DrLLPS - Data resource of LLPS

LLPS-Cae-1374
nubp-1

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Cytosolic Fe-S cluster assembly factor NUBP1 homolog; Nucleotide binding protein 1 homolog
Gene Name:	nubp-1, F10G8.6
Ensembl Gene:	WBGene00008664
Ensembl Protein:	F10G8.6
Organism:	Caenorhabditis elegans
Taxa ID:	6239
LLPS Type:	Client

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nucleolus	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Arabidopsis thaliana	LLPS-Art-0579	Q8H1Q2	Client	Nucleolus	49.42	4e-108	326

▼ FUNCTION

Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity). Regulates cilium formation and structure (PubMed:23807208).

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	F10G8.6	F10G8.6
UniProt		Q93459, NUBP1_CAEEL
GeneBank	Z80216	CAB02285.2
RefSeq	NM_060252.4	NP_492653.2
Entrez	172868

▼ SEQUENCE

Protein Sequence (FASTA)
1 MSDVPDDANA GCPGTGSAGA GKASGCAGCP NQGSCATGQG PPPDADVPKI QDRFSRIKHK 60 61 ILILSGKGGV GKSTLTSNLA RALASDPSKQ VAILDVDICG PSQPRMMGVE DEEVHNSADG 120 121 WTPVGIQPNL TLMSIAFLLG DKNDAVIWRG ARKNGMIKQF LKDVDWGEVD YLLIDTPPGT 180 181 SDEHISLVQF LLQAGPLDGA LIVSTPQEVS LLDVRKEVSF CVKTKVPILG VVENMARFVC 240 241 PNCAHTTLLF PTSTGGAEQM CKDSNLELLA QLPLEPALAK ALDNGEDFFE TNPDSTLAKS 300 301 FLDLAEKVKA KLV 313
Nucleotide CDS Sequence (FASTA)
1 ATGTCTGACG TACCTGACGA CGCTAACGCC GGATGCCCGG GAACTGGAAG TGCCGGAGCT 60 61 GGTAAGGCTT CAGGATGTGC TGGATGTCCA AATCAGGGGT CTTGTGCTAC TGGTCAAGGA 120 121 CCACCACCAG ACGCAGATGT GCCGAAGATT CAGGATAGGT TCAGCAGAAT TAAGCATAAG 180 181 ATTCTGATTC TCAGTGGAAA AGGAGGAGTC GGTAAAAGTA CTCTCACATC GAATCTTGCT 240 241 CGAGCCCTTG CCTCTGATCC ATCAAAACAA GTTGCAATTC TTGACGTGGA CATTTGTGGA 300 301 CCATCTCAAC CAAGAATGAT GGGAGTTGAG GACGAGGAAG TTCATAACAG TGCAGATGGA 360 361 TGGACTCCTG TCGGAATTCA GCCAAATCTG ACCCTGATGA GCATTGCTTT CTTGCTCGGT 420 421 GACAAGAACG ATGCTGTGAT TTGGCGTGGA GCTCGCAAGA ACGGAATGAT CAAGCAATTT 480 481 CTGAAAGACG TCGATTGGGG AGAGGTTGAT TATTTGCTGA TTGATACACC TCCAGGAACA 540 541 TCTGATGAAC ATATTTCTCT TGTTCAATTC TTATTGCAAG CAGGTCCATT GGATGGTGCA 600 601 TTGATTGTCA GTACTCCGCA AGAAGTTTCA TTGCTTGATG TCAGAAAAGA GGTCAGCTTC 660 661 TGCGTCAAGA CTAAAGTCCC GATTCTTGGT GTTGTTGAGA ACATGGCTCG TTTCGTATGC 720 721 CCCAACTGTG CTCATACAAC TCTCCTCTTC CCAACATCCA CCGGCGGAGC TGAGCAAATG 780 781 TGCAAAGATT CGAATCTTGA GCTTCTAGCT CAACTCCCAT TGGAACCAGC ACTTGCAAAA 840 841 GCTCTTGACA ATGGAGAAGA CTTTTTCGAG ACAAATCCAG ATTCAACGCT GGCAAAATCG 900 901 TTTTTGGATC TTGCTGAGAA AGTTAAGGCA AAGCTTGTTT AA 942

▼ KEYWORD

ID	Family
KW-0004	4Fe-4S
KW-0067	ATP-binding
KW-0966	Cell projection
KW-0969	Cilium
KW-0970	Cilium biogenesis/degradation
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0408	Iron
KW-0411	Iron-sulfur
KW-0479	Metal-binding
KW-0547	Nucleotide-binding
KW-1185	Reference proteome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005929	Cellular Component	Cilium
GO:0005829	Cellular Component	Cytosol
GO:0051539	Molecular Function	4 iron, 4 sulfur cluster binding
GO:0005524	Molecular Function	ATP binding
GO:0051536	Molecular Function	Iron-sulfur cluster binding
GO:0046872	Molecular Function	Metal ion binding
GO:0030030	Biological Process	Cell projection organization
GO:0016226	Biological Process	Iron-sulfur cluster assembly
GO:1902855	Biological Process	Regulation of non-motile cilium assembly

▼ KEGG

cel:CELE_F10G8.6

▼ ANNOTATION

Disorder
IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD
PROSITE	Gene3D

PTM
EPSD	dbPTM

Interaction
HINT	Mentha	PINA	IID	iRefIndex
MIST

Physicochemical
Compute pI/Mw	AAindex

Function
PIRSF

Element
RAID	microRNA.org

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Gas-0919	Galdieria sulphuraria	63.08	9e-100	303
LLPS-Coc-2274	Corchorus capsularis	62.5	5e-78	251
LLPS-Otg-1566	Otolemur garnettii	61.64	2e-100	304
LLPS-Dac-2267	Daucus carota	61.42	2e-79	251
LLPS-Vir-2207	Vigna radiata	61.34	2e-70	228
LLPS-Cus-1898	Cucumis sativus	61.22	2e-77	246
LLPS-Chc-0549	Chondrus crispus	60.23	5e-101	308
LLPS-Php-0575	Physcomitrella patens	60.17	7e-87	271
LLPS-Gaa-3002	Gasterosteus aculeatus	60.16	4e-105	315
LLPS-Phv-2606	Phaseolus vulgaris	60.0	1e-79	253
LLPS-Thc-0665	Theobroma cacao	59.58	3e-86	271
LLPS-Via-1314	Vigna angularis	59.58	4e-79	251
LLPS-Pot-0254	Populus trichocarpa	59.57	2e-79	252
LLPS-Tar-3634	Takifugu rubripes	59.55	3e-117	348
LLPS-Scm-3681	Scophthalmus maximus	59.55	2e-117	348
LLPS-Glm-0263	Glycine max	59.34	1e-79	253
LLPS-Sem-1132	Selaginella moellendorffii	59.17	2e-85	267
LLPS-Met-1995	Medicago truncatula	59.17	1e-78	250
LLPS-Dar-2156	Danio rerio	58.58	3e-117	348
LLPS-Pof-1801	Poecilia formosa	58.58	7e-116	345
LLPS-Scf-3341	Scleropages formosus	58.25	4e-114	340
LLPS-Arl-1811	Arabidopsis lyrata	58.02	2e-90	281
LLPS-Hea-0913	Helianthus annuus	57.75	3e-85	267
LLPS-Chr-0603	Chlamydomonas reinhardtii	57.72	9e-83	262
LLPS-Sus-3206	Sus scrofa	57.71	3e-99	300
LLPS-Chs-2145	Chlorocebus sabaeus	57.71	1e-100	303
LLPS-Xim-0511	Xiphophorus maculatus	57.61	1e-114	341
LLPS-Myl-3699	Myotis lucifugus	57.38	7e-109	327
LLPS-Scs-0914	Sclerotinia sclerotiorum	57.3	6e-101	307
LLPS-Orn-2766	Oreochromis niloticus	57.28	9e-114	339
LLPS-Mua-2134	Musa acuminata	57.04	7e-90	278
LLPS-Mae-1350	Manihot esculenta	56.98	6e-80	253
LLPS-Mup-0401	Mustela putorius furo	56.96	4e-108	325
LLPS-Mod-3068	Monodelphis domestica	56.96	2e-113	338
LLPS-Fec-3443	Felis catus	56.96	3e-110	330
LLPS-Anc-3990	Anolis carolinensis	56.79	1e-110	331
LLPS-Leo-0351	Lepisosteus oculatus	56.63	1e-111	333
LLPS-Gaga-2777	Gallus gallus	56.38	2e-105	318
LLPS-Sah-0680	Sarcophilus harrisii	56.31	2e-113	338
LLPS-Eqc-0673	Equus caballus	56.31	2e-110	330
LLPS-Tag-0766	Taeniopygia guttata	56.23	4e-107	322
LLPS-Asni-0687	Aspergillus niger	56.18	5e-96	294
LLPS-Asn-1167	Aspergillus nidulans	56.18	5e-97	297
LLPS-Nia-2633	Nicotiana attenuata	56.15	1e-78	250
LLPS-Lac-1771	Latimeria chalumnae	56.13	4e-114	340
LLPS-Caj-3728	Callithrix jacchus	55.99	2e-109	328
LLPS-Pes-3109	Pelodiscus sinensis	55.99	1e-110	331
LLPS-Ict-3254	Ictidomys tridecemlineatus	55.99	6e-110	329
LLPS-Ora-3459	Ornithorhynchus anatinus	55.93	2e-63	206
LLPS-Fia-0241	Ficedula albicollis	55.85	4e-103	310
LLPS-Icp-3210	Ictalurus punctatus	55.81	7e-106	319
LLPS-Ast-1372	Aspergillus terreus	55.81	7e-95	291
LLPS-Drm-1901	Drosophila melanogaster	55.67	3e-85	266
LLPS-Sei-1799	Setaria italica	55.63	4e-91	282
LLPS-Mea-2993	Mesocricetus auratus	55.59	2e-109	328
LLPS-Org-1135	Oryza glaberrima	55.41	9e-91	281
LLPS-Orc-3706	Oryctolagus cuniculus	55.37	2e-108	325
LLPS-Aim-2710	Ailuropoda melanoleuca	55.34	1e-108	326
LLPS-Urm-2678	Ursus maritimus	55.34	1e-108	326
LLPS-Poa-1942	Pongo abelii	55.34	2e-110	330
LLPS-Cap-2737	Cavia porcellus	55.34	2e-109	328
LLPS-Aon-1710	Aotus nancymaae	55.29	4e-57	192
LLPS-Abg-1874	Absidia glauca	55.19	2e-102	310
LLPS-Asm-3141	Astyanax mexicanus	55.02	4e-105	317
LLPS-Gog-3094	Gorilla gorilla	55.02	1e-109	328
LLPS-Cea-2945	Cercocebus atys	55.02	1e-109	328
LLPS-Maf-4644	Macaca fascicularis	55.02	2e-109	328
LLPS-Paa-2643	Papio anubis	55.02	2e-109	328
LLPS-Ova-4271	Ovis aries	55.02	9e-109	326
LLPS-Bot-3831	Bos taurus	55.02	8e-109	326
LLPS-Man-4282	Macaca nemestrina	55.02	2e-109	328
LLPS-Pap-3316	Pan paniscus	55.02	2e-109	328
LLPS-Pat-3834	Pan troglodytes	55.02	2e-109	328
LLPS-Mam-4477	Macaca mulatta	55.02	2e-109	328
LLPS-Caf-2761	Canis familiaris	55.02	2e-107	323
LLPS-Scp-1600	Schizosaccharomyces pombe	54.95	4e-96	294
LLPS-Mum-3437	Mus musculus	54.93	4e-109	327
LLPS-Ran-4438	Rattus norvegicus	54.93	3e-108	325
LLPS-Orl-3953	Oryzias latipes	54.9	8e-98	300
LLPS-Asc-0101	Aspergillus clavatus	54.84	4e-99	302
LLPS-Orgl-1969	Oryza glumaepatula	54.73	2e-89	278
LLPS-Fud-1300	Fukomys damarensis	54.69	8e-110	329
LLPS-Rhb-3890	Rhinopithecus bieti	54.69	3e-109	327
LLPS-Hos-4073	Homo sapiens	54.69	5e-109	327
LLPS-Nol-0040	Nomascus leucogenys	54.69	9e-109	326
LLPS-Cas-3471	Carlito syrichta	54.69	2e-109	328
LLPS-Tra-2418	Triticum aestivum	54.58	1e-91	283
LLPS-Pyt-0079	Pyrenophora teres	54.58	5e-102	310
LLPS-Nef-0574	Neosartorya fischeri	54.58	5e-99	302
LLPS-Sob-2472	Sorghum bicolor	54.58	2e-90	281
LLPS-Tru-1954	Triticum urartu	54.58	3e-88	284
LLPS-Asfu-1385	Aspergillus fumigatus	54.58	5e-99	302
LLPS-Zem-0799	Zea mays	54.42	8e-91	281
LLPS-Orp-0991	Oryza punctata	54.39	3e-90	280
LLPS-Dio-1069	Dipodomys ordii	54.37	3e-109	328
LLPS-Scj-0784	Schizosaccharomyces japonicus	54.3	1e-97	298
LLPS-Orb-1816	Oryza barthii	54.24	6e-90	279
LLPS-Hov-1601	Hordeum vulgare	54.24	1e-90	281
LLPS-Zyt-0095	Zymoseptoria tritici	54.23	7e-101	307
LLPS-Pytr-1459	Pyrenophora triticirepentis	54.23	7e-101	307
LLPS-Beb-1394	Beauveria bassiana	54.13	1e-102	311
LLPS-Orbr-1323	Oryza brachyantha	54.05	9e-90	278
LLPS-Ori-1029	Oryza indica	53.9	1e-89	278
LLPS-Brd-0852	Brachypodium distachyon	53.9	5e-91	281
LLPS-Orr-1706	Oryza rufipogon	53.9	2e-88	278
LLPS-Orm-1334	Oryza meridionalis	53.9	1e-89	278
LLPS-Fuv-0201	Fusarium verticillioides	53.87	3e-98	300
LLPS-Blg-0859	Blumeria graminis	53.87	1e-100	306
LLPS-Nec-0324	Neurospora crassa	53.85	9e-97	296
LLPS-Loa-2659	Loxodonta africana	53.72	6e-107	322
LLPS-Orni-2349	Oryza nivara	53.56	1e-89	278
LLPS-Lep-2012	Leersia perrieri	53.56	2e-87	278
LLPS-Crn-1140	Cryptococcus neoformans	53.53	5e-102	310
LLPS-Map-1387	Magnaporthe poae	53.52	4e-98	300
LLPS-Gag-0354	Gaeumannomyces graminis	53.52	3e-98	300
LLPS-Fus-0425	Fusarium solani	53.52	2e-98	300
LLPS-Scc-1355	Schizosaccharomyces cryophilus	53.4	1e-100	305
LLPS-Asf-1025	Aspergillus flavus	53.21	1e-93	288
LLPS-Aso-1163	Aspergillus oryzae	53.21	1e-93	288
LLPS-Mao-0669	Magnaporthe oryzae	53.17	1e-98	301
LLPS-Ved-1261	Verticillium dahliae	53.17	2e-96	295
LLPS-Cii-1928	Ciona intestinalis	53.09	1e-104	315
LLPS-Yal-1392	Yarrowia lipolytica	53.02	3e-100	305
LLPS-Dos-0275	Dothistroma septosporum	52.82	1e-98	301
LLPS-Sac-1402	Saccharomyces cerevisiae	52.81	6e-92	283
LLPS-Cis-0316	Ciona savignyi	52.77	1e-102	310
LLPS-Kop-1341	Komagataella pastoris	52.69	9e-97	295
LLPS-Cog-1130	Colletotrichum gloeosporioides	52.67	2e-96	295
LLPS-Ors-2248	Oryza sativa	52.59	8e-82	258
LLPS-Phn-0182	Phaeosphaeria nodorum	52.46	7e-101	306
LLPS-Cogr-1573	Colletotrichum graminicola	52.3	7e-97	296
LLPS-Tum-1150	Tuber melanosporum	52.11	6e-92	284
LLPS-Trr-0975	Trichoderma reesei	52.11	1e-94	291
LLPS-Trv-1387	Trichoderma virens	52.11	6e-95	291
LLPS-Lem-1206	Leptosphaeria maculans	51.79	4e-95	292
LLPS-Amt-2287	Amborella trichopoda	51.53	3e-84	265
LLPS-Prp-1641	Prunus persica	51.35	1e-85	271
LLPS-Miv-0400	Microbotryum violaceum	51.12	1e-86	286
LLPS-Fuo-0446	Fusarium oxysporum	50.68	4e-68	221
LLPS-Coo-1577	Colletotrichum orbiculare	50.5	9e-96	294
LLPS-Mal-1843	Mandrillus leucophaeus	50.49	6e-91	280
LLPS-Spr-0951	Sporisorium reilianum	50.43	9e-95	292
LLPS-Cym-0671	Cyanidioschyzon merolae	50.38	5e-78	248
LLPS-Sol-2052	Solanum lycopersicum	50.34	6e-78	248
LLPS-Viv-1170	Vitis vinifera	49.83	3e-79	252
LLPS-Anp-3135	Anas platyrhynchos	49.62	3e-77	244
LLPS-Mel-1443	Melampsora laricipopulina	49.52	3e-91	282
LLPS-Asg-1251	Ashbya gossypii	49.44	9e-86	274
LLPS-Art-0579	Arabidopsis thaliana	49.42	7e-91	281
LLPS-Meg-0807	Meleagris gallopavo	49.21	3e-75	239
LLPS-Osl-0648	Ostreococcus lucimarinus	48.83	6e-84	264
LLPS-Tut-0708	Tursiops truncatus	48.82	6e-74	235
LLPS-Brn-2398	Brassica napus	48.69	1e-88	276
LLPS-Brr-0525	Brassica rapa	48.69	1e-88	276
LLPS-Bro-2227	Brassica oleracea	48.69	1e-88	276
LLPS-Sot-0568	Solanum tuberosum	48.65	3e-72	234
LLPS-Gor-2127	Gossypium raimondii	48.41	1e-86	271
LLPS-Xet-1295	Xenopus tropicalis	47.6	4e-80	253
LLPS-Ten-3106	Tetraodon nigroviridis	47.08	4e-74	236
LLPS-Usm-1480	Ustilago maydis	45.81	9e-89	278
LLPS-Put-0149	Puccinia triticina	45.76	2e-76	244
LLPS-Pug-0226	Puccinia graminis	45.06	2e-82	261

LLPS-Cae-1374nubp-1

Protein Sequence

Nucleotide Sequence

LLPS-Cae-1374
nubp-1