• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Osl-0964
OSTLU_33883

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
Gene Name: OSTLU_33883
Ensembl Gene: OSTLU_33883
Ensembl Protein: ABO94968
Organism: Ostreococcus lucimarinus
Taxa ID: 436017
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblABO94968ABO94968
UniProtA4RUI2, A4RUI2_OSTLU
GeneBankCP000583ABO94968.1
RefSeqXM_001416638.1XP_001416675.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSEHAAPTRD  ARKQSSRSGA  SSASKHPIVT  LGVCAMDKKS  RSSAMREILT  RIESFGEFEI  60
61    VIFGDECVVN  EPVENWPKVD  ALIAFYSNGF  PLQKVERYVE  MHKPFVVNEP  NDQWTLLDRR  120
121   LVYKRLQEHD  IPVPNHVVVN  LALPDQPTFE  PKNFSQDEEY  VEINGKRIYK  PFVEKPANAE  180
181   DHNIFIYYPH  SVGGGYKRLF  RKIGNQSSQY  YPPPETTAAG  ELSYAPVRET  TSFIYEDFMS  240
241   TNGTDVKVYT  VGPNYAHAEA  RKSPVVDGRV  QRDESGKEVR  YPVLLTPEEK  EIARRVCIAF  300
301   GQRVCGFDLL  RAKGRSYVCD  VNGWSFVKNS  KKYYDDASVC  LRAMILKAVA  PNHFSTQPAQ  360
361   KAAASASVEE  PDIILDGNDA  ELKETRLEKA  PSPKEPPEEL  RAVLGVIRHG  DRTPKQKMKL  420
421   RVKNRELLDL  MLRCTNGRTR  KQAKLKTPQT  LQELLNICRD  IYKSLSKQTL  APKDEEGHEE  480
481   AQEELEAWKQ  VVSILEEGGH  FSGINRKAQL  KPLEWETIDA  GTLDSHTEKV  TEALLIIKFG  540
541   GVLTYLGKYQ  AETLGKAFRV  RMYPRGNYYG  SDADGLLRLH  STYRHDLKIY  SSDEGRVQIT  600
601   AAAFAKGLLA  LDTHHGQLTP  ILASLVTKDA  KLLDFVTHYV  EEDILHSKHK  LAGESSHHDT  660
661   TQKAVTLSTN  LMGVPKQPLK  KLEMLYELTK  SISVQLRTML  SSHQVRYDSD  SGTRINWADT  720
721   HSAVAPRGSL  PKGGIQQLKT  MIVPAGGESF  LLMYSRWKKL  EQDLYHSRKA  RFDISKVPDV  780
781   YDAVKYDAIH  NEHLALEGLE  ALYEIAKELA  DCIVPNEYGT  TASSKLRIGG  TVANSLIAKL  840
841   LSDLNNTREE  SFAVESGGMS  SNEMRRVSIS  EKIPVLNEED  EAETIDEETE  REREEQEEEE  900
901   EELNTTRLNL  RYATAHGVHS  PFRHVRTRLY  FTSESHLHSL  INVLQYAHLD  KPREDRERGR  960
961   SPYHTEHSES  DELDYLTHIV  FRMFERFHVP  PSDPRRFRIE  ILFSNGVSLH  PFKTNAIELF  1020
1021  DSSARNGVAD  EDEEMISDDL  LKEIQIQNDK  IMPGQDYLTL  STMEEYLVNY  NRRWNKGGDS  1080
1081  ADGTPGKGAR  SSSVGSERIR  AGKNLFT  1107
Nucleotide CDS Sequence (FASTA)
1     ATGTCCGAAC  ACGCGGCGCC  GACGCGCGAC  GCGCGGAAGC  AAAGCTCGCG  CTCGGGCGCG  60
61    TCGAGCGCGT  CCAAGCACCC  GATCGTCACG  CTGGGCGTGT  GCGCGATGGA  TAAAAAGTCG  120
121   CGCTCGAGCG  CGATGCGAGA  GATCCTGACG  CGGATCGAAT  CGTTCGGGGA  GTTTGAGATT  180
181   GTGATATTCG  GGGACGAGTG  CGTGGTGAAC  GAACCGGTGG  AAAATTGGCC  CAAGGTGGAC  240
241   GCGCTGATCG  CGTTCTACAG  CAATGGGTTT  CCGTTGCAAA  AGGTGGAGCG  GTACGTGGAG  300
301   ATGCACAAGC  CCTTTGTGGT  GAACGAGCCG  AACGACCAGT  GGACGCTGCT  GGATCGGAGA  360
361   TTGGTGTATA  AGCGGTTGCA  GGAACACGAT  ATTCCAGTGC  CGAATCACGT  GGTGGTGAAT  420
421   CTGGCGTTGC  CCGATCAACC  GACGTTCGAG  CCAAAGAATT  TCTCACAGGA  CGAAGAGTAC  480
481   GTGGAAATCA  ACGGGAAAAG  GATATATAAG  CCCTTTGTGG  AGAAGCCGGC  GAACGCGGAG  540
541   GATCATAACA  TTTTTATCTA  CTACCCACAC  AGCGTCGGTG  GGGGGTACAA  GCGCTTGTTT  600
601   CGGAAGATTG  GTAATCAATC  GAGTCAGTAC  TACCCTCCTC  CTGAAACCAC  CGCGGCGGGC  660
661   GAGTTGTCTT  ACGCCCCGGT  TCGGGAGACG  ACATCTTTCA  TTTACGAAGA  TTTCATGTCA  720
721   ACGAACGGTA  CAGATGTAAA  AGTGTATACT  GTTGGTCCGA  ATTACGCCCA  CGCCGAAGCT  780
781   AGAAAGAGTC  CAGTCGTCGA  TGGAAGAGTG  CAGAGAGACG  AGAGCGGCAA  GGAGGTGCGT  840
841   TACCCGGTAT  TGTTGACGCC  AGAGGAGAAA  GAAATCGCAC  GCCGTGTGTG  TATAGCGTTT  900
901   GGGCAGCGAG  TTTGTGGATT  TGATTTACTT  CGTGCGAAAG  GTCGAAGCTA  CGTTTGTGAC  960
961   GTCAATGGAT  GGAGTTTTGT  GAAAAACTCC  AAAAAATACT  ATGACGACGC  TTCGGTGTGC  1020
1021  TTGCGAGCGA  TGATTTTGAA  AGCCGTAGCG  CCGAATCACT  TTAGCACTCA  GCCTGCTCAA  1080
1081  AAAGCCGCGG  CATCGGCTAG  TGTTGAAGAG  CCTGATATCA  TTTTAGATGG  TAATGATGCC  1140
1141  GAATTGAAGG  AAACCAGACT  CGAGAAGGCG  CCATCACCCA  AGGAACCGCC  TGAGGAGTTG  1200
1201  CGCGCCGTAC  TCGGCGTCAT  TCGGCACGGC  GATCGCACGC  CCAAGCAAAA  GATGAAACTG  1260
1261  AGAGTGAAAA  ATCGTGAACT  TCTTGATCTC  ATGCTTCGAT  GCACGAACGG  TCGAACTCGC  1320
1321  AAGCAAGCTA  AATTGAAGAC  GCCTCAGACA  TTGCAAGAAC  TCTTGAATAT  TTGCAGGGAC  1380
1381  ATTTACAAAA  GTTTGTCTAA  GCAAACCTTG  GCGCCGAAAG  ACGAGGAGGG  ACATGAAGAG  1440
1441  GCGCAAGAAG  AACTCGAAGC  GTGGAAACAA  GTAGTGTCGA  TTCTCGAAGA  AGGAGGACAC  1500
1501  TTTAGTGGTA  TCAATCGTAA  AGCGCAGCTC  AAACCTCTTG  AGTGGGAGAC  AATCGATGCT  1560
1561  GGAACGCTAG  ACTCTCACAC  AGAAAAAGTC  ACCGAGGCTC  TCCTCATCAT  CAAGTTCGGC  1620
1621  GGTGTTTTGA  CTTATTTGGG  TAAATATCAA  GCCGAAACAC  TCGGTAAGGC  ATTTAGAGTA  1680
1681  CGAATGTATC  CTCGTGGTAA  CTATTACGGC  TCGGACGCTG  ATGGTTTACT  GAGATTACAT  1740
1741  TCAACCTATC  GCCACGATTT  GAAGATTTAC  TCCTCCGATG  AAGGTCGAGT  GCAGATCACT  1800
1801  GCTGCAGCTT  TTGCGAAAGG  TTTACTCGCC  CTCGATACCC  ATCATGGACA  GCTCACGCCG  1860
1861  ATTCTCGCTT  CTCTCGTTAC  CAAAGATGCA  AAGTTGTTGG  ATTTCGTGAC  TCATTACGTG  1920
1921  GAAGAGGACA  TCTTACACTC  AAAGCACAAG  CTCGCTGGCG  AATCATCCCA  CCACGATACG  1980
1981  ACTCAAAAAG  CTGTCACGCT  TTCAACCAAT  CTCATGGGTG  TACCGAAGCA  GCCACTCAAG  2040
2041  AAACTCGAAA  TGCTGTATGA  ACTCACGAAA  TCAATTTCGG  TGCAGCTTAG  AACGATGCTT  2100
2101  TCTAGCCACC  AAGTGCGATA  TGATTCCGAT  TCCGGCACTA  GAATCAACTG  GGCCGACACG  2160
2161  CATTCCGCCG  TCGCCCCACG  TGGTTCACTT  CCAAAAGGAG  GTATTCAACA  GCTTAAAACC  2220
2221  ATGATCGTTC  CCGCTGGCGG  TGAGTCCTTT  TTGCTCATGT  ATTCCAGATG  GAAAAAGTTA  2280
2281  GAGCAAGATC  TTTACCATTC  GCGTAAAGCT  AGGTTTGACA  TCTCGAAAGT  ACCAGACGTC  2340
2341  TACGACGCGG  TAAAATACGA  TGCCATTCAT  AACGAACATT  TGGCTTTAGA  GGGACTCGAG  2400
2401  GCGTTGTACG  AAATCGCGAA  AGAGCTAGCA  GATTGCATTG  TTCCGAATGA  ATACGGTACG  2460
2461  ACGGCTTCGA  GCAAGCTACG  AATTGGGGGC  ACCGTTGCCA  ACAGCTTGAT  TGCAAAATTG  2520
2521  CTAAGCGATT  TGAACAACAC  TCGCGAGGAA  TCTTTCGCCG  TCGAAAGCGG  TGGAATGTCA  2580
2581  TCGAATGAAA  TGCGCCGTGT  TTCTATCAGC  GAAAAGATAC  CGGTTTTAAA  TGAAGAAGAC  2640
2641  GAGGCCGAAA  CGATCGACGA  AGAGACTGAG  CGAGAACGTG  AGGAGCAGGA  AGAAGAAGAG  2700
2701  GAAGAGCTGA  ACACGACTCG  ATTGAATTTG  CGATACGCCA  CGGCGCACGG  TGTGCATAGC  2760
2761  CCATTCAGAC  ACGTGCGCAC  GCGGCTTTAT  TTCACCTCTG  AATCTCACTT  GCATTCGCTC  2820
2821  ATCAATGTAC  TTCAGTACGC  GCACCTGGAC  AAGCCTCGAG  AAGATCGCGA  GCGAGGTCGC  2880
2881  TCTCCGTATC  ACACCGAACA  TAGCGAAAGC  GACGAGCTCG  ATTATCTTAC  CCACATCGTG  2940
2941  TTTAGAATGT  TCGAACGTTT  CCATGTTCCT  CCGTCAGATC  CTCGACGCTT  TCGGATTGAA  3000
3001  ATTTTGTTCT  CCAACGGCGT  CAGTTTACAC  CCGTTTAAGA  CCAATGCCAT  CGAACTTTTC  3060
3061  GACAGCAGCG  CTAGGAACGG  TGTAGCAGAT  GAAGACGAGG  AGATGATATC  TGATGATTTG  3120
3121  CTCAAAGAAA  TACAGATTCA  AAACGATAAA  ATCATGCCTG  GACAGGATTA  TCTCACTCTT  3180
3181  AGCACCATGG  AAGAGTACTT  GGTAAACTAC  AATCGACGCT  GGAACAAGGG  AGGGGATTCA  3240
3241  GCCGATGGCA  CGCCCGGGAA  AGGCGCGAGG  AGCTCGAGTG  TTGGCAGCGA  GCGAATCAGG  3300
3301  GCGGGAAAGA  ACCTCTTTAC  TTGA  3324

▼ KEYWORD

ID
Family
ATP-binding
Coiled coil
Complete proteome
Cytoplasm
Kinase
Nucleotide-binding
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Molecular Function
5-diphosphoinositol pentakisphosphate 3-kinase activity
Molecular Function
ATP binding
Molecular Function
Diphosphoinositol-pentakisphosphate kinase activity
Molecular Function
Inositol heptakisphosphate kinase activity
Molecular Function
Inositol hexakisphosphate 1-kinase activity
Molecular Function
Inositol hexakisphosphate 3-kinase activity
Molecular Function
Inositol hexakisphosphate 5-kinase activity

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Chs-4011Chlorocebus sabaeus68.426e-43 175
LLPS-Chr-0291Chlamydomonas reinhardtii67.655e-0758.5
LLPS-Rhb-2391Rhinopithecus bieti54.982e-104 359
LLPS-Cea-1529Cercocebus atys54.381e-83 301
LLPS-Via-1572Vigna angularis53.750.0 560
LLPS-Coc-1571Corchorus capsularis52.865e-144 447
LLPS-Lep-1965Leersia perrieri51.512e-100 347
LLPS-Orbr-1773Oryza brachyantha49.490.0 708
LLPS-Zem-1347Zea mays47.720.0 819
LLPS-Sei-1680Setaria italica47.70.0 835
LLPS-Php-0573Physcomitrella patens47.610.0 835
LLPS-Tra-2387Triticum aestivum47.490.0 833
LLPS-Phv-2551Phaseolus vulgaris47.390.0 830
LLPS-Prp-1289Prunus persica46.940.0 748
LLPS-Cii-1916Ciona intestinalis46.748e-1480.5
LLPS-Sob-0827Sorghum bicolor46.250.0 787
LLPS-Brd-0593Brachypodium distachyon45.480.0 793
LLPS-Cus-1943Cucumis sativus45.480.0 806
LLPS-Hov-0738Hordeum vulgare45.460.0 791
LLPS-Scs-0947Sclerotinia sclerotiorum45.435e-85 307
LLPS-Dac-2322Daucus carota45.190.0 799
LLPS-Bro-1729Brassica oleracea45.170.0 829
LLPS-Gaa-1277Gasterosteus aculeatus45.168e-1377.4
LLPS-Org-1708Oryza glaberrima45.080.0 794
LLPS-Mua-1032Musa acuminata45.00.0 593
LLPS-Pot-1627Populus trichocarpa44.980.0 807
LLPS-Sol-1785Solanum lycopersicum44.840.0 781
LLPS-Thc-1462Theobroma cacao44.810.0 792
LLPS-Brn-1081Brassica napus44.720.0 818
LLPS-Brr-2502Brassica rapa44.70.0 826
LLPS-Sem-1627Selaginella moellendorffii44.690.0 781
LLPS-Arl-2534Arabidopsis lyrata44.520.0 823
LLPS-Ast-1512Aspergillus terreus44.412e-82 297
LLPS-Meg-0775Meleagris gallopavo44.40.0 627
LLPS-Fia-3427Ficedula albicollis44.40.0 626
LLPS-Gaga-1973Gallus gallus44.40.0 624
LLPS-Anc-2791Anolis carolinensis44.40.0 623
LLPS-Gor-1129Gossypium raimondii44.230.0 816
LLPS-Dar-1834Danio rerio44.215e-1378.2
LLPS-Icp-4012Ictalurus punctatus44.216e-1377.8
LLPS-Art-2741Arabidopsis thaliana44.190.0 821
LLPS-Vir-2128Vigna radiata44.110.0 776
LLPS-Xim-1363Xiphophorus maculatus44.094e-1275.1
LLPS-Scf-1154Scleropages formosus44.099e-1377.4
LLPS-Met-1367Medicago truncatula43.890.0 802
LLPS-Orp-0000Oryza punctata43.820.0 729
LLPS-Leo-3206Lepisosteus oculatus43.740.0 611
LLPS-Orl-3165Oryzias latipes43.730.0 602
LLPS-Ict-2951Ictidomys tridecemlineatus43.690.0 616
LLPS-Sus-4526Sus scrofa43.620.0 619
LLPS-Bot-2999Bos taurus43.570.0 619
LLPS-Hos-0020Homo sapiens43.50.0 619
LLPS-Fud-2254Fukomys damarensis43.50.0 615
LLPS-Fec-0523Felis catus43.450.0 617
LLPS-Cap-2676Cavia porcellus43.450.0 614
LLPS-Orn-2231Oreochromis niloticus43.440.0 605
LLPS-Ova-3415Ovis aries43.420.0 614
LLPS-Mea-3611Mesocricetus auratus43.40.0 614
LLPS-Pat-4722Pan troglodytes43.380.0 618
LLPS-Caf-3845Canis familiaris43.380.0 618
LLPS-Mup-0913Mustela putorius furo43.380.0 617
LLPS-Mod-0570Monodelphis domestica43.280.0 609
LLPS-Caj-4172Callithrix jacchus43.280.0 615
LLPS-Eqc-4631Equus caballus43.270.0 619
LLPS-Mam-3125Macaca mulatta43.270.0 615
LLPS-Cas-1777Carlito syrichta43.270.0 615
LLPS-Maf-2332Macaca fascicularis43.270.0 616
LLPS-Loa-3860Loxodonta africana43.210.0 616
LLPS-Pes-1960Pelodiscus sinensis43.210.0 619
LLPS-Ran-3898Rattus norvegicus43.210.0 613
LLPS-Tar-3201Takifugu rubripes43.20.0 607
LLPS-Myl-4093Myotis lucifugus43.20.0 616
LLPS-Aim-1563Ailuropoda melanoleuca43.180.0 609
LLPS-Paa-2029Papio anubis43.180.0 610
LLPS-Asm-3217Astyanax mexicanus43.163e-1275.5
LLPS-Orc-3951Oryctolagus cuniculus43.150.0 613
LLPS-Aon-2190Aotus nancymaae43.150.0 614
LLPS-Gog-1786Gorilla gorilla43.150.0 613
LLPS-Nol-3231Nomascus leucogenys43.130.0 603
LLPS-Mum-3442Mus musculus43.10.0 608
LLPS-Dio-3369Dipodomys ordii43.10.0 610
LLPS-Scm-2277Scophthalmus maximus42.960.0 600
LLPS-Pof-3742Poecilia formosa42.940.0 593
LLPS-Mal-4225Mandrillus leucophaeus42.930.0 612
LLPS-Sah-3355Sarcophilus harrisii42.890.0 596
LLPS-Otg-1233Otolemur garnettii42.860.0 603
LLPS-Ten-0414Tetraodon nigroviridis42.840.0 597
LLPS-Man-3749Macaca nemestrina42.60.0 601
LLPS-Urm-2469Ursus maritimus40.955e-167 539
LLPS-Tag-2938Taeniopygia guttata40.320.0 629
LLPS-Anp-3286Anas platyrhynchos40.220.0 626
LLPS-Poa-3618Pongo abelii39.735e-100 348
LLPS-Lac-3410Latimeria chalumnae39.694e-161 518
LLPS-Crn-1025Cryptococcus neoformans39.014e-77 280
LLPS-Chc-0772Chondrus crispus38.737e-50 184
LLPS-Kop-1071Komagataella pastoris36.657e-95 332
LLPS-Abg-0109Absidia glauca36.642e-97 337
LLPS-Sac-0946Saccharomyces cerevisiae36.331e-95 336
LLPS-Asg-1483Ashbya gossypii35.57e-92 325
LLPS-Scc-1133Schizosaccharomyces cryophilus33.151e-116 390
LLPS-Scp-0564Schizosaccharomyces pombe32.968e-117 390
LLPS-Pug-1223Puccinia graminis32.653e-102 352
LLPS-Scj-0957Schizosaccharomyces japonicus32.393e-116 389
LLPS-Mel-0310Melampsora laricipopulina31.999e-106 360
LLPS-Miv-1071Microbotryum violaceum31.92e-106 362
LLPS-Put-1114Puccinia triticina31.858e-93 325
LLPS-Tum-0515Tuber melanosporum31.844e-102 357
LLPS-Spr-1238Sporisorium reilianum31.084e-94 328
LLPS-Phn-1530Phaeosphaeria nodorum31.082e-75 277