LLPS-Mum-0801
Pdcd4

▼ OVERVIEW

Status: Reviewed
Protein Name: Programmed cell death protein 4; Protein MA-3; Topoisomerase-inhibitor suppressed protein
Gene Name: Pdcd4, Ma3, Tis
Ensembl Gene: ENSMUSG00000024975.12
Ensembl Protein: ENSMUSP00000133135.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Regulator
PDB: 2KZT (A, B) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Stress granule
"...Ectopic expression of truncated Pdcd4 that depleted specific RNA-binding motif significantly disrupted the SG formation, suggesting the direct involvement of Pdcd4 in ox-LDL-induced SGs through its RNA-binding activity. Additionally, Pdcd4 deficiency drove AKT activation and suppression of eIF2α phosphorylation, thereby contributing to the resistance to ox-LDL or HFD-induced SG formation. Collectively, our data suggest that Pdcd4 as a crucial regulator in SGs induced by ox-LDL or HFD maybe a potential target for mitigating SG-associated stress responses in obesity and related diseases."
C57BL/627454120

▼ FUNCTION

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDIENEQTLN  VNPTDPDNLS  DSLFSGDEEN  AGTEEIKNEI  NGNWISASTI  NEARINAKAK  60
61    RRLRKNSSRD  SGRGDSVSDN  GSEAVRSGVA  VPTSPKGRLL  DRRSRSGKGR  GLPKKGGAGG  120
121   KGVWGTPGQV  YDVEEVDVKD  PNYDDDQENC  VYETVVLPLD  ETAFEKTLTP  IIQEYFEHGD  180
181   TNEVAEMLRD  LNLGEMKSGV  PVLAVSLALE  GKASHREMTS  KLLSDLCGTV  MSTNDVEKSF  240
241   DKLLKDLPEL  ALDTPRAPQL  VGQFIARAVG  DGILCNTYID  SYKGTVDCVQ  ARAALDKATV  300
301   LLSMSKGGKR  KDSVWGSGGG  QQPVNHLVKE  IDMLLKEYLL  SGDISEAEHC  LKELEVPHFH  360
361   HELVYEAIVM  VLESTGESAF  KMILDLLKSL  WKSSTITIDQ  MKRGYERIYN  EIPDINLDVP  420
421   HSYSVLERFV  EECFQAGIIS  KQLRDLCPSR  GRKRFVSEGD  GGRLKPESY  469
Nucleotide CDS Sequence (FASTA)
1     ATGGATATAG  AAAATGAGCA  GACACTGAAT  GTGAACCCCA  CTGACCCTGA  CAATTTAAGC  60
61    GACTCTCTCT  TTTCTGGAGA  TGAAGAAAAT  GCTGGCACTG  AAGAAATAAA  GAATGAAATA  120
121   AATGGAAATT  GGATTTCCGC  ATCTACTATT  AATGAAGCTA  GAATCAATGC  AAAAGCCAAA  180
181   AGACGACTGC  GGAAAAATTC  ATCCCGGGAC  TCTGGCCGAG  GAGACTCAGT  CAGTGACAAT  240
241   GGAAGTGAAG  CGGTTAGAAG  TGGAGTTGCT  GTGCCCACCA  GTCCAAAAGG  AAGGTTGCTA  300
301   GATAGGCGGT  CCAGATCTGG  GAAAGGAAGG  GGGCTGCCAA  AGAAAGGTGG  TGCAGGCGGC  360
361   AAGGGTGTCT  GGGGCACACC  TGGACAGGTG  TATGATGTGG  AAGAGGTGGA  TGTGAAAGAT  420
421   CCAAACTATG  ATGACGACCA  GGAGAACTGT  GTTTATGAAA  CTGTAGTTTT  GCCCCTGGAT  480
481   GAGACCGCAT  TTGAGAAGAC  TCTAACACCA  ATTATACAGG  AATACTTTGA  GCATGGAGAT  540
541   ACAAATGAAG  TTGCGGAGAT  GTTAAGAGAC  TTAAACCTTG  GGGAGATGAA  GAGTGGCGTG  600
601   CCGGTGTTGG  CAGTGTCCTT  AGCCTTGGAG  GGGAAGGCCA  GCCACCGGGA  GATGACATCC  660
661   AAGCTGCTTT  CTGACCTTTG  CGGGACGGTG  ATGAGCACAA  ATGACGTGGA  AAAGTCATTT  720
721   GACAAGTTGC  TGAAGGATCT  CCCTGAGCTA  GCCTTGGACA  CTCCTAGGGC  ACCGCAGTTG  780
781   GTGGGCCAGT  TTATTGCTAG  AGCTGTTGGA  GATGGAATCT  TATGTAATAC  CTATATCGAT  840
841   AGTTACAAAG  GAACTGTAGA  TTGTGTACAG  GCTCGAGCTG  CTCTGGATAA  GGCTACTGTG  900
901   CTCCTGAGTA  TGTCCAAAGG  CGGGAAGCGG  AAAGACAGTG  TGTGGGGATC  TGGAGGCGGG  960
961   CAACAGCCTG  TCAATCACCT  TGTTAAAGAG  ATTGATATGC  TGCTTAAAGA  GTATTTACTC  1020
1021  TCTGGAGATA  TATCTGAAGC  TGAACACTGC  CTTAAGGAAC  TGGAAGTACC  TCATTTTCAC  1080
1081  CACGAGCTTG  TATATGAAGC  CATTGTAATG  GTTTTAGAGT  CAACTGGAGA  AAGTGCATTC  1140
1141  AAGATGATCT  TAGATTTATT  AAAATCCTTG  TGGAAGTCTT  CTACTATTAC  CATAGACCAA  1200
1201  ATGAAAAGAG  GCTATGAGAG  AATTTACAAT  GAAATCCCAG  ACATTAATCT  GGATGTCCCA  1260
1261  CACTCATACT  CTGTTCTTGA  GAGATTTGTG  GAGGAATGTT  TTCAGGCTGG  AATAATTTCC  1320
1321  AAACAACTCC  GTGATCTTTG  TCCATCAAGG  GGAAGAAAGC  GTTTTGTAAG  TGAAGGAGAT  1380
1381  GGAGGCCGTC  TTAAACCTGA  GAGCTACTGA  1410

▼ KEYWORD

ID
Family
3D-structure
Acetylation
Apoptosis
Complete proteome
Cytoplasm
Nucleus
Phosphoprotein
Reference proteome
Repeat
RNA-binding
Tumor suppressor
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Cytosol
Cellular Component
Nucleus
Molecular Function
RNA binding
Biological Process
Apoptotic process
Biological Process
BMP signaling pathway
Biological Process
Cell aging
Biological Process
Cellular response to lipopolysaccharide
Biological Process
Epithelial to mesenchymal transition involved in cardiac fibroblast development
Biological Process
Negative regulation of apoptotic process
Biological Process
Negative regulation of cytokine production involved in inflammatory response
Biological Process
Negative regulation of JUN kinase activity
Biological Process
Negative regulation of myofibroblast differentiation
Biological Process
Negative regulation of transcription, DNA-templated
Biological Process
Negative regulation of vascular smooth muscle cell differentiation
Biological Process
Negative regulation of vascular smooth muscle cell proliferation
Biological Process
Positive regulation of endothelial cell apoptotic process
Biological Process
Positive regulation of inflammatory response
Biological Process
Positive regulation of NIK/NF-kappaB signaling
Biological Process
Positive regulation of smooth muscle cell apoptotic process
Biological Process
Positive regulation of vascular associated smooth muscle cell apoptotic process
Biological Process
Regulation of protein metabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ran-4353Rattus norvegicus99.150.0 845
LLPS-Dio-1628Dipodomys ordii98.510.0 840
LLPS-Eqc-1141Equus caballus98.460.0 810
LLPS-Fec-4783Felis catus98.080.0 838
LLPS-Mup-0498Mustela putorius furo98.080.0 837
LLPS-Mea-2992Mesocricetus auratus98.080.0 838
LLPS-Ict-3685Ictidomys tridecemlineatus97.870.0 836
LLPS-Cas-3717Carlito syrichta97.870.0 834
LLPS-Caf-4530Canis familiaris97.660.0 832
LLPS-Urm-3282Ursus maritimus97.650.0 832
LLPS-Otg-2442Otolemur garnettii97.440.0 832
LLPS-Pat-1489Pan troglodytes97.230.0 831
LLPS-Pap-3879Pan paniscus97.230.0 831
LLPS-Orc-2343Oryctolagus cuniculus97.230.0 831
LLPS-Gog-0930Gorilla gorilla97.230.0 828
LLPS-Aim-2080Ailuropoda melanoleuca97.020.0 827
LLPS-Myl-2602Myotis lucifugus97.010.0 829
LLPS-Hos-3828Homo sapiens96.80.0 830
LLPS-Ova-3538Ovis aries96.80.0 827
LLPS-Sus-4211Sus scrofa96.80.0 827
LLPS-Bot-3671Bos taurus96.590.0 827
LLPS-Aon-3993Aotus nancymaae96.380.0 824
LLPS-Fud-0288Fukomys damarensis96.380.0 823
LLPS-Poa-3723Pongo abelii96.160.0 817
LLPS-Chs-2063Chlorocebus sabaeus96.160.0 823
LLPS-Caj-3019Callithrix jacchus96.160.0 822
LLPS-Mam-3528Macaca mulatta96.10.0 799
LLPS-Nol-4455Nomascus leucogenys96.10.0 796
LLPS-Mal-3962Mandrillus leucophaeus96.10.0 800
LLPS-Paa-3955Papio anubis96.10.0 800
LLPS-Cea-2234Cercocebus atys95.950.0 822
LLPS-Man-2265Macaca nemestrina95.870.0 797
LLPS-Maf-0837Macaca fascicularis95.870.0 797
LLPS-Cap-1711Cavia porcellus95.740.0 815
LLPS-Mod-3659Monodelphis domestica94.880.0 813
LLPS-Sah-1964Sarcophilus harrisii94.880.0 813
LLPS-Rhb-4554Rhinopithecus bieti94.210.0 792
LLPS-Ora-0937Ornithorhynchus anatinus92.750.0 798
LLPS-Loa-2885Loxodonta africana89.810.0 747
LLPS-Pes-0037Pelodiscus sinensis85.930.0 718
LLPS-Anp-2784Anas platyrhynchos85.50.0 719
LLPS-Fia-1126Ficedula albicollis85.50.0 714
LLPS-Tag-1332Taeniopygia guttata85.290.0 714
LLPS-Gaga-3889Gallus gallus84.860.0 717
LLPS-Anc-0272Anolis carolinensis84.650.0 719
LLPS-Meg-3038Meleagris gallopavo83.80.0 709
LLPS-Xet-1249Xenopus tropicalis73.190.0 608
LLPS-Leo-0275Lepisosteus oculatus72.980.0 605
LLPS-Lac-2491Latimeria chalumnae72.490.0 604
LLPS-Scf-3007Scleropages formosus70.560.0 578
LLPS-Asm-3156Astyanax mexicanus70.550.0 568
LLPS-Dar-4184Danio rerio70.130.0 577
LLPS-Icp-3080Ictalurus punctatus68.860.0 552
LLPS-Orn-2565Oreochromis niloticus68.490.0 558
LLPS-Pof-2161Poecilia formosa67.780.0 528
LLPS-Orl-3849Oryzias latipes67.544e-165 481
LLPS-Scm-3401Scophthalmus maximus66.950.0 541
LLPS-Gaa-0971Gasterosteus aculeatus66.742e-180 521
LLPS-Tar-2980Takifugu rubripes66.450.0 529
LLPS-Ten-3386Tetraodon nigroviridis65.127e-176 509
LLPS-Xim-0897Xiphophorus maculatus63.737e-169 492
LLPS-Cii-2199Ciona intestinalis44.416e-84 273
LLPS-Cis-2071Ciona savignyi41.762e-82 268
LLPS-Drm-2019Drosophila melanogaster41.674e-82 270
LLPS-Via-1892Vigna angularis34.347e-38 150
LLPS-Vir-1876Vigna radiata34.349e-38 150
LLPS-Orbr-0163Oryza brachyantha34.062e-33 137
LLPS-Sei-1444Setaria italica34.061e-32 136
LLPS-Phv-1438Phaseolus vulgaris34.041e-37 150
LLPS-Viv-0163Vitis vinifera33.754e-37 148
LLPS-Sob-1741Sorghum bicolor33.71e-32 135
LLPS-Hea-0247Helianthus annuus33.672e-36 146
LLPS-Php-1996Physcomitrella patens33.554e-38 151
LLPS-Nia-2624Nicotiana attenuata33.443e-38 152
LLPS-Sol-1136Solanum lycopersicum33.442e-35 144
LLPS-Orm-1009Oryza meridionalis33.333e-33 137
LLPS-Orp-2404Oryza punctata33.333e-33 137
LLPS-Lep-0563Leersia perrieri33.331e-32 135
LLPS-Thc-2180Theobroma cacao33.332e-34 140
LLPS-Met-2157Medicago truncatula33.132e-32 135
LLPS-Cus-0623Cucumis sativus33.134e-35 142
LLPS-Coc-1389Corchorus capsularis33.124e-34 140
LLPS-Org-1896Oryza glaberrima33.129e-39 153
LLPS-Pot-2231Populus trichocarpa33.128e-36 145
LLPS-Tru-1224Triticum urartu33.029e-40 155
LLPS-Orr-1241Oryza rufipogon32.974e-33 137
LLPS-Ors-1969Oryza sativa32.974e-33 137
LLPS-Orgl-1079Oryza glumaepatula32.974e-33 137
LLPS-Brd-0810Brachypodium distachyon32.973e-31 131
LLPS-Ori-1400Oryza indica32.974e-33 137
LLPS-Orb-1723Oryza barthii32.974e-33 137
LLPS-Orni-1797Oryza nivara32.974e-33 137
LLPS-Glm-0865Glycine max32.932e-35 143
LLPS-Mua-1772Musa acuminata32.921e-36 145
LLPS-Prp-0133Prunus persica32.94e-34 139
LLPS-Gor-2627Gossypium raimondii32.812e-35 143
LLPS-Tra-0747Triticum aestivum32.818e-40 156
LLPS-Hov-2030Hordeum vulgare32.812e-39 155
LLPS-Mae-2080Manihot esculenta32.662e-32 135
LLPS-Zem-1181Zea mays32.611e-31 132
LLPS-Sem-1095Selaginella moellendorffii32.582e-39 154
LLPS-Bro-2874Brassica oleracea32.392e-29 125
LLPS-Brr-0026Brassica rapa32.047e-29 124
LLPS-Brn-2563Brassica napus32.041e-28 124
LLPS-Amt-0164Amborella trichopoda31.911e-31 132
LLPS-Dac-2381Daucus carota31.885e-30 127
LLPS-Art-2867Arabidopsis thaliana31.694e-28 122
LLPS-Arl-1294Arabidopsis lyrata31.413e-28 122
LLPS-Chr-1522Chlamydomonas reinhardtii31.212e-34 141
LLPS-Sot-1122Solanum tuberosum29.64e-26 115
LLPS-Osl-1203Ostreococcus lucimarinus28.212e-30 125