LLPS-Brn-1081
BnaA10g29770D
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase |
| Gene Name: | BnaA10g29770D, GSBRNA2T00044075001 |
| Ensembl Gene: | GSBRNA2T00130018001 |
| Ensembl Protein: | CDX78605 |
| Organism: | Brassica napus |
| Taxa ID: | 3708 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | CDX78605 | CDX78605 |
| UniProt | A0A078JBP8, A0A078JBP8_BRANA | |
| GeneBank | LK034638 | CDY65043.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGMEEGAGVD KKITIGVCVM EKKVFSAPMG QIMDRLQAFG EFEIIHFGDK VILEDPVESW 60 61 PICDCLIAFH SSGYPLEKVQ AYSSLRKPFL VNDLDPQYLL HDRRKVYEHL EMYGIPVPRY 120 121 ACVNRKVPNQ DLDYFVEDED FVEVKGERFW KPFVEKPVNG DDHSIMIYYP SSAGGGMKEL 180 181 FRKVGNRSSE FHPEVRRVRR EGSYIYEEFM PTGGTDVKAL VIIQVYTVGP EYAHAEARKS 240 241 PVVDGVVMRN PDGKEVRYPV LLTPAEKQMA REVCIAFRQA VCGFDLLRSE GSSYVCDVNG 300 301 WSFVKNSYKY YDDAACVLRK MFLDAKAPHL SSTVPPILPW KINEPVLSNE GLTRQGSGII 360 361 GTFGQSEELR CVIAVIRHGD RTPKQKVKLK VTEEKLLNLM LKYNGGKPRA ETKLKSAVEL 420 421 QDLLDATRML IPRTGPGESD SDAEDLEHAD KLRQVKAVLE EGGHFSGIYR KVQLKPLKWE 480 481 KVTKSDGEGE EERPVEALMV LKYGGVLTHA GRKQAEELGR YFRNNMYPGE GTGLLRLHST 540 541 YRHDLKIYSS DEGRVQMSAA AFAKGLLDLE GQLTPILVSL VSKDSSMLDG LDTASTEMEE 600 601 AKAQLNEIIT AGTKLVNDYV SSELPWMIDG AGLPPHADEH LPELIKLAKK VTEQVRLLAK 660 661 DEEENHTEPS AYDLAPPYDQ AKALGKSNID VGRIAAGLPC GSEGFLLMYA RWKKLERDLY 720 721 NERRDRFDIT QIPDVYDSCK YDLLHNSHLD LKGLDELFKI AQLLADGVIP NEYGINPQQK 780 781 LKIGSKIARR LLGKILIDLR NTREEAMSVA ELKNSQDQVS VSLYSSKKED RYSQPKLYIK 840 841 SDELKRPTNG ENKDEDDDKE TKYRLDPKYA NVMTPERHVR TRLYFTSESH IHSLMNVLRY 900 901 CNLDESLQGE ESLVCQSALE RLCKTKELDY MSYIVLRLFE NTEESLEDPE RFRIELTCSR 960 961 GADLSPLEKK DEEAKSLLRE HTLPIMGPER LQEVGSCLTL ETMEKMIRPF AMPPEDFPPP 1020 1021 SIPAGFSGYF SKSAAVLERL VKLWPFNKN 1049 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGGATGG AAGAAGGAGC TGGTGTTGAT AAGAAGATAA CGATTGGAGT CTGCGTCATG 60 61 GAAAAGAAGG TTTTCTCAGC TCCCATGGGA CAAATCATGG ATAGATTGCA AGCGTTTGGC 120 121 GAATTTGAGA TCATTCATTT TGGGGACAAG GTTATTCTTG AAGATCCTGT AGAAAGTTGG 180 181 CCGATTTGTG ATTGTCTGAT TGCTTTCCAT TCCTCTGGAT ATCCTCTTGA GAAAGTTCAA 240 241 GCATATTCTT CTTTAAGAAA GCCTTTTTTA GTGAATGATT TGGATCCGCA ATACCTTCTT 300 301 CATGACCGCC GGAAAGTGTA TGAGCATCTG GAGATGTATG GTATTCCAGT TCCTAGATAT 360 361 GCTTGTGTCA ATAGAAAAGT ACCCAACCAA GACCTTGATT ATTTCGTTGA GGATGAAGAT 420 421 TTTGTTGAGG TTAAAGGTGA ACGATTCTGG AAGCCATTTG TGGAAAAACC CGTCAATGGA 480 481 GATGACCATA GCATAATGAT ATACTACCCT AGCTCAGCAG GTGGAGGCAT GAAAGAATTG 540 541 TTTCGTAAGG TTGGGAATCG TTCAAGTGAA TTTCATCCTG AGGTCAGAAG AGTAAGGAGA 600 601 GAAGGTTCTT ATATATATGA GGAGTTTATG CCTACTGGAG GAACTGATGT CAAGGCTCTT 660 661 GTCATTATCC AGGTCTACAC TGTGGGTCCC GAATACGCAC ACGCTGAAGC AAGAAAGTCG 720 721 CCTGTTGTTG ATGGTGTTGT TATGAGAAAC CCAGATGGAA AGGAAGTGAG GTATCCAGTT 780 781 TTGCTAACAC CTGCTGAGAA GCAAATGGCG AGAGAAGTTT GCATTGCATT TAGGCAAGCG 840 841 GTCTGTGGAT TTGATCTCTT ACGATCTGAG GGAAGTTCAT ACGTTTGTGA CGTTAATGGA 900 901 TGGAGTTTTG TGAAGAACTC TTATAAGTAC TACGACGATG CTGCTTGTGT GTTGCGGAAA 960 961 ATGTTTTTAG ATGCAAAGGC TCCTCATCTT TCTTCGACAG TTCCTCCCAT TCTGCCATGG 1020 1021 AAGATCAATG AACCTGTCCT ATCTAACGAA GGTTTAACTC GCCAAGGGAG TGGCATCATT 1080 1081 GGAACATTTG GGCAGTCGGA AGAGCTACGT TGTGTCATTG CTGTTATTCG GCACGGTGAT 1140 1141 AGAACCCCTA AGCAAAAAGT GAAACTAAAA GTTACAGAGG AAAAGCTGTT AAACTTGATG 1200 1201 CTGAAGTACA ATGGAGGAAA GCCAAGAGCT GAGACAAAAC TTAAAAGTGC CGTCGAATTG 1260 1261 CAAGATCTAT TGGATGCTAC AAGAATGTTA ATTCCTCGCA CAGGACCAGG TGAAAGTGAT 1320 1321 AGTGATGCAG AAGACCTTGA ACATGCTGAC AAGCTTCGGC AAGTGAAAGC TGTTCTTGAA 1380 1381 GAGGGTGGAC ATTTCTCTGG CATATACAGA AAGGTTCAGC TAAAGCCGCT AAAATGGGAA 1440 1441 AAAGTAACAA AAAGTGATGG CGAAGGTGAA GAAGAACGCC CAGTGGAGGC TCTTATGGTT 1500 1501 CTGAAATATG GGGGTGTTCT AACTCATGCT GGTCGAAAGC AGGCAGAAGA ACTTGGTAGA 1560 1561 TACTTCCGAA ACAATATGTA TCCAGGTGAA GGTACCGGTT TGCTCCGTCT CCATAGTACA 1620 1621 TACCGTCATG ACCTTAAAAT TTACAGTTCT GACGAGGGAC GTGTTCAGAT GTCTGCAGCT 1680 1681 GCTTTTGCTA AAGGCCTGCT GGACCTAGAA GGACAGCTGA CCCCAATCCT GGTTTCTCTG 1740 1741 GTTAGCAAGG ACTCTTCCAT GTTGGATGGC CTTGATACTG CGAGCACTGA AATGGAAGAA 1800 1801 GCCAAGGCTC AGTTGAATGA GATCATTACC GCTGGCACAA AGTTGGTAAA TGATTACGTC 1860 1861 TCTTCTGAAT TACCTTGGAT GATTGATGGG GCTGGACTTC CTCCTCACGC TGATGAGCAC 1920 1921 CTACCTGAAT TGATAAAACT AGCTAAAAAG GTTACTGAAC AAGTGAGGCT ACTTGCAAAA 1980 1981 GATGAAGAGG AGAATCACAC TGAGCCTAGT GCTTATGATT TAGCCCCTCC CTATGATCAA 2040 2041 GCAAAGGCCC TTGGCAAGTC AAACATTGAC GTTGGCCGGA TTGCTGCTGG ATTACCTTGT 2100 2101 GGTAGTGAAG GATTCCTTTT GATGTATGCT CGGTGGAAAA AACTCGAACG GGATCTCTAC 2160 2161 AACGAAAGAA GAGACCGGTT TGACATAACG CAGATTCCTG ATGTTTACGA TTCATGCAAG 2220 2221 TATGATCTGT TACATAATTC TCATCTCGAC CTGAAAGGAC TAGACGAACT CTTCAAAATT 2280 2281 GCTCAGTTAC TTGCAGACGG TGTAATACCA AATGAGTATG GGATCAATCC ACAGCAAAAG 2340 2341 CTCAAAATCG GTTCAAAGAT TGCTCGTCGC TTGCTTGGTA AAATCTTGAT CGACTTGAGG 2400 2401 AATACTCGAG AAGAGGCCAT GAGTGTTGCT GAACTGAAGA ACAGTCAAGA CCAAGTCTCA 2460 2461 GTGTCATTAT ATTCGTCGAA AAAGGAGGAT AGATATAGTC AACCGAAACT TTACATTAAA 2520 2521 AGCGATGAGT TGAAACGGCC TACAAATGGA GAGAATAAAG ATGAAGATGA TGATAAAGAA 2580 2581 ACCAAATATC GACTAGATCC AAAGTATGCA AATGTCATGA CGCCTGAACG TCATGTGAGG 2640 2641 ACACGCCTTT ACTTCACATC TGAATCACAT ATTCATTCTC TGATGAACGT TCTACGGTAT 2700 2701 TGTAACCTCG ACGAATCTCT TCAAGGAGAA GAAAGTCTCG TCTGCCAAAG CGCTTTGGAA 2760 2761 CGCCTTTGTA AGACTAAAGA GCTTGATTAC ATGAGCTACA TTGTCCTAAG ACTGTTCGAG 2820 2821 AACACTGAGG AATCTCTGGA AGACCCGGAA CGGTTCAGAA TCGAACTAAC ATGTAGCCGT 2880 2881 GGCGCAGATT TGTCTCCCTT AGAGAAGAAG GACGAGGAAG CAAAATCATT ACTTAGGGAA 2940 2941 CACACACTTC CAATAATGGG ACCAGAGAGG CTTCAAGAGG TTGGTTCGTG TTTGACACTG 3000 3001 GAGACAATGG AGAAGATGAT ACGTCCCTTT GCAATGCCGC CAGAGGATTT CCCCCCGCCG 3060 3061 TCAATTCCGG CTGGCTTCTC CGGTTACTTT TCAAAAAGCG CCGCCGTGCT CGAGCGTCTT 3120 3121 GTAAAACTCT GGCCCTTCAA CAAGAACTAA 3150 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Molecular Function | 5-diphosphoinositol pentakisphosphate 3-kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | Diphosphoinositol-pentakisphosphate kinase activity | |
Molecular Function | Inositol heptakisphosphate kinase activity | |
Molecular Function | Inositol hexakisphosphate 1-kinase activity | |
Molecular Function | Inositol hexakisphosphate 3-kinase activity | |
Molecular Function | Inositol hexakisphosphate 5-kinase activity | |
Molecular Function | Protein kinase activity |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Bro-1729 | Brassica oleracea | 99.05 | 0.0 | 2055 |
| LLPS-Arl-2534 | Arabidopsis lyrata | 94.38 | 0.0 | 1978 |
| LLPS-Art-2741 | Arabidopsis thaliana | 93.01 | 0.0 | 1961 |
| LLPS-Brr-2502 | Brassica rapa | 92.78 | 0.0 | 1939 |
| LLPS-Via-1572 | Vigna angularis | 89.74 | 0.0 | 981 |
| LLPS-Coc-1571 | Corchorus capsularis | 86.74 | 0.0 | 758 |
| LLPS-Pot-1627 | Populus trichocarpa | 84.38 | 0.0 | 1716 |
| LLPS-Thc-1462 | Theobroma cacao | 82.55 | 0.0 | 1703 |
| LLPS-Vir-2128 | Vigna radiata | 81.65 | 0.0 | 1663 |
| LLPS-Gor-1129 | Gossypium raimondii | 81.3 | 0.0 | 1727 |
| LLPS-Met-1367 | Medicago truncatula | 80.89 | 0.0 | 1670 |
| LLPS-Prp-1289 | Prunus persica | 80.87 | 0.0 | 1724 |
| LLPS-Dac-2322 | Daucus carota | 80.81 | 0.0 | 1697 |
| LLPS-Orbr-1773 | Oryza brachyantha | 80.66 | 0.0 | 1247 |
| LLPS-Phv-2551 | Phaseolus vulgaris | 80.37 | 0.0 | 1647 |
| LLPS-Cus-1943 | Cucumis sativus | 79.89 | 0.0 | 1659 |
| LLPS-Sol-1785 | Solanum lycopersicum | 79.64 | 0.0 | 1635 |
| LLPS-Sei-1680 | Setaria italica | 78.73 | 0.0 | 1622 |
| LLPS-Tra-2387 | Triticum aestivum | 77.44 | 0.0 | 1590 |
| LLPS-Mua-1032 | Musa acuminata | 77.36 | 0.0 | 1228 |
| LLPS-Zem-1347 | Zea mays | 75.16 | 0.0 | 1598 |
| LLPS-Lep-1965 | Leersia perrieri | 72.54 | 1e-168 | 529 |
| LLPS-Brd-0593 | Brachypodium distachyon | 72.11 | 0.0 | 1421 |
| LLPS-Sob-0827 | Sorghum bicolor | 70.79 | 0.0 | 1408 |
| LLPS-Hov-0738 | Hordeum vulgare | 70.5 | 0.0 | 1393 |
| LLPS-Php-0573 | Physcomitrella patens | 69.03 | 0.0 | 1384 |
| LLPS-Sem-1627 | Selaginella moellendorffii | 68.83 | 0.0 | 1387 |
| LLPS-Org-1708 | Oryza glaberrima | 68.6 | 0.0 | 1395 |
| LLPS-Orp-0000 | Oryza punctata | 67.66 | 0.0 | 1342 |
| LLPS-Chr-0291 | Chlamydomonas reinhardtii | 67.52 | 3e-36 | 153 |
| LLPS-Chs-4011 | Chlorocebus sabaeus | 60.15 | 3e-40 | 166 |
| LLPS-Cea-1529 | Cercocebus atys | 59.26 | 2e-91 | 324 |
| LLPS-Rhb-2391 | Rhinopithecus bieti | 58.77 | 4e-115 | 388 |
| LLPS-Ast-1512 | Aspergillus terreus | 45.87 | 3e-80 | 290 |
| LLPS-Bot-2999 | Bos taurus | 45.58 | 0.0 | 713 |
| LLPS-Tar-3201 | Takifugu rubripes | 45.37 | 0.0 | 712 |
| LLPS-Orc-3951 | Oryctolagus cuniculus | 45.34 | 0.0 | 714 |
| LLPS-Ova-3415 | Ovis aries | 45.33 | 0.0 | 706 |
| LLPS-Icp-4012 | Ictalurus punctatus | 45.28 | 0.0 | 712 |
| LLPS-Caj-4172 | Callithrix jacchus | 45.24 | 0.0 | 715 |
| LLPS-Asm-3217 | Astyanax mexicanus | 45.22 | 0.0 | 705 |
| LLPS-Ict-2951 | Ictidomys tridecemlineatus | 45.2 | 0.0 | 714 |
| LLPS-Pat-4722 | Pan troglodytes | 45.14 | 0.0 | 716 |
| LLPS-Mam-3125 | Macaca mulatta | 45.14 | 0.0 | 719 |
| LLPS-Maf-2332 | Macaca fascicularis | 45.14 | 0.0 | 719 |
| LLPS-Aon-2190 | Aotus nancymaae | 45.14 | 0.0 | 714 |
| LLPS-Paa-2029 | Papio anubis | 45.14 | 0.0 | 714 |
| LLPS-Scs-0947 | Sclerotinia sclerotiorum | 45.13 | 7e-83 | 300 |
| LLPS-Cas-1777 | Carlito syrichta | 45.1 | 0.0 | 716 |
| LLPS-Sus-4526 | Sus scrofa | 45.08 | 0.0 | 713 |
| LLPS-Orn-2231 | Oreochromis niloticus | 45.04 | 0.0 | 711 |
| LLPS-Gog-1786 | Gorilla gorilla | 45.04 | 0.0 | 714 |
| LLPS-Scm-2277 | Scophthalmus maximus | 45.02 | 0.0 | 705 |
| LLPS-Loa-3860 | Loxodonta africana | 45.02 | 0.0 | 715 |
| LLPS-Osl-0964 | Ostreococcus lucimarinus | 45.01 | 0.0 | 812 |
| LLPS-Gaga-1973 | Gallus gallus | 45.01 | 0.0 | 719 |
| LLPS-Myl-4093 | Myotis lucifugus | 44.99 | 0.0 | 709 |
| LLPS-Fia-3427 | Ficedula albicollis | 44.98 | 0.0 | 722 |
| LLPS-Leo-3206 | Lepisosteus oculatus | 44.97 | 0.0 | 701 |
| LLPS-Ran-3898 | Rattus norvegicus | 44.95 | 0.0 | 707 |
| LLPS-Hos-0020 | Homo sapiens | 44.93 | 0.0 | 717 |
| LLPS-Pes-1960 | Pelodiscus sinensis | 44.93 | 0.0 | 723 |
| LLPS-Ten-0414 | Tetraodon nigroviridis | 44.93 | 0.0 | 702 |
| LLPS-Tag-2938 | Taeniopygia guttata | 44.93 | 0.0 | 725 |
| LLPS-Fec-0523 | Felis catus | 44.89 | 0.0 | 711 |
| LLPS-Eqc-4631 | Equus caballus | 44.89 | 0.0 | 719 |
| LLPS-Mup-0913 | Mustela putorius furo | 44.89 | 0.0 | 710 |
| LLPS-Dar-1834 | Danio rerio | 44.87 | 0.0 | 712 |
| LLPS-Anp-3286 | Anas platyrhynchos | 44.79 | 0.0 | 719 |
| LLPS-Anc-2791 | Anolis carolinensis | 44.75 | 0.0 | 712 |
| LLPS-Scf-1154 | Scleropages formosus | 44.7 | 0.0 | 700 |
| LLPS-Aim-1563 | Ailuropoda melanoleuca | 44.7 | 0.0 | 705 |
| LLPS-Mea-3611 | Mesocricetus auratus | 44.69 | 0.0 | 704 |
| LLPS-Man-3749 | Macaca nemestrina | 44.65 | 0.0 | 701 |
| LLPS-Meg-0775 | Meleagris gallopavo | 44.63 | 0.0 | 721 |
| LLPS-Mod-0570 | Monodelphis domestica | 44.58 | 0.0 | 716 |
| LLPS-Caf-3845 | Canis familiaris | 44.49 | 0.0 | 713 |
| LLPS-Cap-2676 | Cavia porcellus | 44.43 | 0.0 | 712 |
| LLPS-Mal-4225 | Mandrillus leucophaeus | 44.42 | 0.0 | 714 |
| LLPS-Dio-3369 | Dipodomys ordii | 44.33 | 0.0 | 697 |
| LLPS-Otg-1233 | Otolemur garnettii | 44.26 | 0.0 | 704 |
| LLPS-Nol-3231 | Nomascus leucogenys | 44.26 | 0.0 | 702 |
| LLPS-Mum-3442 | Mus musculus | 44.07 | 0.0 | 700 |
| LLPS-Fud-2254 | Fukomys damarensis | 44.02 | 0.0 | 711 |
| LLPS-Gaa-1277 | Gasterosteus aculeatus | 43.99 | 0.0 | 679 |
| LLPS-Orl-3165 | Oryzias latipes | 43.89 | 0.0 | 683 |
| LLPS-Pof-3742 | Poecilia formosa | 43.83 | 0.0 | 677 |
| LLPS-Sah-3355 | Sarcophilus harrisii | 43.83 | 0.0 | 702 |
| LLPS-Chc-0772 | Chondrus crispus | 43.28 | 6e-53 | 193 |
| LLPS-Xim-1363 | Xiphophorus maculatus | 42.93 | 0.0 | 659 |
| LLPS-Cii-1916 | Ciona intestinalis | 42.08 | 0.0 | 644 |
| LLPS-Urm-2469 | Ursus maritimus | 41.24 | 0.0 | 619 |
| LLPS-Lac-3410 | Latimeria chalumnae | 40.86 | 0.0 | 605 |
| LLPS-Poa-3618 | Pongo abelii | 40.66 | 8e-128 | 424 |
| LLPS-Asg-1483 | Ashbya gossypii | 37.18 | 2e-114 | 387 |
| LLPS-Tum-0515 | Tuber melanosporum | 36.55 | 4e-113 | 387 |
| LLPS-Crn-1025 | Cryptococcus neoformans | 36.4 | 2e-71 | 262 |
| LLPS-Abg-0109 | Absidia glauca | 35.03 | 2e-103 | 353 |
| LLPS-Pug-1223 | Puccinia graminis | 34.58 | 1e-105 | 360 |
| LLPS-Miv-1071 | Microbotryum violaceum | 34.5 | 1e-127 | 419 |
| LLPS-Scj-0957 | Schizosaccharomyces japonicus | 34.37 | 7e-123 | 405 |
| LLPS-Sac-0946 | Saccharomyces cerevisiae | 34.22 | 1e-110 | 377 |
| LLPS-Mel-0310 | Melampsora laricipopulina | 33.84 | 5e-110 | 370 |
| LLPS-Scc-1133 | Schizosaccharomyces cryophilus | 33.78 | 6e-124 | 408 |
| LLPS-Spr-1238 | Sporisorium reilianum | 33.61 | 2e-111 | 374 |
| LLPS-Put-1114 | Puccinia triticina | 33.33 | 1e-98 | 340 |
| LLPS-Scp-0564 | Schizosaccharomyces pombe | 33.15 | 9e-126 | 413 |
| LLPS-Kop-1071 | Komagataella pastoris | 32.42 | 3e-115 | 388 |
| LLPS-Phn-1530 | Phaeosphaeria nodorum | 31.48 | 9e-84 | 301 |