• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Paa-4483
ROCK1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Rho-associated protein kinase
Gene Name: ROCK1
Ensembl Gene: ENSPANG00000023561.2
Ensembl Protein: ENSPANP00000022511.1
Organism: Papio anubis
Taxa ID: 9555
LLPS Type: Client


▼ PROPERTY


▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole body, Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSTGDSFETR  FEKIDNLLRD  PKSEVNSDCL  LDGLDALVYD  LDFPALRKNK  NIDNFLSRYK  60
61    DTINKIRDLR  MKAEDYEVVK  VIGRGAFGEV  QLVRHKSTRK  VYAMKLLSKF  EMIKRSDSAF  120
121   FWEERDIMAF  ANSPWVVQLF  YAFQDDRYLY  MVMEYMPGGD  LVNLMSNYDV  PEKWARFYTA  180
181   EVVLALDAIH  SMGFIHRDVK  PDNMLLDKSG  HLKLADFGTC  MKMNKEGMVR  CDTAVGTPDY  240
241   ISPEVLKSQG  GDGYYGRECD  WWSVGVFLYE  MLVGDTPFYA  DSLVGTYSKI  MNHKNSLTFP  300
301   DDNDISKEAK  NLICAFLTDR  EVRLGRNGVE  EIKRHLFFKN  DQWAWETLRD  TVAPVVPDLS  360
361   SDIDTSNFDD  LEEDKGEEET  FPIPKAFVGN  QLPFVGFTYY  SNRRYLSSAN  PNDNRTSSNA  420
421   DKSLQESLQK  TIYKLEEQLH  NEMQLKDEME  QKCRTSNIKL  DKIMKELDEE  GNQRRNLEST  480
481   VSQIEKEKML  LQHRINEYQR  KAEQENEKRR  NVENEVSTLK  DQLEDLKKVS  QNSQLANEKL  540
541   SQLQKQLEEA  NDLLRTESDT  AVRLRKSHTE  MSKSISQLES  LNRELQERNR  ILENSKSQTD  600
601   KDYYQLQAIL  EAERRDRGHD  SEMIGDLQAR  ITSLQEEVKH  LKHNLEKVEG  ERKEAQDMLN  660
661   HSEKEKNNLE  IDLNYKLKSL  QQRLEQEVNE  HKVTKARLTD  KHQSIEEAKS  VAMCEMEKKL  720
721   KEEREAREKA  ENRVVQIEKQ  CSMLDVDLKQ  SQQKLEHLTG  NKERMEDEVK  NLTLLLEQES  780
781   NKRLLLQNEL  KTQAFEADNL  KGLEKQMKQE  INTLLEAKRL  LEFELAQLTK  QYRGNEGQMR  840
841   ELQDQLEAEQ  YFSTLYKTQV  KELKEEIEEK  NRENLKKIQE  LQNEKETLAT  QLDLAETKAE  900
901   SEQLARGLLE  EQYFELTQES  KKAASRNRQE  ITDKDHTVSR  LEETNSMLTK  DMEILRRENE  960
961   ELTEKMKKAE  EEYKLEKEEE  ISNLKAAFEK  NINTERTLKT  QAVNKLAEIM  NRKDFKIDRK  1020
1021  KANTQDLRKK  EKENRKLQLE  LNQEREKFNQ  MVVKHQKELN  DMQAQLVEEC  AHRNELQMQL  1080
1081  ASKESDIEQL  RAKLLDLSDS  TSVASFPSAD  ETDGNLPVDS  ACIPYLFIFY  SCLLIEGWLS  1140
1141  VPNRGNIKRY  GWKKQYVVVS  SKKILFYNDE  QDKEQSNPSM  VLDIDKLFHV  RPVTQGDVYR  1200
1201  AETEEIPKIF  QILYANEGEC  RKDVEMEPVQ  QAEKTNFQNH  KGHEFIPTLY  HFPANCDACA  1260
1261  KPLWHVFKPP  PALECRRCHV  KCHRDHLDKK  EDLICPCKVS  YDVTSARDML  LLACSQDEQK  1320
1321  KWVTHLVKKI  PKNPPSGFVR  ASPRTLSTRS  TANQSFRKVV  KNTSGKTR  1368
Nucleotide CDS Sequence (FASTA)
1     ATGTCGACTG  GGGACAGTTT  TGAGACTCGA  TTTGAAAAAA  TCGACAACCT  GCTGCGGGAT  60
61    CCCAAATCGG  AAGTGAATTC  GGATTGTTTG  CTGGATGGAT  TGGATGCTTT  GGTATATGAT  120
121   TTGGATTTTC  CTGCCTTAAG  AAAAAACAAA  AATATTGACA  ACTTTTTAAG  CAGATATAAA  180
181   GACACAATAA  ATAAAATCAG  AGATTTACGA  ATGAAAGCCG  AAGATTATGA  AGTAGTGAAG  240
241   GTGATTGGTA  GAGGTGCATT  TGGAGAAGTT  CAATTGGTAA  GGCATAAATC  CACCAGGAAG  300
301   GTATATGCTA  TGAAGCTTCT  CAGCAAATTT  GAAATGATTA  AGAGATCTGA  TTCTGCTTTT  360
361   TTCTGGGAAG  AAAGGGACAT  CATGGCTTTT  GCTAATAGTC  CGTGGGTTGT  TCAGCTTTTT  420
421   TATGCATTCC  AAGATGATCG  TTATCTCTAC  ATGGTGATGG  AATACATGCC  TGGTGGAGAT  480
481   CTTGTAAACT  TAATGAGCAA  CTATGATGTG  CCTGAAAAAT  GGGCACGATT  CTATACTGCA  540
541   GAAGTAGTTC  TTGCATTGGA  TGCAATCCAT  TCCATGGGTT  TTATTCACAG  AGATGTGAAG  600
601   CCTGATAACA  TGCTGCTGGA  TAAATCTGGA  CATTTGAAGT  TAGCAGATTT  TGGTACTTGT  660
661   ATGAAGATGA  ATAAGGAAGG  CATGGTACGA  TGTGATACAG  CAGTTGGAAC  ACCTGATTAT  720
721   ATTTCCCCTG  AAGTATTAAA  ATCCCAAGGT  GGTGATGGTT  ATTATGGAAG  AGAATGTGAC  780
781   TGGTGGTCGG  TTGGGGTATT  TTTATACGAA  ATGCTTGTAG  GTGATACACC  TTTTTATGCA  840
841   GATTCTTTGG  TTGGAACTTA  CAGTAAAATT  ATGAACCATA  AAAATTCACT  TACCTTTCCT  900
901   GATGATAATG  ACATATCAAA  AGAAGCAAAA  AACCTTATTT  GTGCCTTCCT  TACTGACAGG  960
961   GAAGTGAGAT  TAGGACGAAA  TGGTGTAGAA  GAAATCAAAC  GACATCTCTT  CTTCAAAAAT  1020
1021  GACCAGTGGG  CTTGGGAAAC  ACTCCGAGAT  ACTGTAGCAC  CAGTTGTACC  TGATTTAAGT  1080
1081  AGTGACATTG  ATACTAGTAA  TTTTGATGAC  TTGGAAGAAG  ATAAAGGAGA  GGAAGAAACA  1140
1141  TTCCCTATTC  CTAAAGCTTT  TGTTGGCAAT  CAACTACCTT  TTGTAGGATT  TACATATTAT  1200
1201  AGCAATCGTA  GATACTTATC  TTCAGCAAAT  CCTAATGATA  ACAGGACTAG  CTCCAATGCA  1260
1261  GATAAAAGCT  TGCAGGAAAG  TTTGCAGAAA  ACAATCTATA  AGCTGGAAGA  ACAGCTGCAT  1320
1321  AATGAAATGC  AGTTAAAAGA  TGAAATGGAG  CAGAAGTGCA  GAACCTCAAA  CATAAAACTA  1380
1381  GACAAGATAA  TGAAAGAATT  GGATGAAGAG  GGAAATCAAA  GAAGAAATCT  AGAATCTACA  1440
1441  GTGTCTCAGA  TTGAGAAGGA  GAAAATGTTG  CTACAGCATA  GAATTAATGA  GTACCAAAGA  1500
1501  AAAGCTGAAC  AGGAAAATGA  GAAGAGAAGA  AATGTAGAAA  ATGAAGTTTC  TACATTAAAG  1560
1561  GATCAGTTGG  AAGACTTAAA  GAAAGTAAGT  CAGAATTCAC  AACTTGCTAA  TGAGAAGCTG  1620
1621  TCCCAGTTAC  AAAAGCAGCT  GGAAGAAGCC  AATGACTTAC  TTAGGACAGA  ATCAGACACA  1680
1681  GCTGTAAGAC  TGAGGAAGAG  TCACACAGAA  ATGAGCAAGT  CAATTAGTCA  GTTAGAGTCC  1740
1741  CTGAACAGAG  AGTTGCAAGA  GAGAAATCGA  ATTTTAGAGA  ATTCTAAGTC  ACAAACAGAC  1800
1801  AAAGATTATT  ACCAGCTGCA  AGCTATATTG  GAAGCTGAAC  GAAGAGACAG  AGGTCATGAC  1860
1861  TCTGAGATGA  TTGGAGACCT  TCAAGCTCGA  ATTACATCTT  TACAAGAGGA  GGTGAAGCAT  1920
1921  CTCAAACATA  ATCTTGAAAA  AGTGGAAGGA  GAAAGAAAAG  AGGCTCAAGA  CATGCTTAAT  1980
1981  CACTCAGAAA  AGGAAAAGAA  TAATTTAGAA  ATAGATTTAA  ACTACAAACT  TAAATCATTA  2040
2041  CAACAACGGT  TAGAACAAGA  GGTAAATGAA  CACAAAGTAA  CCAAAGCTCG  TTTAACTGAC  2100
2101  AAACATCAAT  CTATTGAAGA  GGCAAAGTCT  GTGGCAATGT  GTGAGATGGA  AAAAAAGCTG  2160
2161  AAAGAAGAAA  GAGAAGCTCG  AGAGAAGGCT  GAAAATCGGG  TTGTTCAGAT  TGAGAAACAG  2220
2221  TGTTCCATGC  TAGACGTTGA  TCTGAAGCAA  TCTCAGCAGA  AACTAGAACA  TTTGACTGGA  2280
2281  AATAAAGAAA  GGATGGAGGA  TGAAGTTAAG  AATCTAACCC  TGCTACTGGA  GCAGGAATCA  2340
2341  AATAAGCGGC  TGCTGTTACA  AAATGAATTG  AAGACTCAAG  CATTTGAGGC  AGACAATTTA  2400
2401  AAAGGTTTAG  AAAAGCAGAT  GAAACAGGAA  ATAAATACTT  TATTGGAAGC  AAAGAGATTA  2460
2461  TTAGAATTTG  AGTTAGCTCA  GCTTACGAAA  CAGTATAGAG  GGAATGAAGG  ACAGATGCGG  2520
2521  GAGCTGCAAG  ATCAGCTTGA  AGCTGAACAA  TATTTCTCGA  CACTTTATAA  AACCCAGGTA  2580
2581  AAGGAACTTA  AAGAAGAAAT  TGAAGAAAAA  AACAGAGAAA  ATTTAAAGAA  AATACAGGAA  2640
2641  CTACAAAATG  AAAAAGAAAC  TCTTGCTACT  CAGTTGGATC  TAGCAGAAAC  AAAAGCTGAG  2700
2701  TCTGAGCAGT  TGGCTCGAGG  CCTTCTGGAA  GAACAGTATT  TTGAATTGAC  TCAAGAAAGC  2760
2761  AAGAAAGCTG  CTTCAAGAAA  TAGACAAGAG  ATTACAGATA  AAGATCACAC  TGTTAGTCGG  2820
2821  CTTGAAGAAA  CAAACAGCAT  GCTAACCAAA  GATATGGAAA  TATTAAGAAG  AGAGAACGAA  2880
2881  GAGCTAACAG  AGAAAATGAA  GAAGGCAGAG  GAAGAATATA  AATTGGAGAA  GGAGGAGGAG  2940
2941  ATCAGTAATC  TTAAGGCTGC  CTTTGAAAAG  AATATCAACA  CTGAGCGAAC  CCTTAAAACA  3000
3001  CAGGCTGTTA  ACAAGTTGGC  AGAAATAATG  AATCGAAAAG  ATTTTAAAAT  TGATAGAAAG  3060
3061  AAAGCTAATA  CACAAGATTT  GAGAAAGAAA  GAAAAGGAAA  ATCGAAAGCT  ACAACTGGAA  3120
3121  CTCAACCAAG  AAAGAGAGAA  ATTCAACCAG  ATGGTAGTGA  AACATCAGAA  GGAGCTGAAT  3180
3181  GACATGCAAG  CGCAATTGGT  AGAAGAATGT  GCACATAGGA  ATGAGCTTCA  GATGCAGTTG  3240
3241  GCCAGCAAAG  AGAGTGATAT  TGAGCAATTG  CGTGCTAAAC  TTTTGGACCT  CTCGGATTCT  3300
3301  ACAAGTGTTG  CTAGTTTTCC  TAGTGCTGAT  GAAACTGATG  GAAACCTCCC  AGAGTCAAGA  3360
3361  ATTGAAGGTT  GGCTTTCAGT  ACCAAATAGA  GGAAATATCA  AACGATATGG  CTGGAAGAAA  3420
3421  CAGTATGTTG  TGGTAAGCAG  CAAAAAAATT  TTGTTCTATA  ATGATGAACA  AGATAAGGAG  3480
3481  CAATCCAATC  CCTCTATGGT  ATTGGACATA  GATAAACTGT  TTCACGTTAG  ACCTGTAACC  3540
3541  CAAGGAGATG  TGTATAGAGC  TGAAACTGAA  GAAATTCCTA  AAATATTCCA  GATACTATAT  3600
3601  GCAAATGAAG  GTGAATGTAG  AAAAGATGTA  GAGATGGAAC  CAGTACAACA  AGCTGAAAAA  3660
3661  ACTAATTTCC  AAAATCACAA  AGGCCATGAG  TTTATTCCTA  CACTCTACCA  CTTTCCTGCC  3720
3721  AATTGTGATG  CCTGTGCCAA  ACCTCTCTGG  CATGTTTTTA  AGCCACCCCC  TGCCCTAGAG  3780
3781  TGTCGAAGAT  GCCATGTTAA  GTGCCACAGA  GATCACTTAG  ATAAGAAAGA  GGACTTAATT  3840
3841  TGTCCATGTA  AAGTAAGTTA  TGACGTAACA  TCAGCAAGAG  ATATGCTGCT  CTTAGCATGT  3900
3901  TCTCAGGATG  AACAAAAAAA  ATGGGTAACT  CATTTAGTAA  AGAAAATCCC  TAAGAATCCA  3960
3961  CCATCTGGTT  TTGTTCGTGC  CTCCCCTCGA  ACACTTTCTA  CAAGATCCAC  TGCAAATCAG  4020
4021  TCTTTCCGGA  AAGTGGTCAA  AAATACATCT  GGAAAAACTA  GTTAA  4065

▼ KEYWORD

ID
Family
ATP-binding
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Reference proteome
Serine/threonine-protein kinase
Transferase
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Amyloid-beta complex
Cellular Component
Cytoplasmic stress granule
Cellular Component
Cytoskeleton
Cellular Component
Lamellipodium
Cellular Component
Plasma membrane
Cellular Component
Ruffle
Molecular Function
ATP binding
Molecular Function
GTP-Rho binding
Molecular Function
Metal ion binding
Molecular Function
Rho-dependent protein serine/threonine kinase activity
Biological Process
Apical constriction
Biological Process
Bleb assembly
Biological Process
Cortical actin cytoskeleton organization
Biological Process
I-kappaB kinase/NF-kappaB signaling
Biological Process
Leukocyte tethering or rolling
Biological Process
Membrane to membrane docking
Biological Process
MRNA destabilization
Biological Process
Myoblast migration
Biological Process
Negative regulation of amyloid-beta formation
Biological Process
Negative regulation of angiogenesis
Biological Process
Negative regulation of bicellular tight junction assembly
Biological Process
Negative regulation of myosin-light-chain-phosphatase activity
Biological Process
Negative regulation of neuron apoptotic process
Biological Process
Negative regulation of protein binding
Biological Process
Neuron projection arborization
Biological Process
Peptidyl-serine phosphorylation
Biological Process
Positive regulation of amyloid-beta clearance
Biological Process
Positive regulation of autophagy
Biological Process
Positive regulation of cardiac muscle hypertrophy
Biological Process
Positive regulation of connective tissue replacement
Biological Process
Positive regulation of focal adhesion assembly
Biological Process
Positive regulation of gene expression
Biological Process
Positive regulation of MAPK cascade
Biological Process
Protein localization to plasma membrane
Biological Process
Regulation of angiotensin-activated signaling pathway
Biological Process
Regulation of blood vessel diameter
Biological Process
Regulation of establishment of cell polarity
Biological Process
Regulation of establishment of endothelial barrier
Biological Process
Regulation of keratinocyte differentiation
Biological Process
Regulation of neuron differentiation
Biological Process
Regulation of stress fiber assembly
Biological Process
Regulation of synaptic vesicle endocytosis
Biological Process
Response to angiotensin
Biological Process
Response to transforming growth factor beta
Biological Process
Rho protein signal transduction

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Man-3462Macaca nemestrina100.00.02675
LLPS-Mal-2884Mandrillus leucophaeus100.00.02675
LLPS-Mam-1197Macaca mulatta99.930.02674
LLPS-Maf-0925Macaca fascicularis99.850.02671
LLPS-Pat-1004Pan troglodytes99.780.02670
LLPS-Pap-2952Pan paniscus99.630.02666
LLPS-Caj-0663Callithrix jacchus99.20.02659
LLPS-Chs-0201Chlorocebus sabaeus98.680.02623
LLPS-Hos-1271Homo sapiens98.460.02618
LLPS-Gog-4213Gorilla gorilla98.380.02467
LLPS-Nol-3613Nomascus leucogenys98.250.02608
LLPS-Ict-2459Ictidomys tridecemlineatus97.950.02629
LLPS-Aon-4208Aotus nancymaae97.820.02619
LLPS-Cas-4026Carlito syrichta97.810.02620
LLPS-Rhb-3737Rhinopithecus bieti97.730.02590
LLPS-Dio-2952Dipodomys ordii97.510.02623
LLPS-Cap-3286Cavia porcellus97.220.02625
LLPS-Fud-1957Fukomys damarensis96.930.02616
LLPS-Mea-4419Mesocricetus auratus96.860.02612
LLPS-Eqc-2537Equus caballus96.630.02582
LLPS-Sus-2119Sus scrofa96.630.02583
LLPS-Aim-3818Ailuropoda melanoleuca96.630.02585
LLPS-Orc-4281Oryctolagus cuniculus96.610.02441
LLPS-Urm-0250Ursus maritimus96.490.02581
LLPS-Caf-3604Canis familiaris96.420.02575
LLPS-Myl-2254Myotis lucifugus96.350.02571
LLPS-Fec-4390Felis catus96.340.02578
LLPS-Bot-4568Bos taurus96.270.02575
LLPS-Loa-0604Loxodonta africana96.20.02576
LLPS-Ova-0633Ovis aries96.050.02565
LLPS-Mup-1890Mustela putorius furo96.040.02366
LLPS-Ran-4690Rattus norvegicus95.760.02580
LLPS-Mum-3635Mus musculus95.390.02556
LLPS-Cea-3778Cercocebus atys95.280.02545
LLPS-Poa-4384Pongo abelii94.220.02460
LLPS-Otg-3249Otolemur garnettii93.210.02474
LLPS-Mod-1092Monodelphis domestica89.340.02357
LLPS-Meg-0756Meleagris gallopavo86.850.02312
LLPS-Anp-0041Anas platyrhynchos86.60.02293
LLPS-Pes-1850Pelodiscus sinensis86.220.02322
LLPS-Gaga-0788Gallus gallus86.160.02325
LLPS-Tag-0434Taeniopygia guttata86.00.02274
LLPS-Fia-0187Ficedula albicollis85.750.01885
LLPS-Anc-1141Anolis carolinensis85.640.02297
LLPS-Xet-1031Xenopus tropicalis81.170.02147
LLPS-Leo-0228Lepisosteus oculatus79.040.01290
LLPS-Lac-3125Latimeria chalumnae78.770.02054
LLPS-Scf-3295Scleropages formosus74.850.02008
LLPS-Gaa-3344Gasterosteus aculeatus74.570.02001
LLPS-Tar-2982Takifugu rubripes74.310.02026
LLPS-Xim-3806Xiphophorus maculatus74.220.02017
LLPS-Orn-2727Oreochromis niloticus74.030.02004
LLPS-Dar-3921Danio rerio73.80.02006
LLPS-Ten-1324Tetraodon nigroviridis73.790.02005
LLPS-Scm-0989Scophthalmus maximus73.650.01987
LLPS-Icp-1987Ictalurus punctatus73.280.01995
LLPS-Pof-0556Poecilia formosa73.120.01982
LLPS-Orl-3533Oryzias latipes72.890.01983
LLPS-Cae-0735Caenorhabditis elegans63.971e-171 551
LLPS-Asm-2691Astyanax mexicanus53.780.01330
LLPS-Usm-0691Ustilago maydis43.344e-86 301
LLPS-Spr-0331Sporisorium reilianum43.342e-85 298
LLPS-Put-0632Puccinia triticina43.342e-75 259
LLPS-Tum-0580Tuber melanosporum43.133e-92 315
LLPS-Mel-0807Melampsora laricipopulina43.02e-90 306
LLPS-Sah-0265Sarcophilus harrisii42.193e-96 347
LLPS-Yal-1495Yarrowia lipolytica42.176e-68 247
LLPS-Pug-0507Puccinia graminis40.967e-89 303
LLPS-Crn-0726Cryptococcus neoformans40.294e-83 288
LLPS-Miv-0258Microbotryum violaceum40.192e-91 313
LLPS-Drm-0211Drosophila melanogaster39.755e-83 305
LLPS-Trv-0668Trichoderma virens39.746e-63 233
LLPS-Scc-0960Schizosaccharomyces cryophilus39.532e-64 235
LLPS-Cogr-0691Colletotrichum graminicola38.242e-62 232
LLPS-Asg-1095Ashbya gossypii38.249e-67 246
LLPS-Kop-1137Komagataella pastoris38.137e-77 274
LLPS-Ora-3494Ornithorhynchus anatinus37.914e-63 225
LLPS-Nec-0765Neurospora crassa37.93e-63 234
LLPS-Abg-1404Absidia glauca37.533e-63 231
LLPS-Sac-0660Saccharomyces cerevisiae37.262e-64 238