• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Chs-1586
TIMM44

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Mitochondrial import inner membrane translocase subunit TIM44
Gene Name: TIMM44
Ensembl Gene: ENSCSAG00000008162.1
Ensembl Protein: ENSCSAP00000004421.1
Organism: Chlorocebus sabaeus
Taxa ID: 60711
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MRRPGGELPL  SKSYSSGNRK  GFLSGLLDNV  KQELAKNKEM  KESIKKFRDE  ARRLEESDVL  60
61    QEARRKYKTI  ESETMRTSEV  LRKKLGELTG  TVKESLHEVS  KSDLGRKIKE  GVEEAAKTAK  120
121   QSAESVSKGG  EKLGRTAAFR  ALSQGVESVK  KEIDDSVLGQ  TGPYRRPQRL  RKRTEFAGEK  180
181   FKEEKVFEPN  EEALGVVLHK  DSKWYQQWKD  FKENNVVFNR  FFEMKMKYDE  SDNAFIRASR  240
241   ALTDKVTDLL  GGLFSKTEMS  EVLTEILRVD  PAFDKDRFLK  QCENDIIPNV  LEAMISGELD  300
301   ILKDWCYEAT  YSQLAYPIQQ  AKALGLQFHS  RILDIDNIDL  AMGKMMEPGP  VLIITFQAQL  360
361   VMVVRNPKGE  VVEGDPDKVL  RMLYVWALCR  DQDELNPYAA  WRLLDISASS  TEQIL  415
Nucleotide CDS Sequence (FASTA)
1     ATGCGCCGGC  CGGGCGGAGA  GCTGCCACTG  TCCAAATCAT  ATTCTTCTGG  AAACAGAAAA  60
61    GGCTTTCTGT  CCGGCTTGCT  AGATAATGTC  AAACAAGAAT  TAGCCAAAAA  CAAAGAAATG  120
121   AAAGAAAGTA  TAAAAAAATT  CCGTGACGAG  GCCAGAAGGC  TAGAAGAATC  AGACGTGCTC  180
181   CAGGAGGCCA  GAAGGAAATA  CAAAACCATC  GAGTCAGAAA  CCATGCGGAC  GAGCGAGGTG  240
241   CTACGGAAGA  AGCTTGGGGA  GCTGACGGGC  ACCGTGAAGG  AGAGCCTTCA  TGAAGTCAGT  300
301   AAAAGTGATC  TGGGCCGGAA  AATCAAGGAG  GGTGTGGAAG  AAGCAGCCAA  GACGGCCAAG  360
361   CAGTCAGCCG  AGTCAGTATC  CAAAGGTGGG  GAGAAGCTGG  GCAGGACGGC  GGCCTTCAGA  420
421   GCCCTCTCCC  AGGGGGTGGA  GTCGGTGAAG  AAGGAAATTG  ACGACAGCGT  CCTGGGGCAG  480
481   ACCGGGCCCT  ACCGGAGGCC  CCAGCGACTC  CGGAAGAGAA  CGGAGTTTGC  GGGAGAGAAG  540
541   TTCAAGGAGG  AGAAAGTGTT  TGAGCCAAAT  GAGGAGGCAC  TGGGGGTCGT  GCTACACAAG  600
601   GACTCCAAGT  GGTACCAGCA  GTGGAAGGAC  TTCAAGGAGA  ACAACGTGGT  GTTTAACCGG  660
661   TTCTTCGAGA  TGAAGATGAA  GTATGATGAA  AGCGACAACG  CGTTCATCCG  GGCATCCCGG  720
721   GCCCTTACGG  ACAAGGTCAC  CGACTTGCTG  GGGGGCCTGT  TCTCCAAGAC  AGAGATGTCG  780
781   GAGGTGCTCA  CAGAGATCCT  CCGGGTGGAC  CCGGCCTTTG  ACAAGGACCG  GTTTCTGAAG  840
841   CAGTGCGAGA  ACGACATCAT  CCCCAATGTC  CTGGAGGCCA  TGATTTCTGG  AGAGCTTGAC  900
901   ATTCTCAAAG  ACTGGTGCTA  TGAAGCTACT  TACAGCCAGC  TGGCCTACCC  CATCCAGCAG  960
961   GCCAAGGCGC  TGGGTCTCCA  GTTCCATTCT  CGCATCCTAG  ACATTGACAA  CATTGACCTG  1020
1021  GCCATGGGCA  AGATGATGGA  GCCGGGGCCA  GTGCTCATCA  TCACCTTCCA  GGCGCAGCTG  1080
1081  GTGATGGTGG  TCCGGAACCC  TAAAGGCGAG  GTGGTGGAGG  GCGACCCGGA  CAAGGTGCTG  1140
1141  CGGATGCTGT  ACGTGTGGGC  GCTCTGCCGA  GACCAGGACG  AGCTCAACCC  CTACGCGGCC  1200
1201  TGGCGGCTCC  TGGACATCTC  AGCCTCCAGC  ACCGAGCAGA  TCCTCTGA  1248

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Membrane
Mitochondrion
Mitochondrion inner membrane
Protein transport
Reference proteome
Translocation
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Mitochondrial inner membrane
Cellular Component
Mitochondrial matrix
Molecular Function
Chaperone binding
Biological Process
Protein import into mitochondrial matrix

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Paa-0069Papio anubis100.00.0 848
LLPS-Mal-1986Mandrillus leucophaeus99.760.0 846
LLPS-Maf-3893Macaca fascicularis99.760.0 846
LLPS-Man-0705Macaca nemestrina99.730.0 764
LLPS-Mam-0295Macaca mulatta99.520.0 845
LLPS-Rhb-3421Rhinopithecus bieti99.520.0 845
LLPS-Hos-0354Homo sapiens98.80.0 840
LLPS-Gog-2011Gorilla gorilla98.550.0 837
LLPS-Pat-1761Pan troglodytes98.310.0 833
LLPS-Poa-1257Pongo abelii98.070.0 826
LLPS-Pap-1768Pan paniscus97.830.0 830
LLPS-Cea-2819Cercocebus atys96.880.0 808
LLPS-Aon-4204Aotus nancymaae96.390.0 826
LLPS-Caj-1372Callithrix jacchus95.90.0 817
LLPS-Otg-2534Otolemur garnettii93.950.0 798
LLPS-Nol-0199Nomascus leucogenys93.320.0 778
LLPS-Ict-0311Ictidomys tridecemlineatus93.220.0 800
LLPS-Eqc-2296Equus caballus93.010.0 799
LLPS-Caf-0392Canis familiaris93.010.0 801
LLPS-Cas-0628Carlito syrichta92.960.0 792
LLPS-Bot-0568Bos taurus92.940.0 791
LLPS-Mup-1764Mustela putorius furo92.750.0 796
LLPS-Dio-0549Dipodomys ordii92.530.0 801
LLPS-Sus-1093Sus scrofa92.530.0 790
LLPS-Fec-4175Felis catus92.290.0 794
LLPS-Urm-1536Ursus maritimus92.290.0 794
LLPS-Ova-0027Ovis aries92.010.0 758
LLPS-Orc-1538Oryctolagus cuniculus91.810.0 790
LLPS-Cap-2488Cavia porcellus91.750.0 781
LLPS-Fud-3056Fukomys damarensis91.570.0 766
LLPS-Mea-1663Mesocricetus auratus90.120.0 783
LLPS-Myl-1950Myotis lucifugus89.880.0 770
LLPS-Ran-2328Rattus norvegicus89.40.0 772
LLPS-Mum-3720Mus musculus88.190.0 763
LLPS-Loa-4018Loxodonta africana87.590.0 736
LLPS-Pes-1340Pelodiscus sinensis86.750.0 746
LLPS-Sah-0267Sarcophilus harrisii86.170.0 748
LLPS-Gaga-3086Gallus gallus85.960.0 754
LLPS-Meg-1479Meleagris gallopavo85.960.0 752
LLPS-Anp-0285Anas platyrhynchos85.540.0 749
LLPS-Fia-2540Ficedula albicollis85.470.0 743
LLPS-Mod-1061Monodelphis domestica84.720.0 664
LLPS-Tag-3148Taeniopygia guttata84.620.0 601
LLPS-Dar-1101Danio rerio82.090.0 688
LLPS-Scf-2891Scleropages formosus81.590.0 676
LLPS-Xim-1203Xiphophorus maculatus81.250.0 672
LLPS-Xet-1207Xenopus tropicalis80.60.0 692
LLPS-Pof-1320Poecilia formosa80.150.0 666
LLPS-Icp-3349Ictalurus punctatus80.00.0 671
LLPS-Orn-2845Oreochromis niloticus79.750.0 657
LLPS-Orl-3122Oryzias latipes79.50.0 667
LLPS-Ora-2730Ornithorhynchus anatinus79.230.0 664
LLPS-Scm-2163Scophthalmus maximus78.40.0 662
LLPS-Asm-1331Astyanax mexicanus78.380.0 659
LLPS-Ten-2508Tetraodon nigroviridis78.120.0 678
LLPS-Gaa-2403Gasterosteus aculeatus78.00.0 659
LLPS-Tar-1649Takifugu rubripes76.260.0 660
LLPS-Lac-0444Latimeria chalumnae75.370.0 624
LLPS-Leo-0701Lepisosteus oculatus72.550.0 597
LLPS-Drm-2035Drosophila melanogaster51.863e-151 444
LLPS-Cym-0201Cyanidioschyzon merolae44.832e-1165.1
LLPS-Cae-1940Caenorhabditis elegans42.932e-117 356
LLPS-Cii-2053Ciona intestinalis42.442e-110 338
LLPS-Cis-0086Ciona savignyi41.41e-107 331
LLPS-Gas-0054Galdieria sulphuraria36.537e-30 123
LLPS-Phn-0429Phaeosphaeria nodorum36.231e-33 135
LLPS-Fuv-0620Fusarium verticillioides34.73e-36 142
LLPS-Chc-0659Chondrus crispus33.742e-25 110
LLPS-Pyt-1015Pyrenophora teres32.13e-41 158
LLPS-Pytr-0305Pyrenophora triticirepentis32.14e-42 160
LLPS-Abg-0956Absidia glauca31.192e-58 211
LLPS-Cog-0476Colletotrichum gloeosporioides31.099e-40 154
LLPS-Ast-0875Aspergillus terreus31.089e-47 173
LLPS-Ved-1253Verticillium dahliae30.432e-44 167
LLPS-Cogr-1385Colletotrichum graminicola30.411e-41 159
LLPS-Tum-0765Tuber melanosporum30.358e-48 176
LLPS-Trv-0579Trichoderma virens30.23e-46 169
LLPS-Asni-0924Aspergillus niger30.152e-46 172
LLPS-Put-0631Puccinia triticina30.143e-1375.5
LLPS-Pug-0667Puccinia graminis30.142e-1375.9
LLPS-Yal-0060Yarrowia lipolytica30.051e-38 149
LLPS-Gag-1440Gaeumannomyces graminis30.051e-42 162
LLPS-Coo-0590Colletotrichum orbiculare30.04e-40 154
LLPS-Fus-0410Fusarium solani30.02e-41 158
LLPS-Kop-0675Komagataella pastoris29.64e-36 142
LLPS-Nia-1272Nicotiana attenuata29.598e-0857.8
LLPS-Map-0639Magnaporthe poae29.558e-42 160
LLPS-Tra-0155Triticum aestivum29.413e-1787.8
LLPS-Tru-0662Triticum urartu29.414e-1787.4
LLPS-Osl-0832Ostreococcus lucimarinus29.343e-1579.3
LLPS-Nec-1412Neurospora crassa29.183e-43 164
LLPS-Lem-1605Leptosphaeria maculans29.158e-41 157
LLPS-Chr-1042Chlamydomonas reinhardtii29.142e-1375.5
LLPS-Zyt-0104Zymoseptoria tritici29.15e-39 151
LLPS-Orgl-0663Oryza glumaepatula29.17e-1889.4
LLPS-Orni-0498Oryza nivara29.19e-1888.6
LLPS-Ori-0134Oryza indica29.19e-1889.4
LLPS-Orb-0143Oryza barthii29.19e-1889.4
LLPS-Org-0198Oryza glaberrima29.19e-1889.0
LLPS-Orr-0333Oryza rufipogon29.19e-1889.4
LLPS-Ors-1545Oryza sativa29.19e-1889.4
LLPS-Orp-1157Oryza punctata29.14e-1890.1
LLPS-Asc-0751Aspergillus clavatus29.077e-40 154
LLPS-Beb-0760Beauveria bassiana29.057e-42 159
LLPS-Trr-0741Trichoderma reesei28.978e-45 168
LLPS-Mao-1424Magnaporthe oryzae28.862e-41 158
LLPS-Fuo-0337Fusarium oxysporum28.757e-41 157
LLPS-Asfu-0204Aspergillus fumigatus28.432e-38 150
LLPS-Asn-0065Aspergillus nidulans28.325e-43 163
LLPS-Nef-1474Neosartorya fischeri28.255e-40 154
LLPS-Sob-1914Sorghum bicolor28.041e-1788.6
LLPS-Usm-0154Ustilago maydis27.937e-27 116
LLPS-Asf-0317Aspergillus flavus27.575e-39 151
LLPS-Aso-0419Aspergillus oryzae27.576e-39 151
LLPS-Blg-0269Blumeria graminis27.542e-35 141
LLPS-Dos-0156Dothistroma septosporum27.542e-39 153
LLPS-Orbr-0152Oryza brachyantha27.546e-1889.7
LLPS-Hov-0570Hordeum vulgare27.516e-1786.7
LLPS-Scp-0358Schizosaccharomyces pombe27.482e-44 165
LLPS-Gor-2501Gossypium raimondii27.472e-22 102
LLPS-Bro-0799Brassica oleracea27.397e-1992.0
LLPS-Sac-1395Saccharomyces cerevisiae27.074e-33 133
LLPS-Brd-1698Brachypodium distachyon26.985e-1787.0
LLPS-Spr-1449Sporisorium reilianum26.873e-25 111
LLPS-Crn-0477Cryptococcus neoformans26.682e-29 122
LLPS-Zem-1578Zea mays26.671e-1582.8
LLPS-Sol-1641Solanum lycopersicum26.569e-2095.1
LLPS-Sot-0605Solanum tuberosum26.492e-1579.3
LLPS-Via-0877Vigna angularis26.232e-2097.1
LLPS-Cus-1398Cucumis sativus26.197e-0958.5
LLPS-Prp-1736Prunus persica26.187e-2198.2
LLPS-Scc-0271Schizosaccharomyces cryophilus26.172e-39 151
LLPS-Asg-0003Ashbya gossypii26.054e-31 127
LLPS-Lep-1851Leersia perrieri26.032e-1066.6
LLPS-Sei-0375Setaria italica25.861e-1891.7
LLPS-Glm-0999Glycine max25.825e-2095.9
LLPS-Phv-1552Phaseolus vulgaris25.828e-2095.1
LLPS-Amt-0255Amborella trichopoda25.694e-1787.4
LLPS-Brn-1840Brassica napus25.271e-23 105
LLPS-Scj-0970Schizosaccharomyces japonicus25.061e-32 132
LLPS-Brr-0914Brassica rapa25.055e-23 104
LLPS-Hea-1068Helianthus annuus25.08e-1889.4
LLPS-Sem-2146Selaginella moellendorffii24.881e-1891.7
LLPS-Pot-0875Populus trichocarpa24.732e-25 111
LLPS-Miv-0485Microbotryum violaceum24.457e-27 115
LLPS-Art-0307Arabidopsis thaliana24.41e-1994.4
LLPS-Viv-1757Vitis vinifera23.881e-23 106
LLPS-Mae-0173Manihot esculenta23.713e-25 110
LLPS-Vir-0958Vigna radiata23.577e-1477.4
LLPS-Arl-1260Arabidopsis lyrata23.538e-2095.1
LLPS-Mel-0112Melampsora laricipopulina23.332e-25 111
LLPS-Met-0324Medicago truncatula23.114e-22 101
LLPS-Php-0171Physcomitrella patens23.088e-1683.2
LLPS-Thc-0860Theobroma cacao23.088e-22 100
LLPS-Mua-1782Musa acuminata22.833e-1478.6
LLPS-Dac-0144Daucus carota21.91e-1788.6
LLPS-Coc-0030Corchorus capsularis21.32e-1891.3