LLPS-Pap-1768
TIMM44
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Mitochondrial import inner membrane translocase subunit TIM44 |
| Gene Name: | TIMM44 |
| Ensembl Gene: | ENSPPAG00000043896.1 |
| Ensembl Protein: | ENSPPAP00000042688.1 |
| Organism: | Pan paniscus |
| Taxa ID: | 9597 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSPPAT00000065618.1 | ENSPPAP00000042688.1 |
| UniProt | A0A2R9CNC2, A0A2R9CNC2_PANPA | |
| GeneBank | AJFE02031098, AJFE02031095, AJFE02031097, AJFE02031096 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 NMAAAALRSG WCRCPRRCLG SGIQFLSSHN LPHGSTYQMR RPGGELPLSK SYSSGNRKGF 60 61 LSGLLDNVKQ ELAKNKEMKE SIKKFRDEAR RLEESDVLQE ARRKYKTIES ETVRTSEVLR 120 121 KKLGELTGTV KESLHEVSKS DLGRKIKEGV EEAAKTAKQS AESVSKGGEK LGRTAAFRAL 180 181 SQGVESVKKE IDDSVLGQTG PYRRPQRLRK RTEFAGDTFK EEKVFEPNEE ALGVVLHKDS 240 241 KWYQQWKDFK ENNMVFNRFF EMKMKYDESD NAFIRASRAL TDKVTDLLGG LFSKTEMSEV 300 301 LTEILRVDPA FDKDRFLKQC ENDIIPNVLE AMISGELDIL KDWCYEATYS QLAHPIQQAK 360 361 ALGLQFHSRI LDIDNVDLAM GKMMEQGPVL IITFQAQLVM VVRNLKGEVV EGDPDKVLRM 420 421 LYVWALCRDQ DELNPYVAWR LLDISASSTE QIL 453 |
| Nucleotide CDS Sequence (FASTA) |
1 AACATGGCGG CGGCGGCCCT GCGGAGTGGC TGGTGCCGCT GTCCACGGAG ATGCCTCGGC 60 61 AGTGGAATCC AATTTCTTTC CAGCCACAAC CTACCGCATG GGTCGACCTA TCAGATGCGC 120 121 CGGCCGGGCG GAGAGCTGCC ACTGTCCAAA TCATATTCTT CTGGAAACAG AAAAGGCTTT 180 181 TTGTCCGGCT TGCTAGATAA TGTCAAACAA GAATTAGCCA AAAACAAAGA AATGAAAGAA 240 241 AGTATAAAAA AATTCCGTGA TGAGGCCAGA AGGCTAGAAG AATCAGATGT GCTCCAGGAG 300 301 GCCAGAAGGA AATACAAAAC CATCGAGTCA GAAACCGTGC GGACGAGCGA GGTGCTACGG 360 361 AAGAAGCTTG GGGAGCTGAC GGGCACCGTG AAGGAGAGCC TTCACGAAGT CAGTAAAAGT 420 421 GATCTCGGCC GGAAAATCAA GGAGGGCGTG GAGGAAGCAG CCAAGACGGC CAAGCAGTCG 480 481 GCCGAGTCGG TATCCAAAGG CGGGGAGAAG CTGGGCAGGA CAGCGGCCTT CAGAGCCCTC 540 541 TCCCAGGGGG TGGAGTCCGT GAAGAAGGAA ATTGACGACA GCGTCCTGGG ACAGACCGGG 600 601 CCCTACCGGA GGCCCCAGCG ACTCCGGAAG AGAACGGAGT TTGCGGGAGA TACGTTCAAG 660 661 GAGGAGAAAG TGTTTGAGCC AAACGAGGAG GCCCTGGGGG TCGTGCTGCA CAAGGACTCC 720 721 AAGTGGTACC AGCAGTGGAA GGACTTCAAG GAGAACAACA TGGTGTTTAA CCGGTTCTTC 780 781 GAGATGAAGA TGAAGTATGA CGAAAGCGAC AACGCGTTCA TCCGGGCATC CCGGGCCCTT 840 841 ACGGACAAGG TCACTGACTT GCTGGGGGGC CTGTTCTCCA AGACAGAGAT GTCAGAGGTG 900 901 CTCACGGAGA TCCTCCGGGT GGACCCGGCC TTTGACAAGG ACCGGTTTCT GAAACAGTGC 960 961 GAGAACGACA TCATCCCCAA TGTCCTGGAG GCCATGATTT CTGGAGAGCT TGACATTCTC 1020 1021 AAAGACTGGT GCTATGAAGC TACTTACAGC CAGCTGGCCC ACCCCATCCA GCAGGCCAAG 1080 1081 GCACTGGGTC TCCAGTTCCA TTCTCGCATC CTAGATATTG ACAACGTCGA CCTGGCCATG 1140 1141 GGCAAGATGA TGGAGCAGGG GCCGGTGCTG ATCATCACCT TCCAGGCACA GCTGGTGATG 1200 1201 GTGGTCAGGA ACCTCAAAGG CGAGGTGGTG GAGGGCGACC CGGACAAGGT GCTGCGGATG 1260 1261 CTGTACGTGT GGGCGCTCTG CCGAGACCAG GACGAGCTCA ACCCCTACGT GGCCTGGCGG 1320 1321 CTCCTGGACA TCTCGGCCTC CAGCACCGAG CAGATTCTCT GA 1362 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrial inner membrane | |
Cellular Component | Mitochondrial matrix | |
Molecular Function | Chaperone binding | |
Biological Process | Protein import into mitochondrial matrix |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-0354 | Homo sapiens | 99.12 | 0.0 | 924 |
| LLPS-Pat-1761 | Pan troglodytes | 99.12 | 0.0 | 924 |
| LLPS-Gog-2011 | Gorilla gorilla | 98.9 | 0.0 | 925 |
| LLPS-Chs-1586 | Chlorocebus sabaeus | 97.83 | 0.0 | 830 |
| LLPS-Paa-0069 | Papio anubis | 97.78 | 0.0 | 909 |
| LLPS-Man-0705 | Macaca nemestrina | 97.57 | 0.0 | 827 |
| LLPS-Mal-1986 | Mandrillus leucophaeus | 97.56 | 0.0 | 906 |
| LLPS-Poa-1257 | Pongo abelii | 97.35 | 0.0 | 902 |
| LLPS-Mam-0295 | Macaca mulatta | 97.34 | 0.0 | 906 |
| LLPS-Rhb-3421 | Rhinopithecus bieti | 97.34 | 0.0 | 905 |
| LLPS-Aon-4204 | Aotus nancymaae | 96.02 | 0.0 | 903 |
| LLPS-Maf-3893 | Macaca fascicularis | 95.97 | 0.0 | 872 |
| LLPS-Cea-2819 | Cercocebus atys | 94.91 | 0.0 | 870 |
| LLPS-Caj-1372 | Callithrix jacchus | 94.25 | 0.0 | 884 |
| LLPS-Nol-0199 | Nomascus leucogenys | 93.65 | 0.0 | 857 |
| LLPS-Otg-2534 | Otolemur garnettii | 92.48 | 0.0 | 862 |
| LLPS-Ict-0311 | Ictidomys tridecemlineatus | 92.04 | 0.0 | 875 |
| LLPS-Dio-0549 | Dipodomys ordii | 91.72 | 0.0 | 864 |
| LLPS-Caf-0392 | Canis familiaris | 91.65 | 0.0 | 863 |
| LLPS-Eqc-2296 | Equus caballus | 91.19 | 0.0 | 857 |
| LLPS-Orc-1538 | Oryctolagus cuniculus | 91.15 | 0.0 | 864 |
| LLPS-Urm-1536 | Ursus maritimus | 90.99 | 0.0 | 856 |
| LLPS-Fud-3056 | Fukomys damarensis | 90.49 | 0.0 | 840 |
| LLPS-Mup-1764 | Mustela putorius furo | 90.31 | 0.0 | 845 |
| LLPS-Bot-0568 | Bos taurus | 90.29 | 0.0 | 851 |
| LLPS-Cas-0628 | Carlito syrichta | 90.27 | 0.0 | 848 |
| LLPS-Cap-2488 | Cavia porcellus | 90.04 | 0.0 | 853 |
| LLPS-Fec-4175 | Felis catus | 89.87 | 0.0 | 853 |
| LLPS-Sus-1093 | Sus scrofa | 89.67 | 0.0 | 843 |
| LLPS-Mea-1663 | Mesocricetus auratus | 89.6 | 0.0 | 854 |
| LLPS-Ran-2328 | Rattus norvegicus | 89.4 | 0.0 | 844 |
| LLPS-Myl-1950 | Myotis lucifugus | 89.01 | 0.0 | 837 |
| LLPS-Mum-3720 | Mus musculus | 88.94 | 0.0 | 847 |
| LLPS-Ova-0027 | Ovis aries | 87.42 | 0.0 | 793 |
| LLPS-Loa-4018 | Loxodonta africana | 86.27 | 0.0 | 803 |
| LLPS-Sah-0267 | Sarcophilus harrisii | 83.33 | 0.0 | 791 |
| LLPS-Pes-1340 | Pelodiscus sinensis | 82.55 | 0.0 | 762 |
| LLPS-Anp-0285 | Anas platyrhynchos | 81.98 | 0.0 | 766 |
| LLPS-Meg-1479 | Meleagris gallopavo | 81.67 | 0.0 | 761 |
| LLPS-Mod-1061 | Monodelphis domestica | 81.4 | 0.0 | 704 |
| LLPS-Scf-2891 | Scleropages formosus | 81.07 | 0.0 | 671 |
| LLPS-Gaga-3086 | Gallus gallus | 80.92 | 0.0 | 767 |
| LLPS-Fia-2540 | Ficedula albicollis | 79.65 | 0.0 | 757 |
| LLPS-Tag-3148 | Taeniopygia guttata | 79.62 | 0.0 | 611 |
| LLPS-Xet-1207 | Xenopus tropicalis | 78.33 | 0.0 | 696 |
| LLPS-Tar-1649 | Takifugu rubripes | 76.02 | 0.0 | 657 |
| LLPS-Ora-2730 | Ornithorhynchus anatinus | 75.6 | 0.0 | 700 |
| LLPS-Lac-0444 | Latimeria chalumnae | 75.12 | 0.0 | 625 |
| LLPS-Pof-1320 | Poecilia formosa | 74.94 | 0.0 | 673 |
| LLPS-Xim-1203 | Xiphophorus maculatus | 74.78 | 0.0 | 679 |
| LLPS-Dar-1101 | Danio rerio | 74.45 | 0.0 | 691 |
| LLPS-Ten-2508 | Tetraodon nigroviridis | 74.12 | 0.0 | 687 |
| LLPS-Scm-2163 | Scophthalmus maximus | 73.74 | 0.0 | 676 |
| LLPS-Orn-2845 | Oreochromis niloticus | 73.41 | 0.0 | 661 |
| LLPS-Asm-1331 | Astyanax mexicanus | 73.23 | 0.0 | 663 |
| LLPS-Gaa-2403 | Gasterosteus aculeatus | 73.0 | 0.0 | 680 |
| LLPS-Orl-3122 | Oryzias latipes | 72.81 | 0.0 | 673 |
| LLPS-Icp-3349 | Ictalurus punctatus | 72.77 | 0.0 | 677 |
| LLPS-Leo-0701 | Lepisosteus oculatus | 66.52 | 0.0 | 597 |
| LLPS-Drm-2035 | Drosophila melanogaster | 51.61 | 2e-150 | 443 |
| LLPS-Cym-0201 | Cyanidioschyzon merolae | 48.28 | 6e-13 | 69.7 |
| LLPS-Cii-2053 | Ciona intestinalis | 42.93 | 3e-110 | 339 |
| LLPS-Cae-1940 | Caenorhabditis elegans | 41.38 | 8e-118 | 358 |
| LLPS-Cis-0086 | Ciona savignyi | 39.47 | 4e-108 | 333 |
| LLPS-Gas-0054 | Galdieria sulphuraria | 37.72 | 5e-31 | 126 |
| LLPS-Phn-0429 | Phaeosphaeria nodorum | 36.23 | 6e-33 | 133 |
| LLPS-Fuv-0620 | Fusarium verticillioides | 34.7 | 2e-35 | 140 |
| LLPS-Chc-0659 | Chondrus crispus | 34.36 | 1e-25 | 112 |
| LLPS-Pytr-0305 | Pyrenophora triticirepentis | 31.83 | 3e-40 | 155 |
| LLPS-Pyt-1015 | Pyrenophora teres | 31.83 | 1e-39 | 154 |
| LLPS-Abg-0956 | Absidia glauca | 31.67 | 4e-59 | 214 |
| LLPS-Ast-0875 | Aspergillus terreus | 31.08 | 4e-45 | 169 |
| LLPS-Tum-0765 | Tuber melanosporum | 31.02 | 4e-48 | 178 |
| LLPS-Nia-1272 | Nicotiana attenuata | 30.61 | 7e-08 | 58.2 |
| LLPS-Ved-1253 | Verticillium dahliae | 30.53 | 4e-43 | 164 |
| LLPS-Cog-0476 | Colletotrichum gloeosporioides | 30.53 | 2e-37 | 148 |
| LLPS-Gag-1440 | Gaeumannomyces graminis | 30.3 | 5e-42 | 161 |
| LLPS-Cogr-1385 | Colletotrichum graminicola | 30.15 | 6e-40 | 155 |
| LLPS-Asni-0924 | Aspergillus niger | 30.15 | 1e-45 | 171 |
| LLPS-Trv-0579 | Trichoderma virens | 29.95 | 1e-43 | 163 |
| LLPS-Osl-0832 | Ostreococcus lucimarinus | 29.94 | 2e-15 | 80.5 |
| LLPS-Chr-1042 | Chlamydomonas reinhardtii | 29.94 | 5e-14 | 77.8 |
| LLPS-Put-0631 | Puccinia triticina | 29.85 | 2e-12 | 73.2 |
| LLPS-Pug-0667 | Puccinia graminis | 29.85 | 1e-12 | 73.9 |
| LLPS-Map-0639 | Magnaporthe poae | 29.8 | 2e-41 | 159 |
| LLPS-Nec-1412 | Neurospora crassa | 29.75 | 4e-42 | 161 |
| LLPS-Coo-0590 | Colletotrichum orbiculare | 29.74 | 7e-39 | 151 |
| LLPS-Yal-0060 | Yarrowia lipolytica | 29.55 | 4e-37 | 145 |
| LLPS-Lem-1605 | Leptosphaeria maculans | 29.47 | 2e-39 | 154 |
| LLPS-Kop-0675 | Komagataella pastoris | 29.43 | 8e-36 | 141 |
| LLPS-Org-0198 | Oryza glaberrima | 29.1 | 9e-18 | 89.7 |
| LLPS-Orr-0333 | Oryza rufipogon | 29.1 | 8e-18 | 89.7 |
| LLPS-Ors-1545 | Oryza sativa | 29.1 | 8e-18 | 89.7 |
| LLPS-Orp-1157 | Oryza punctata | 29.1 | 4e-18 | 90.9 |
| LLPS-Orgl-0663 | Oryza glumaepatula | 29.1 | 7e-18 | 89.7 |
| LLPS-Orni-0498 | Oryza nivara | 29.1 | 9e-18 | 89.0 |
| LLPS-Ori-0134 | Oryza indica | 29.1 | 8e-18 | 89.7 |
| LLPS-Orb-0143 | Oryza barthii | 29.1 | 8e-18 | 89.7 |
| LLPS-Asc-0751 | Aspergillus clavatus | 29.07 | 7e-39 | 152 |
| LLPS-Fus-0410 | Fusarium solani | 28.89 | 2e-40 | 156 |
| LLPS-Mao-1424 | Magnaporthe oryzae | 28.86 | 1e-40 | 157 |
| LLPS-Tru-0662 | Triticum urartu | 28.82 | 2e-16 | 85.9 |
| LLPS-Tra-0155 | Triticum aestivum | 28.82 | 1e-16 | 85.9 |
| LLPS-Hov-0570 | Hordeum vulgare | 28.82 | 3e-16 | 84.7 |
| LLPS-Beb-0760 | Beauveria bassiana | 28.79 | 1e-40 | 157 |
| LLPS-Trr-0741 | Trichoderma reesei | 28.72 | 7e-43 | 164 |
| LLPS-Zyt-0104 | Zymoseptoria tritici | 28.61 | 4e-38 | 149 |
| LLPS-Asn-0065 | Aspergillus nidulans | 28.32 | 8e-42 | 160 |
| LLPS-Nef-1474 | Neosartorya fischeri | 28.25 | 6e-39 | 152 |
| LLPS-Fuo-0337 | Fusarium oxysporum | 28.24 | 6e-40 | 155 |
| LLPS-Sob-1914 | Sorghum bicolor | 28.04 | 2e-17 | 89.0 |
| LLPS-Gor-2501 | Gossypium raimondii | 27.9 | 3e-22 | 102 |
| LLPS-Bro-0799 | Brassica oleracea | 27.8 | 2e-18 | 91.3 |
| LLPS-Usm-0154 | Ustilago maydis | 27.8 | 2e-26 | 115 |
| LLPS-Asf-0317 | Aspergillus flavus | 27.57 | 7e-38 | 149 |
| LLPS-Aso-0419 | Aspergillus oryzae | 27.57 | 8e-38 | 149 |
| LLPS-Dos-0156 | Dothistroma septosporum | 27.54 | 2e-38 | 151 |
| LLPS-Orbr-0152 | Oryza brachyantha | 27.54 | 4e-18 | 90.5 |
| LLPS-Asfu-0204 | Aspergillus fumigatus | 27.52 | 2e-37 | 147 |
| LLPS-Scp-0358 | Schizosaccharomyces pombe | 27.48 | 4e-43 | 162 |
| LLPS-Spr-1449 | Sporisorium reilianum | 27.31 | 9e-25 | 110 |
| LLPS-Scc-0271 | Schizosaccharomyces cryophilus | 27.11 | 3e-39 | 151 |
| LLPS-Sot-0605 | Solanum tuberosum | 27.03 | 3e-15 | 79.0 |
| LLPS-Sol-1641 | Solanum lycopersicum | 27.03 | 5e-20 | 96.7 |
| LLPS-Blg-0269 | Blumeria graminis | 26.91 | 7e-35 | 140 |
| LLPS-Sac-1395 | Saccharomyces cerevisiae | 26.83 | 1e-31 | 129 |
| LLPS-Crn-0477 | Cryptococcus neoformans | 26.68 | 6e-29 | 122 |
| LLPS-Zem-1578 | Zea mays | 26.67 | 1e-15 | 83.2 |
| LLPS-Brd-1698 | Brachypodium distachyon | 26.46 | 2e-16 | 85.9 |
| LLPS-Phv-1552 | Phaseolus vulgaris | 26.39 | 4e-20 | 96.7 |
| LLPS-Cus-1398 | Cucumis sativus | 26.19 | 1e-08 | 58.2 |
| LLPS-Prp-1736 | Prunus persica | 26.18 | 2e-20 | 97.8 |
| LLPS-Asg-0003 | Ashbya gossypii | 26.05 | 2e-30 | 125 |
| LLPS-Sei-0375 | Setaria italica | 25.86 | 1e-18 | 92.0 |
| LLPS-Vir-0958 | Vigna radiata | 25.47 | 5e-16 | 84.3 |
| LLPS-Hea-1068 | Helianthus annuus | 25.43 | 1e-17 | 89.4 |
| LLPS-Scj-0970 | Schizosaccharomyces japonicus | 25.39 | 1e-30 | 126 |
| LLPS-Brn-1840 | Brassica napus | 25.27 | 3e-23 | 105 |
| LLPS-Glm-0999 | Glycine max | 25.16 | 3e-20 | 97.1 |
| LLPS-Brr-0914 | Brassica rapa | 25.05 | 1e-22 | 103 |
| LLPS-Miv-0485 | Microbotryum violaceum | 24.69 | 5e-28 | 119 |
| LLPS-Sem-2146 | Selaginella moellendorffii | 24.65 | 6e-18 | 90.1 |
| LLPS-Art-0307 | Arabidopsis thaliana | 24.62 | 3e-19 | 94.0 |
| LLPS-Pot-0875 | Populus trichocarpa | 24.59 | 6e-25 | 110 |
| LLPS-Viv-1757 | Vitis vinifera | 24.31 | 4e-22 | 102 |
| LLPS-Mae-0173 | Manihot esculenta | 23.92 | 4e-25 | 111 |
| LLPS-Arl-1260 | Arabidopsis lyrata | 23.64 | 8e-20 | 95.5 |
| LLPS-Mel-0112 | Melampsora laricipopulina | 23.57 | 2e-24 | 109 |
| LLPS-Php-0171 | Physcomitrella patens | 23.53 | 5e-16 | 84.0 |
| LLPS-Lep-1851 | Leersia perrieri | 23.39 | 9e-11 | 67.4 |
| LLPS-Met-0324 | Medicago truncatula | 23.33 | 3e-23 | 105 |
| LLPS-Amt-0255 | Amborella trichopoda | 23.24 | 4e-17 | 87.8 |
| LLPS-Mua-1782 | Musa acuminata | 23.15 | 2e-14 | 79.3 |
| LLPS-Thc-0860 | Theobroma cacao | 23.02 | 4e-22 | 102 |
| LLPS-Via-0877 | Vigna angularis | 22.96 | 6e-21 | 99.4 |
| LLPS-Dac-0144 | Daucus carota | 22.34 | 5e-18 | 90.5 |
| LLPS-Coc-0030 | Corchorus capsularis | 21.9 | 1e-19 | 95.1 |