LLPS-Ran-1700
Arpc1b

▼ OVERVIEW

Status: Unreviewed
Protein Name: Actin-related protein 2/3 complex subunit 1B; Arp2/3 complex 41 kDa subunit; p41-ARC
Gene Name: Arpc1b
Ensembl Gene: ENSRNOG00000000991.6
Ensembl Protein: ENSRNOP00000001315.4
Organism: Rattus norvegicus
Taxa ID: 10116
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Centrosome/Spindle pole body, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAYHSFLVEP  ISCHAWNKDR  TQIAICPNNH  EVHIYEKSGA  KWNKVHELKE  HNGQVTGIDW  60
61    APESNRIVTC  GTDRNAYVWT  LKGRTWKPTL  VILRINRAAR  CVRWAPNENK  FAVGSGSRVI  120
121   SICYFEQEND  WWVCKHIKKP  IRSTVLSLDW  HPNNVLLAAG  SCDFKCRIFS  AYIKEVEERP  180
181   APTPWGSKMP  FGELMFESSS  SCGWVHGVCF  SAGGSRVAWV  SHDSTVCLVD  AEKKMAVATL  240
241   ASETLPLLAI  TFITENSLVA  AGHDCFPVLF  TYDNAAGTLS  FGGRLDVPKQ  NSQRGLTARE  300
301   RFQNLDKKAS  SEGGAATGAG  LDSLHKNSVS  QISVLSGGKA  KCSQFCTTGM  DGGMSIWDVK  360
361   SLESALKDLK  IR  372
Nucleotide CDS Sequence (FASTA)
1     ATGGCTTACC  ACAGCTTCCT  GGTGGAACCC  ATCAGCTGCC  ATGCCTGGAA  CAAGGACCGT  60
61    ACTCAGATCG  CCATCTGCCC  CAACAACCAC  GAGGTGCACA  TCTACGAGAA  GAGCGGTGCC  120
121   AAGTGGAACA  AGGTGCACGA  GCTCAAGGAG  CACAACGGGC  AGGTGACAGG  CATCGACTGG  180
181   GCCCCCGAGA  GTAACCGCAT  TGTGACCTGC  GGCACAGACC  GCAATGCCTA  TGTGTGGACG  240
241   CTGAAGGGCC  GCACGTGGAA  GCCCACGCTG  GTCATCCTTC  GGATTAATCG  AGCTGCCCGC  300
301   TGCGTGCGCT  GGGCCCCCAA  TGAGAACAAG  TTCGCCGTGG  GCAGTGGCTC  CCGTGTCATT  360
361   TCCATCTGTT  ATTTTGAGCA  GGAGAATGAC  TGGTGGGTGT  GCAAACACAT  CAAAAAGCCC  420
421   ATCCGCTCCA  CTGTCCTTAG  CCTGGACTGG  CACCCCAACA  ACGTGCTCCT  GGCTGCAGGC  480
481   TCCTGTGACT  TCAAGTGCAG  GATCTTCTCT  GCCTATATCA  AGGAGGTGGA  GGAACGGCCA  540
541   GCCCCTACAC  CGTGGGGCTC  CAAGATGCCC  TTTGGGGAGC  TGATGTTTGA  ATCGAGCAGC  600
601   AGCTGTGGCT  GGGTGCATGG  TGTCTGCTTC  TCGGCCGGTG  GGAGCCGAGT  TGCTTGGGTC  660
661   AGCCATGACA  GCACTGTGTG  CCTGGTAGAT  GCTGAGAAGA  AGATGGCCGT  GGCAACCCTG  720
721   GCCTCTGAGA  CATTACCGCT  CCTGGCCATC  ACCTTCATCA  CAGAAAATAG  TCTCGTGGCA  780
781   GCGGGCCACG  ACTGCTTCCC  GGTGCTGTTT  ACCTATGACA  ACGCTGCGGG  GACATTGAGC  840
841   TTTGGTGGCC  GGCTGGATGT  GCCCAAGCAG  AACTCCCAGC  GTGGCCTGAC  AGCCCGAGAG  900
901   CGCTTCCAGA  ACCTCGACAA  GAAGGCCAGC  TCTGAAGGGG  GTGCAGCCAC  AGGGGCTGGC  960
961   CTGGATTCAC  TGCACAAGAA  CAGCGTCAGT  CAAATCTCGG  TGCTCAGCGG  GGGCAAGGCC  1020
1021  AAGTGCTCGC  AGTTCTGCAC  CACAGGCATG  GACGGTGGCA  TGAGCATCTG  GGATGTGAAG  1080
1081  AGCTTGGAGT  CAGCCTTGAA  GGACCTGAAG  ATCAGATGA  1119

▼ KEYWORD

ID
Family
Actin-binding
Complete proteome
Cytoplasm
Cytoskeleton
Nucleus
Reference proteome
Repeat
WD repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Arp2/3 protein complex
Cellular Component
Cytoplasm
Cellular Component
Nucleus
Cellular Component
Tubulobulbar complex
Molecular Function
Actin filament binding
Molecular Function
Protein-containing complex binding
Molecular Function
Structural constituent of cytoskeleton
Biological Process
Arp2/3 complex-mediated actin nucleation
Biological Process
Response to estradiol
Biological Process
Response to estrogen

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mea-1286Mesocricetus auratus98.390.0 739
LLPS-Cas-3882Carlito syrichta97.320.0 538
LLPS-Mum-0511Mus musculus97.070.0 731
LLPS-Gog-3278Gorilla gorilla97.040.0 733
LLPS-Hos-1581Homo sapiens96.770.0 730
LLPS-Pap-2621Pan paniscus96.770.0 730
LLPS-Fec-2838Felis catus96.770.0 731
LLPS-Otg-0986Otolemur garnettii96.770.0 731
LLPS-Cap-1671Cavia porcellus96.770.0 729
LLPS-Pat-2079Pan troglodytes96.510.0 728
LLPS-Poa-1973Pongo abelii96.510.0 734
LLPS-Ict-0081Ictidomys tridecemlineatus96.510.0 728
LLPS-Sus-1979Sus scrofa96.510.0 728
LLPS-Cea-2105Cercocebus atys96.240.0 729
LLPS-Maf-3393Macaca fascicularis96.240.0 729
LLPS-Caj-1263Callithrix jacchus95.970.0 731
LLPS-Urm-1546Ursus maritimus95.740.0 642
LLPS-Myl-1992Myotis lucifugus95.70.0 728
LLPS-Fud-0299Fukomys damarensis95.430.0 724
LLPS-Tut-1507Tursiops truncatus95.430.0 728
LLPS-Mup-1341Mustela putorius furo95.430.0 724
LLPS-Bot-0130Bos taurus95.420.0 719
LLPS-Aon-1788Aotus nancymaae95.170.0 719
LLPS-Caf-1015Canis familiaris95.160.0 723
LLPS-Dio-0839Dipodomys ordii95.160.0 720
LLPS-Paa-0276Papio anubis94.950.0 723
LLPS-Aim-1510Ailuropoda melanoleuca94.950.0 722
LLPS-Ova-0182Ovis aries94.070.0 702
LLPS-Rhb-0043Rhinopithecus bieti93.870.0 706
LLPS-Man-0062Macaca nemestrina93.60.0 706
LLPS-Loa-3188Loxodonta africana93.090.0 704
LLPS-Orc-1575Oryctolagus cuniculus91.940.0 696
LLPS-Eqc-2699Equus caballus87.860.0 710
LLPS-Chs-0908Chlorocebus sabaeus87.630.0 671
LLPS-Ora-3081Ornithorhynchus anatinus87.10.0 687
LLPS-Fia-0146Ficedula albicollis86.630.0 682
LLPS-Meg-0175Meleagris gallopavo86.290.0 684
LLPS-Gaga-0289Gallus gallus86.290.0 684
LLPS-Mod-0477Monodelphis domestica85.750.0 659
LLPS-Xet-0696Xenopus tropicalis80.650.0 632
LLPS-Leo-3010Lepisosteus oculatus80.050.0 649
LLPS-Dar-2482Danio rerio79.780.0 638
LLPS-Asm-0773Astyanax mexicanus79.170.0 622
LLPS-Lac-0506Latimeria chalumnae78.710.0 633
LLPS-Scf-0947Scleropages formosus77.90.0 635
LLPS-Anp-2045Anas platyrhynchos76.149e-104 311
LLPS-Orn-3016Oreochromis niloticus75.590.0 622
LLPS-Orl-1667Oryzias latipes75.390.0 620
LLPS-Ten-1179Tetraodon nigroviridis75.00.0 613
LLPS-Icp-1025Ictalurus punctatus74.310.0 572
LLPS-Gaa-0018Gasterosteus aculeatus74.280.0 609
LLPS-Pof-0800Poecilia formosa73.750.0 603
LLPS-Tar-1317Takifugu rubripes73.680.0 607
LLPS-Xim-0609Xiphophorus maculatus72.220.0 561
LLPS-Scm-1426Scophthalmus maximus70.70.0 540
LLPS-Mam-1468Macaca mulatta67.40.0 530
LLPS-Nol-4310Nomascus leucogenys66.760.0 544
LLPS-Tag-2823Taeniopygia guttata66.760.0 537
LLPS-Anc-0679Anolis carolinensis66.490.0 536
LLPS-Sah-2146Sarcophilus harrisii66.310.0 540
LLPS-Pes-1033Pelodiscus sinensis66.220.0 536
LLPS-Mal-3748Mandrillus leucophaeus65.482e-178 508
LLPS-Spr-1200Sporisorium reilianum55.865e-110 336
LLPS-Usm-1163Ustilago maydis55.092e-108 331
LLPS-Cis-0769Ciona savignyi52.235e-127 377
LLPS-Cii-2329Ciona intestinalis51.353e-125 372
LLPS-Cae-1715Caenorhabditis elegans50.552e-127 378
LLPS-Phv-2528Phaseolus vulgaris50.433e-75 240
LLPS-Drm-1624Drosophila melanogaster50.03e-132 390
LLPS-Amt-2206Amborella trichopoda49.294e-60 202
LLPS-Hov-1473Hordeum vulgare47.552e-82 263
LLPS-Sol-0504Solanum lycopersicum47.467e-74 251
LLPS-Via-2132Vigna angularis45.638e-76 248
LLPS-Miv-0360Microbotryum violaceum44.563e-102 315
LLPS-Php-1030Physcomitrella patens44.411e-95 299
LLPS-Asni-1565Aspergillus niger44.262e-100 308
LLPS-Ast-1398Aspergillus terreus44.231e-102 315
LLPS-Abg-0834Absidia glauca44.28e-104 318
LLPS-Scj-1410Schizosaccharomyces japonicus44.095e-95 295
LLPS-Sem-2445Selaginella moellendorffii43.851e-95 297
LLPS-Crn-1480Cryptococcus neoformans43.652e-108 331
LLPS-Gor-0445Gossypium raimondii43.322e-95 296
LLPS-Pot-1876Populus trichocarpa43.211e-93 291
LLPS-Asc-0587Aspergillus clavatus43.219e-101 310
LLPS-Mel-0026Melampsora laricipopulina42.978e-103 317
LLPS-Zyt-0493Zymoseptoria tritici42.931e-95 296
LLPS-Hea-2431Helianthus annuus42.784e-92 288
LLPS-Asf-1538Aspergillus flavus42.784e-90 291
LLPS-Asn-1331Aspergillus nidulans42.669e-100 307
LLPS-Put-1335Puccinia triticina42.573e-105 323
LLPS-Thc-1435Theobroma cacao42.552e-93 291
LLPS-Scs-1040Sclerotinia sclerotiorum42.51e-94 294
LLPS-Coo-1452Colletotrichum orbiculare42.424e-95 295
LLPS-Aso-1473Aspergillus oryzae42.383e-95 295
LLPS-Orbr-0347Oryza brachyantha42.318e-92 287
LLPS-Asfu-0290Aspergillus fumigatus42.313e-101 311
LLPS-Cus-1470Cucumis sativus42.284e-91 285
LLPS-Scp-0433Schizosaccharomyces pombe42.255e-95 295
LLPS-Sob-2167Sorghum bicolor42.233e-95 296
LLPS-Mua-0378Musa acuminata42.233e-90 283
LLPS-Kop-0341Komagataella pastoris42.192e-87 275
LLPS-Fus-0415Fusarium solani42.153e-94 293
LLPS-Cog-0983Colletotrichum gloeosporioides42.154e-94 292
LLPS-Tra-1085Triticum aestivum42.127e-89 279
LLPS-Brd-0826Brachypodium distachyon42.124e-90 283
LLPS-Fuo-0081Fusarium oxysporum42.085e-94 292
LLPS-Nef-0952Neosartorya fischeri42.032e-100 309
LLPS-Prp-0222Prunus persica41.965e-95 295
LLPS-Ved-0132Verticillium dahliae41.921e-94 294
LLPS-Nia-0531Nicotiana attenuata41.896e-91 285
LLPS-Cogr-1658Colletotrichum graminicola41.872e-95 296
LLPS-Phn-1331Phaeosphaeria nodorum41.87e-94 293
LLPS-Mae-1009Manihot esculenta41.769e-92 287
LLPS-Pug-0005Puccinia graminis41.732e-103 318
LLPS-Pytr-0976Pyrenophora triticirepentis41.715e-97 300
LLPS-Ors-0129Oryza sativa41.691e-91 286
LLPS-Ori-0691Oryza indica41.699e-92 287
LLPS-Dac-1064Daucus carota41.691e-88 279
LLPS-Tum-1563Tuber melanosporum41.692e-92 287
LLPS-Orr-1912Oryza rufipogon41.643e-90 285
LLPS-Orm-1729Oryza meridionalis41.644e-90 285
LLPS-Orb-0875Oryza barthii41.643e-90 285
LLPS-Orni-0974Oryza nivara41.643e-90 285
LLPS-Lem-0667Leptosphaeria maculans41.648e-94 292
LLPS-Orgl-1846Oryza glumaepatula41.644e-90 285
LLPS-Viv-0992Vitis vinifera41.621e-96 299
LLPS-Bro-1482Brassica oleracea41.622e-93 291
LLPS-Dos-1175Dothistroma septosporum41.534e-94 293
LLPS-Brn-2199Brassica napus41.517e-97 300
LLPS-Lep-0877Leersia perrieri41.56e-90 283
LLPS-Art-2859Arabidopsis thaliana41.461e-92 289
LLPS-Coc-0388Corchorus capsularis41.466e-92 287
LLPS-Pyt-1261Pyrenophora teres41.373e-97 300
LLPS-Fuv-1401Fusarium verticillioides41.322e-93 291
LLPS-Yal-1389Yarrowia lipolytica41.295e-86 272
LLPS-Blg-1376Blumeria graminis41.214e-91 285
LLPS-Sei-1261Setaria italica41.032e-91 286
LLPS-Brr-0629Brassica rapa40.768e-94 292
LLPS-Met-2364Medicago truncatula40.758e-96 297
LLPS-Mao-0724Magnaporthe oryzae40.661e-91 286
LLPS-Arl-1539Arabidopsis lyrata40.651e-91 287
LLPS-Nec-1072Neurospora crassa40.651e-93 291
LLPS-Beb-1636Beauveria bassiana40.52e-90 283
LLPS-Glm-1553Glycine max40.485e-93 290
LLPS-Gag-1297Gaeumannomyces graminis40.392e-91 286
LLPS-Zem-1804Zea mays40.365e-90 283
LLPS-Trr-0084Trichoderma reesei40.331e-90 283
LLPS-Trv-0229Trichoderma virens40.285e-90 282
LLPS-Vir-1099Vigna radiata40.222e-91 285
LLPS-Tru-0675Triticum urartu40.063e-78 252
LLPS-Scc-0280Schizosaccharomyces cryophilus39.891e-91 286
LLPS-Asg-0143Ashbya gossypii37.837e-74 241
LLPS-Sac-1174Saccharomyces cerevisiae35.74e-70 231
LLPS-Orp-2305Oryza punctata33.74e-57 197
LLPS-Chr-1120Chlamydomonas reinhardtii33.335e-40 152