• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Icp-2266
kdm1a

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Lysine-specific histone demethylase
Gene Name: kdm1a
Ensembl Gene: ENSIPUG00000004255.1
Ensembl Protein: ENSIPUP00000006134.1
Organism: Ictalurus punctatus
Taxa ID: 7998
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDISRCTEKW  ERPLSSSIML  SNKKDPGSSS  SSSSSSGGNG  ADRALETSAG  SQSVAPTGSS  60
61    ASSADVKKKE  RASPSGEASG  PPLPHLPGSA  GADQDSAEGR  RTSRRKRAKV  EYREMDESLA  120
121   NLSEDEYYSE  EERNAKAEKE  RKQVVPPPAP  PVEEENDSEP  EEPSGLEGAA  FQSRLPHDRM  180
181   TSQEAACFPD  IISGPQQTQK  VFLYIRNRTL  QLWLDNPKVQ  LTFESTVQQL  EAPYNSDAGL  240
241   VHRIHSYLER  HGLINFGIYK  RVKPLPSKKT  GKVIVIGGGV  SGLAAARQLQ  SFGMDVTVLE  300
301   ARDRVGGRVA  TFRKGNYVAD  LGAMVVTGLG  GNPMAVISKQ  VNMELAKIKQ  KCPLYEANGQ  360
361   AGERCTSVPK  EKDEMVEQEF  NRLLEATSYL  SHQLDFNFLN  NKPVSLGQAL  EVVIQLQEKH  420
421   VKDEQIEHWK  KIVKTQEELK  DLLNKMVSTK  EKVKELHQQY  KEASEVKPPR  DITAEFLVKS  480
481   KHRDLTALCK  EYDALAEQQV  KLEERLQELE  ANPPSDVYLS  SRDRQILDWH  FANLEFANAT  540
541   PLSTLSLKHW  DQDDDFEFTG  SHLTVRNGYS  CVPVALAEGL  DIKLNTAVRQ  VRYTSSGCEV  600
601   IAVNTRSTTQ  TFIYKCDAVL  CTLPLGVMKQ  QPPAVQFVPP  LPEWKTSAIQ  RMGFGNLNKV  660
661   VLCFDRVFWD  PSVNLFGHVG  STTASRGELF  LFWNLYKAPI  LLALMAGEAA  GIMENISDDV  720
721   IVGRCLAILK  GIFGSSAVPQ  PKETVVTRWR  ADPWARGSYS  YVAAGSSGND  YDLMAQPITP  780
781   GPAIPGASQP  VPRLFFAGEH  TIRNYPATVH  GALLSGLREA  GRIADQFLGA  MYTVPRQNTP  840
841   AANPQPSPSV  850
Nucleotide CDS Sequence (FASTA)
1     ATGGATATTT  CCCGGTGCAC  CGAGAAATGG  GAGAGGCCTC  TGTCATCCTC  CATCATGCTC  60
61    TCAAATAAGA  AAGACCCAGG  CTCTTCCTCC  TCCTCTTCCT  CTTCCTCAGG  AGGGAACGGG  120
121   GCTGATCGGG  CCCTGGAGAC  CTCTGCGGGC  TCCCAGTCGG  TAGCTCCGAC  AGGTTCTTCT  180
181   GCTTCTTCCG  CAGACGTGAA  GAAGAAAGAA  AGGGCCTCCC  CTAGCGGAGA  GGCGAGCGGA  240
241   CCACCGCTGC  CTCACCTACC  CGGCTCGGCA  GGAGCGGATC  AGGACTCGGC  CGAAGGGCGC  300
301   AGGACCAGCC  GGCGCAAGAG  AGCCAAAGTG  GAGTACAGGG  AGATGGACGA  GAGCCTGGCG  360
361   AACCTGTCGG  AGGACGAGTA  CTACTCGGAG  GAGGAGAGGA  ACGCTAAAGC  GGAGAAAGAA  420
421   CGAAAGCAGG  TGGTCCCTCC  ACCTGCTCCA  CCTGTGGAGG  AGGAAAACGA  CAGTGAGCCA  480
481   GAGGAGCCCT  CGGGTTTAGA  GGGCGCAGCC  TTTCAGAGTC  GCCTCCCACA  TGATCGAATG  540
541   ACATCACAGG  AAGCAGCGTG  TTTCCCTGAC  ATCATCAGCG  GGCCACAGCA  GACTCAGAAG  600
601   GTCTTCCTGT  ACATCAGGAA  CCGCACGCTC  CAGCTCTGGT  TGGATAACCC  AAAGGTCCAG  660
661   CTCACGTTTG  AGTCTACAGT  CCAACAGCTG  GAGGCACCTT  ACAACAGTGA  TGCTGGCCTA  720
721   GTTCACAGAA  TCCACAGCTA  CCTGGAGAGG  CATGGCCTCA  TCAACTTTGG  CATCTACAAG  780
781   AGAGTCAAAC  CTCTACCAAG  TAAGAAGACA  GGGAAGGTGA  TTGTGATTGG  GGGAGGAGTG  840
841   TCTGGTCTGG  CGGCTGCGAG  GCAGCTGCAG  AGCTTCGGCA  TGGACGTCAC  TGTGCTGGAA  900
901   GCCAGGGATC  GTGTTGGAGG  AAGAGTGGCC  ACCTTTCGTA  AAGGCAATTA  CGTAGCAGAC  960
961   CTGGGAGCAA  TGGTGGTTAC  AGGCCTAGGT  GGAAACCCTA  TGGCTGTTAT  CAGTAAGCAA  1020
1021  GTGAATATGG  AACTGGCCAA  GATTAAACAG  AAGTGTCCCC  TCTATGAGGC  CAATGGCCAG  1080
1081  GCTGGAGAGC  GATGCACAAG  TGTTCCTAAG  GAGAAGGATG  AGATGGTGGA  GCAAGAGTTT  1140
1141  AACAGGCTTC  TGGAGGCCAC  GTCCTATCTC  AGCCACCAAC  TTGACTTCAA  CTTCCTCAAT  1200
1201  AACAAACCTG  TGTCTCTTGG  CCAAGCCTTG  GAAGTGGTCA  TACAGCTGCA  GGAGAAGCAT  1260
1261  GTGAAGGATG  AGCAGATCGA  GCACTGGAAG  AAGATCGTAA  AGACGCAGGA  GGAGCTTAAA  1320
1321  GACCTGCTTA  ATAAGATGGT  GTCCACTAAG  GAGAAAGTAA  AGGAGCTGCA  TCAACAGTAT  1380
1381  AAAGAGGCGA  GTGAGGTGAA  GCCTCCCAGG  GACATCACGG  CCGAGTTCCT  GGTCAAGAGC  1440
1441  AAACATCGTG  ATCTTACCGC  CCTCTGCAAG  GAATATGATG  CATTGGCTGA  GCAGCAGGTG  1500
1501  AAACTTGAGG  AGAGATTGCA  AGAGCTGGAG  GCTAATCCAC  CCAGCGACGT  GTATCTGTCC  1560
1561  TCAAGAGACA  GACAGATTCT  GGACTGGCAC  TTTGCAAACC  TGGAGTTTGC  CAACGCCACA  1620
1621  CCTCTGTCTA  CACTCTCACT  CAAACACTGG  GATCAGGACG  ATGATTTTGA  GTTCACAGGG  1680
1681  AGTCACCTGA  CCGTGAGGAA  TGGCTACTCG  TGTGTTCCGG  TGGCGCTGGC  CGAGGGTTTG  1740
1741  GACATCAAAC  TTAACACAGC  TGTGCGTCAG  GTGCGCTACA  CCTCCTCAGG  TTGTGAGGTG  1800
1801  ATAGCCGTGA  ACACACGCTC  AACCACGCAG  ACATTTATCT  ATAAATGTGA  TGCGGTGCTG  1860
1861  TGTACGCTTC  CTCTGGGAGT  GATGAAGCAG  CAGCCACCCG  CGGTACAGTT  TGTGCCTCCG  1920
1921  CTGCCCGAGT  GGAAGACGTC  TGCTATTCAG  AGGATGGGTT  TCGGCAACCT  CAACAAGGTG  1980
1981  GTGCTGTGTT  TCGACCGTGT  GTTTTGGGAC  CCAAGCGTGA  ACCTGTTCGG  TCACGTAGGG  2040
2041  AGCACCACAG  CCAGCCGTGG  AGAGCTCTTC  CTTTTCTGGA  ACCTCTACAA  AGCCCCCATT  2100
2101  CTGCTGGCGC  TAATGGCCGG  AGAGGCTGCA  GGAATTATGG  AGAACATCAG  CGATGATGTC  2160
2161  ATCGTGGGAC  GTTGCCTAGC  GATCCTAAAA  GGAATCTTCG  GTAGCAGTGC  AGTTCCTCAG  2220
2221  CCGAAAGAGA  CGGTGGTGAC  GCGATGGCGT  GCAGACCCCT  GGGCTCGTGG  CTCATACTCT  2280
2281  TACGTGGCAG  CTGGTTCCTC  TGGCAATGAC  TATGACCTCA  TGGCCCAGCC  AATCACGCCT  2340
2341  GGACCTGCAA  TACCTGGGGC  CTCACAGCCC  GTTCCTCGAC  TCTTCTTCGC  CGGGGAGCAC  2400
2401  ACAATCCGGA  ACTATCCAGC  GACGGTACAC  GGAGCTCTGC  TGAGTGGCCT  CAGGGAGGCA  2460
2461  GGACGCATCG  CTGATCAATT  TCTCGGAGCC  ATGTACACAG  TGCCACGGCA  GAACACACCC  2520
2521  GCTGCCAACC  CCCAGCCCTC  TCCCAGTGTG  TAG  2553

▼ KEYWORD

ID
Family
Chromatin regulator
Coiled coil
Complete proteome
FAD
Flavoprotein
Methyltransferase
Nucleus
Oxidoreductase
Reference proteome
Repressor
Transcription
Transcription regulation
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleus
Molecular Function
DNA binding
Molecular Function
Flavin adenine dinucleotide binding
Molecular Function
Methyltransferase activity
Molecular Function
Oxidoreductase activity
Biological Process
Histone H3-K4 demethylation
Biological Process
Nervous system development
Biological Process
Regulation of hemopoiesis
Biological Process
Regulation of retinoic acid biosynthetic process
Biological Process
Regulation of transcription, DNA-templated

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asm-2075Astyanax mexicanus95.180.01452
LLPS-Fia-2599Ficedula albicollis94.810.01283
LLPS-Scf-4182Scleropages formosus94.750.01430
LLPS-Urm-0861Ursus maritimus94.620.0 936
LLPS-Xim-3902Xiphophorus maculatus94.20.01398
LLPS-Tag-3063Taeniopygia guttata93.890.01296
LLPS-Orn-0592Oreochromis niloticus93.850.01395
LLPS-Anp-0654Anas platyrhynchos93.740.01293
LLPS-Meg-3145Meleagris gallopavo93.590.01289
LLPS-Pes-0618Pelodiscus sinensis93.450.01288
LLPS-Nol-1636Nomascus leucogenys93.450.01293
LLPS-Fud-3408Fukomys damarensis93.30.01291
LLPS-Ova-4403Ovis aries93.30.01290
LLPS-Myl-2156Myotis lucifugus93.30.01291
LLPS-Cap-4555Cavia porcellus93.30.01286
LLPS-Ict-1162Ictidomys tridecemlineatus93.30.01290
LLPS-Dio-1561Dipodomys ordii93.160.01288
LLPS-Pof-3176Poecilia formosa92.80.01444
LLPS-Dar-3042Danio rerio92.760.01392
LLPS-Ten-1062Tetraodon nigroviridis92.420.01403
LLPS-Tar-3520Takifugu rubripes91.660.01431
LLPS-Scm-0722Scophthalmus maximus91.340.01430
LLPS-Gaa-4009Gasterosteus aculeatus91.040.01391
LLPS-Orl-3844Oryzias latipes90.960.01428
LLPS-Leo-1160Lepisosteus oculatus90.820.01440
LLPS-Mod-2519Monodelphis domestica90.310.01309
LLPS-Xet-1789Xenopus tropicalis89.720.01323
LLPS-Gaga-0795Gallus gallus89.480.01343
LLPS-Mal-0930Mandrillus leucophaeus88.120.01307
LLPS-Anc-3484Anolis carolinensis87.980.01317
LLPS-Cas-2281Carlito syrichta87.890.01310
LLPS-Aim-0421Ailuropoda melanoleuca87.320.01310
LLPS-Fec-2864Felis catus87.040.01312
LLPS-Caf-2598Canis familiaris87.040.01313
LLPS-Orc-2965Oryctolagus cuniculus86.950.01309
LLPS-Ran-1973Rattus norvegicus86.30.01314
LLPS-Sus-1117Sus scrofa85.490.01315
LLPS-Caj-4386Callithrix jacchus85.490.01318
LLPS-Poa-0841Pongo abelii85.490.01315
LLPS-Bot-3485Bos taurus85.370.01314
LLPS-Eqc-3832Equus caballus85.370.01311
LLPS-Otg-0829Otolemur garnettii85.090.01317
LLPS-Loa-0308Loxodonta africana85.010.01305
LLPS-Mum-3550Mus musculus84.970.01312
LLPS-Cea-0875Cercocebus atys84.630.01319
LLPS-Maf-0383Macaca fascicularis84.630.01318
LLPS-Chs-4356Chlorocebus sabaeus84.630.01318
LLPS-Gog-0164Gorilla gorilla84.630.01317
LLPS-Paa-1747Papio anubis84.630.01318
LLPS-Man-3919Macaca nemestrina84.630.01318
LLPS-Pap-1552Pan paniscus84.630.01317
LLPS-Pat-3029Pan troglodytes84.630.01317
LLPS-Hos-0152Homo sapiens84.630.01317
LLPS-Mam-3198Macaca mulatta84.630.01318
LLPS-Aon-3100Aotus nancymaae84.350.01318
LLPS-Rhb-1458Rhinopithecus bieti83.310.01304
LLPS-Mea-1140Mesocricetus auratus82.880.01319
LLPS-Mup-4378Mustela putorius furo80.730.01191
LLPS-Sah-3403Sarcophilus harrisii78.650.0 831
LLPS-Lac-3354Latimeria chalumnae74.540.0 939
LLPS-Drm-2355Drosophila melanogaster58.00.0 794
LLPS-Cii-1657Ciona intestinalis55.510.0 734
LLPS-Cis-1670Ciona savignyi52.370.0 641
LLPS-Prp-2203Prunus persica44.971e-66 248
LLPS-Orm-1377Oryza meridionalis44.976e-68 252
LLPS-Tru-0219Triticum urartu44.764e-69 256
LLPS-Gor-1842Gossypium raimondii44.741e-67 251
LLPS-Orb-1047Oryza barthii44.652e-66 248
LLPS-Ori-1499Oryza indica44.657e-67 249
LLPS-Orni-0485Oryza nivara44.657e-67 249
LLPS-Orgl-1701Oryza glumaepatula44.657e-67 249
LLPS-Glm-2510Glycine max44.591e-64 242
LLPS-Met-1955Medicago truncatula44.597e-65 243
LLPS-Sot-2251Solanum tuberosum44.445e-65 242
LLPS-Ors-2403Oryza sativa44.347e-67 246
LLPS-Orr-1592Oryza rufipogon44.343e-66 247
LLPS-Sol-0683Solanum lycopersicum44.174e-65 244
LLPS-Aso-1416Aspergillus oryzae43.818e-66 243
LLPS-Asf-1236Aspergillus flavus43.818e-66 243
LLPS-Brn-1693Brassica napus43.714e-66 246
LLPS-Brr-2829Brassica rapa43.714e-66 246
LLPS-Coc-1946Corchorus capsularis43.241e-65 245
LLPS-Asfu-0696Aspergillus fumigatus42.67e-63 234
LLPS-Asni-0953Aspergillus niger42.522e-63 234
LLPS-Dac-2297Daucus carota42.392e-64 242
LLPS-Nef-0191Neosartorya fischeri42.33e-62 232
LLPS-Lep-2113Leersia perrieri41.894e-68 240
LLPS-Orbr-0002Oryza brachyantha41.761e-70 247
LLPS-Tum-1360Tuber melanosporum41.218e-67 244
LLPS-Dos-0020Dothistroma septosporum40.83e-59 224
LLPS-Cog-1072Colletotrichum gloeosporioides40.63e-61 229
LLPS-Phn-1253Phaeosphaeria nodorum39.764e-65 238
LLPS-Osl-1485Ostreococcus lucimarinus39.687e-58 219
LLPS-Chr-1723Chlamydomonas reinhardtii38.691e-50 197
LLPS-Map-1217Magnaporthe poae38.64e-59 223
LLPS-Gag-1587Gaeumannomyces graminis38.273e-59 224
LLPS-Php-2340Physcomitrella patens37.129e-87 309
LLPS-Tra-2592Triticum aestivum36.965e-87 310
LLPS-Sem-0203Selaginella moellendorffii36.923e-86 304
LLPS-Sei-1196Setaria italica36.91e-84 302
LLPS-Zem-2567Zea mays36.772e-82 296
LLPS-Hov-0899Hordeum vulgare36.433e-83 298
LLPS-Pot-2548Populus trichocarpa36.013e-79 286
LLPS-Amt-1133Amborella trichopoda35.832e-75 275
LLPS-Mae-1677Manihot esculenta35.592e-77 281
LLPS-Thc-1599Theobroma cacao35.216e-78 283
LLPS-Pyt-0667Pyrenophora teres33.432e-81 289
LLPS-Pytr-0139Pyrenophora triticirepentis33.06e-81 288
LLPS-Ved-1429Verticillium dahliae32.113e-79 282
LLPS-Fuv-1011Fusarium verticillioides31.651e-66 241
LLPS-Coo-1313Colletotrichum orbiculare31.632e-76 274
LLPS-Blg-0701Blumeria graminis31.622e-69 253
LLPS-Asc-1684Aspergillus clavatus31.595e-74 267
LLPS-Lem-0374Leptosphaeria maculans31.523e-74 268
LLPS-Fuo-1338Fusarium oxysporum31.486e-67 242
LLPS-Yal-1237Yarrowia lipolytica31.352e-71 261
LLPS-Nec-1182Neurospora crassa31.322e-74 270
LLPS-Asn-1123Aspergillus nidulans31.141e-71 261
LLPS-Beb-0809Beauveria bassiana31.082e-75 271
LLPS-Zyt-0389Zymoseptoria tritici31.072e-72 261
LLPS-Ast-1519Aspergillus terreus31.032e-70 256
LLPS-Fus-0191Fusarium solani30.758e-78 276
LLPS-Chc-1053Chondrus crispus30.364e-74 264
LLPS-Cogr-1518Colletotrichum graminicola30.336e-75 270
LLPS-Mao-0932Magnaporthe oryzae29.933e-64 239
LLPS-Cae-0780Caenorhabditis elegans28.046e-55 207