• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Pof-3176

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Lysine-specific histone demethylase
Ensembl Gene: ENSPFOG00000010119.2
Ensembl Protein: ENSPFOP00000010348.2
Organism: Poecilia formosa
Taxa ID: 48698
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDITRCTEKW  ERPPSSSIML  SSKKSDAGSS  SSSSSSSVGA  AGGERPLGAD  VQSGPSASAA  60
61    GPLDPKKKER  SSPSGEPGGP  PFPHQSGPAG  ADADSAEVRR  TSRRKRAKVE  YREMDESLAN  120
121   LSEDEYYSEE  ERNAKAEKER  KQVIPPPAPP  PEEENDSEPE  EPSGLEGAAF  QSRLPHDRMT  180
181   SQEAACFPDI  ISGPQQTQKV  FLYIRNRTIQ  LWLDNPKIQL  TFEATVQQLE  APYNSDTVLV  240
241   HRVHSYLERH  GLINFGIYKR  VKPLPTKKTG  KVIIIGGGVS  GLAAARQLQS  FGMDVTVLEA  300
301   RDRVGGRVAT  FRKGNYVADL  GAMVVTGLGG  NPMAVVSKQV  NMELAKIKQK  CPLYEANGQA  360
361   GERCTSVPKE  KDEMVEQEFN  RLLEATSYLS  HQLDFNFLNN  KPVSLGQALE  VVIQLQEKHV  420
421   KDEQIEHWKK  IVKTQEELRD  LLNKMVSTKE  RVKELHQQYK  EASEVKPPRD  ITAEFLVKSK  480
481   HRDLTALCKE  YDELAEMQVK  LEEKLQELEA  NPPSDVYLSS  RDRQILDWHF  ANLEFANATP  540
541   LSTLSLKHWD  QDDDFEFTGS  HLTVRNGYSC  VPVALAEGLD  IKLNTAVRQV  RYTASGCEVI  600
601   AVNTRSTTQT  FIYKCDAVLC  TLPLGVLKQQ  PPAVQFVPPL  PEWKTSAIQR  MGFGNLNKVV  660
661   LCFDRVFWDP  SVNLFGHVGS  TTASRGELFL  FWNLYKAPIL  LALMAGEAAG  IMENISDDVI  720
721   VGRCLAILKG  IFGSSAVPQP  KETVVTRWRA  DPWARGSYSY  VAAGSSGNDY  DLMAQPITPG  780
781   PAIPGASQPV  PRLFFAGEHT  IRNYPATVHG  ALLSGLREAG  RIADQFLGAM  YTLPRQATPT  840
841   ATTNPQQAQP  AAAV  854
Nucleotide CDS Sequence (FASTA)
1     ATGGATATTA  CCAGGTGTAC  GGAGAAATGG  GAGAGGCCTC  CATCGTCTTC  CATTATGCTG  60
61    TCTAGCAAGA  AATCAGATGC  AGGCTCTTCG  TCCTCCTCCT  CTTCATCTTC  TGTGGGAGCA  120
121   GCGGGGGGCG  AACGGCCGCT  AGGAGCCGAT  GTCCAGAGCG  GCCCGTCCGC  CTCGGCCGCT  180
181   GGGCCGCTGG  ACCCGAAGAA  AAAGGAGAGA  TCGTCCCCGA  GCGGGGAGCC  CGGCGGGCCC  240
241   CCGTTCCCCC  ACCAGTCAGG  GCCTGCAGGC  GCCGACGCTG  ACTCGGCTGA  AGTCCGCAGA  300
301   ACGAGTCGGC  GGAAGCGAGC  AAAAGTGGAG  TACCGCGAGA  TGGACGAAAG  CCTGGCCAAC  360
361   TTGTCCGAGG  ATGAGTATTA  CTCTGAGGAG  GAGAGGAACG  CCAAGGCGGA  GAAGGAAAGG  420
421   AAGCAGGTCA  TCCCTCCTCC  GGCGCCGCCT  CCGGAGGAGG  AGAACGACAG  CGAACCTGAA  480
481   GAACCATCAG  GTCTGGAAGG  AGCTGCTTTC  CAGAGCCGCC  TTCCTCACGA  CAGAATGACG  540
541   TCCCAGGAAG  CCGCCTGCTT  CCCCGACATC  ATCAGCGGCC  CTCAGCAGAC  GCAGAAAGTC  600
601   TTCCTGTACA  TCCGCAACCG  CACCATCCAG  CTGTGGCTGG  ACAACCCGAA  GATTCAGCTC  660
661   ACCTTTGAGG  CGACTGTTCA  GCAGCTGGAA  GCTCCATACA  ACAGCGATAC  GGTTTTGGTT  720
721   CACAGAGTTC  ACAGCTACTT  AGAGAGGCAC  GGCCTCATTA  ACTTCGGCAT  TTACAAGAGA  780
781   GTCAAGCCTT  TACCCACGAA  GAAGACGGGG  AAGGTCATCA  TCATCGGCGG  CGGCGTTTCC  840
841   GGCCTGGCTG  CAGCCAGACA  GCTGCAGAGT  TTTGGGATGG  ATGTTACAGT  TCTGGAAGCC  900
901   AGGGACCGCG  TGGGAGGAAG  AGTCGCCACG  TTCAGGAAGG  GAAACTATGT  AGCCGACCTG  960
961   GGAGCCATGG  TGGTAACCGG  ACTGGGAGGG  AATCCCATGG  CGGTGGTCAG  TAAGCAGGTC  1020
1021  AACATGGAGC  TGGCCAAGAT  CAAGCAGAAG  TGTCCTCTGT  ACGAAGCCAA  CGGCCAGGCT  1080
1081  GGTGAACGGT  GCACCAGTGT  CCCGAAGGAA  AAAGACGAGA  TGGTGGAGCA  GGAGTTCAAC  1140
1141  CGGCTGCTGG  AGGCGACCTC  CTACCTGAGC  CACCAGCTGG  ACTTCAACTT  CCTCAACAAC  1200
1201  AAGCCGGTTT  CACTGGGCCA  GGCGCTGGAG  GTGGTCATCC  AGCTGCAGGA  GAAACATGTT  1260
1261  AAAGACGAGC  AGATTGAACA  CTGGAAGAAG  ATCGTTAAGA  CTCAGGAAGA  GCTGAGAGAT  1320
1321  CTCCTCAACA  AGATGGTTTC  CACTAAGGAG  CGCGTCAAGG  AGCTCCACCA  GCAGTACAAG  1380
1381  GAAGCGAGCG  AAGTGAAGCC  GCCCAGAGAC  ATCACTGCTG  AGTTCCTGGT  GAAGAGCAAA  1440
1441  CACCGAGACC  TGACGGCGCT  CTGCAAGGAG  TACGATGAGC  TGGCGGAGAT  GCAGGTGAAG  1500
1501  CTGGAGGAGA  AGCTGCAGGA  GCTGGAGGCC  AACCCCCCCA  GTGATGTTTA  CCTTTCATCC  1560
1561  CGGGATCGGC  AGATCCTAGA  CTGGCACTTT  GCCAACCTGG  AGTTTGCCAA  CGCCACTCCC  1620
1621  CTCTCCACCC  TGTCTCTGAA  GCACTGGGAT  CAGGACGACG  ACTTCGAGTT  CACCGGCAGC  1680
1681  CACCTGACGG  TGCGGAACGG  CTACTCGTGC  GTCCCTGTGG  CACTGGCCGA  GGGTTTGGAC  1740
1741  ATCAAGCTGA  ACACGGCGGT  GCGGCAGGTC  CGATACACGG  CGTCCGGATG  TGAGGTCATC  1800
1801  GCCGTCAACA  CGCGCTCCAC  CACGCAGACC  TTCATATATA  AGTGCGACGC  CGTCCTGTGC  1860
1861  ACGCTGCCGC  TGGGCGTGCT  GAAGCAGCAG  CCGCCCGCCG  TCCAGTTTGT  CCCGCCGCTG  1920
1921  CCAGAGTGGA  AGACCTCGGC  CATTCAGAGG  ATGGGCTTTG  GAAACCTCAA  CAAGGTGGTG  1980
1981  CTGTGCTTCG  ACCGGGTCTT  CTGGGATCCG  AGCGTCAACC  TGTTTGGTCA  TGTCGGCTCC  2040
2041  ACCACCGCCA  GCCGGGGCGA  ACTCTTCCTC  TTCTGGAACC  TCTACAAAGC  GCCCATCCTG  2100
2101  CTGGCCCTGA  TGGCCGGAGA  GGCGGCCGGC  ATCATGGAGA  ACATCAGCGA  CGACGTCATC  2160
2161  GTCGGGCGCT  GCCTCGCCAT  TCTCAAAGGG  ATATTTGGGA  GCAGCGCCGT  GCCTCAGCCG  2220
2221  AAGGAGACGG  TGGTGACGCG  GTGGCGGGCC  GACCCCTGGG  CCAGGGGCTC  GTACTCGTAC  2280
2281  GTGGCGGCCG  GCTCTTCGGG  TAACGACTAC  GACCTGATGG  CCCAGCCCAT  CACGCCCGGC  2340
2341  CCGGCCATCC  CAGGAGCCTC  ACAGCCCGTC  CCTCGGCTCT  TCTTCGCCGG  CGAGCACACC  2400
2401  ATCAGAAACT  ACCCGGCCAC  CGTTCACGGC  GCCCTGCTGA  GCGGCCTGCG  CGAGGCCGGC  2460
2461  CGCATCGCCG  ACCAGTTCCT  GGGCGCCATG  TACACGCTGC  CCCGACAGGC  CACGCCCACC  2520
2521  GCCACCACCA  ACCCTCAGCA  GGCGCAGCCC  GCCGCCGCCG  TCTGA  2565

▼ KEYWORD

ID
Family
Chromatin regulator
Coiled coil
Complete proteome
FAD
Flavoprotein
Nucleus
Oxidoreductase
Reference proteome
Repressor
Transcription
Transcription regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleus
Molecular Function
DNA binding
Molecular Function
Flavin adenine dinucleotide binding
Molecular Function
Oxidoreductase activity
Biological Process
Histone H3-K4 demethylation
Biological Process
Nervous system development
Biological Process
Regulation of hemopoiesis
Biological Process
Regulation of retinoic acid biosynthetic process
Biological Process
Regulation of transcription, DNA-templated

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Xim-3902Xiphophorus maculatus99.110.01400
LLPS-Urm-0861Ursus maritimus96.570.0 897
LLPS-Tag-3063Taeniopygia guttata96.420.01266
LLPS-Fia-2599Ficedula albicollis96.420.01264
LLPS-Meg-3145Meleagris gallopavo96.420.01265
LLPS-Anp-0654Anas platyrhynchos96.420.01267
LLPS-Pes-0618Pelodiscus sinensis96.130.01260
LLPS-Nol-1636Nomascus leucogenys95.830.01263
LLPS-Orl-3844Oryzias latipes95.830.01404
LLPS-Orn-0592Oreochromis niloticus95.820.01370
LLPS-Gaa-4009Gasterosteus aculeatus95.80.01362
LLPS-Ict-1162Ictidomys tridecemlineatus95.680.01260
LLPS-Cap-4555Cavia porcellus95.680.01257
LLPS-Myl-2156Myotis lucifugus95.680.01260
LLPS-Ova-4403Ovis aries95.680.01260
LLPS-Dio-1561Dipodomys ordii95.680.01260
LLPS-Fud-3408Fukomys damarensis95.530.01258
LLPS-Scm-0722Scophthalmus maximus95.470.01390
LLPS-Ten-1062Tetraodon nigroviridis95.460.01370
LLPS-Tar-3520Takifugu rubripes95.450.01395
LLPS-Gaga-0795Gallus gallus95.140.01299
LLPS-Scf-4182Scleropages formosus94.560.01346
LLPS-Dar-3042Danio rerio94.260.01318
LLPS-Icp-2266Ictalurus punctatus93.170.01368
LLPS-Asm-2075Astyanax mexicanus92.680.01342
LLPS-Anc-3484Anolis carolinensis92.190.01287
LLPS-Poa-0841Pongo abelii91.980.01278
LLPS-Caf-2598Canis familiaris91.980.01276
LLPS-Fec-2864Felis catus91.980.01278
LLPS-Mod-2519Monodelphis domestica91.980.01277
LLPS-Pat-3029Pan troglodytes91.980.01279
LLPS-Pap-1552Pan paniscus91.980.01279
LLPS-Hos-0152Homo sapiens91.980.01279
LLPS-Aim-0421Ailuropoda melanoleuca91.980.01277
LLPS-Mal-0930Mandrillus leucophaeus91.980.01272
LLPS-Gog-0164Gorilla gorilla91.980.01279
LLPS-Mum-3550Mus musculus91.850.01276
LLPS-Orc-2965Oryctolagus cuniculus91.720.01274
LLPS-Cas-2281Carlito syrichta91.550.01279
LLPS-Rhb-1458Rhinopithecus bieti90.410.01265
LLPS-Leo-1160Lepisosteus oculatus90.390.01343
LLPS-Cea-0875Cercocebus atys90.370.01279
LLPS-Xet-1789Xenopus tropicalis89.170.01276
LLPS-Ran-1973Rattus norvegicus87.420.01273
LLPS-Mam-3198Macaca mulatta87.410.01279
LLPS-Otg-0829Otolemur garnettii87.410.01276
LLPS-Man-3919Macaca nemestrina87.410.01279
LLPS-Paa-1747Papio anubis87.410.01279
LLPS-Bot-3485Bos taurus87.410.01277
LLPS-Caj-4386Callithrix jacchus87.410.01279
LLPS-Chs-4356Chlorocebus sabaeus87.410.01279
LLPS-Maf-0383Macaca fascicularis87.410.01279
LLPS-Aon-3100Aotus nancymaae87.410.01279
LLPS-Eqc-3832Equus caballus87.210.01280
LLPS-Sus-1117Sus scrofa87.210.01279
LLPS-Loa-0308Loxodonta africana86.720.01270
LLPS-Mea-1140Mesocricetus auratus86.270.01278
LLPS-Mup-4378Mustela putorius furo85.060.01154
LLPS-Sah-3403Sarcophilus harrisii79.780.0 811
LLPS-Lac-3354Latimeria chalumnae75.10.0 900
LLPS-Drm-2355Drosophila melanogaster58.30.0 783
LLPS-Cii-1657Ciona intestinalis54.930.0 719
LLPS-Cis-1670Ciona savignyi52.30.0 627
LLPS-Gor-1842Gossypium raimondii45.683e-67 250
LLPS-Prp-2203Prunus persica45.283e-66 247
LLPS-Sem-0203Selaginella moellendorffii45.022e-70 258
LLPS-Orgl-1701Oryza glumaepatula44.972e-66 248
LLPS-Orni-0485Oryza nivara44.972e-66 248
LLPS-Ori-1499Oryza indica44.972e-66 248
LLPS-Orb-1047Oryza barthii44.974e-66 246
LLPS-Met-1955Medicago truncatula44.92e-64 242
LLPS-Glm-2510Glycine max44.92e-64 241
LLPS-Orbr-0002Oryza brachyantha44.876e-70 246
LLPS-Sot-2251Solanum tuberosum44.758e-65 241
LLPS-Orr-1592Oryza rufipogon44.656e-66 246
LLPS-Ors-2403Oryza sativa44.651e-66 246
LLPS-Dac-2297Daucus carota44.656e-64 240
LLPS-Thc-1599Theobroma cacao44.483e-64 241
LLPS-Lep-2113Leersia perrieri44.444e-67 238
LLPS-Coc-1946Corchorus capsularis44.144e-65 243
LLPS-Asf-1236Aspergillus flavus44.118e-66 243
LLPS-Aso-1416Aspergillus oryzae44.118e-66 243
LLPS-Pot-2548Populus trichocarpa44.047e-65 243
LLPS-Mae-1677Manihot esculenta43.965e-63 237
LLPS-Brr-2829Brassica rapa43.711e-65 245
LLPS-Brn-1693Brassica napus43.711e-65 244
LLPS-Asni-0953Aspergillus niger43.075e-63 233
LLPS-Ast-1519Aspergillus terreus42.864e-62 231
LLPS-Asfu-0696Aspergillus fumigatus42.771e-62 233
LLPS-Nef-0191Neosartorya fischeri42.774e-62 231
LLPS-Asn-1123Aspergillus nidulans42.423e-63 236
LLPS-Amt-1133Amborella trichopoda42.242e-59 226
LLPS-Fuo-1338Fusarium oxysporum41.743e-65 237
LLPS-Fus-0191Fusarium solani41.744e-63 233
LLPS-Fuv-1011Fusarium verticillioides41.742e-64 234
LLPS-Tum-1360Tuber melanosporum41.574e-66 242
LLPS-Dos-0020Dothistroma septosporum41.441e-58 222
LLPS-Cogr-1518Colletotrichum graminicola41.215e-62 231
LLPS-Cog-1072Colletotrichum gloeosporioides40.96e-61 228
LLPS-Osl-1485Ostreococcus lucimarinus40.322e-58 221
LLPS-Phn-1253Phaeosphaeria nodorum40.067e-65 237
LLPS-Nec-1182Neurospora crassa40.066e-60 227
LLPS-Gag-1587Gaeumannomyces graminis39.475e-59 223
LLPS-Chr-1723Chlamydomonas reinhardtii39.42e-50 196
LLPS-Map-1217Magnaporthe poae38.892e-59 224
LLPS-Orm-1377Oryza meridionalis37.359e-84 300
LLPS-Chc-1053Chondrus crispus37.138e-50 192
LLPS-Tru-0219Triticum urartu37.019e-87 309
LLPS-Tra-2592Triticum aestivum37.015e-87 310
LLPS-Sei-1196Setaria italica36.941e-84 302
LLPS-Zem-2567Zea mays36.644e-82 295
LLPS-Hov-0899Hordeum vulgare36.482e-83 299
LLPS-Php-2340Physcomitrella patens36.357e-85 303
LLPS-Sol-0683Solanum lycopersicum35.892e-77 281
LLPS-Pyt-0667Pyrenophora teres32.911e-78 281
LLPS-Pytr-0139Pyrenophora triticirepentis32.395e-78 280
LLPS-Asc-1684Aspergillus clavatus31.987e-72 261
LLPS-Ved-1429Verticillium dahliae31.971e-76 275
LLPS-Lem-0374Leptosphaeria maculans31.544e-73 265
LLPS-Beb-0809Beauveria bassiana31.492e-74 268
LLPS-Blg-0701Blumeria graminis31.223e-68 250
LLPS-Zyt-0389Zymoseptoria tritici30.99e-69 250
LLPS-Yal-1237Yarrowia lipolytica30.798e-71 259
LLPS-Coo-1313Colletotrichum orbiculare30.651e-72 263
LLPS-Mao-0932Magnaporthe oryzae29.572e-64 239
LLPS-Cae-0780Caenorhabditis elegans27.936e-53 201