LLPS-Ran-3898
Ppip5k1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Gene Name: Ppip5k1, Hisppd2a, Vip1
Ensembl Gene: ENSRNOG00000014436.7
Ensembl Protein: ENSRNOP00000021562.5
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Client


▼ PROPERTY


▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MWSLTANEDE  DESATAHFFL  GAGDEGLGTC  GIGMRTGESD  SELLEDEEDE  VPPEPQIIVG  60
61    ICAMTKKSKS  KPMTQILERL  CRFDYLTVVI  LGEDVILNEP  VENWPPCHCL  ISFHSKGFPL  120
121   DKAVAYSKLR  NPFLINDLTM  QYYIQDRREV  YRILQEEGID  LPRYAVLNRD  PACPEECNLI  180
181   EGEDQVEVNG  AVFPKPFVEK  PVSAEDHNVY  IYYPSSAGGG  SQRLFRKIGS  RSSVYSPESS  240
241   VRKTGSYIYE  EFMPTDGTDV  KVYTVGPDYA  HAEARKSPAL  DGKVERDSEG  KEVRYPVMLT  300
301   AMEKLVARKV  CVAFKQTVCG  FDLLRANGHS  FVCDVNGFSF  VKNSMKYYDD  CAKILGNTIM  360
361   RELAPQFQIP  WSIPTEAEDI  PIVPTTSGTM  MELRCVIAII  RHGDRTPKQK  MKMEVTHPRF  420
421   FALFEKHGGY  KTGKLKLKRP  EQLQEVLDIT  RLLLAELEKE  PGAEIEEKTG  KLEQLKSVLE  480
481   MYGHFSGINR  KVQLTYYPHG  VKASSEGQDL  QREPPAPSLL  LVLKWGGELT  PDGRVQAEEL  540
541   GRAFRCMYPG  GQGDYAGFPG  CGLLRLHSTF  RHDLKIYASD  EGRVQMTAAA  FAKGLLALEG  600
601   ELTPILVQMV  KSANMNGLLD  SDSDSLSSCQ  HRVKARLHHI  LQQDAPFGPE  DYDQLAPTGS  660
661   TSLLNSMSVI  QNPVKVCDQV  FALIENLTHQ  IRERMQDPSS  VDLQLYHSET  LELMLQRWSK  720
721   LERDFRQKSG  RYDISKIPDI  YDCVKYDVQH  NGSLGLQGTA  ELLRLSKALA  DVVIPQEYGI  780
781   SREEKVEIAV  GFCLPLLRKI  LLDLQRTHED  ESVNKLHPLY  SRGVLSPGRH  VRTRLYFTSE  840
841   SHVHSLLSVF  RYGGLLDETK  DAQWQRALAY  LSAISELNYM  TQIVIMLYED  NTRDPLSEER  900
901   FHVELHFSPG  VKGVEEGSAP  AGCGFRPASS  ENEEMKTDPG  SIENLCPAKP  SDEPDRALQT  960
961   SPQPVEGTGL  PRRSPLIRNR  KAGSMEVLSE  TSSSRPGGYR  LFSSSRPPTE  MKQSGLGSQC  1020
1021  TGLFSTTVLG  GSSSAPNLQD  YARTHGKKLP  PAGLKHRDEL  LFVPAVKRFS  VSFAKHPTNG  1080
1081  FEGCSMVPTI  YPLETLHNAL  SLRQVSEFLT  KVCQRHTDAH  AQASAALFDS  MHNHQASDNP  1140
1141  FSPPRTLHSP  PLQLRHRSEK  PPWYSSGPSS  TVSSAGPSSP  TTVDGNSHFG  FSDQSSVNTQ  1200
1201  MIEEKQGLGL  LQETPGDGTP  EFHIELAEST  QSPQEPPVEI  SPPGSQDDTE  VNQTCQEVPD  1260
1261  TIQPCHDILE  EIGQPNQEVP  DISQLLLKNH  DTATNTCQPC  QASQLSKKVY  EEICQLCQDN  1320
1321  PEESNQLCQE  VSVELGRMVH  RFPVSIGSTT  QETLMEIGRP  TQEIPEEPCQ  EFSEKVGMLT  1380
1381  QKASAISELS  QDILETDNPS  QELSEETDLQ  AQEVSEEIDQ  EPEVVPEVVD  ELSNEDIS  1438
Nucleotide CDS Sequence (FASTA)
1     ATGTCGGTCC  CAAGCGCACT  CATGAAGCAG  CCGCCCATTC  AGTCTACGGC  TGGGGCCGTC  60
61    CCAGTTCGCA  ATGAGAAAGG  TGAGATCTCA  ATGGAAAAAG  TGAAGGTAAA  ACGTTATGTG  120
121   TCCGGAAAAA  GACCAGATTA  TGCCCCTATG  GAGTCCTCAG  ATGAAGAGGA  TGAAGAATTT  180
181   CAGTTCATTA  AGAAAGCTAA  GGAACAAGAA  GCAGAGCCTG  AGGAACAGGA  GGAGGATTCA  240
241   TCCAGTGACC  CCCGACTTCG  GCGGTTACAG  AACCGCATCA  GTGAAGATGT  GGAAGAGAGG  300
301   TTGGCTCGAC  ACAGAAAAAT  AGTGGAACCT  GAAGTAGTGG  GAGAAAGTGA  CTCAGAAGTA  360
361   GAAGGAGATG  CTTGGCGCCT  GGAACGAGAA  GATAGCAGTG  AGGAAGAGGA  GGAGGAAATC  420
421   GATGACGAAG  AAATAGAGCG  GCGCCGCGGC  ATGATGCGGC  AGCGAGCACA  GGAGAGGAAA  480
481   AATGAAGAGA  TGGAGGTCAT  GGAGGTGGAA  GATGAAGGAC  GCTCTGGGGA  GGAGTCCGAG  540
541   TCAGAGTCTG  AGTATGAGGA  GTACACAGAC  AGTGAAGATG  AAATGGAGCC  TCGACTTAAG  600
601   CCTGTCTTCA  TTCGAAAGAA  GGATCGTGTG  ACAGTTCAAG  AACGAGAAGC  TGAGGCATTG  660
661   AGACAGAAGG  AATTGGAGCA  GGAAGCAAAA  CGCATGGCTG  AGGAGCGGCG  CAAGTACACC  720
721   CTCAAGATTG  TAGAAGAAGA  GACCAAGAAA  GAGCTGGAGG  AGAACAAGCG  GTCCCTTGCC  780
781   GCCCTGGATG  CACTCAATAC  AGATGATGAA  AATGACGAGG  AGGAGTATGA  GGCGTGGAAA  840
841   GTCCGAGAGC  TCAAAAGAAT  CAAGCGGGAC  AGAGAGGACC  GAGAAGCGCT  TGAAAAGGAG  900
901   AAAGCAGAAA  TTGAACGCAT  GAGAAACCTG  ACTGAGGAAG  AAAGGCGGGC  TGAACTTCGG  960
961   GCAAATGGCA  AAGTCATTAC  CAACAAAGCT  GTTAAAGGCA  AATACAAGTT  TCTACAAAAG  1020
1021  TATTATCACC  GAGGTGCCTT  CTTCATGGAT  GAGGATGAAG  AAGTCTACAA  GAGAGATTTT  1080
1081  AGTGCACCTA  CTCTCGAGGA  CCATTTCAAT  AAAACCATTC  TTCCAAAAGT  CATGCAGGTC  1140
1141  AAGAATTTTG  GACGGTCTGG  TCGCACCAAG  TACACCCACC  TTGTGGATCA  AGATACCACT  1200
1201  TCTTTTGACT  CTGCATGGGG  CCAAGAGAGT  GCCCAGAACA  CAAAATTCTT  TAAACAAAAG  1260
1261  GCCGCAGGGG  TACGAGATGT  ATTTGAACGG  CCATCTGCCA  AGAAGAGGAA  AACCACCTAG  1320

▼ KEYWORD

ID
Family
ATP-binding
Cell membrane
Complete proteome
Cytoplasm
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Plasma membrane
Molecular Function
5-diphosphoinositol pentakisphosphate 3-kinase activity
Molecular Function
ATP binding
Molecular Function
Diphosphoinositol-pentakisphosphate kinase activity
Molecular Function
Inositol heptakisphosphate kinase activity
Molecular Function
Inositol hexakisphosphate 1-kinase activity
Molecular Function
Inositol hexakisphosphate 3-kinase activity
Molecular Function
Inositol hexakisphosphate 5-kinase activity
Molecular Function
Inositol hexakisphosphate kinase activity
Molecular Function
Inositol-1,3,4,5,6-pentakisphosphate kinase activity
Biological Process
Inositol metabolic process
Biological Process
Inositol phosphate biosynthetic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mup-0913Mustela putorius furo96.670.02057
LLPS-Dio-3369Dipodomys ordii96.420.01622
LLPS-Sus-4526Sus scrofa96.020.02042
LLPS-Mum-3442Mus musculus95.560.02628
LLPS-Bot-2999Bos taurus95.560.02033
LLPS-Mea-3611Mesocricetus auratus93.530.02576
LLPS-Gog-1786Gorilla gorilla91.950.02023
LLPS-Pat-4722Pan troglodytes89.650.02466
LLPS-Hos-0020Homo sapiens89.470.02460
LLPS-Fec-0523Felis catus88.960.02438
LLPS-Cas-1777Carlito syrichta88.930.02350
LLPS-Mal-4225Mandrillus leucophaeus88.840.02441
LLPS-Aim-1563Ailuropoda melanoleuca87.940.02389
LLPS-Poa-3618Pongo abelii87.910.01942
LLPS-Nol-3231Nomascus leucogenys87.730.02400
LLPS-Aon-2190Aotus nancymaae87.70.02402
LLPS-Ova-3415Ovis aries87.670.02400
LLPS-Otg-1233Otolemur garnettii87.20.02376
LLPS-Maf-2332Macaca fascicularis87.10.02368
LLPS-Caj-4172Callithrix jacchus87.070.02355
LLPS-Paa-2029Papio anubis86.760.02347
LLPS-Man-3749Macaca nemestrina86.540.02344
LLPS-Loa-3860Loxodonta africana86.40.02293
LLPS-Mam-3125Macaca mulatta86.30.02333
LLPS-Caf-3845Canis familiaris85.880.02421
LLPS-Fud-2254Fukomys damarensis85.650.02330
LLPS-Eqc-4631Equus caballus85.430.02421
LLPS-Ict-2951Ictidomys tridecemlineatus85.290.02388
LLPS-Cap-2676Cavia porcellus84.990.02323
LLPS-Orc-3951Oryctolagus cuniculus84.830.02365
LLPS-Myl-4093Myotis lucifugus84.290.02360
LLPS-Pes-1960Pelodiscus sinensis84.070.01841
LLPS-Rhb-2391Rhinopithecus bieti83.840.01793
LLPS-Mod-0570Monodelphis domestica82.30.02192
LLPS-Tag-2938Taeniopygia guttata81.180.01877
LLPS-Anp-3286Anas platyrhynchos81.160.01884
LLPS-Sah-3355Sarcophilus harrisii80.920.02155
LLPS-Urm-2469Ursus maritimus80.880.02222
LLPS-Cea-1529Cercocebus atys80.330.02122
LLPS-Orn-2231Oreochromis niloticus80.030.01763
LLPS-Ten-0414Tetraodon nigroviridis79.720.01748
LLPS-Dar-1834Danio rerio79.640.01767
LLPS-Asm-3217Astyanax mexicanus79.620.01644
LLPS-Leo-3206Lepisosteus oculatus78.410.01795
LLPS-Fia-3427Ficedula albicollis78.320.01830
LLPS-Anc-2791Anolis carolinensis78.220.01777
LLPS-Orl-3165Oryzias latipes77.960.01636
LLPS-Icp-4012Ictalurus punctatus77.550.01777
LLPS-Meg-0775Meleagris gallopavo77.520.01862
LLPS-Xim-1363Xiphophorus maculatus76.970.01632
LLPS-Scf-1154Scleropages formosus76.750.01791
LLPS-Gaga-1973Gallus gallus76.340.01838
LLPS-Pof-3742Poecilia formosa76.080.01655
LLPS-Tar-3201Takifugu rubripes75.560.01702
LLPS-Scm-2277Scophthalmus maximus73.890.01713
LLPS-Gaa-1277Gasterosteus aculeatus73.020.01611
LLPS-Lac-3410Latimeria chalumnae70.810.01614
LLPS-Chs-4011Chlorocebus sabaeus70.140.01491
LLPS-Cii-1916Ciona intestinalis62.420.01283
LLPS-Chr-0291Chlamydomonas reinhardtii58.628e-24 114
LLPS-Via-1572Vigna angularis56.238e-172 532
LLPS-Coc-1571Corchorus capsularis53.48e-135 429
LLPS-Gor-1129Gossypium raimondii48.513e-1379.3
LLPS-Orbr-1773Oryza brachyantha48.160.0 618
LLPS-Prp-1289Prunus persica48.020.0 658
LLPS-Dac-2322Daucus carota47.820.0 654
LLPS-Sei-1680Setaria italica46.260.0 729
LLPS-Zem-1347Zea mays46.250.0 705
LLPS-Sol-1785Solanum lycopersicum45.950.0 691
LLPS-Phv-2551Phaseolus vulgaris45.70.0 703
LLPS-Pot-1627Populus trichocarpa45.560.0 692
LLPS-Php-0573Physcomitrella patens45.450.0 713
LLPS-Chc-0772Chondrus crispus45.221e-54 199
LLPS-Bro-1729Brassica oleracea45.170.0 711
LLPS-Arl-2534Arabidopsis lyrata45.160.0 705
LLPS-Met-1367Medicago truncatula44.970.0 694
LLPS-Art-2741Arabidopsis thaliana44.720.0 701
LLPS-Brn-1081Brassica napus44.70.0 707
LLPS-Cus-1943Cucumis sativus44.460.0 692
LLPS-Scs-0947Sclerotinia sclerotiorum44.446e-84 308
LLPS-Sob-0827Sorghum bicolor44.130.0 689
LLPS-Brd-0593Brachypodium distachyon43.920.0 679
LLPS-Ast-1512Aspergillus terreus43.99e-78 286
LLPS-Brr-2502Brassica rapa43.670.0 683
LLPS-Thc-1462Theobroma cacao43.60.0 626
LLPS-Tra-2387Triticum aestivum43.570.0 665
LLPS-Hov-0738Hordeum vulgare43.250.0 684
LLPS-Vir-2128Vigna radiata43.080.0 644
LLPS-Mua-1032Musa acuminata42.998e-153 492
LLPS-Org-1708Oryza glaberrima42.940.0 672
LLPS-Sem-1627Selaginella moellendorffii42.270.0 613
LLPS-Orp-0000Oryza punctata41.490.0 635
LLPS-Lep-1965Leersia perrieri40.950.0 590
LLPS-Osl-0964Ostreococcus lucimarinus40.290.0 647
LLPS-Tum-0515Tuber melanosporum38.572e-99 353
LLPS-Crn-1025Cryptococcus neoformans38.192e-75 278
LLPS-Kop-1071Komagataella pastoris36.383e-111 384
LLPS-Sac-0946Saccharomyces cerevisiae36.145e-110 382
LLPS-Asg-1483Ashbya gossypii35.733e-108 377
LLPS-Abg-0109Absidia glauca34.383e-97 340
LLPS-Spr-1238Sporisorium reilianum33.882e-111 380
LLPS-Scj-0957Schizosaccharomyces japonicus33.876e-127 424
LLPS-Pug-1223Puccinia graminis33.75e-104 361
LLPS-Put-1114Puccinia triticina33.568e-102 355
LLPS-Phn-1530Phaeosphaeria nodorum33.334e-0862.8
LLPS-Scp-0564Schizosaccharomyces pombe33.261e-124 418
LLPS-Scc-1133Schizosaccharomyces cryophilus32.375e-125 419
LLPS-Miv-1071Microbotryum violaceum31.772e-117 399
LLPS-Mel-0310Melampsora laricipopulina31.51e-111 381