• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Meg-3145
KDM1A

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Lysine-specific histone demethylase
Gene Name: KDM1A
Ensembl Gene: ENSMGAG00000001236.1
Ensembl Protein: ENSMGAP00000000665.1
Organism: Meleagris gallopavo
Taxa ID: 9103
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSMGAT00000001310.1ENSMGAP00000000665.1
UniProtG1MR81, G1MR81_MELGA

▼ SEQUENCE

Protein Sequence (FASTA)
1     QVEYREMDES  LANLSEDEYY  SEEERNAKAE  KEKKLPPPPP  PAPAEEENES  EPEEPSGQAG  60
61    GLQDDNSGGY  GDGQASVGVE  GAAFQSRLPH  DRMTSQEAAC  FPDIISGPQQ  TQKVFLYIRN  120
121   RTLQLWLDNP  KIQLTFEATI  QQLEAPYNSD  TVLVHRVHSY  LERHGLINFG  IYKRVKPLPT  180
181   KKTGKVIIIG  SGVSGLAAAR  QLQSFGMDVT  VLEARDRVGG  RVATFRKGNY  VADLGAMVVT  240
241   GLGGNPMAVV  SKQVNMELAK  IKQKCPLYEA  NGQAVPKEKD  EMVEQEFNRL  LEATSYLSHQ  300
301   LDFNVLNNKP  VSLGQALEVV  IQLQEKHVKD  EQIEHWKKIV  KTQEELKDLL  NKMVNLKEKI  360
361   KELHQQYKEA  SEVKPPRDIT  AEFLVKSKHR  DLTALCKEYD  ELAETQGKLE  EKLQELEANP  420
421   PSDVYLSSRD  RQILDWHFAN  LEFANATPLS  TLSLKHWDQD  DDFEFTGSHL  TVRNGYSCVP  480
481   VALAEGLDIK  LNTAVRQVRY  TASGCEVIAV  NTRSTSQTFI  YKCDAVLCTL  PLGVLKQQPP  540
541   AVQFVPPLPE  WKTSAVQRMG  FGNLNKVVLC  FDRVFWDPSV  NLFGHVGSTT  ASRGELFLFW  600
601   NLYKAPILLA  LVAGEAAGIM  ENISDDVIVG  RCLAILKGIF  GSSAVPQPKE  TVVSRWRADP  660
661   WARGSYSYVA  AGSSGNDYDL  MAQPITPGPA  IPGAPQPIPR  LFFAGEHTIR  NYPATVHGAL  720
721   LSGLREAGRI  ADQFLGAMYT  LPRQPTPGVP  TQQATTI  757
Nucleotide CDS Sequence (FASTA)
1     CAGGTAGAGT  ATAGAGAGAT  GGATGAGAGC  CTTGCAAATC  TCTCAGAAGA  TGAGTATTAC  60
61    TCCGAAGAAG  AGAGAAACGC  TAAAGCTGAG  AAAGAGAAGA  AGCTGCCACC  TCCACCTCCA  120
121   CCTGCTCCTG  CAGAAGAAGA  GAATGAAAGT  GAGCCCGAGG  AGCCATCTGG  GCAAGCAGGA  180
181   GGACTTCAAG  ACGACAATTC  TGGAGGGTAT  GGAGACGGCC  AAGCATCAGT  AGGTGTGGAG  240
241   GGTGCAGCTT  TCCAGAGTAG  ACTTCCACAT  GACCGTATGA  CATCTCAAGA  AGCTGCCTGC  300
301   TTCCCTGATA  TAATCAGTGG  GCCACAGCAG  ACTCAGAAGG  TGTTTCTGTA  CATCAGGAAC  360
361   CGCACCCTGC  AGCTCTGGTT  GGATAACCCA  AAGATTCAGT  TGACATTTGA  GGCAACCATC  420
421   CAGCAATTAG  AAGCACCTTA  CAATAGTGAT  ACAGTGCTCG  TTCACAGGGT  GCACAGCTAT  480
481   CTGGAGCGGC  ATGGGCTGAT  CAACTTTGGC  ATCTACAAGA  GAGTGAAGCC  TCTTCCAACC  540
541   AAGAAGACTG  GGAAGGTGAT  CATCATTGGT  TCTGGTGTGT  CTGGGTTGGC  AGCAGCTCGC  600
601   CAGTTGCAGA  GTTTTGGGAT  GGATGTCACA  GTTCTGGAAG  CCAGGGACCG  AGTGGGAGGA  660
661   AGAGTTGCTA  CCTTTCGTAA  AGGGAACTAC  GTGGCTGATT  TGGGAGCAAT  GGTGGTAACA  720
721   GGACTTGGAG  GAAATCCCAT  GGCTGTGGTC  AGCAAACAAG  TGAACATGGA  GTTGGCTAAG  780
781   ATCAAACAGA  AGTGCCCACT  GTATGAAGCA  AATGGACAAG  CTGTTCCAAA  AGAGAAAGAT  840
841   GAAATGGTGG  AGCAAGAATT  CAATCGTCTG  TTGGAAGCCA  CTTCTTATCT  CAGTCATCAG  900
901   CTGGATTTTA  ATGTTCTCAA  TAATAAGCCT  GTCTCCCTAG  GTCAGGCTCT  GGAGGTTGTC  960
961   ATACAATTGC  AGGAGAAACA  CGTGAAGGAT  GAGCAGATTG  AACACTGGAA  AAAGATTGTG  1020
1021  AAAACACAGG  AGGAATTGAA  AGATCTTCTT  AACAAGATGG  TAAACTTGAA  AGAGAAGATT  1080
1081  AAAGAGCTCC  ATCAGCAGTA  TAAGGAAGCA  TCAGAAGTGA  AGCCACCTCG  GGATATTACA  1140
1141  GCAGAGTTCC  TTGTAAAGAG  TAAACACAGA  GATCTGACTG  CACTTTGCAA  GGAATACGAT  1200
1201  GAATTGGCAG  AAACGCAAGG  AAAGCTGGAA  GAGAAGCTGC  AGGAACTTGA  AGCCAATCCA  1260
1261  CCAAGTGATG  TTTATCTGTC  TTCAAGGGAT  AGGCAAATAC  TTGACTGGCA  TTTTGCAAAC  1320
1321  CTGGAATTTG  CTAATGCTAC  ACCTCTCTCT  ACACTTTCAC  TGAAGCACTG  GGACCAGGAT  1380
1381  GATGACTTTG  AATTCACAGG  CAGCCACCTG  ACAGTGAGGA  ATGGGTATTC  CTGCGTGCCC  1440
1441  GTGGCCTTGG  CAGAGGGGTT  GGATATTAAG  TTGAACACAG  CAGTTCGGCA  GGTTCGCTAT  1500
1501  ACAGCTTCAG  GCTGTGAAGT  GATTGCTGTA  AACACACGAT  CTACCAGCCA  GACGTTCATT  1560
1561  TATAAATGTG  ATGCTGTGCT  CTGTACCCTT  CCCCTGGGAG  TCCTGAAGCA  GCAGCCTCCA  1620
1621  GCAGTACAGT  TTGTGCCACC  TCTCCCAGAG  TGGAAAACTT  CAGCTGTGCA  ACGTATGGGA  1680
1681  TTTGGCAACC  TTAACAAGGT  TGTGTTGTGT  TTTGATCGTG  TCTTCTGGGA  TCCAAGTGTC  1740
1741  AATTTGTTTG  GTCACGTTGG  TAGCACTACT  GCAAGCAGAG  GGGAACTTTT  CTTGTTTTGG  1800
1801  AACCTGTACA  AAGCCCCCAT  CTTGTTGGCC  TTGGTAGCAG  GAGAAGCAGC  AGGAATCATG  1860
1861  GAAAATATCA  GTGATGATGT  CATTGTTGGA  CGATGTCTTG  CCATCCTCAA  AGGCATATTT  1920
1921  GGCAGCAGTG  CTGTGCCACA  GCCCAAAGAG  ACTGTGGTCT  CCCGTTGGCG  TGCTGATCCG  1980
1981  TGGGCCCGGG  GCTCGTACTC  CTATGTAGCA  GCTGGATCTT  CTGGAAATGA  CTATGACTTG  2040
2041  ATGGCTCAAC  CAATTACTCC  AGGGCCAGCC  ATTCCAGGTG  CTCCACAGCC  CATTCCTCGC  2100
2101  CTGTTTTTTG  CAGGAGAGCA  CACAATTCGC  AACTACCCTG  CCACTGTGCA  TGGTGCTTTA  2160
2161  CTGAGTGGAC  TGAGAGAAGC  AGGGCGCATT  GCAGACCAAT  TTCTTGGGGC  CATGTATACT  2220
2221  TTGCCCCGCC  AGCCTACTCC  TGGGGTGCCC  ACACAACAAG  CTACCACCAT  CTAA  2274

▼ KEYWORD

ID
Family
Chromatin regulator
Coiled coil
Complete proteome
FAD
Flavoprotein
Nucleus
Oxidoreductase
Reference proteome
Repressor
Transcription
Transcription regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
DNA repair complex
Cellular Component
Nuclear chromatin
Cellular Component
Nuclear chromosome, telomeric region
Cellular Component
Nucleoplasm
Molecular Function
Androgen receptor binding
Molecular Function
Chromatin binding
Molecular Function
Enzyme binding
Molecular Function
Flavin adenine dinucleotide binding
Molecular Function
Histone demethylase activity (H3-dimethyl-K4 specific)
Molecular Function
Histone demethylase activity (H3-K9 specific)
Molecular Function
MRF binding
Molecular Function
Nuclear receptor transcription coactivator activity
Molecular Function
Oxidoreductase activity
Molecular Function
P53 binding
Molecular Function
Telomeric DNA binding
Molecular Function
Telomeric repeat-containing RNA binding
Biological Process
Cellular response to gamma radiation
Biological Process
Cellular response to UV
Biological Process
Negative regulation of DNA damage response, signal transduction by p53 class mediator
Biological Process
Negative regulation of DNA-binding transcription factor activity
Biological Process
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Biological Process
Negative regulation of protein binding
Biological Process
Negative regulation of transcription by RNA polymerase II
Biological Process
Positive regulation of DNA-binding transcription factor activity
Biological Process
Positive regulation of histone ubiquitination
Biological Process
Positive regulation of neuroblast proliferation
Biological Process
Positive regulation of transcription by RNA polymerase II
Biological Process
Regulation of cellular protein localization
Biological Process
Regulation of double-strand break repair via homologous recombination

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gaga-0795Gallus gallus99.850.01273
LLPS-Anp-0654Anas platyrhynchos99.740.01318
LLPS-Fia-2599Ficedula albicollis99.60.01287
LLPS-Tag-3063Taeniopygia guttata99.210.01311
LLPS-Pes-0618Pelodiscus sinensis98.680.01307
LLPS-Anc-3484Anolis carolinensis98.390.01290
LLPS-Myl-2156Myotis lucifugus98.020.01301
LLPS-Cap-4555Cavia porcellus97.890.01301
LLPS-Dio-1561Dipodomys ordii97.880.01299
LLPS-Ova-4403Ovis aries97.880.01301
LLPS-Ict-1162Ictidomys tridecemlineatus97.880.01301
LLPS-Bot-3485Bos taurus97.750.01305
LLPS-Mal-0930Mandrillus leucophaeus97.750.01300
LLPS-Aim-0421Ailuropoda melanoleuca97.750.01302
LLPS-Chs-4356Chlorocebus sabaeus97.750.01305
LLPS-Eqc-3832Equus caballus97.750.01301
LLPS-Cas-2281Carlito syrichta97.750.01303
LLPS-Fec-2864Felis catus97.750.01303
LLPS-Fud-3408Fukomys damarensis97.720.01286
LLPS-Ran-1973Rattus norvegicus97.620.01303
LLPS-Sus-1117Sus scrofa97.620.01301
LLPS-Mum-3550Mus musculus97.620.01303
LLPS-Mea-1140Mesocricetus auratus97.490.01300
LLPS-Orc-2965Oryctolagus cuniculus97.490.01300
LLPS-Caf-2598Canis familiaris97.370.01298
LLPS-Loa-0308Loxodonta africana97.360.01295
LLPS-Paa-1747Papio anubis97.240.01299
LLPS-Aon-3100Aotus nancymaae97.240.01299
LLPS-Cea-0875Cercocebus atys97.240.01299
LLPS-Maf-0383Macaca fascicularis97.240.01299
LLPS-Caj-4386Callithrix jacchus97.240.01299
LLPS-Gog-0164Gorilla gorilla97.240.01298
LLPS-Mam-3198Macaca mulatta97.240.01299
LLPS-Poa-0841Pongo abelii97.240.01298
LLPS-Nol-1636Nomascus leucogenys97.240.01293
LLPS-Man-3919Macaca nemestrina97.240.01299
LLPS-Hos-0152Homo sapiens97.240.01299
LLPS-Pat-3029Pan troglodytes97.240.01298
LLPS-Pap-1552Pan paniscus97.240.01298
LLPS-Otg-0829Otolemur garnettii97.240.01298
LLPS-Mod-2519Monodelphis domestica97.110.01296
LLPS-Xet-1789Xenopus tropicalis96.450.01224
LLPS-Xim-3902Xiphophorus maculatus96.320.01237
LLPS-Gaa-4009Gasterosteus aculeatus96.120.01229
LLPS-Rhb-1458Rhinopithecus bieti96.090.01291
LLPS-Scm-0722Scophthalmus maximus95.710.01223
LLPS-Pof-3176Poecilia formosa95.620.01230
LLPS-Tar-3520Takifugu rubripes95.560.01221
LLPS-Orl-3844Oryzias latipes95.270.01224
LLPS-Leo-1160Lepisosteus oculatus95.190.01228
LLPS-Dar-3042Danio rerio94.560.01226
LLPS-Scf-4182Scleropages formosus94.460.01225
LLPS-Icp-2266Ictalurus punctatus93.590.01222
LLPS-Asm-2075Astyanax mexicanus93.290.01216
LLPS-Ten-1062Tetraodon nigroviridis92.30.01223
LLPS-Orn-0592Oreochromis niloticus91.970.01236
LLPS-Mup-4378Mustela putorius furo90.780.01179
LLPS-Urm-0861Ursus maritimus86.030.01077
LLPS-Sah-3403Sarcophilus harrisii82.770.0 824
LLPS-Lac-3354Latimeria chalumnae74.820.0 846
LLPS-Drm-2355Drosophila melanogaster57.160.0 769
LLPS-Cii-1657Ciona intestinalis55.960.0 719
LLPS-Cis-1670Ciona savignyi52.150.0 620
LLPS-Gor-1842Gossypium raimondii45.684e-65 242
LLPS-Glm-2510Glycine max45.227e-63 235
LLPS-Tra-2592Triticum aestivum45.087e-67 247
LLPS-Prp-2203Prunus persica44.977e-64 238
LLPS-Orm-1377Oryza meridionalis44.971e-64 241
LLPS-Sem-0203Selaginella moellendorffii44.692e-68 251
LLPS-Orgl-1701Oryza glumaepatula44.651e-63 237
LLPS-Orb-1047Oryza barthii44.653e-63 236
LLPS-Ori-1499Oryza indica44.651e-63 237
LLPS-Orni-0485Oryza nivara44.651e-63 237
LLPS-Dac-2297Daucus carota44.652e-62 234
LLPS-Orbr-0002Oryza brachyantha44.552e-68 240
LLPS-Thc-1599Theobroma cacao44.384e-62 233
LLPS-Orr-1592Oryza rufipogon44.344e-63 236
LLPS-Ors-2403Oryza sativa44.341e-63 235
LLPS-Sot-2251Solanum tuberosum44.142e-62 233
LLPS-Coc-1946Corchorus capsularis44.143e-63 236
LLPS-Lep-2113Leersia perrieri44.121e-65 232
LLPS-Pot-2548Populus trichocarpa44.049e-63 235
LLPS-Mae-1677Manihot esculenta43.967e-61 229
LLPS-Brn-1693Brassica napus43.717e-64 238
LLPS-Brr-2829Brassica rapa43.718e-64 238
LLPS-Aso-1416Aspergillus oryzae42.571e-62 232
LLPS-Asf-1236Aspergillus flavus42.571e-62 232
LLPS-Amt-1133Amborella trichopoda42.061e-1379.3
LLPS-Ast-1519Aspergillus terreus41.452e-59 222
LLPS-Asni-0953Aspergillus niger41.331e-59 221
LLPS-Asfu-0696Aspergillus fumigatus41.048e-60 223
LLPS-Nef-0191Neosartorya fischeri41.047e-59 220
LLPS-Fuv-1011Fusarium verticillioides40.942e-61 225
LLPS-Fuo-1338Fusarium oxysporum40.943e-62 227
LLPS-Fus-0191Fusarium solani40.942e-60 224
LLPS-Osl-1485Ostreococcus lucimarinus40.854e-57 216
LLPS-Asn-1123Aspergillus nidulans40.86e-62 231
LLPS-Dos-0020Dothistroma septosporum40.363e-55 210
LLPS-Beb-0809Beauveria bassiana40.185e-59 221
LLPS-Tum-1360Tuber melanosporum39.61e-63 233
LLPS-Phn-1253Phaeosphaeria nodorum39.462e-61 225
LLPS-Chr-1723Chlamydomonas reinhardtii38.996e-50 194
LLPS-Mao-0932Magnaporthe oryzae38.879e-59 221
LLPS-Nec-1182Neurospora crassa38.863e-56 214
LLPS-Cog-1072Colletotrichum gloeosporioides38.815e-57 215
LLPS-Gag-1587Gaeumannomyces graminis38.63e-55 211
LLPS-Cogr-1518Colletotrichum graminicola38.385e-58 218
LLPS-Map-1217Magnaporthe poae37.723e-56 214
LLPS-Sei-1196Setaria italica37.36e-83 295
LLPS-Chc-1053Chondrus crispus37.134e-49 189
LLPS-Tru-0219Triticum urartu36.947e-85 301
LLPS-Php-2340Physcomitrella patens36.628e-84 298
LLPS-Hov-0899Hordeum vulgare36.589e-82 291
LLPS-Zem-2567Zea mays36.492e-79 285
LLPS-Sol-0683Solanum lycopersicum36.42e-80 288
LLPS-Met-1955Medicago truncatula36.272e-74 270
LLPS-Pytr-0139Pyrenophora triticirepentis32.072e-74 267
LLPS-Pyt-0667Pyrenophora teres31.986e-75 268
LLPS-Lem-0374Leptosphaeria maculans31.672e-69 251
LLPS-Asc-1684Aspergillus clavatus31.622e-70 255
LLPS-Ved-1429Verticillium dahliae31.384e-73 263
LLPS-Coo-1313Colletotrichum orbiculare31.046e-72 259
LLPS-Yal-1237Yarrowia lipolytica30.724e-71 258
LLPS-Zyt-0389Zymoseptoria tritici30.188e-70 252
LLPS-Blg-0701Blumeria graminis30.052e-64 237
LLPS-Cae-0780Caenorhabditis elegans27.844e-53 201