• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Poa-1942
NUBP1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Cytosolic Fe-S cluster assembly factor NUBP1; Nucleotide-binding protein 1; NBP 1
Gene Name: NUBP1, CR201_G0047255
Ensembl Gene: ENSPPYG00000007093.2
Ensembl Protein: ENSPPYP00000008020.2
Organism: Pongo abelii
Taxa ID: 9601
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEEVPHDCPG  ADSAQAGRGA  SCQGCPNQRL  CASGAGATPD  PAIEEIKEKM  KTVKHKILVL  60
61    SGKGGVGKST  FSAHLARGLA  EDENTQIALL  DIDICGPSIP  KIMGLEGEQV  HQSGSGWSPV  120
121   YVEDNLGVMS  VGFLLSSPDD  AVIWRGPKKN  GMIKQFLRDV  DWGEVDYLIV  DTPPGTSDEH  180
181   LSVVQYLAAA  HIDGAVIITT  PQEVSLQDVR  KEINFCRKVK  LPIIGVVENM  SGFICPKCKK  240
241   ESQIFPPTTG  GAELMCQDLE  VPLLGRVPLD  PLIGKNCDKG  HSFFIDTPDS  PATLAYRSII  300
301   QRIQEFCNLH  QSKEENLISS  320
Nucleotide CDS Sequence (FASTA)
1     ATGGAGGAGG  TGCCTCACGA  CTGTCCAGGG  GCCGACAGCG  CCCAGGCGGG  CAGAGGGGCT  60
61    TCATGTCAGG  GATGCCCCAA  CCAGCGGCTG  TGCGCTTCTG  GAGCAGGGGC  CACTCCAGAC  120
121   CCGGCTATAG  AGGAAATCAA  AGAGAAAATG  AAGACCGTAA  AACACAAAAT  CTTGGTATTG  180
181   TCTGGGAAAG  GCGGTGTTGG  GAAAAGCACA  TTCAGCGCCC  ACCTTGCCCG  TGGCCTAGCA  240
241   GAGGATGAAA  ACACACAGAT  TGCTCTTCTA  GACATCGATA  TATGTGGGCC  ATCGATTCCC  300
301   AAGATAATGG  GATTGGAAGG  AGAGCAGGTT  CACCAGAGTG  GCTCAGGCTG  GTCTCCAGTG  360
361   TACGTGGAAG  ACAACCTGGG  GGTGATGTCA  GTGGGCTTCC  TGCTCAGCAG  TCCTGATGAC  420
421   GCTGTTATCT  GGAGGGGACC  CAAGAAAAAC  GGCATGATCA  AGCAGTTCCT  CCGAGATGTG  480
481   GACTGGGGAG  AGGTTGACTA  CCTCATTGTG  GACACCCCAC  CTGGAACGTC  GGATGAACAC  540
541   CTCTCAGTCG  TCCAGTACCT  GGCCGCGGCA  CACATCGATG  GAGCAGTGAT  CATCACCACT  600
601   CCCCAGGAGG  TGTCACTCCA  GGATGTCCGG  AAAGAAATCA  ACTTCTGCCG  CAAGGTGAAG  660
661   CTGCCCATCA  TCGGGGTGGT  GGAGAACATG  AGTGGCTTCA  TCTGTCCTAA  ATGCAAGAAA  720
721   GAATCTCAGA  TATTCCCTCC  CACAACCGGG  GGCGCGGAGC  TCATGTGCCA  GGACTTGGAG  780
781   GTCCCTCTCC  TCGGCAGAGT  GCCCCTGGAT  CCACTCATAG  GTAAGAATTG  TGACAAAGGC  840
841   CACTCTTTTT  TCATTGACAC  CCCAGATTCC  CCAGCCACGT  TAGCCTACAG  AAGTATAATT  900
901   CAGAGAATCC  AAGAGTTTTG  TAATCTCCAT  CAGTCAAAAG  AAGAGAACCT  CATCAGTTCC  960
961   TGA  963

▼ KEYWORD

ID
Family
4Fe-4S
ATP-binding
Complete proteome
Cytoplasm
Iron
Iron-sulfur
Metal-binding
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Plasma membrane
Molecular Function
4 iron, 4 sulfur cluster binding
Molecular Function
ATP binding
Molecular Function
Metal ion binding
Biological Process
Cellular iron ion homeostasis
Biological Process
Centrosome localization
Biological Process
Iron-sulfur cluster assembly
Biological Process
Negative regulation of centrosome duplication
Biological Process
Protein localization to cell cortex
Biological Process
Regulation of cell growth

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gog-3094Gorilla gorilla98.750.0 649
LLPS-Pap-3316Pan paniscus98.750.0 647
LLPS-Pat-3834Pan troglodytes98.750.0 647
LLPS-Hos-4073Homo sapiens98.120.0 644
LLPS-Nol-0040Nomascus leucogenys97.810.0 643
LLPS-Cea-2945Cercocebus atys97.50.0 640
LLPS-Maf-4644Macaca fascicularis97.50.0 640
LLPS-Mam-4477Macaca mulatta97.50.0 640
LLPS-Man-4282Macaca nemestrina97.50.0 640
LLPS-Paa-2643Papio anubis97.190.0 638
LLPS-Chs-2145Chlorocebus sabaeus97.050.0 539
LLPS-Rhb-3890Rhinopithecus bieti96.880.0 637
LLPS-Caj-3728Callithrix jacchus96.250.0 638
LLPS-Cas-3471Carlito syrichta94.690.0 623
LLPS-Cap-2737Cavia porcellus92.090.0 608
LLPS-Fud-1300Fukomys damarensis91.880.0 613
LLPS-Orc-3706Oryctolagus cuniculus91.850.0 610
LLPS-Mea-2993Mesocricetus auratus91.260.0 590
LLPS-Aim-2710Ailuropoda melanoleuca90.940.0 602
LLPS-Eqc-0673Equus caballus90.940.0 607
LLPS-Ict-3254Ictidomys tridecemlineatus90.620.0 608
LLPS-Caf-2761Canis familiaris90.620.0 598
LLPS-Ova-4271Ovis aries90.310.0 600
LLPS-Bot-3831Bos taurus90.310.0 601
LLPS-Loa-2659Loxodonta africana90.310.0 602
LLPS-Urm-2678Ursus maritimus90.310.0 597
LLPS-Dio-1069Dipodomys ordii89.690.0 599
LLPS-Mal-1843Mandrillus leucophaeus89.380.0 566
LLPS-Fec-3443Felis catus89.380.0 596
LLPS-Mum-3437Mus musculus89.340.0 598
LLPS-Myl-3699Myotis lucifugus88.920.0 589
LLPS-Mup-0401Mustela putorius furo88.440.0 575
LLPS-Mod-3068Monodelphis domestica88.440.0 593
LLPS-Sah-0680Sarcophilus harrisii88.40.0 590
LLPS-Ran-4438Rattus norvegicus87.770.0 591
LLPS-Sus-3206Sus scrofa86.351e-174 492
LLPS-Otg-1566Otolemur garnettii86.323e-173 489
LLPS-Ora-3459Ornithorhynchus anatinus83.074e-117 343
LLPS-Anc-3990Anolis carolinensis81.790.0 538
LLPS-Pes-3109Pelodiscus sinensis81.590.0 537
LLPS-Fia-0241Ficedula albicollis81.392e-169 479
LLPS-Lac-1771Latimeria chalumnae80.190.0 530
LLPS-Tag-0766Taeniopygia guttata79.810.0 523
LLPS-Gaga-2777Gallus gallus79.620.0 521
LLPS-Leo-0351Lepisosteus oculatus79.250.0 538
LLPS-Scf-3341Scleropages formosus77.880.0 515
LLPS-Xim-0511Xiphophorus maculatus77.20.0 513
LLPS-Gaa-3002Gasterosteus aculeatus76.781e-155 444
LLPS-Dar-2156Danio rerio76.420.0 523
LLPS-Orn-2766Oreochromis niloticus76.190.0 517
LLPS-Tar-3634Takifugu rubripes75.97e-180 508
LLPS-Scm-3681Scophthalmus maximus74.761e-179 507
LLPS-Pof-1801Poecilia formosa74.66e-179 505
LLPS-Icp-3210Ictalurus punctatus73.332e-170 484
LLPS-Asm-3141Astyanax mexicanus71.664e-167 475
LLPS-Orl-3953Oryzias latipes70.672e-154 444
LLPS-Xet-1295Xenopus tropicalis68.55e-159 455
LLPS-Crn-1140Cryptococcus neoformans65.152e-149 431
LLPS-Yal-1392Yarrowia lipolytica65.123e-144 418
LLPS-Abg-1874Absidia glauca63.434e-148 427
LLPS-Cii-1928Ciona intestinalis62.741e-150 433
LLPS-Cis-0316Ciona savignyi62.342e-147 425
LLPS-Scp-1600Schizosaccharomyces pombe62.25e-135 393
LLPS-Scj-0784Schizosaccharomyces japonicus61.729e-134 390
LLPS-Asn-1167Aspergillus nidulans61.595e-136 397
LLPS-Phn-0182Phaeosphaeria nodorum61.363e-132 387
LLPS-Zyt-0095Zymoseptoria tritici60.874e-132 387
LLPS-Scs-0914Sclerotinia sclerotiorum60.85e-137 399
LLPS-Ved-1261Verticillium dahliae60.83e-133 390
LLPS-Pyt-0079Pyrenophora teres60.524e-135 394
LLPS-Ast-1372Aspergillus terreus60.262e-130 383
LLPS-Dos-0275Dothistroma septosporum60.135e-132 387
LLPS-Pytr-1459Pyrenophora triticirepentis60.064e-133 390
LLPS-Asfu-1385Aspergillus fumigatus59.932e-131 385
LLPS-Miv-0400Microbotryum violaceum59.878e-129 398
LLPS-Mao-0669Magnaporthe oryzae59.82e-131 385
LLPS-Beb-1394Beauveria bassiana59.86e-133 389
LLPS-Asf-1025Aspergillus flavus59.66e-131 383
LLPS-Aso-1163Aspergillus oryzae59.66e-131 383
LLPS-Asc-0101Aspergillus clavatus59.62e-133 390
LLPS-Nef-0574Neosartorya fischeri59.64e-131 384
LLPS-Fuv-0201Fusarium verticillioides59.532e-132 388
LLPS-Kop-1341Komagataella pastoris59.472e-132 387
LLPS-Gag-0354Gaeumannomyces graminis59.472e-131 385
LLPS-Drm-1901Drosophila melanogaster59.363e-112 335
LLPS-Mua-2134Musa acuminata59.211e-125 370
LLPS-Fus-0425Fusarium solani59.23e-130 382
LLPS-Map-1387Magnaporthe poae59.145e-130 382
LLPS-Asni-0687Aspergillus niger58.861e-130 383
LLPS-Blg-0859Blumeria graminis58.81e-132 388
LLPS-Nec-0324Neurospora crassa58.531e-128 378
LLPS-Ors-2248Oryza sativa58.458e-115 343
LLPS-Scc-1355Schizosaccharomyces cryophilus58.419e-136 395
LLPS-Cogr-1573Colletotrichum graminicola57.815e-131 384
LLPS-Tum-1150Tuber melanosporum57.741e-123 365
LLPS-Cog-1130Colletotrichum gloeosporioides57.552e-121 359
LLPS-Orb-1816Oryza barthii57.313e-129 380
LLPS-Orni-2349Oryza nivara57.015e-129 379
LLPS-Ori-1029Oryza indica57.015e-129 379
LLPS-Orr-1706Oryza rufipogon57.011e-127 379
LLPS-Orm-1334Oryza meridionalis57.015e-129 379
LLPS-Chc-0549Chondrus crispus56.913e-126 372
LLPS-Sei-1799Setaria italica56.87e-128 376
LLPS-Brd-0852Brachypodium distachyon56.81e-129 380
LLPS-Org-1135Oryza glaberrima56.86e-128 377
LLPS-Lem-1206Leptosphaeria maculans56.634e-127 374
LLPS-Mel-1443Melampsora laricipopulina56.64e-125 369
LLPS-Hov-1601Hordeum vulgare56.514e-128 377
LLPS-Tra-2418Triticum aestivum56.512e-128 377
LLPS-Lep-2012Leersia perrieri56.512e-126 378
LLPS-Tru-1954Triticum urartu56.514e-124 377
LLPS-Orp-0991Oryza punctata56.519e-128 376
LLPS-Orgl-1969Oryza glumaepatula56.472e-127 375
LLPS-Gas-0919Galdieria sulphuraria56.319e-125 367
LLPS-Orbr-1323Oryza brachyantha56.212e-127 375
LLPS-Trv-1387Trichoderma virens56.192e-123 365
LLPS-Trr-0975Trichoderma reesei56.196e-123 363
LLPS-Coo-1577Colletotrichum orbiculare56.031e-129 381
LLPS-Aon-1710Aotus nancymaae56.06e-64 210
LLPS-Dac-2267Daucus carota55.825e-106 320
LLPS-Coc-2274Corchorus capsularis55.822e-106 325
LLPS-Arl-1811Arabidopsis lyrata55.793e-124 367
LLPS-Php-0575Physcomitrella patens55.657e-129 379
LLPS-Zem-0799Zea mays55.622e-126 373
LLPS-Cae-1374Caenorhabditis elegans55.341e-127 374
LLPS-Sob-2472Sorghum bicolor55.333e-124 369
LLPS-Sac-1402Saccharomyces cerevisiae54.821e-122 362
LLPS-Art-0579Arabidopsis thaliana54.63e-122 362
LLPS-Vir-2207Vigna radiata54.486e-95 292
LLPS-Brn-2398Brassica napus54.193e-119 354
LLPS-Bro-2227Brassica oleracea54.193e-119 354
LLPS-Brr-0525Brassica rapa54.192e-119 355
LLPS-Thc-0665Theobroma cacao54.175e-122 363
LLPS-Nia-2633Nicotiana attenuata54.172e-115 345
LLPS-Gor-2127Gossypium raimondii54.172e-118 352
LLPS-Asg-1251Ashbya gossypii54.151e-117 356
LLPS-Amt-2287Amborella trichopoda53.985e-123 364
LLPS-Spr-0951Sporisorium reilianum53.943e-128 378
LLPS-Sol-2052Solanum lycopersicum53.571e-113 340
LLPS-Mae-1350Manihot esculenta53.571e-114 343
LLPS-Cus-1898Cucumis sativus53.546e-104 314
LLPS-Osl-0648Ostreococcus lucimarinus53.291e-115 345
LLPS-Viv-1170Vitis vinifera53.278e-113 338
LLPS-Prp-1641Prunus persica53.252e-119 357
LLPS-Met-1995Medicago truncatula53.182e-114 342
LLPS-Pot-0254Populus trichocarpa53.162e-114 342
LLPS-Sot-0568Solanum tuberosum53.123e-110 332
LLPS-Sem-1132Selaginella moellendorffii53.081e-121 360
LLPS-Via-1314Vigna angularis52.962e-110 332
LLPS-Phv-2606Phaseolus vulgaris52.968e-111 333
LLPS-Tut-0708Tursiops truncatus52.923e-91 280
LLPS-Glm-0263Glycine max52.663e-110 332
LLPS-Hea-0913Helianthus annuus52.631e-113 340
LLPS-Put-0149Puccinia triticina51.034e-95 292
LLPS-Chr-0603Chlamydomonas reinhardtii50.438e-110 332
LLPS-Meg-0807Meleagris gallopavo50.192e-87 270
LLPS-Ten-3106Tetraodon nigroviridis50.08e-85 263
LLPS-Anp-3135Anas platyrhynchos49.811e-87 270
LLPS-Cym-0671Cyanidioschyzon merolae49.654e-101 307
LLPS-Pug-0226Puccinia graminis49.563e-110 333
LLPS-Fuo-0446Fusarium oxysporum49.363e-73 234
LLPS-Usm-1480Ustilago maydis48.568e-124 368