-Tag-1332Taeniopygia guttata85.070.0 712
LLPS-Anc-0272Anolis carolinensis84.650.0 720
LLPS-Gaga-3889Gallus gallus84.650.0 718
LLPS-Meg-3038Meleagris gallopavo84.220.0 712
LLPS-Xet-1249Xenopus tropicalis73.190.0 607
LLPS-Leo-0275Lepisosteus oculatus72.770.0 603
LLPS-Lac-2491Latimeria chalumnae72.490.0 604
LLPS-Scf-3007Scleropages formosus70.630.0 579
LLPS-Asm-3156Astyanax mexicanus70.340.0 567
LLPS-Dar-4184Danio rerio70.130.0 577
LLPS-Icp-3080Ictalurus punctatus68.640.0 551
LLPS-Orn-2565Oreochromis niloticus68.490.0 558
LLPS-Pof-2161Poecilia formosa67.780.0 528
LLPS-Orl-3849Oryzias latipes67.251e-164 479
LLPS-Scm-3401Scophthalmus maximus66.950.0 540
LLPS-Gaa-0971Gasterosteus aculeatus66.744e-180 520
LLPS-Tar-2980Takifugu rubripes65.330.0 528
LLPS-Ten-3386Tetraodon nigroviridis64.99e-176 509
LLPS-Xim-0897Xiphophorus maculatus63.737e-169 492
LLPS-Cii-2199Ciona intestinalis44.414e-84 273
LLPS-Drm-2019Drosophila melanogaster41.952e-82 270
LLPS-Cis-2071Ciona savignyi41.762e-82 269
LLPS-Via-1892Vigna angularis34.642e-38 152
LLPS-Vir-1876Vigna radiata34.642e-38 152
LLPS-Phv-1438Phaseolus vulgaris34.343e-38 152
LLPS-Sei-1444Setaria italica34.062e-32 135
LLPS-Sol-1136Solanum lycopersicum33.722e-32 135
LLPS-Sob-1741Sorghum bicolor33.71e-32 135
LLPS-Orbr-0163Oryza brachyantha33.71e-32 135
LLPS-Thc-2180Theobroma cacao33.664e-35 142
LLPS-Viv-0163Vitis vinifera33.448e-37 147
LLPS-Tru-1224Triticum urartu33.332e-31 131
LLPS-Hea-0247Helianthus annuus33.335e-36 145
LLPS-Glm-0865Glycine max33.235e-36 145
LLPS-Php-1996Physcomitrella patens33.238e-38 150
LLPS-Met-2157Medicago truncatula33.132e-32 135
LLPS-Gor-2627Gossypium raimondii33.126e-36 145
LLPS-Nia-2624Nicotiana attenuata33.128e-38 150
LLPS-Orp-2404Oryza punctata32.971e-32 135
LLPS-Orm-1009Oryza meridionalis32.972e-32 135
LLPS-Lep-0563Leersia perrieri32.976e-32 133
LLPS-Brd-0810Brachypodium distachyon32.973e-31 131
LLPS-Cus-0623Cucumis sativus32.821e-34 141
LLPS-Pot-2231Populus trichocarpa32.812e-35 144
LLPS-Org-1896Oryza glaberrima32.813e-38 152
LLPS-Coc-1389Corchorus capsularis32.799e-34 139
LLPS-Ors-1969Oryza sativa32.612e-32 134
LLPS-Orr-1241Oryza rufipogon32.615e-38 151
LLPS-Zem-1181Zea mays32.612e-31 131
LLPS-Ori-1400Oryza indica32.612e-32 134
LLPS-Orb-1723Oryza barthii32.614e-38 151
LLPS-Orni-1797Oryza nivara32.612e-32 135
LLPS-Mua-1772Musa acuminata32.613e-36 144
LLPS-Orgl-1079Oryza glumaepatula32.615e-38 151
LLPS-Hov-2030Hordeum vulgare32.593e-30 128
LLPS-Prp-0133Prunus persica32.589e-34 139
LLPS-Tra-0747Triticum aestivum32.52e-39 155
LLPS-Bro-2874Brassica oleracea32.392e-29 125
LLPS-Mae-2080Manihot esculenta32.324e-32 134
LLPS-Amt-0164Amborella trichopoda32.277e-32 133
LLPS-Sem-1095Selaginella moellendorffii32.263e-39 154
LLPS-Brr-0026Brassica rapa32.047e-29 124
LLPS-Brn-2563Brassica napus32.041e-28 123
LLPS-Dac-2381Daucus carota31.888e-30 127
LLPS-Art-2867Arabidopsis thaliana31.693e-28 122
LLPS-Arl-1294Arabidopsis lyrata31.413e-28 122
LLPS-Chr-1522Chlamydomonas reinhardtii31.215e-34 140
LLPS-Sot-1122Solanum tuberosum29.63e-26 116
LLPS-Osl-1203Ostreococcus lucimarinus27.98e-30 124