• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Crn-1327
CNN01190

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: RNA polymerase II transcription factor B subunit 2
Gene Name: CNN01190
Ensembl Gene: CNN01190
Ensembl Protein: AAW47046
Organism: Cryptococcus neoformans
Taxa ID: 214684
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblAAW47046AAW47046
UniProtQ5K741, Q5K741_CRYNJ
GeneBankAE017356AAW47046.1
RefSeqXM_568563.1XP_568563.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MVQPFVSAPK  KDATKQASPT  LALDIFLDNQ  HQSYFEELYR  LLPPVCRQII  LHALWSHHPL  60
61    RTVDVKLLLQ  MDVHAPLEEC  DEVMRPAIDR  KVLHPMHYKK  QRMQWSLNDS  FKKGLRNALT  120
121   GLGTSNSFGV  PFERHQATDL  DLPSEDELVA  YGEDTFESIL  KYMVSSGLGT  EFSGSRPQPE  180
181   VLQLLHTSGL  MTDSVDMNGR  NPNINRLTIT  SKGFQFLLEK  RQTQLWEILM  YYLSAKEANS  240
241   ERSSEVLSMF  FSLGCMQLGQ  DYSASNSFPG  AQEALDDLAQ  YGFIYKSSPD  SDQFWPTHLA  300
301   TSLCSGDASA  IQSQSADDKR  FLILETNYKI  YAYTSNELEI  AILNLFVDIR  IRYPNLVVGK  360
361   LDRQHVKAAM  EKGISARQII  AYLSSHAHPQ  MYNSPPPLLH  PTIVDQLYLW  DRERNRLQTE  420
421   ETVMYEFFSK  ELFDDTVNEA  KANAALQHAA  ISQKLLFIEP  HTKPAITEFV  KQRQNVLRGG  480
481   Y  481
Nucleotide CDS Sequence (FASTA)
1     ATGGTACAAC  CATTCGTTTC  AGCTCCCAAG  AAGGATGCGA  CCAAACAGGC  ATCGCCGACA  60
61    TTGGCTCTTG  ACATCTTTCT  CGATAACCAG  CACCAGTCGT  ATTTTGAGGA  GCTCTACAGA  120
121   TTACTACCGC  CAGTATGCCG  TCAAATTATT  CTCCATGCCT  TGTGGTCCCA  TCATCCATTA  180
181   CGGACGGTCG  ATGTCAAGCT  GCTTCTCCAG  ATGGATGTCC  ATGCTCCTTT  AGAAGAATGC  240
241   GACGAGGTCA  TGCGACCAGC  TATAGACAGG  AAGGTCCTCC  ATCCAATGCA  TTATAAGAAA  300
301   CAGAGAATGC  AGTGGTCCTT  GAATGATTCT  TTCAAGAAGG  GCCTGAGAAA  TGCCTTGACA  360
361   GGATTAGGAA  CATCAAATTC  GTTCGGTGTA  CCCTTTGAAA  GACATCAGGC  AACTGACCTT  420
421   GATCTTCCCT  CCGAGGACGA  GCTCGTGGCG  TATGGCGAGG  ATACGTTTGA  GTCTATTCTC  480
481   AAATACATGG  TGTCTTCCGG  TCTCGGTACA  GAATTCTCTG  GATCCAGACC  ACAGCCTGAG  540
541   GTCCTCCAGC  TCTTACATAC  CAGCGGCCTC  ATGACGGATT  CTGTCGATAT  GAACGGAAGA  600
601   AATCCCAATA  TAAATCGGCT  CACAATCACT  TCCAAAGGCT  TTCAATTTTT  GCTCGAGAAG  660
661   AGACAGACTC  AGTTGTGGGA  GATACTCATG  TACTACTTGA  GTGCCAAAGA  AGCAAACTCT  720
721   GAACGGTCAT  CCGAGGTCTT  GTCAATGTTC  TTCTCCCTCG  GATGTATGCA  ACTAGGACAA  780
781   GACTATTCCG  CGTCCAACTC  CTTCCCTGGC  GCTCAAGAAG  CTCTCGACGA  CCTCGCCCAA  840
841   TACGGTTTCA  TTTACAAATC  ATCGCCTGAC  AGCGATCAAT  TTTGGCCCAC  CCACCTTGCC  900
901   ACCTCTTTGT  GTTCCGGCGA  CGCTTCTGCC  ATCCAGTCTC  AGAGTGCAGA  CGACAAGCGT  960
961   TTCCTAATAT  TGGAAACCAA  TTACAAAATT  TACGCATATA  CTTCAAACGA  GCTCGAGATC  1020
1021  GCCATCCTTA  ATCTCTTTGT  CGACATTCGC  ATTCGGTACC  CCAACCTCGT  TGTAGGAAAA  1080
1081  CTCGATCGTC  AGCACGTTAA  AGCCGCCATG  GAAAAGGGTA  TCTCAGCCCG  GCAGATCATC  1140
1141  GCCTATTTGT  CCAGTCATGC  CCATCCACAA  ATGTACAACT  CTCCCCCACC  ATTATTACAT  1200
1201  CCCACCATTG  TCGATCAACT  TTATTTATGG  GATCGAGAGA  GGAATAGATT  ACAGACGGAA  1260
1261  GAGACTGTTA  TGTACGAATT  CTTCAGCAAA  GAACTCTTTG  ACGATACTGT  CAATGAAGCC  1320
1321  AAAGCGAATG  CGGCTCTACA  GCATGCCGCT  ATATCTCAAA  AACTATTATT  CATCGAGCCA  1380
1381  CATACGAAGC  CTGCGATCAC  AGAATTCGTC  AAACAAAGAC  AGAACGTCCT  TAGAGGGGGC  1440
1441  TATTAG  1446

▼ KEYWORD

ID
Family
Complete proteome
DNA damage
DNA repair
Nucleus
Reference proteome
Transcription
Transcription regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Transcription factor TFIIH core complex
Cellular Component
Transcription factor TFIIH holo complex
Molecular Function
ATPase activator activity
Molecular Function
Double-stranded DNA binding
Biological Process
Nucleotide-excision repair
Biological Process
Phosphorylation of RNA polymerase II C-terminal domain

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Pug-0881Puccinia graminis38.72e-84 284
LLPS-Scc-1606Schizosaccharomyces cryophilus37.646e-82 267
LLPS-Put-0578Puccinia triticina37.421e-47 176
LLPS-Scp-0817Schizosaccharomyces pombe37.331e-80 264
LLPS-Phn-0858Phaeosphaeria nodorum37.173e-68 231
LLPS-Spr-0706Sporisorium reilianum36.973e-82 270
LLPS-Usm-0767Ustilago maydis36.733e-83 272
LLPS-Scj-1262Schizosaccharomyces japonicus36.436e-81 265
LLPS-Mel-0933Melampsora laricipopulina36.431e-76 254
LLPS-Scs-0937Sclerotinia sclerotiorum36.295e-64 219
LLPS-Miv-0894Microbotryum violaceum35.424e-72 244
LLPS-Abg-1684Absidia glauca35.062e-74 249
LLPS-Xet-2190Xenopus tropicalis34.454e-51 184
LLPS-Yal-0890Yarrowia lipolytica34.067e-72 241
LLPS-Zyt-1111Zymoseptoria tritici33.568e-58 205
LLPS-Dos-1570Dothistroma septosporum33.262e-65 225
LLPS-Lem-1134Leptosphaeria maculans33.192e-65 225
LLPS-Pytr-1549Pyrenophora triticirepentis33.118e-69 234
LLPS-Pyt-1428Pyrenophora teres33.117e-69 234
LLPS-Tum-0728Tuber melanosporum33.034e-65 224
LLPS-Pes-1235Pelodiscus sinensis32.692e-0860.5
LLPS-Anc-1426Anolis carolinensis32.577e-58 204
LLPS-Asn-1168Aspergillus nidulans32.549e-65 223
LLPS-Gaa-0044Gasterosteus aculeatus32.297e-62 215
LLPS-Ten-0568Tetraodon nigroviridis32.23e-59 208
LLPS-Dar-1066Danio rerio32.082e-62 217
LLPS-Fud-2092Fukomys damarensis31.972e-52 188
LLPS-Orl-0277Oryzias latipes31.911e-58 206
LLPS-Asf-0420Aspergillus flavus31.882e-67 230
LLPS-Aso-1209Aspergillus oryzae31.882e-67 230
LLPS-Icp-1458Ictalurus punctatus31.875e-59 207
LLPS-Orn-1939Oreochromis niloticus31.712e-58 206
LLPS-Nef-1040Neosartorya fischeri31.672e-64 221
LLPS-Ast-1351Aspergillus terreus31.654e-66 226
LLPS-Asm-3251Astyanax mexicanus31.654e-58 205
LLPS-Asni-0674Aspergillus niger31.611e-69 236
LLPS-Sac-1004Saccharomyces cerevisiae31.571e-53 194
LLPS-Tar-3140Takifugu rubripes31.578e-59 207
LLPS-Mao-1079Magnaporthe oryzae31.534e-68 232
LLPS-Mod-0004Monodelphis domestica31.442e-58 206
LLPS-Drm-1711Drosophila melanogaster31.278e-54 194
LLPS-Asfu-1004Aspergillus fumigatus31.261e-64 223
LLPS-Caf-4104Canis familiaris31.214e-57 202
LLPS-Loa-0759Loxodonta africana31.212e-57 203
LLPS-Ova-3736Ovis aries31.213e-58 205
LLPS-Xim-3239Xiphophorus maculatus31.131e-56 201
LLPS-Asc-1659Aspergillus clavatus31.052e-63 219
LLPS-Kop-0508Komagataella pastoris31.041e-50 186
LLPS-Blg-0440Blumeria graminis31.033e-58 205
LLPS-Eqc-0258Equus caballus30.983e-57 202
LLPS-Fec-3835Felis catus30.984e-57 202
LLPS-Urm-3201Ursus maritimus30.983e-57 202
LLPS-Aim-3896Ailuropoda melanoleuca30.984e-57 202
LLPS-Scf-3717Scleropages formosus30.966e-56 199
LLPS-Chc-1180Chondrus crispus30.923e-33 135
LLPS-Pof-2563Poecilia formosa30.775e-51 186
LLPS-Nol-0069Nomascus leucogenys30.751e-56 201
LLPS-Ict-0023Ictidomys tridecemlineatus30.755e-57 202
LLPS-Cas-1341Carlito syrichta30.751e-56 201
LLPS-Mam-2149Macaca mulatta30.752e-56 201
LLPS-Cap-0698Cavia porcellus30.751e-56 201
LLPS-Poa-0660Pongo abelii30.751e-56 201
LLPS-Rhb-4809Rhinopithecus bieti30.752e-56 200
LLPS-Otg-2830Otolemur garnettii30.751e-56 201
LLPS-Man-3858Macaca nemestrina30.752e-56 201
LLPS-Hos-0151Homo sapiens30.751e-56 201
LLPS-Pap-4641Pan paniscus30.751e-56 201
LLPS-Pat-3712Pan troglodytes30.751e-56 201
LLPS-Paa-3317Papio anubis30.751e-56 201
LLPS-Mal-0595Mandrillus leucophaeus30.751e-56 201
LLPS-Ran-1158Rattus norvegicus30.759e-57 201
LLPS-Bot-3665Bos taurus30.756e-56 199
LLPS-Caj-1107Callithrix jacchus30.751e-56 201
LLPS-Gog-0566Gorilla gorilla30.751e-56 201
LLPS-Sus-0538Sus scrofa30.755e-56 199
LLPS-Cea-0797Cercocebus atys30.751e-56 201
LLPS-Chs-4374Chlorocebus sabaeus30.751e-56 201
LLPS-Mum-4682Mus musculus30.751e-56 201
LLPS-Maf-1697Macaca fascicularis30.751e-56 201
LLPS-Mea-0677Mesocricetus auratus30.754e-57 202
LLPS-Fus-0786Fusarium solani30.721e-59 210
LLPS-Map-1365Magnaporthe poae30.693e-62 217
LLPS-Scm-3768Scophthalmus maximus30.624e-56 199
LLPS-Trr-0271Trichoderma reesei30.613e-57 203
LLPS-Gag-0439Gaeumannomyces graminis30.512e-64 223
LLPS-Trv-1538Trichoderma virens30.481e-55 199
LLPS-Chr-1438Chlamydomonas reinhardtii30.399e-28 120
LLPS-Tru-1567Triticum urartu30.325e-2197.8
LLPS-Cis-1527Ciona savignyi30.322e-40 155
LLPS-Aon-3414Aotus nancymaae30.272e-55 197
LLPS-Cii-2048Ciona intestinalis30.262e-30 123
LLPS-Nec-1228Neurospora crassa29.984e-51 187
LLPS-Cogr-0549Colletotrichum graminicola29.397e-49 180
LLPS-Asg-0652Ashbya gossypii29.392e-54 196
LLPS-Pot-2738Populus trichocarpa29.345e-41 157
LLPS-Coo-1604Colletotrichum orbiculare29.062e-46 174
LLPS-Php-1166Physcomitrella patens29.054e-52 189
LLPS-Sem-0134Selaginella moellendorffii28.863e-40 155
LLPS-Fuo-0771Fusarium oxysporum28.776e-59 208
LLPS-Fuv-1483Fusarium verticillioides28.772e-58 206
LLPS-Osl-1139Ostreococcus lucimarinus28.653e-36 144
LLPS-Beb-0889Beauveria bassiana28.276e-52 189
LLPS-Gor-1426Gossypium raimondii28.153e-41 158
LLPS-Lac-2693Latimeria chalumnae28.051e-41 159
LLPS-Cym-0779Cyanidioschyzon merolae27.955e-1478.6
LLPS-Ved-1552Verticillium dahliae27.97e-48 177
LLPS-Art-2895Arabidopsis thaliana27.873e-38 150
LLPS-Mua-2038Musa acuminata27.847e-39 151
LLPS-Coc-1386Corchorus capsularis27.692e-38 152
LLPS-Thc-2150Theobroma cacao27.694e-40 155
LLPS-Sei-0821Setaria italica27.624e-45 169
LLPS-Orm-1215Oryza meridionalis27.314e-45 169
LLPS-Orbr-1804Oryza brachyantha27.319e-45 168
LLPS-Bro-2621Brassica oleracea27.258e-36 143
LLPS-Sob-1248Sorghum bicolor27.191e-43 165
LLPS-Lep-1552Leersia perrieri27.14e-43 163
LLPS-Prp-1501Prunus persica26.988e-37 145
LLPS-Arl-1443Arabidopsis lyrata26.971e-39 153
LLPS-Org-0485Oryza glaberrima26.883e-43 164
LLPS-Orr-1160Oryza rufipogon26.882e-43 164
LLPS-Ors-1114Oryza sativa26.882e-43 164
LLPS-Orgl-2032Oryza glumaepatula26.882e-43 164
LLPS-Cus-2378Cucumis sativus26.812e-35 142
LLPS-Zem-1275Zea mays26.774e-42 160
LLPS-Amt-2221Amborella trichopoda26.736e-37 146
LLPS-Brd-1575Brachypodium distachyon26.715e-39 152
LLPS-Orp-2344Oryza punctata26.694e-42 160
LLPS-Mae-2686Manihot esculenta26.622e-36 144
LLPS-Hea-0906Helianthus annuus26.611e-37 147
LLPS-Dac-2009Daucus carota26.63e-35 140
LLPS-Ori-2367Oryza indica26.581e-42 162
LLPS-Tra-0085Triticum aestivum26.121e-39 154
LLPS-Gas-1269Galdieria sulphuraria26.062e-30 129
LLPS-Brr-2657Brassica rapa25.818e-37 145
LLPS-Brn-1147Brassica napus25.812e-36 144
LLPS-Nia-1774Nicotiana attenuata25.77e-37 148
LLPS-Orb-0481Oryza barthii25.311e-38 151
LLPS-Glm-2782Glycine max25.277e-37 145
LLPS-Sol-2177Solanum lycopersicum25.164e-38 149
LLPS-Via-1240Vigna angularis25.115e-36 143
LLPS-Vir-2010Vigna radiata24.834e-27 117
LLPS-Phv-0795Phaseolus vulgaris24.781e-36 145
LLPS-Met-1198Medicago truncatula24.621e-33 136
LLPS-Cae-0512Caenorhabditis elegans23.877e-31 128
LLPS-Orni-2025Oryza nivara23.665e-33 134