LLPS-Mel-0310
MELLADRAFT_44124
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase |
| Gene Name: | MELLADRAFT_44124 |
| Ensembl Gene: | MELLADRAFT_44124 |
| Ensembl Protein: | EGG04697 |
| Organism: | Melampsora laricipopulina |
| Taxa ID: | 747676 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | EGG04697 | EGG04697 |
| UniProt | F4RSG1, F4RSG1_MELLP | |
| GeneBank | GL883117 | EGG04697.1 |
| RefSeq | XM_007412074.1 | XP_007412136.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAPVPVPEAK PAEDITESDE ETHLIKIGVA AMDRKARSKP MRNILSRLVA TNRFECIIFG 60 61 DKVIMDEDVE HWPVCDFLIS FFSTGFPMDK AIRYVKLRKP ISINDLPLQK IFWDRRLVLA 120 121 VLDKIGVPTP ARLELSRDGG PRLDPEVASE LETRLGIKLN EPRPVPTSVE LEGDTALIID 180 181 GKRIEKPFVE KPVSGEDHNI NIYFGNGMGG RRLFRKIANQ SSTLDPDLCE VRDEGSYVYE 240 241 EFMKTDNSED IKIYTLGPDI VHAETRKSPV VDGIVKRNLD GKEIRYIIEL TPEEREIARR 300 301 ISCAFSQNIC GFDILRVRGK SYVIDVNGWS FVKGNDSYYD KCADTLSKFC LKAMPSKAKI 360 361 PIRLPIAEDP VKDKSKKKRP VSAASWCLKG TVCVFRHADR TPKNKLKFNF LVGEPGSDPF 420 421 FKLLQGRTDE IILRTQSHLK LIANATDEAF HIEGSDQTKL NQLKFILNSK MGKQGLKAQL 480 481 KPSFSKTAPT ELEKMNIVVK WGGEFTHAAR YQSRDIGENF AQDLKVMSKT MLDNVTIFSS 540 541 SESRVVATAE IFSAGMLQGS KLHHSKTAEP NPIPLIIRKD LLDDSNAAKE PMDKVKKRLK 600 601 VLLRHNQGTE VNWPIADKEP VDIVQEVIVI LKEQREIMNR NWEELDVDQI QSRWCCGECP 660 661 FLFKERWEKL FSDWCDGALD PSRVCELYDS LKYDSLHNRT FLETIFSSST YPSSINDTPP 720 721 LNMPGSAQLI FSITTVAPSE YGIEKSEKRE IGLLTSLPLL QKILEDLNDA RESQDGLARF 780 781 YFTKESHMHT LVNLIKMSSL KLAHRDVLEL DYMSYLSFEV YERISGDCGK KEHSVRISLS 840 841 EGAHGIPLDT SLDAKHALQV IPRRQLIPHT DLDEVIGTLE DWGEDLAELK KSTTPFDGFL 900 901 PVEGEEVFSI QSNPTD 916 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCTCCAG TTCCAGTCCC AGAGGCCAAG CCAGCTGAAG ATATCACCGA GTCTGATGAA 60 61 GAAACACATC TGATCAAGAT TGGAGTTGCG GCTATGGATC GAAAAGCGCG TTCGAAACCA 120 121 ATGCGCAATA TTTTGTCGCG ACTCGTCGCC ACCAATCGTT TCGAATGTAT CATCTTTGGC 180 181 GACAAGGTAA TCATGGACGA AGATGTCGAA CATTGGCCTG TTTGCGATTT CTTGATTAGC 240 241 TTTTTCTCTA CAGGATTTCC TATGGACAAA GCTATCCGGT ATGTCAAATT GCGCAAGCCA 300 301 ATTTCAATCA ATGACCTTCC GCTACAAAAG ATCTTCTGGG ATCGCCGTTT AGTGCTAGCA 360 361 GTACTTGACA AGATCGGGGT CCCTACACCT GCGCGATTAG AGCTTAGTCG TGACGGCGGA 420 421 CCACGTTTAG ATCCAGAGGT GGCGAGTGAG TTGGAGACAC GGCTGGGCAT CAAGCTCAAC 480 481 GAGCCGCGTC CAGTGCCCAC TTCTGTTGAA CTCGAAGGTG ACACTGCCTT GATCATCGAT 540 541 GGGAAACGGA TTGAAAAACC CTTTGTTGAA AAGCCAGTCA GCGGCGAAGA TCATAACATC 600 601 AACATTTATT TCGGTAACGG AATGGGTGGC AGGCGATTGT TTCGCAAAAT TGCCAATCAG 660 661 TCCTCAACCC TGGACCCGGA CCTCTGTGAG GTCCGGGACG AAGGATCTTA TGTCTATGAA 720 721 GAGTTTATGA AAACCGATAA CAGTGAAGAT ATCAAAATTT ATACTCTAGG GCCAGATATT 780 781 GTACATGCTG AGACTCGAAA ATCACCTGTG GTAGATGGCA TTGTAAAAAG AAACTTGGAT 840 841 GGTAAAGAAA TAAGATATAT CATCGAATTA ACGCCGGAAG AGCGAGAGAT CGCACGTCGA 900 901 ATCAGTTGCG CTTTTAGTCA AAATATTTGT GGGTTTGACA TCTTGAGAGT CCGTGGCAAG 960 961 AGTTATGTGA TCGATGTCAA TGGCTGGAGT TTTGTCAAAG GCAATGACAG TTACTATGAT 1020 1021 AAATGCGCCG ACACACTGTC AAAATTTTGT TTGAAAGCTA TGCCATCCAA AGCTAAGATC 1080 1081 CCAATAAGGC TCCCTATCGC TGAAGATCCC GTGAAAGATA AATCAAAGAA GAAACGACCC 1140 1141 GTGTCAGCGG CTTCATGGTG TTTGAAGGGT ACAGTTTGCG TGTTTCGACA TGCTGATAGG 1200 1201 ACACCCAAAA ATAAATTAAA GTTCAATTTC CTCGTGGGGG AACCCGGCTC AGACCCGTTT 1260 1261 TTCAAACTAT TACAAGGTCG TACGGACGAA ATCATTCTAC GCACTCAGTC CCATCTTAAA 1320 1321 CTCATCGCCA ATGCTACCGA TGAAGCTTTC CACATTGAAG GATCAGATCA GACAAAGCTC 1380 1381 AATCAATTAA AATTCATTTT AAATTCAAAA ATGGGTAAAC AAGGACTCAA AGCGCAACTG 1440 1441 AAGCCTAGTT TCTCAAAGAC TGCGCCTACC GAATTGGAAA AGATGAACAT TGTGGTAAAG 1500 1501 TGGGGTGGTG AATTCACTCA TGCGGCTAGA TATCAATCTA GAGATATTGG GGAGAACTTT 1560 1561 GCGCAAGATC TCAAAGTGAT GAGCAAGACA ATGCTGGACA ATGTGACAAT CTTTTCTAGC 1620 1621 TCGGAGAGTC GAGTTGTGGC GACTGCCGAA ATATTCAGCG CAGGGATGCT GCAAGGCTCT 1680 1681 AAGTTGCACC ACAGCAAGAC TGCTGAACCC AATCCGATCC CATTGATCAT CCGTAAAGAT 1740 1741 CTACTGGATG ATTCTAATGC AGCCAAAGAA CCGATGGATA AAGTGAAGAA GCGATTGAAA 1800 1801 GTGCTTTTGA GGCATAATCA GGGCACCGAA GTTAATTGGC CAATTGCAGA CAAAGAACCA 1860 1861 GTAGATATTG TGCAAGAAGT CATTGTGATC TTGAAAGAAC AGCGTGAAAT CATGAATCGT 1920 1921 AATTGGGAAG AGCTGGATGT GGATCAAATC CAATCGCGCT GGTGTTGTGG AGAATGCCCA 1980 1981 TTCTTGTTCA AAGAGCGCTG GGAAAAGCTT TTTAGTGATT GGTGTGATGG GGCATTAGAT 2040 2041 CCATCAAGAG TCTGTGAACT TTATGATTCT CTTAAATATG ATTCTTTGCA CAATCGGACT 2100 2101 TTTCTCGAGA CGATCTTTTC ATCCTCAACT TACCCCTCAT CCATCAATGA TACACCACCA 2160 2161 CTCAATATGC CCGGTTCAGC GCAATTAATC TTTTCAATCA CTACAGTTGC TCCGTCAGAA 2220 2221 TATGGGATAG AGAAAAGTGA GAAAAGAGAG ATCGGTTTGT TGACCTCCTT ACCGTTACTT 2280 2281 CAAAAAATAC TTGAAGATCT TAATGACGCT CGAGAAAGTC AAGATGGTTT GGCACGATTT 2340 2341 TATTTTACTA AAGAATCACA CATGCATACG TTGGTGAATT TGATCAAGAT GTCATCTTTG 2400 2401 AAATTAGCAC ATCGAGATGT ATTGGAATTG GATTACATGT CTTATCTTTC TTTTGAAGTT 2460 2461 TACGAAAGGA TCTCAGGTGA TTGTGGTAAG AAAGAACATT CAGTACGAAT CTCTTTATCA 2520 2521 GAAGGAGCCC ATGGAATTCC ATTAGACACA AGTCTTGATG CAAAACATGC CTTACAAGTG 2580 2581 ATCCCTAGAC GACAATTGAT TCCTCATACC GATTTAGATG AAGTGATTGG TACATTAGAA 2640 2641 GATTGGGGTG AAGATTTAGC AGAATTAAAG AAAAGTACGA CTCCTTTTGA TGGATTCTTA 2700 2701 CCTGTGGAAG GTGAAGAAGT GTTTTCGATT CAATCTAATC CAACGGACTA A 2751 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Cytoskeleton | |
Molecular Function | 5-diphosphoinositol pentakisphosphate 3-kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | Diphosphoinositol-pentakisphosphate kinase activity | |
Molecular Function | Inositol heptakisphosphate kinase activity | |
Molecular Function | Inositol hexakisphosphate 1-kinase activity | |
Molecular Function | Inositol hexakisphosphate 3-kinase activity | |
Molecular Function | Inositol hexakisphosphate 5-kinase activity | |
Molecular Function | Metal ion binding |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Put-1114 | Puccinia triticina | 80.87 | 4e-86 | 303 |
| LLPS-Pug-1223 | Puccinia graminis | 80.11 | 2e-86 | 304 |
| LLPS-Scs-0947 | Sclerotinia sclerotiorum | 58.93 | 7e-121 | 408 |
| LLPS-Miv-1071 | Microbotryum violaceum | 57.58 | 0.0 | 1028 |
| LLPS-Tum-0515 | Tuber melanosporum | 50.7 | 0.0 | 668 |
| LLPS-Chs-4011 | Chlorocebus sabaeus | 50.0 | 3e-31 | 136 |
| LLPS-Phn-1530 | Phaeosphaeria nodorum | 50.0 | 1e-14 | 82.8 |
| LLPS-Crn-1025 | Cryptococcus neoformans | 49.9 | 2e-137 | 446 |
| LLPS-Scp-0564 | Schizosaccharomyces pombe | 49.83 | 0.0 | 814 |
| LLPS-Ast-1512 | Aspergillus terreus | 49.49 | 1e-130 | 431 |
| LLPS-Spr-1238 | Sporisorium reilianum | 49.41 | 0.0 | 813 |
| LLPS-Sac-0946 | Saccharomyces cerevisiae | 48.83 | 0.0 | 649 |
| LLPS-Scc-1133 | Schizosaccharomyces cryophilus | 48.67 | 0.0 | 796 |
| LLPS-Scj-0957 | Schizosaccharomyces japonicus | 48.14 | 0.0 | 804 |
| LLPS-Kop-1071 | Komagataella pastoris | 45.96 | 0.0 | 724 |
| LLPS-Abg-0109 | Absidia glauca | 45.53 | 0.0 | 729 |
| LLPS-Asg-1483 | Ashbya gossypii | 44.19 | 0.0 | 691 |
| LLPS-Coc-1571 | Corchorus capsularis | 43.78 | 2e-96 | 317 |
| LLPS-Chc-0772 | Chondrus crispus | 40.77 | 9e-59 | 208 |
| LLPS-Chr-0291 | Chlamydomonas reinhardtii | 39.74 | 5e-84 | 301 |
| LLPS-Org-1708 | Oryza glaberrima | 39.55 | 1e-104 | 356 |
| LLPS-Orp-0000 | Oryza punctata | 39.06 | 8e-103 | 351 |
| LLPS-Tra-2387 | Triticum aestivum | 38.65 | 8e-102 | 347 |
| LLPS-Hov-0738 | Hordeum vulgare | 38.41 | 1e-103 | 352 |
| LLPS-Via-1572 | Vigna angularis | 37.78 | 1e-91 | 307 |
| LLPS-Mua-1032 | Musa acuminata | 37.46 | 5e-48 | 188 |
| LLPS-Bot-2999 | Bos taurus | 37.26 | 4e-100 | 348 |
| LLPS-Ova-3415 | Ovis aries | 37.07 | 3e-98 | 342 |
| LLPS-Brd-0593 | Brachypodium distachyon | 35.15 | 2e-112 | 377 |
| LLPS-Cus-1943 | Cucumis sativus | 34.61 | 3e-114 | 381 |
| LLPS-Sol-1785 | Solanum lycopersicum | 34.34 | 7e-111 | 372 |
| LLPS-Orbr-1773 | Oryza brachyantha | 34.24 | 6e-109 | 360 |
| LLPS-Arl-2534 | Arabidopsis lyrata | 34.2 | 9e-113 | 377 |
| LLPS-Php-0573 | Physcomitrella patens | 34.08 | 2e-115 | 385 |
| LLPS-Phv-2551 | Phaseolus vulgaris | 34.01 | 4e-113 | 378 |
| LLPS-Art-2741 | Arabidopsis thaliana | 33.96 | 8e-113 | 378 |
| LLPS-Zem-1347 | Zea mays | 33.96 | 4e-110 | 371 |
| LLPS-Prp-1289 | Prunus persica | 33.88 | 7e-112 | 375 |
| LLPS-Gor-1129 | Gossypium raimondii | 33.84 | 4e-113 | 379 |
| LLPS-Bro-1729 | Brassica oleracea | 33.84 | 4e-111 | 373 |
| LLPS-Dac-2322 | Daucus carota | 33.77 | 5e-107 | 362 |
| LLPS-Sei-1680 | Setaria italica | 33.76 | 5e-114 | 381 |
| LLPS-Sob-0827 | Sorghum bicolor | 33.66 | 8e-115 | 384 |
| LLPS-Pot-1627 | Populus trichocarpa | 33.65 | 8e-109 | 367 |
| LLPS-Brn-1081 | Brassica napus | 33.57 | 3e-109 | 368 |
| LLPS-Vir-2128 | Vigna radiata | 33.22 | 1e-104 | 355 |
| LLPS-Sem-1627 | Selaginella moellendorffii | 33.14 | 4e-99 | 340 |
| LLPS-Met-1367 | Medicago truncatula | 33.1 | 9e-113 | 377 |
| LLPS-Orc-3951 | Oryctolagus cuniculus | 33.08 | 3e-116 | 394 |
| LLPS-Cas-1777 | Carlito syrichta | 33.05 | 1e-116 | 394 |
| LLPS-Caf-3845 | Canis familiaris | 33.05 | 6e-116 | 394 |
| LLPS-Brr-2502 | Brassica rapa | 33.02 | 8e-105 | 362 |
| LLPS-Mup-0913 | Mustela putorius furo | 32.83 | 5e-115 | 391 |
| LLPS-Gaa-1277 | Gasterosteus aculeatus | 32.79 | 1e-115 | 388 |
| LLPS-Anc-2791 | Anolis carolinensis | 32.77 | 4e-119 | 400 |
| LLPS-Pof-3742 | Poecilia formosa | 32.75 | 1e-116 | 390 |
| LLPS-Lep-1965 | Leersia perrieri | 32.72 | 9e-92 | 318 |
| LLPS-Fec-0523 | Felis catus | 32.72 | 2e-114 | 389 |
| LLPS-Loa-3860 | Loxodonta africana | 32.68 | 5e-117 | 395 |
| LLPS-Sah-3355 | Sarcophilus harrisii | 32.62 | 5e-114 | 386 |
| LLPS-Dio-3369 | Dipodomys ordii | 32.62 | 2e-119 | 392 |
| LLPS-Mod-0570 | Monodelphis domestica | 32.55 | 1e-115 | 392 |
| LLPS-Sus-4526 | Sus scrofa | 32.52 | 2e-116 | 395 |
| LLPS-Gaga-1973 | Gallus gallus | 32.5 | 5e-116 | 393 |
| LLPS-Icp-4012 | Ictalurus punctatus | 32.43 | 1e-113 | 385 |
| LLPS-Myl-4093 | Myotis lucifugus | 32.42 | 6e-116 | 394 |
| LLPS-Thc-1462 | Theobroma cacao | 32.41 | 2e-98 | 338 |
| LLPS-Dar-1834 | Danio rerio | 32.39 | 1e-112 | 382 |
| LLPS-Paa-2029 | Papio anubis | 32.35 | 2e-117 | 397 |
| LLPS-Xim-1363 | Xiphophorus maculatus | 32.34 | 2e-114 | 388 |
| LLPS-Maf-2332 | Macaca fascicularis | 32.33 | 1e-114 | 389 |
| LLPS-Mam-3125 | Macaca mulatta | 32.33 | 2e-114 | 389 |
| LLPS-Pes-1960 | Pelodiscus sinensis | 32.32 | 6e-118 | 393 |
| LLPS-Aon-2190 | Aotus nancymaae | 32.31 | 6e-117 | 395 |
| LLPS-Pat-4722 | Pan troglodytes | 32.31 | 9e-117 | 395 |
| LLPS-Ict-2951 | Ictidomys tridecemlineatus | 32.31 | 2e-115 | 392 |
| LLPS-Ten-0414 | Tetraodon nigroviridis | 32.3 | 5e-115 | 387 |
| LLPS-Eqc-4631 | Equus caballus | 32.24 | 9e-117 | 396 |
| LLPS-Mal-4225 | Mandrillus leucophaeus | 32.22 | 1e-114 | 389 |
| LLPS-Asm-3217 | Astyanax mexicanus | 32.21 | 3e-112 | 380 |
| LLPS-Caj-4172 | Callithrix jacchus | 32.21 | 1e-116 | 394 |
| LLPS-Gog-1786 | Gorilla gorilla | 32.21 | 7e-118 | 395 |
| LLPS-Cap-2676 | Cavia porcellus | 32.19 | 8e-115 | 389 |
| LLPS-Otg-1233 | Otolemur garnettii | 32.17 | 2e-111 | 380 |
| LLPS-Orl-3165 | Oryzias latipes | 32.09 | 2e-110 | 378 |
| LLPS-Hos-0020 | Homo sapiens | 32.08 | 9e-116 | 392 |
| LLPS-Mea-3611 | Mesocricetus auratus | 32.03 | 3e-115 | 391 |
| LLPS-Osl-0964 | Ostreococcus lucimarinus | 32.03 | 2e-105 | 358 |
| LLPS-Orn-2231 | Oreochromis niloticus | 32.0 | 1e-115 | 389 |
| LLPS-Leo-3206 | Lepisosteus oculatus | 31.94 | 1e-115 | 391 |
| LLPS-Fud-2254 | Fukomys damarensis | 31.9 | 8e-115 | 389 |
| LLPS-Anp-3286 | Anas platyrhynchos | 31.86 | 2e-116 | 391 |
| LLPS-Mum-3442 | Mus musculus | 31.82 | 1e-114 | 389 |
| LLPS-Fia-3427 | Ficedula albicollis | 31.79 | 2e-115 | 391 |
| LLPS-Ran-3898 | Rattus norvegicus | 31.78 | 3e-114 | 388 |
| LLPS-Aim-1563 | Ailuropoda melanoleuca | 31.77 | 3e-112 | 383 |
| LLPS-Man-3749 | Macaca nemestrina | 31.75 | 8e-109 | 372 |
| LLPS-Scf-1154 | Scleropages formosus | 31.73 | 2e-113 | 384 |
| LLPS-Meg-0775 | Meleagris gallopavo | 31.72 | 3e-117 | 394 |
| LLPS-Tar-3201 | Takifugu rubripes | 31.67 | 2e-113 | 384 |
| LLPS-Tag-2938 | Taeniopygia guttata | 31.62 | 2e-116 | 390 |
| LLPS-Nol-3231 | Nomascus leucogenys | 31.5 | 2e-112 | 382 |
| LLPS-Scm-2277 | Scophthalmus maximus | 31.48 | 2e-113 | 385 |
| LLPS-Rhb-2391 | Rhinopithecus bieti | 30.85 | 2e-101 | 347 |
| LLPS-Cii-1916 | Ciona intestinalis | 30.83 | 8e-106 | 359 |
| LLPS-Cea-1529 | Cercocebus atys | 30.0 | 2e-86 | 307 |
| LLPS-Lac-3410 | Latimeria chalumnae | 29.99 | 8e-93 | 325 |
| LLPS-Urm-2469 | Ursus maritimus | 29.21 | 2e-86 | 308 |
| LLPS-Poa-3618 | Pongo abelii | 27.43 | 3e-42 | 171 |