• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Paa-1747
KDM1A

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: Lysine-specific histone demethylase
Gene Name: KDM1A
Ensembl Gene: ENSPANG00000017802.2
Ensembl Protein: ENSPANP00000039540.1
Organism: Papio anubis
Taxa ID: 9555
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION


Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me.

▼ SEQUENCE


Protein Sequence (FASTA)
1     MLSGKKAAAA  AAAAAAAAAG  TEAGPGTAGG  SENGSEVAAQ  PAGLSGPAEV  GPGAAGERTP  60
61    RKKEPPRASP  PGGLAEPPGS  AGPQAGPTVV  PGSATPMETG  IAETPEGRRT  SRRKRAKVEY  120
121   REMDESLANL  SEDEYYSEEE  RNAKAEKEKK  LPPPPPQAPP  EEENESEPEE  PSGQAGGLQD  180
181   DSSGGYGDGQ  ASGVEGAAFQ  SRLPHDRMTS  QEAACFPDII  SGPQQTQKVF  LFIRNRTLQL  240
241   WLDNPKIQLT  FEATLQQLEA  PYNSDTVLVH  RVHSYLERHG  LINFGIYKRI  KPLPTKKTGK  300
301   VIIIGSGVSG  LAAARQLQSF  GMDVTLLEAR  DRVGGRVATF  RKGNYVADLG  AMVVTGLGGN  360
361   PMAVVSKQVN  MELAKIKQKC  PLYEANGQAD  TVKVPKEKDE  MVEQEFNRLL  EATSYLSHQL  420
421   DFNVLNNKPV  SLGQALEVVI  QLQEKHVKDE  QIEHWKKIVK  TQEELKELLN  KMVNLKEKIK  480
481   ELHQQYKEAS  EVKPPRDITA  EFLVKSKHRD  LTALCKEYDE  LAETQGKLEE  KLQELEANPP  540
541   SDVYLSSRDR  QILDWHFANL  EFANATPLST  LSLKHWDQDD  DFEFTGSHLT  VRNGYSCVPV  600
601   ALAEGLDIKL  NTAVRQVRYT  ASGCEVIAVN  TRSTSQTFIY  KCDAVLCTLP  LGVLKQQPPA  660
661   VQFVPPLPEW  KTSAVQRMGF  GNLNKVVLCF  DRVFWDPSVN  LFGHVGSTTA  SRGELFLFWN  720
721   LYKAPILLAL  VAGEAAGIME  NISDDVIVGR  CLAILKGIFG  SSAVPQPKET  VVSRWRADPW  780
781   ARGSYSYVAA  GSSGNDYDLM  AQPITPGPSI  PGAPQPIPRL  FFAGEHTIRN  YPATVHGALL  840
841   SGLREAGRIA  DQFLGAMYTL  PRQATPGVPA  QQSPSM  876
Nucleotide CDS Sequence (FASTA)
1     ATGTTGTCTG  GGAAGAAGGC  GGCAGCCGCG  GCGGCGGCGG  CTGCAGCGGC  GGCAGCCGGG  60
61    ACGGAGGCTG  GCCCCGGGAC  AGCGGGCGGC  TCTGAGAATG  GGTCTGAGGT  GGCCGCGCAA  120
121   CCCGCGGGCC  TGTCGGGCCC  AGCCGAGGTC  GGGCCGGGGG  CGGCCGGGGA  ACGCACACCC  180
181   CGCAAGAAAG  AGCCTCCGCG  GGCCTCGCCC  CCCGGGGGCC  TGGCCGAACC  GCCAGGGTCC  240
241   GCGGGGCCTC  AGGCCGGGCC  CACCGTCGTG  CCTGGGTCTG  CGACCCCCAT  GGAAACTGGA  300
301   ATAGCAGAGA  CTCCGGAGGG  GCGTCGGACC  AGCCGGCGCA  AGCGGGCGAA  GGTAGAGTAC  360
361   AGAGAGATGG  ATGAAAGCTT  GGCCAACCTC  TCAGAAGATG  AGTATTATTC  AGAAGAAGAG  420
421   AGAAATGCCA  AAGCAGAGAA  GGAAAAGAAA  CTTCCCCCAC  CACCCCCTCA  AGCCCCACCT  480
481   GAGGAAGAAA  ATGAAAGTGA  GCCTGAAGAA  CCATCGGGGC  AAGCAGGAGG  ACTTCAAGAC  540
541   GACAGTTCTG  GAGGGTATGG  AGACGGCCAA  GCATCAGGTG  TGGAGGGCGC  AGCTTTCCAG  600
601   AGCCGACTTC  CTCATGACCG  GATGACTTCT  CAAGAAGCAG  CCTGTTTTCC  AGATATTATC  660
661   AGTGGACCAC  AACAGACCCA  GAAGGTTTTT  CTGTTCATTA  GAAACCGCAC  ACTGCAGTTG  720
721   TGGTTGGATA  ATCCAAAGAT  TCAGCTGACA  TTTGAGGCTA  CTCTCCAACA  ATTAGAAGCA  780
781   CCTTATAACA  GTGATACTGT  GCTTGTCCAC  CGAGTTCACA  GTTATTTAGA  GCGTCATGGT  840
841   CTTATCAACT  TTGGCATCTA  TAAGAGGATA  AAACCCCTAC  CAACTAAAAA  GACAGGAAAG  900
901   GTAATTATTA  TAGGCTCTGG  GGTCTCAGGC  TTGGCAGCAG  CTCGACAGTT  ACAAAGTTTT  960
961   GGAATGGATG  TCACACTTTT  GGAAGCCAGG  GATCGTGTGG  GTGGACGAGT  TGCCACATTT  1020
1021  CGCAAAGGAA  ACTATGTAGC  TGATCTTGGA  GCCATGGTGG  TAACAGGTCT  TGGAGGGAAT  1080
1081  CCTATGGCTG  TGGTCAGCAA  ACAAGTAAAT  ATGGAACTGG  CCAAGATCAA  GCAAAAATGC  1140
1141  CCACTTTATG  AAGCCAACGG  ACAAGCTGTT  CCTAAAGAGA  AAGATGAAAT  GGTAGAGCAA  1200
1201  GAGTTTAACC  GGTTGCTAGA  AGCTACATCT  TACCTTAGTC  ATCAACTAGA  CTTCAATGTC  1260
1261  CTCAATAATA  AGCCTGTGTC  CCTTGGCCAG  GCATTGGAAG  TTGTCATTCA  GTTACAAGAG  1320
1321  AAGCATGTCA  AAGATGAGCA  GATTGAACAT  TGGAAGAAGA  TAGTGAAAAC  TCAGGAAGAA  1380
1381  TTGAAAGAAC  TTCTTAACAA  GATGGTAAAT  TTGAAAGAGA  AAATTAAAGA  ACTCCATCAG  1440
1441  CAATACAAAG  AAGCATCTGA  AGTAAAGCCG  CCCAGAGATA  TCACTGCTGA  GTTCTTAGTG  1500
1501  AAAAGCAAAC  ACAGGGATCT  GACCGCCCTA  TGCAAGGAGT  ATGATGAATT  AGCCGAAACA  1560
1561  CAAGGAAAGC  TAGAAGAAAA  ACTTCAAGAA  TTGGAAGCGA  ATCCCCCAAG  TGATGTATAT  1620
1621  CTCTCATCAA  GAGACAGACA  AATACTTGAT  TGGCATTTTG  CAAATCTCGA  ATTTGCTAAT  1680
1681  GCCACACCTC  TCTCAACTCT  CTCCCTTAAG  CACTGGGATC  AGGATGATGA  CTTTGAGTTC  1740
1741  ACTGGCAGCC  ACCTGACAGT  AAGGAATGGC  TACTCATGTG  TGCCTGTGGC  TTTAGCAGAA  1800
1801  GGCCTAGACA  TTAAACTGAA  TACAGCAGTG  CGACAGGTTC  GCTATACGGC  TTCAGGATGT  1860
1861  GAAGTGATAG  CTGTGAATAC  CCGCTCCACG  AGTCAAACCT  TTATTTATAA  ATGTGATGCA  1920
1921  GTTCTCTGTA  CCCTTCCCCT  GGGTGTGCTG  AAGCAGCAGC  CACCAGCTGT  TCAGTTTGTG  1980
1981  CCACCTCTCC  CTGAGTGGAA  AACATCTGCA  GTCCAAAGGA  TGGGATTTGG  CAACCTTAAC  2040
2041  AAGGTGGTGT  TGTGTTTTGA  CCGGGTGTTC  TGGGATCCAA  GTGTCAATTT  GTTCGGGCAT  2100
2101  GTTGGCAGCA  CGACTGCCAG  CAGGGGTGAG  CTCTTCCTCT  TCTGGAACCT  CTATAAAGCT  2160
2161  CCAATACTGT  TGGCACTAGT  GGCAGGAGAA  GCTGCTGGTA  TCATGGAAAA  CATAAGTGAC  2220
2221  GATGTGATTG  TTGGCCGATG  CCTGGCCATT  CTCAAAGGGA  TTTTTGGTAG  CAGTGCAGTA  2280
2281  CCCCAGCCCA  AGGAAACTGT  GGTGTCTCGT  TGGCGAGCTG  ATCCCTGGGC  CCGGGGCTCT  2340
2341  TATTCCTATG  TTGCTGCAGG  ATCATCTGGA  AATGACTATG  ATTTAATGGC  TCAGCCCATC  2400
2401  ACTCCGGGCC  CCTCGATTCC  AGGTGCCCCA  CAGCCGATTC  CACGACTCTT  CTTTGCGGGA  2460
2461  GAACATACAA  TCCGTAACTA  CCCAGCCACA  GTGCATGGTG  CTCTGCTGAG  TGGGCTGCGA  2520
2521  GAAGCAGGAA  GAATTGCAGA  CCAGTTTTTG  GGGGCCATGT  ATACGCTGCC  TCGCCAGGCC  2580
2581  ACACCAGGTG  TTCCTGCACA  GCAGTCCCCA  AGCATGTGA  2619

▼ KEYWORD


ID
Family
Chromatin regulator
Coiled coil
Complete proteome
FAD
Flavoprotein
Nucleus
Oxidoreductase
Reference proteome
Repressor
Transcription
Transcription regulation

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
DNA repair complex
Cellular Component
Nuclear chromatin
Cellular Component
Nuclear chromosome, telomeric region
Cellular Component
Nucleoplasm
Molecular Function
Androgen receptor binding
Molecular Function
Chromatin binding
Molecular Function
Enzyme binding
Molecular Function
Flavin adenine dinucleotide binding
Molecular Function
Histone demethylase activity (H3-dimethyl-K4 specific)
Molecular Function
Histone demethylase activity (H3-K9 specific)
Molecular Function
MRF binding
Molecular Function
Nuclear receptor transcription coactivator activity
Molecular Function
Oxidoreductase activity
Molecular Function
P53 binding
Molecular Function
Telomeric DNA binding
Molecular Function
Telomeric repeat-containing RNA binding
Biological Process
Cellular response to gamma radiation
Biological Process
Cellular response to UV
Biological Process
Negative regulation of DNA damage response, signal transduction by p53 class mediator
Biological Process
Negative regulation of DNA-binding transcription factor activity
Biological Process
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Biological Process
Negative regulation of protein binding
Biological Process
Negative regulation of transcription by RNA polymerase II
Biological Process
Positive regulation of DNA-binding transcription factor activity
Biological Process
Positive regulation of histone ubiquitination
Biological Process
Positive regulation of neuroblast proliferation
Biological Process
Positive regulation of transcription by RNA polymerase II
Biological Process
Regulation of cellular protein localization
Biological Process
Regulation of double-strand break repair via homologous recombination

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Man-3919Macaca nemestrina100.00.01481
LLPS-Mam-3198Macaca mulatta100.00.01481
LLPS-Maf-0383Macaca fascicularis100.00.01481
LLPS-Pap-1552Pan paniscus99.890.01481
LLPS-Pat-3029Pan troglodytes99.890.01481
LLPS-Gog-0164Gorilla gorilla99.890.01481
LLPS-Nol-1636Nomascus leucogenys99.870.01331
LLPS-Hos-0152Homo sapiens99.770.01481
LLPS-Poa-0841Pongo abelii99.770.01479
LLPS-Cea-0875Cercocebus atys99.770.01479
LLPS-Caj-4386Callithrix jacchus99.660.01477
LLPS-Aon-3100Aotus nancymaae99.650.01473
LLPS-Chs-4356Chlorocebus sabaeus99.540.01467
LLPS-Ict-1162Ictidomys tridecemlineatus99.470.01320
LLPS-Ova-4403Ovis aries99.470.01320
LLPS-Dio-1561Dipodomys ordii99.340.01318
LLPS-Myl-2156Myotis lucifugus99.340.01318
LLPS-Caf-2598Canis familiaris99.290.01464
LLPS-Eqc-3832Equus caballus99.290.01454
LLPS-Otg-0829Otolemur garnettii99.170.01462
LLPS-Fud-3408Fukomys damarensis99.120.01305
LLPS-Bot-3485Bos taurus99.050.01457
LLPS-Cas-2281Carlito syrichta98.980.01365
LLPS-Fec-2864Felis catus98.970.01460
LLPS-Loa-0308Loxodonta africana98.930.01449
LLPS-Sus-1117Sus scrofa98.930.01453
LLPS-Mal-0930Mandrillus leucophaeus98.880.01398
LLPS-Orc-2965Oryctolagus cuniculus98.520.01408
LLPS-Mum-3550Mus musculus98.340.01455
LLPS-Ran-1973Rattus norvegicus98.290.01412
LLPS-Mea-1140Mesocricetus auratus98.110.01449
LLPS-Rhb-1458Rhinopithecus bieti98.080.01454
LLPS-Gaga-0795Gallus gallus97.80.01296
LLPS-Pes-0618Pelodiscus sinensis97.770.01306
LLPS-Tag-3063Taeniopygia guttata97.630.01304
LLPS-Anp-0654Anas platyrhynchos97.50.01303
LLPS-Aim-0421Ailuropoda melanoleuca97.440.01393
LLPS-Meg-3145Meleagris gallopavo97.110.01298
LLPS-Mod-2519Monodelphis domestica97.080.01397
LLPS-Fia-2599Ficedula albicollis96.020.01292
LLPS-Anc-3484Anolis carolinensis95.80.01363
LLPS-Cap-4555Cavia porcellus95.370.01346
LLPS-Mup-4378Mustela putorius furo92.820.01335
LLPS-Dar-3042Danio rerio90.440.01286
LLPS-Xet-1789Xenopus tropicalis90.320.01316
LLPS-Asm-2075Astyanax mexicanus90.080.01288
LLPS-Leo-1160Lepisosteus oculatus88.460.01310
LLPS-Scf-4182Scleropages formosus88.440.01304
LLPS-Xim-3902Xiphophorus maculatus88.410.01297
LLPS-Pof-3176Poecilia formosa88.20.01298
LLPS-Orn-0592Oreochromis niloticus87.960.01290
LLPS-Scm-0722Scophthalmus maximus87.830.01288
LLPS-Ten-1062Tetraodon nigroviridis87.80.01286
LLPS-Gaa-4009Gasterosteus aculeatus87.670.01291
LLPS-Tar-3520Takifugu rubripes87.320.01287
LLPS-Urm-0861Ursus maritimus87.120.01137
LLPS-Orl-3844Oryzias latipes86.580.01286
LLPS-Icp-2266Ictalurus punctatus84.870.01295
LLPS-Sah-3403Sarcophilus harrisii81.360.0 820
LLPS-Lac-3354Latimeria chalumnae74.560.0 890
LLPS-Drm-2355Drosophila melanogaster59.020.0 783
LLPS-Cii-1657Ciona intestinalis55.860.0 719
LLPS-Cis-1670Ciona savignyi52.740.0 631
LLPS-Gor-1842Gossypium raimondii45.293e-67 250
LLPS-Glm-2510Glycine max45.221e-64 242
LLPS-Prp-2203Prunus persica44.979e-66 246
LLPS-Orm-1377Oryza meridionalis44.974e-67 250
LLPS-Orb-1047Oryza barthii44.651e-65 245
LLPS-Ori-1499Oryza indica44.656e-66 246
LLPS-Orni-0485Oryza nivara44.655e-66 247
LLPS-Dac-2297Daucus carota44.654e-64 241
LLPS-Orgl-1701Oryza glumaepatula44.655e-66 246
LLPS-Orbr-0002Oryza brachyantha44.558e-70 245
LLPS-Thc-1599Theobroma cacao44.385e-64 241
LLPS-Ors-2403Oryza sativa44.345e-66 244
LLPS-Orr-1592Oryza rufipogon44.342e-65 245
LLPS-Lep-2113Leersia perrieri44.125e-67 238
LLPS-Coc-1946Corchorus capsularis43.773e-65 244
LLPS-Sot-2251Solanum tuberosum43.773e-64 239
LLPS-Brr-2829Brassica rapa43.711e-65 245
LLPS-Brn-1693Brassica napus43.711e-65 245
LLPS-Pot-2548Populus trichocarpa43.582e-65 245
LLPS-Sem-0203Selaginella moellendorffii43.417e-71 259
LLPS-Mae-1677Manihot esculenta43.324e-63 238
LLPS-Aso-1416Aspergillus oryzae42.941e-64 240
LLPS-Asf-1236Aspergillus flavus42.941e-64 240
LLPS-Ast-1519Aspergillus terreus42.555e-61 228
LLPS-Asni-0953Aspergillus niger42.428e-62 230
LLPS-Nef-0191Neosartorya fischeri42.126e-61 228
LLPS-Asfu-0696Aspergillus fumigatus42.121e-61 230
LLPS-Lem-0374Leptosphaeria maculans42.078e-67 246
LLPS-Amt-1133Amborella trichopoda41.932e-59 226
LLPS-Fus-0191Fusarium solani41.691e-62 232
LLPS-Fuo-1338Fusarium oxysporum41.692e-64 234
LLPS-Fuv-1011Fusarium verticillioides41.691e-63 232
LLPS-Asn-1123Aspergillus nidulans41.524e-62 233
LLPS-Beb-0809Beauveria bassiana40.914e-61 229
LLPS-Tum-1360Tuber melanosporum40.918e-65 238
LLPS-Osl-1485Ostreococcus lucimarinus40.855e-58 220
LLPS-Cog-1072Colletotrichum gloeosporioides40.02e-59 223
LLPS-Dos-0020Dothistroma septosporum39.772e-57 218
LLPS-Phn-1253Phaeosphaeria nodorum39.76e-64 234
LLPS-Cogr-1518Colletotrichum graminicola39.472e-60 226
LLPS-Nec-1182Neurospora crassa39.165e-59 224
LLPS-Chr-1723Chlamydomonas reinhardtii38.992e-50 196
LLPS-Gag-1587Gaeumannomyces graminis38.64e-58 221
LLPS-Map-1217Magnaporthe poae38.012e-58 221
LLPS-Chc-1053Chondrus crispus37.462e-50 194
LLPS-Php-2340Physcomitrella patens37.085e-85 304
LLPS-Sei-1196Setaria italica36.852e-83 299
LLPS-Tru-0219Triticum urartu36.562e-85 305
LLPS-Tra-2592Triticum aestivum36.561e-85 306
LLPS-Hov-0899Hordeum vulgare36.22e-82 296
LLPS-Zem-2567Zea mays36.193e-80 290
LLPS-Met-1955Medicago truncatula36.011e-74 273
LLPS-Sol-0683Solanum lycopersicum36.01e-80 291
LLPS-Pytr-0139Pyrenophora triticirepentis32.13e-74 268
LLPS-Pyt-0667Pyrenophora teres32.015e-75 271
LLPS-Ved-1429Verticillium dahliae31.293e-73 265
LLPS-Blg-0701Blumeria graminis30.82e-64 238
LLPS-Coo-1313Colletotrichum orbiculare30.794e-72 262
LLPS-Yal-1237Yarrowia lipolytica30.512e-69 256
LLPS-Zyt-0389Zymoseptoria tritici30.143e-68 249
LLPS-Asc-1684Aspergillus clavatus30.012e-70 257
LLPS-Mao-0932Magnaporthe oryzae29.116e-62 232
LLPS-Cae-0780Caenorhabditis elegans27.982e-54 206