• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Pes-1235
GTF2H4

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: General transcription factor IIH subunit 4
Gene Name: GTF2H4
Ensembl Gene: ENSPSIG00000006675.1
Ensembl Protein: ENSPSIP00000007277.1
Organism: Pelodiscus sinensis
Taxa ID: 13735
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDSVMKLQRV  QLKCKNLHEF  LRGLSPGILD  RLYNHPATCL  AVFRELPGLA  KNYVMRMLFL  60
61    EQPLPQAAVA  LWVKKEHVKW  QEESWELLLG  LRLWHTQLLP  GGLQGLVLNP  IFKENLRVAL  120
121   LGGVGTRCYA  SLRRDGSPRA  ELQPFLGRVE  YNMALRGWAQ  VILHFMVGSP  SAAVSQDLAQ  180
181   LLIQAGLMKS  SEPGEPPCIT  SAGTRPQLWY  FMLQYLQSAE  TRGMDLVEIL  SFLFQLSPPF  240
241   FNKLFQDYSV  EGMSDSLLNF  LQHLREFGLV  FQRKVCGLRG  LVPGKDHPSW  QEELWVASRG  300
301   CQPVTLSPSP  ADYSLPTDPS  APCDAETGET  GGPGLCSIDI  IHFLRTRAHP  VMLRQTPVLP  360
361   PTITDQIRLW  EMERDRLRFS  EGVLYNQFLS  QVDFELLRNH  ARDLGVLVFE  NPAKRLMVVT  420
421   PAGHSDVKRF  WKRQKQSS  438
Nucleotide CDS Sequence (FASTA)
1     ATGGACTCCG  TGATGAAGCT  GCAGAGGGTG  CAGTTGAAAT  GCAAGAACCT  GCACGAGTTC  60
61    CTGCGGGGGC  TGAGCCCGGG  GATCCTGGAT  CGACTCTACA  ACCATCCCGC  CACCTGCCTG  120
121   GCTGTGTTCC  GCGAGCTGCC  GGGATTGGCT  AAGAACTACG  TGATGCGGAT  GCTCTTCCTG  180
181   GAGCAGCCCC  TCCCCCAGGC  GGCTGTGGCC  TTGTGGGTAA  AGAAGGAACA  TGTCAAGTGG  240
241   CAGGAGGAGA  GCTGGGAGCT  CTTGCTGGGG  CTGCGGCTCT  GGCACACCCA  GCTGCTCCCG  300
301   GGGGGCCTGC  AGGGGCTGGT  GCTGAACCCC  ATCTTCAAGG  AGAACCTGCG  CGTCGCCTTG  360
361   CTGGGCGGGG  TGGGGACCCG  CTGCTACGCC  TCCCTGCGCA  GAGATGGCTC  GCCCCGTGCT  420
421   GAGTTGCAGC  CGTTTCTGGG  GCGGGTGGAG  TATAACATGG  CCCTGCGGGG  GTGGGCCCAG  480
481   GTGATCCTGC  ATTTCATGGT  GGGCTCCCCC  AGCGCCGCTG  TCAGCCAGGA  TCTAGCCCAG  540
541   CTCCTCATCC  AAGCCGGGCT  GATGAAGAGC  AGTGAACCCG  GAGAGCCCCC  CTGCATCACC  600
601   TCCGCCGGGA  CACGTCCTCA  GCTCTGGTAC  TTCATGCTGC  AGTATCTGCA  GTCCGCCGAG  660
661   ACCCGAGGCA  TGGACCTAGT  AGAGATCCTG  TCCTTCCTCT  TCCAGCTCAG  CCCTCCCTTC  720
721   TTCAACAAAT  TGTTTCAGGA  TTACTCGGTG  GAGGGAATGA  GCGACTCGCT  GCTCAATTTT  780
781   CTTCAACACC  TTCGGGAGTT  TGGTCTGGTC  TTCCAGAGAA  AGGTATGTGG  ATTGCGGGGG  840
841   TTGGTCCCGG  GGAAGGACCA  TCCGAGCTGG  CAGGAAGAGC  TGTGGGTGGC  CTCGCGGGGG  900
901   TGCCAGCCCG  TAACACTTTC  CCCTTCGCCT  GCAGATTATT  CACTTCCTAC  GGACCCGAGC  960
961   GCACCCTGTG  ATGCTGAGAC  AGGTGAGACG  GGGGGCCCTG  GTCTGTGTAG  CATTGACATT  1020
1021  ATTCACTTCC  TACGGACCCG  AGCGCACCCT  GTGATGCTGA  GACAGACCCC  GGTGCTGCCT  1080
1081  CCAACCATCA  CGGATCAGAT  CCGGCTCTGG  GAGATGGAGC  GCGACCGGCT  GCGCTTCTCC  1140
1141  GAGGGCGTGC  TGTACAACCA  GTTCCTGTCC  CAGGTGGACT  TCGAGCTGTT  GCGGAACCAC  1200
1201  GCCCGGGACC  TGGGCGTGCT  GGTCTTCGAA  AACCCGGCCA  AGCGCCTCAT  GGTGGTGACC  1260
1261  CCTGCCGGGC  ACTCTGACGT  CAAGCGTTTT  TGGAAGAGGC  AGAAGCAGAG  CTCCTGA  1317

▼ KEYWORD

ID
Family
Complete proteome
DNA damage
DNA repair
Nucleus
Reference proteome
Transcription
Transcription regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Core TFIIH complex portion of holo TFIIH complex
Cellular Component
Nuclear speck
Cellular Component
Transcription factor TFIID complex
Molecular Function
ATPase activator activity
Molecular Function
DNA-dependent ATPase activity
Molecular Function
RNA polymerase II CTD heptapeptide repeat kinase activity
Molecular Function
RNA polymerase II general transcription initiation factor activity
Biological Process
Nucleotide-excision repair

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asm-3251Astyanax mexicanus75.241e-46 172
LLPS-Anc-1426Anolis carolinensis66.880.0 535
LLPS-Dio-4049Dipodomys ordii66.883e-49 171
LLPS-Hos-0151Homo sapiens65.84e-174 503
LLPS-Pat-3712Pan troglodytes65.84e-174 503
LLPS-Pap-4641Pan paniscus65.84e-174 503
LLPS-Man-3858Macaca nemestrina65.84e-174 504
LLPS-Rhb-4809Rhinopithecus bieti65.85e-174 503
LLPS-Poa-0660Pongo abelii65.84e-174 503
LLPS-Mam-2149Macaca mulatta65.84e-174 504
LLPS-Nol-0069Nomascus leucogenys65.84e-174 503
LLPS-Chs-4374Chlorocebus sabaeus65.84e-174 503
LLPS-Maf-1697Macaca fascicularis65.84e-174 503
LLPS-Cea-0797Cercocebus atys65.84e-174 503
LLPS-Gog-0566Gorilla gorilla65.84e-174 503
LLPS-Caj-1107Callithrix jacchus65.85e-174 503
LLPS-Mal-0595Mandrillus leucophaeus65.84e-174 503
LLPS-Paa-3317Papio anubis65.84e-174 503
LLPS-Otg-2830Otolemur garnettii65.582e-173 501
LLPS-Ict-0023Ictidomys tridecemlineatus65.583e-174 503
LLPS-Mea-0677Mesocricetus auratus65.584e-174 503
LLPS-Mod-0004Monodelphis domestica65.376e-173 500
LLPS-Cap-0698Cavia porcellus65.372e-173 502
LLPS-Cas-1341Carlito syrichta65.371e-172 499
LLPS-Sus-0538Sus scrofa65.375e-172 498
LLPS-Aon-3414Aotus nancymaae65.378e-175 505
LLPS-Ran-1158Rattus norvegicus65.374e-173 501
LLPS-Ova-3736Ovis aries65.233e-172 499
LLPS-Fec-3835Felis catus65.152e-173 501
LLPS-Mum-4682Mus musculus65.152e-172 499
LLPS-Aim-3896Ailuropoda melanoleuca65.156e-174 503
LLPS-Urm-3201Ursus maritimus64.943e-173 501
LLPS-Loa-0759Loxodonta africana64.942e-173 501
LLPS-Caf-4104Canis familiaris64.944e-173 501
LLPS-Bot-3665Bos taurus64.945e-174 503
LLPS-Eqc-0258Equus caballus64.726e-173 500
LLPS-Fud-2092Fukomys damarensis62.478e-135 401
LLPS-Lac-2693Latimeria chalumnae59.485e-152 447
LLPS-Ten-0568Tetraodon nigroviridis57.452e-151 445
LLPS-Scf-3717Scleropages formosus57.23e-152 447
LLPS-Gaa-0044Gasterosteus aculeatus57.172e-150 443
LLPS-Dar-1066Danio rerio57.025e-156 458
LLPS-Orn-1939Oreochromis niloticus56.241e-146 433
LLPS-Tar-3140Takifugu rubripes55.939e-148 436
LLPS-Icp-1458Ictalurus punctatus55.83e-152 447
LLPS-Scm-3768Scophthalmus maximus55.678e-150 441
LLPS-Xim-3239Xiphophorus maculatus55.519e-143 423
LLPS-Orl-0277Oryzias latipes55.063e-142 422
LLPS-Xet-2190Xenopus tropicalis54.093e-111 340
LLPS-Pof-2563Poecilia formosa52.325e-127 383
LLPS-Abg-1684Absidia glauca47.624e-26 113
LLPS-Tum-0728Tuber melanosporum39.816e-1684.0
LLPS-Coo-1604Colletotrichum orbiculare39.766e-1168.6
LLPS-Chr-1438Chlamydomonas reinhardtii39.472e-0654.3
LLPS-Zyt-1111Zymoseptoria tritici38.23e-0756.6
LLPS-Cis-1527Ciona savignyi37.665e-72 240
LLPS-Cii-2048Ciona intestinalis37.54e-39 146
LLPS-Pyt-1428Pyrenophora teres37.55e-1580.9
LLPS-Aso-1209Aspergillus oryzae37.399e-1580.5
LLPS-Asf-0420Aspergillus flavus37.399e-1580.5
LLPS-Beb-0889Beauveria bassiana37.356e-0962.0
LLPS-Chc-1180Chondrus crispus37.119e-1167.8
LLPS-Sac-1004Saccharomyces cerevisiae36.973e-1375.9
LLPS-Drm-1711Drosophila melanogaster36.844e-77 255
LLPS-Pytr-1549Pyrenophora triticirepentis36.542e-1479.3
LLPS-Asc-1659Aspergillus clavatus36.523e-1478.6
LLPS-Asn-1168Aspergillus nidulans35.656e-1477.8
LLPS-Asni-0674Aspergillus niger35.655e-1478.2
LLPS-Nef-1040Neosartorya fischeri35.341e-1376.6
LLPS-Asfu-1004Aspergillus fumigatus35.341e-1376.6
LLPS-Gag-0439Gaeumannomyces graminis34.552e-1376.3
LLPS-Map-1365Magnaporthe poae34.552e-1375.9
LLPS-Nec-1228Neurospora crassa34.555e-1478.2
LLPS-Mao-1079Magnaporthe oryzae34.262e-1479.3
LLPS-Trr-0271Trichoderma reesei33.943e-1272.4
LLPS-Put-0578Puccinia triticina33.946e-23 103
LLPS-Ved-1552Verticillium dahliae33.032e-1273.2
LLPS-Scc-1606Schizosaccharomyces cryophilus32.814e-48 176
LLPS-Asg-0652Ashbya gossypii32.772e-1376.3
LLPS-Crn-1327Cryptococcus neoformans32.692e-0860.5
LLPS-Scp-0817Schizosaccharomyces pombe32.664e-46 171
LLPS-Usm-0767Ustilago maydis32.474e-49 180
LLPS-Yal-0890Yarrowia lipolytica32.359e-54 192
LLPS-Spr-0706Sporisorium reilianum32.331e-49 181
LLPS-Fuo-0771Fusarium oxysporum32.112e-1273.2
LLPS-Cogr-0549Colletotrichum graminicola32.116e-1168.2
LLPS-Fuv-1483Fusarium verticillioides32.112e-1273.2
LLPS-Scj-1262Schizosaccharomyces japonicus31.911e-47 175
LLPS-Fus-0786Fusarium solani31.194e-1168.9
LLPS-Tru-1567Triticum urartu30.436e-1064.7
LLPS-Mel-0933Melampsora laricipopulina30.175e-42 160
LLPS-Miv-0894Microbotryum violaceum29.053e-37 147
LLPS-Orni-2025Oryza nivara28.661e-34 138
LLPS-Orbr-1804Oryza brachyantha28.382e-37 146
LLPS-Sot-1427Solanum tuberosum28.336e-0856.2
LLPS-Ors-1114Oryza sativa28.323e-38 149
LLPS-Orr-1160Oryza rufipogon28.323e-38 149
LLPS-Org-0485Oryza glaberrima28.327e-38 148
LLPS-Orgl-2032Oryza glumaepatula28.323e-38 149
LLPS-Php-1166Physcomitrella patens28.291e-41 158
LLPS-Sei-0821Setaria italica28.291e-36 144
LLPS-Scs-0937Sclerotinia sclerotiorum28.264e-26 113
LLPS-Pug-0881Puccinia graminis28.255e-37 149
LLPS-Brd-1575Brachypodium distachyon28.231e-37 147
LLPS-Ast-1351Aspergillus terreus28.225e-32 130
LLPS-Blg-0440Blumeria graminis28.156e-33 134
LLPS-Orp-2344Oryza punctata28.119e-37 145
LLPS-Dos-1570Dothistroma septosporum27.993e-29 122
LLPS-Tra-0085Triticum aestivum27.981e-36 144
LLPS-Orm-1215Oryza meridionalis27.898e-37 145
LLPS-Sob-1248Sorghum bicolor27.841e-36 144
LLPS-Zem-1275Zea mays27.845e-36 142
LLPS-Ori-2367Oryza indica27.848e-38 148
LLPS-Orb-0481Oryza barthii27.814e-35 140
LLPS-Sem-0134Selaginella moellendorffii27.786e-35 139
LLPS-Lem-1134Leptosphaeria maculans27.53e-28 119
LLPS-Lep-1552Leersia perrieri27.455e-35 139
LLPS-Prp-1501Prunus persica26.858e-33 133
LLPS-Phn-0858Phaeosphaeria nodorum26.621e-21 100
LLPS-Trv-1538Trichoderma virens26.611e-26 115
LLPS-Pot-2738Populus trichocarpa26.582e-30 126
LLPS-Amt-2221Amborella trichopoda26.364e-30 125
LLPS-Phv-0795Phaseolus vulgaris26.293e-32 131
LLPS-Glm-2782Glycine max26.296e-31 127
LLPS-Cus-2378Cucumis sativus26.252e-30 126
LLPS-Art-2895Arabidopsis thaliana26.21e-33 135
LLPS-Sol-2177Solanum lycopersicum26.196e-35 139
LLPS-Brr-2657Brassica rapa26.097e-32 130
LLPS-Brn-1147Brassica napus26.092e-31 129
LLPS-Arl-1443Arabidopsis lyrata26.098e-34 136
LLPS-Bro-2621Brassica oleracea25.978e-32 130
LLPS-Coc-1386Corchorus capsularis25.93e-27 118
LLPS-Mua-2038Musa acuminata25.874e-35 140
LLPS-Via-1240Vigna angularis25.823e-30 125
LLPS-Gor-1426Gossypium raimondii25.764e-28 119
LLPS-Met-1198Medicago truncatula25.766e-32 130
LLPS-Dac-2009Daucus carota25.555e-24 107
LLPS-Nia-1774Nicotiana attenuata25.449e-29 123
LLPS-Mae-2686Manihot esculenta25.437e-31 127
LLPS-Hea-0906Helianthus annuus25.439e-31 127
LLPS-Thc-2150Theobroma cacao25.221e-25 112
LLPS-Kop-0508Komagataella pastoris24.592e-24 109
LLPS-Osl-1139Ostreococcus lucimarinus24.323e-1169.3
LLPS-Vir-2010Vigna radiata24.052e-1994.4
LLPS-Cae-0512Caenorhabditis elegans22.751e-1685.9