• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Asm-3141
NUBP1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Cytosolic Fe-S cluster assembly factor NUBP1; Nucleotide-binding protein 1; NBP 1
Gene Name: NUBP1
Ensembl Gene: ENSAMXG00000002538.2
Ensembl Protein: ENSAMXP00000045418.1
Organism: Astyanax mexicanus
Taxa ID: 7994
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MADVPTDAPE  HCPGTTSEQA  GKSSACQGCP  NQTICASGAA  KAPDPAIEEI  KLKMATVKHK  60
61    ILVLSGKGGV  GKSTFSAHLA  HALASDDSKE  VGLLDIDICG  PSVPKIMGLE  GEQYVEDNLA  120
121   VMSIGFLLGS  PDDAVIWRGP  KKNGMIKQFL  RDVDWGELDY  LIVDTPPGTS  DEHLSAVQYL  180
181   SGAGIDGAVI  ITTPQEVSLQ  DVRKEIRFCQ  KVQLPVIGVV  ENMSAFVCPK  CKNTSQIFPP  240
241   TTGGAQRMCE  ELGLTLLGKV  PLDPRIGRSC  DEGKSFLNEV  PDSPAAAAYQ  TIVQSIKDYC  300
301   SSNATPAPNS  H  311
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGACG  TTCCGACTGA  CGCTCCTGAA  CATTGTCCGG  GCACCACCAG  TGAGCAAGCT  60
61    GGGAAGTCTT  CAGCATGCCA  GGGATGTCCC  AACCAGACAA  TATGCGCCTC  TGGTGCCGCC  120
121   AAAGCTCCTG  ATCCAGCTAT  AGAGGAGATC  AAGTTGAAGA  TGGCCACTGT  GAAGCACAAG  180
181   ATCCTGGTTT  TATCAGGGAA  AGGGGGCGTT  GGTAAAAGCA  CCTTTAGTGC  ACACCTGGCT  240
241   CATGCACTGG  CTAGTGACGA  CTCCAAAGAG  GTGGGTCTGC  TGGACATCGA  CATTTGTGGA  300
301   CCATCAGTAC  CTAAAATAAT  GGGACTGGAA  GGAGAGCAGG  AATACATCTA  CAGTGGTTGG  360
361   CCTGGTGGTC  TGGAAGATAA  TCTGGCAGTC  ATGTCTATTG  GTTTCCTGCT  GGGCAGCCCT  420
421   GATGACGCTG  TTATCTGGAG  AGGGCCGAAG  AAGAACGGTA  TGATAAAGCA  GTTCCTGAGG  480
481   GACGTGGACT  GGGGTGAGCT  GGACTACCTG  ATAGTGGACA  CGCCGCCGGG  CACCTCAGAC  540
541   GAGCACCTGT  CTGCGGTTCA  GTACCTCAGT  GGAGCGGGCA  TCGACGGAGC  CGTCATCATC  600
601   ACCACACCAC  AAGAAGTGTC  TTTACAGGAT  GTGAGGAAAG  AGATCCGATT  CTGCCAGAAG  660
661   GTTCAGCTGC  CGGTGATCGG  CGTGGTGGAG  AACATGAGCG  CTTTTGTGTG  TCCCAAATGC  720
721   AAGAATACCT  CCCAGATCTT  TCCTCCAACC  ACCGGAGGAG  CCCAGAGGAT  GTGTGAGGAG  780
781   CTCGGGCTGA  CCCTGCTCGG  CAAAGTGCCT  CTGGATCCGC  GGATAGGGAG  AAGCTGTGAT  840
841   GAGGGAAAGT  CGTTCCTGAA  TGAAGTCCCA  GACTCTCCCG  CGGCTGCGGC  GTATCAGACC  900
901   ATAGTGCAGA  GTAAGCCTGT  TCTCTAA  927

▼ KEYWORD

ID
Family
4Fe-4S
ATP-binding
Complete proteome
Cytoplasm
Iron
Iron-sulfur
Metal-binding
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Molecular Function
4 iron, 4 sulfur cluster binding
Molecular Function
ATP binding
Molecular Function
Metal ion binding
Biological Process
Iron-sulfur cluster assembly

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Dar-2156Danio rerio85.710.0 564
LLPS-Icp-3210Ictalurus punctatus85.30.0 558
LLPS-Scm-3681Scophthalmus maximus82.280.0 541
LLPS-Xim-0511Xiphophorus maculatus81.650.0 536
LLPS-Gaa-3002Gasterosteus aculeatus80.992e-156 446
LLPS-Tar-3634Takifugu rubripes80.890.0 532
LLPS-Orn-2766Oreochromis niloticus80.370.0 540
LLPS-Leo-0351Lepisosteus oculatus80.250.0 526
LLPS-Scf-3341Scleropages formosus79.740.0 519
LLPS-Pof-1801Poecilia formosa79.440.0 534
LLPS-Ora-3459Ornithorhynchus anatinus78.266e-107 317
LLPS-Sus-3206Sus scrofa76.745e-146 419
LLPS-Myl-3699Myotis lucifugus76.471e-173 491
LLPS-Sah-0680Sarcophilus harrisii76.453e-176 498
LLPS-Lac-1771Latimeria chalumnae76.430.0 510
LLPS-Orl-3953Oryzias latipes76.273e-160 458
LLPS-Mod-3068Monodelphis domestica76.135e-175 494
LLPS-Aim-2710Ailuropoda melanoleuca75.321e-171 486
LLPS-Fec-3443Felis catus75.088e-170 481
LLPS-Caf-2761Canis familiaris75.08e-171 484
LLPS-Urm-2678Ursus maritimus75.05e-171 484
LLPS-Mup-0401Mustela putorius furo74.682e-165 470
LLPS-Orc-3706Oryctolagus cuniculus74.436e-169 479
LLPS-Loa-2659Loxodonta africana74.367e-172 487
LLPS-Cas-3471Carlito syrichta74.041e-171 486
LLPS-Anc-3990Anolis carolinensis73.892e-171 486
LLPS-Dio-1069Dipodomys ordii73.73e-170 483
LLPS-Mea-2993Mesocricetus auratus73.534e-168 477
LLPS-Chs-2145Chlorocebus sabaeus73.415e-144 414
LLPS-Cap-2737Cavia porcellus73.314e-167 474
LLPS-Bot-3831Bos taurus73.253e-170 483
LLPS-Eqc-0673Equus caballus73.111e-166 473
LLPS-Ova-4271Ovis aries72.931e-169 481
LLPS-Mum-3437Mus musculus72.764e-170 482
LLPS-Tag-0766Taeniopygia guttata72.74e-162 461
LLPS-Ict-3254Ictidomys tridecemlineatus72.581e-168 479
LLPS-Gog-3094Gorilla gorilla72.294e-169 480
LLPS-Fia-0241Ficedula albicollis72.121e-145 418
LLPS-Paa-2643Papio anubis71.973e-168 478
LLPS-Cea-2945Cercocebus atys71.971e-168 478
LLPS-Maf-4644Macaca fascicularis71.973e-168 478
LLPS-Mam-4477Macaca mulatta71.973e-168 478
LLPS-Man-4282Macaca nemestrina71.973e-168 478
LLPS-Ran-4438Rattus norvegicus71.889e-169 479
LLPS-Caj-3728Callithrix jacchus71.661e-167 476
LLPS-Poa-1942Pongo abelii71.664e-167 475
LLPS-Pap-3316Pan paniscus71.662e-167 475
LLPS-Pat-3834Pan troglodytes71.662e-167 475
LLPS-Rhb-3890Rhinopithecus bieti71.663e-168 478
LLPS-Fud-1300Fukomys damarensis71.566e-168 477
LLPS-Pes-3109Pelodiscus sinensis71.522e-166 473
LLPS-Nol-0040Nomascus leucogenys71.341e-167 476
LLPS-Hos-4073Homo sapiens71.341e-166 473
LLPS-Otg-1566Otolemur garnettii69.759e-136 394
LLPS-Gaga-2777Gallus gallus69.213e-159 454
LLPS-Crn-1140Cryptococcus neoformans66.671e-147 426
LLPS-Mal-1843Mandrillus leucophaeus66.122e-143 414
LLPS-Xet-1295Xenopus tropicalis65.511e-146 423
LLPS-Cis-0316Ciona savignyi65.054e-145 419
LLPS-Abg-1874Absidia glauca64.57e-147 423
LLPS-Yal-1392Yarrowia lipolytica63.648e-140 406
LLPS-Miv-0400Microbotryum violaceum63.645e-135 414
LLPS-Cii-1928Ciona intestinalis63.346e-144 416
LLPS-Scp-1600Schizosaccharomyces pombe63.274e-134 390
LLPS-Dos-0275Dothistroma septosporum62.887e-132 386
LLPS-Asc-0101Aspergillus clavatus62.543e-134 392
LLPS-Asfu-1385Aspergillus fumigatus61.661e-134 393
LLPS-Zyt-0095Zymoseptoria tritici61.543e-130 382
LLPS-Ved-1261Verticillium dahliae61.544e-130 381
LLPS-Mao-0669Magnaporthe oryzae61.464e-132 387
LLPS-Ast-1372Aspergillus terreus61.092e-128 377
LLPS-Nef-0574Neosartorya fischeri61.022e-133 390
LLPS-Aso-1163Aspergillus oryzae60.873e-129 379
LLPS-Asf-1025Aspergillus flavus60.873e-129 379
LLPS-Scs-0914Sclerotinia sclerotiorum60.872e-132 387
LLPS-Fuv-0201Fusarium verticillioides60.876e-129 378
LLPS-Fus-0425Fusarium solani60.872e-129 380
LLPS-Scc-1355Schizosaccharomyces cryophilus60.734e-134 391
LLPS-Nec-0324Neurospora crassa60.542e-131 385
LLPS-Scj-0784Schizosaccharomyces japonicus60.531e-131 384
LLPS-Coc-2274Corchorus capsularis60.472e-0859.3
LLPS-Asn-1167Aspergillus nidulans60.266e-132 386
LLPS-Blg-0859Blumeria graminis60.138e-129 378
LLPS-Pyt-0079Pyrenophora teres59.873e-127 374
LLPS-Beb-1394Beauveria bassiana59.874e-131 384
LLPS-Kop-1341Komagataella pastoris59.82e-131 384
LLPS-Phn-0182Phaeosphaeria nodorum59.672e-125 369
LLPS-Mel-1443Melampsora laricipopulina59.612e-126 372
LLPS-Asni-0687Aspergillus niger59.534e-130 381
LLPS-Map-1387Magnaporthe poae59.472e-128 377
LLPS-Tum-1150Tuber melanosporum59.339e-128 375
LLPS-Pytr-1459Pyrenophora triticirepentis59.22e-125 369
LLPS-Gag-0354Gaeumannomyces graminis59.146e-127 373
LLPS-Trr-0975Trichoderma reesei58.862e-125 369
LLPS-Mua-2134Musa acuminata58.634e-122 360
LLPS-Trv-1387Trichoderma virens58.536e-124 365
LLPS-Asg-1251Ashbya gossypii58.477e-122 367
LLPS-Lem-1206Leptosphaeria maculans57.863e-123 364
LLPS-Coo-1577Colletotrichum orbiculare57.537e-125 368
LLPS-Cogr-1573Colletotrichum graminicola57.534e-125 369
LLPS-Drm-1901Drosophila melanogaster57.242e-104 315
LLPS-Sac-1402Saccharomyces cerevisiae57.142e-122 361
LLPS-Gas-0919Galdieria sulphuraria56.724e-119 352
LLPS-Orbr-1323Oryza brachyantha56.645e-124 366
LLPS-Cog-1130Colletotrichum gloeosporioides56.521e-113 339
LLPS-Sei-1799Setaria italica56.512e-123 365
LLPS-Orgl-1969Oryza glumaepatula56.341e-123 365
LLPS-Org-1135Oryza glaberrima56.346e-124 366
LLPS-Lep-2012Leersia perrieri56.212e-120 363
LLPS-Zem-0799Zea mays56.051e-124 368
LLPS-Orp-0991Oryza punctata56.053e-123 364
LLPS-Sob-2472Sorghum bicolor55.921e-123 367
LLPS-Chc-0549Chondrus crispus55.631e-118 352
LLPS-Brd-0852Brachypodium distachyon55.624e-123 364
LLPS-Spr-0951Sporisorium reilianum55.431e-128 379
LLPS-Hov-1601Hordeum vulgare55.336e-122 361
LLPS-Tra-2418Triticum aestivum55.331e-121 360
LLPS-Ori-1029Oryza indica55.334e-121 358
LLPS-Orni-2349Oryza nivara55.334e-121 358
LLPS-Orr-1706Oryza rufipogon55.338e-120 358
LLPS-Orm-1334Oryza meridionalis55.334e-121 358
LLPS-Orb-1816Oryza barthii55.035e-121 358
LLPS-Tru-1954Triticum urartu55.033e-117 359
LLPS-Cae-1374Caenorhabditis elegans55.023e-123 363
LLPS-Sol-2052Solanum lycopersicum54.874e-114 341
LLPS-Gor-2127Gossypium raimondii54.621e-119 355
LLPS-Art-0579Arabidopsis thaliana54.553e-119 354
LLPS-Arl-1811Arabidopsis lyrata54.413e-119 354
LLPS-Amt-2287Amborella trichopoda54.341e-120 358
LLPS-Phv-2606Phaseolus vulgaris54.284e-111 333
LLPS-Php-0575Physcomitrella patens54.143e-122 362
LLPS-Hea-0913Helianthus annuus54.074e-114 341
LLPS-Via-1314Vigna angularis53.983e-110 331
LLPS-Ors-2248Oryza sativa53.726e-99 302
LLPS-Brn-2398Brassica napus53.713e-116 346
LLPS-Aon-1710Aotus nancymaae53.719e-57 191
LLPS-Bro-2227Brassica oleracea53.713e-116 346
LLPS-Brr-0525Brassica rapa53.713e-116 346
LLPS-Nia-2633Nicotiana attenuata53.693e-113 339
LLPS-Met-1995Medicago truncatula53.676e-110 330
LLPS-Thc-0665Theobroma cacao53.645e-118 353
LLPS-Viv-1170Vitis vinifera53.554e-111 333
LLPS-Sot-0568Solanum tuberosum53.534e-110 331
LLPS-Vir-2207Vigna radiata53.128e-88 273
LLPS-Glm-0263Glycine max52.948e-109 327
LLPS-Sem-1132Selaginella moellendorffii52.942e-116 347
LLPS-Mae-1350Manihot esculenta52.82e-109 329
LLPS-Prp-1641Prunus persica52.796e-115 346
LLPS-Pot-0254Populus trichocarpa52.22e-110 332
LLPS-Osl-0648Ostreococcus lucimarinus52.013e-105 318
LLPS-Tut-0708Tursiops truncatus51.754e-86 266
LLPS-Dac-2267Daucus carota51.33e-97 297
LLPS-Cus-1898Cucumis sativus51.182e-94 290
LLPS-Chr-0603Chlamydomonas reinhardtii51.158e-107 324
LLPS-Pug-0226Puccinia graminis50.882e-111 336
LLPS-Meg-0807Meleagris gallopavo50.192e-83 259
LLPS-Usm-1480Ustilago maydis49.871e-123 367
LLPS-Put-0149Puccinia triticina49.664e-90 279
LLPS-Cym-0671Cyanidioschyzon merolae49.658e-98 298
LLPS-Anp-3135Anas platyrhynchos48.124e-83 259
LLPS-Ten-3106Tetraodon nigroviridis48.068e-81 253
LLPS-Fuo-0446Fusarium oxysporum45.532e-66 217