LLPS-Cae-0735
let-502

▼ OVERVIEW


Status: Unreviewed
Protein Name: Rho-associated protein kinase let-502; Lethal protein 502; Rho-binding kinase let-502
Gene Name: let-502, C10H11.9
Ensembl Gene: WBGene00002694
Ensembl Protein: C10H11.9
Organism: Caenorhabditis elegans
Taxa ID: 6239
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole body, Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION


Negatively regulates mel-11 to relieve the inhibition of mlc-4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization.

▼ CROSS REFERENCE


DatabaseNucleotide IDProtein ID
EnsemblC10H11.9C10H11.9
UniProtP92199, ROCK_CAEEL
GeneBankFO080502, U85515AAB42081.1, CCD64221.1
RefSeqNM_059039.5NP_491440.1
Entrez172088

▼ SEQUENCE


Protein Sequence (FASTA)
1     MEQDELRDQL  VDPKSPINIE  SLLDTITALV  NDCKIPVLMR  MKSVDNFISR  YERVVESLAA  60
61    LRMKAADFRQ  LKVIGRGAFG  EVHLVRHTRT  NTVYAMKMLN  KDDMIKRADS  AFFWEERDIM  120
121   AHANSEWIVR  LQYAFQDPRH  LYMVMEYMPG  GDLVNLMTSY  EVSEKWTRFY  TAEIVEALAA  180
181   LHSMGYIHRD  VKPDNMLISI  SGHIKLADFG  TCVKMNANGV  VRCSTAVGTP  DYISPEVLRN  240
241   QGQDAEFGKE  VDWWSVGVFI  YEMLVGETPF  YAEALVSTYT  NIMNHKTSLK  FPDEPLISTQ  300
301   AKDIIKKFLS  AAPDRLGRNS  VDDIRNHKFF  VNDEWTFATL  REASPPVIPS  LKSDDDTTHF  360
361   EEIETRDRDN  AGDFQLPKTF  NGNQLPFIGF  TYSNEYSPVK  NLLKGHGAGS  KQNGIEQHKP  420
421   QTVVEQPLTN  GHASGVPEEK  YEAVKMELDS  KNREFELLKD  SIARNEIRAK  MIENEKNSLS  480
481   TKISDLEREL  KDNKDKLRHG  ADSDAKVNEL  AVELRMSKEY  NSEMESELSK  FRDKCEQLKE  540
541   DLRKKSGELA  QEKNETQRVF  QQKKDADEAF  AEIKRDYELL  QTRENEKSVQ  LKKALDERKE  600
601   NGAYQQSVAK  ATDAEWERKM  QFYEKQLEHA  NDERKREEQK  RTAAEFDQSR  VARKLAGIEA  660
661   NYELLQNDYK  SMKEARKDLE  RDLQDVITEK  RRLEIRVEQL  MDSRNTDERV  LSLCQDELVE  720
721   SQEEAKYKED  GLRGKIDGFK  HELENEKMKT  QTLEENLLVA  DKERGMLKME  VQELMQRHKW  780
781   EITNKDQTLK  HLETQLDEIK  QQSKIESSEQ  ESNDKQTIAD  LRKKLDLEKA  HKKAVINKLE  840
841   EEMAKRQPLK  KGEKGVTKSA  LIKKEREIMA  LEQERDTMSK  RIAALFYEND  KQAEHFNIAI  900
901   QDMQTTQDAL  RDELKECKEE  LANRNVNTRY  EDKRSLDSRE  GIPSSLSNQH  IQMEGWLSLR  960
961   DNTKKSRKPK  WTNCFVALNE  YSFTIYVDEK  AVSVILLIEA  GAMAHVRHVT  AADLRNVDDS  1020
1021  QLPKIFHIMY  DDASCNSSRH  ASNSDLSMIE  SFREESWKRH  DFQELSYHIR  TFCDVCNKKL  1080
1081  SDIIRPTPAF  ECKNCHFKTH  KDHVAQGSLP  MCRYNTGLSR  ELVLMAPQTD  NCNKWVSQLR  1140
1141  RFIESSRSAA  VSVSRVSSRR  HAPGSSNSST  IYQ  1173
Nucleotide CDS Sequence (FASTA)
1     ATGGAGCAGG  ATGAGCTGCG  TGATCAGCTG  GTGGATCCAA  AATCCCCGAT  AAACATCGAA  60
61    AGCTTGCTCG  ACACCATCAC  AGCGCTCGTC  AATGATTGCA  AAATTCCGGT  GCTCATGCGG  120
121   ATGAAAAGCG  TCGACAACTT  CATTAGCAGA  TATGAACGAG  TTGTCGAAAG  TTTGGCCGCT  180
181   CTTCGAATGA  AAGCTGCCGA  TTTCAGACAA  TTGAAGGTTA  TTGGAAGAGG  AGCATTCGGA  240
241   GAAGTTCATC  TGGTTCGACA  CACACGAACG  AACACTGTGT  ACGCGATGAA  GATGCTCAAT  300
301   AAGGATGACA  TGATCAAACG  AGCTGACTCT  GCATTCTTCT  GGGAGGAACG  TGATATTATG  360
361   GCTCACGCGA  ATAGCGAATG  GATCGTGAGG  CTTCAGTATG  CATTCCAGGA  TCCTCGTCAT  420
421   TTGTACATGG  TGATGGAATA  TATGCCAGGT  GGAGATCTCG  TGAATCTGAT  GACATCCTAT  480
481   GAAGTATCGG  AAAAGTGGAC  TCGCTTTTAT  ACGGCTGAAA  TTGTCGAGGC  GCTGGCCGCC  540
541   CTTCACAGTA  TGGGATATAT  TCATCGAGAT  GTGAAGCCGG  ACAATATGCT  CATTTCGATC  600
601   AGCGGACACA  TAAAATTGGC  AGATTTTGGA  ACATGCGTGA  AGATGAATGC  CAATGGAGTT  660
661   GTGCGATGCT  CCACAGCAGT  CGGAACTCCT  GATTACATAT  CACCGGAAGT  TTTGAGAAAT  720
721   CAAGGACAAG  ATGCTGAATT  TGGAAAAGAA  GTCGATTGGT  GGTCTGTTGG  TGTGTTCATA  780
781   TATGAAATGC  TTGTTGGAGA  AACACCATTC  TATGCCGAGG  CACTTGTATC  AACTTATACA  840
841   AATATTATGA  ATCATAAAAC  AAGTCTGAAA  TTTCCTGATG  AGCCATTAAT  TTCTACCCAA  900
901   GCCAAGGATA  TTATCAAGAA  ATTCCTCTCG  GCGGCTCCAG  ATCGTCTTGG  AAGAAATAGC  960
961   GTCGATGATA  TTCGAAATCA  CAAGTTTTTT  GTTAATGACG  AATGGACATT  TGCCACTCTC  1020
1021  AGAGAAGCAT  CTCCACCGGT  CATTCCTTCA  TTAAAATCGG  ACGATGACAC  GACACATTTC  1080
1081  GAAGAAATCG  AGACCCGTGA  TCGAGATAAT  GCGGGAGACT  TTCAATTGCC  GAAGACATTT  1140
1141  AACGGAAATC  AACTACCATT  CATCGGCTTT  ACTTATTCGA  ACGAGTACAG  TCCTGTGAAG  1200
1201  AATCTTCTGA  AGGGCCATGG  TGCTGGATCA  AAACAGAACG  GAATTGAACA  GCATAAACCG  1260
1261  CAAACTGTTG  TTGAGCAACC  ATTGACGAAT  GGGCATGCGT  CTGGTGTTCC  TGAAGAAAAA  1320
1321  TATGAAGCAG  TTAAGATGGA  GTTGGACTCG  AAAAACCGAG  AATTCGAACT  TTTGAAGGAT  1380
1381  AGCATTGCTC  GAAATGAGAT  CCGAGCGAAG  ATGATCGAAA  ATGAGAAGAA  CTCATTGTCC  1440
1441  ACAAAAATCT  CCGATCTCGA  ACGAGAACTC  AAGGATAATA  AAGATAAACT  GAGGCATGGC  1500
1501  GCTGATTCGG  ATGCAAAAGT  TAACGAATTG  GCTGTCGAGT  TACGAATGTC  CAAAGAGTAC  1560
1561  AATAGTGAGA  TGGAGAGCGA  ATTGAGCAAG  TTTCGGGACA  AGTGTGAGCA  GCTCAAGGAA  1620
1621  GATCTTCGCA  AAAAATCTGG  AGAGCTTGCT  CAGGAGAAGA  ATGAAACTCA  ACGGGTATTC  1680
1681  CAGCAGAAGA  AGGACGCTGA  TGAAGCATTT  GCCGAGATTA  AACGGGATTA  TGAACTATTA  1740
1741  CAAACCAGAG  AAAATGAAAA  GTCTGTTCAA  TTGAAGAAAG  CGCTTGACGA  ACGAAAAGAG  1800
1801  AACGGAGCCT  ATCAGCAAAG  TGTTGCAAAG  GCGACAGATG  CTGAATGGGA  GCGAAAAATG  1860
1861  CAGTTTTATG  AGAAGCAGTT  GGAGCATGCG  AATGATGAAC  GGAAAAGAGA  AGAGCAAAAG  1920
1921  CGAACGGCTG  CAGAATTCGA  TCAAAGCAGG  GTGGCAAGGA  AATTGGCTGG  GATTGAAGCG  1980
1981  AATTATGAGC  TGCTGCAGAA  TGACTATAAA  AGTATGAAGG  AAGCAAGGAA  GGATCTTGAA  2040
2041  AGAGATCTTC  AGGATGTCAT  TACTGAGAAA  AGGCGACTTG  AAATACGTGT  CGAACAGTTG  2100
2101  ATGGACAGCC  GGAACACCGA  CGAACGGGTA  TTATCGCTCT  GTCAGGATGA  GCTCGTGGAA  2160
2161  AGTCAAGAGG  AAGCAAAGTA  TAAGGAAGAT  GGATTGAGAG  GAAAGATTGA  CGGATTTAAA  2220
2221  CATGAACTTG  AGAATGAGAA  GATGAAGACT  CAAACTTTGG  AGGAAAATCT  TCTGGTAGCT  2280
2281  GATAAGGAGA  GGGGCATGCT  GAAAATGGAA  GTTCAAGAGC  TGATGCAAAG  GCATAAATGG  2340
2341  GAGATTACCA  ACAAAGATCA  AACGCTGAAA  CATCTTGAGA  CTCAACTAGA  CGAAATAAAG  2400
2401  CAACAATCAA  AGATCGAGTC  GTCTGAGCAG  GAATCGAATG  ATAAGCAGAC  GATCGCTGAT  2460
2461  CTTCGAAAGA  AGTTGGATCT  AGAGAAAGCT  CACAAGAAGG  CTGTAATCAA  TAAGTTAGAA  2520
2521  GAGGAAATGG  CAAAGCGGCA  ACCATTGAAA  AAGGGTGAAA  AGGGTGTCAC  AAAGTCTGCG  2580
2581  TTGATAAAGA  AAGAACGAGA  GATTATGGCT  CTCGAACAAG  AACGCGATAC  GATGAGTAAA  2640
2641  AGGATTGCCG  CTCTGTTTTA  CGAAAATGAT  AAGCAAGCCG  AGCATTTCAA  CATTGCGATT  2700
2701  CAAGATATGC  AGACTACACA  AGACGCTTTA  CGAGATGAGC  TTAAAGAATG  CAAAGAGGAG  2760
2761  TTAGCCAACA  GAAATGTGAA  TACTCGATAT  GAAGATAAAC  GATCATTGGA  TTCTCGAGAA  2820
2821  GGGATTCCAT  CTTCGTTAAG  CAATCAACAT  ATTCAAATGG  AAGGCTGGCT  ATCGCTCAGA  2880
2881  GATAATACAA  AGAAGTCACG  GAAACCGAAG  TGGACCAACT  GCTTTGTTGC  GCTTAACGAG  2940
2941  TATTCATTCA  CAATCTATGT  CGACGAAAAA  GCCGTGTCTG  TGATTCTTTT  GATTGAAGCC  3000
3001  GGAGCTATGG  CTCATGTTCG  ACACGTCACT  GCTGCTGATT  TGAGAAATGT  CGACGATAGT  3060
3061  CAGTTACCTA  AGATATTCCA  TATCATGTAT  GACGACGCGT  CGTGCAATTC  GTCACGACAC  3120
3121  GCCTCCAATT  CAGATCTCTC  AATGATTGAA  TCGTTCCGAG  AAGAAAGTTG  GAAGCGGCAC  3180
3181  GATTTCCAAG  AGCTCTCCTA  TCACATACGC  ACGTTTTGTG  ATGTCTGCAA  TAAGAAATTG  3240
3241  TCTGACATTA  TCCGACCGAC  GCCTGCATTC  GAATGCAAAA  ATTGCCATTT  CAAGACACAC  3300
3301  AAGGATCATG  TTGCTCAAGG  ATCGTTGCCA  ATGTGTCGAT  ACAACACGGG  TCTCTCTCGT  3360
3361  GAACTCGTTC  TTATGGCTCC  ACAAACGGAT  AACTGCAATA  AATGGGTATC  ACAACTTCGA  3420
3421  CGCTTCATTG  AATCATCACG  ATCAGCGGCA  GTTTCAGTGT  CTCGTGTCTC  TTCACGACGA  3480
3481  CATGCTCCAG  GATCGTCAAA  CTCTTCCACA  ATCTATCAAT  AG  3522

▼ KEYWORD


ID
Family
ATP-binding
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Developmental protein
Differentiation
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Oogenesis
Reference proteome
Serine/threonine-protein kinase
Transferase
Zinc
Zinc-finger

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Cell-cell adherens junction
Cellular Component
Cleavage furrow
Cellular Component
Contractile fiber
Cellular Component
Cytoplasm
Cellular Component
Cytoskeleton
Cellular Component
Nucleus
Molecular Function
ATP binding
Molecular Function
Metal ion binding
Molecular Function
Protein serine/threonine kinase activity
Biological Process
Embryo development ending in birth or egg hatching
Biological Process
Embryonic body morphogenesis
Biological Process
Nematode larval development
Biological Process
Oogenesis
Biological Process
Pharyngeal gland morphogenesis
Biological Process
Pharynx development
Biological Process
Protein phosphorylation
Biological Process
Regulation of cell shape
Biological Process
Rho protein signal transduction

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Icp-1987Ictalurus punctatus64.231e-174 559
LLPS-Scf-3295Scleropages formosus63.975e-174 557
LLPS-Leo-0228Lepisosteus oculatus63.713e-173 554
LLPS-Dar-3921Danio rerio63.457e-173 554
LLPS-Gaa-3344Gasterosteus aculeatus63.191e-172 553
LLPS-Scm-0989Scophthalmus maximus63.062e-168 541
LLPS-Ten-1324Tetraodon nigroviridis62.699e-172 551
LLPS-Xet-1031Xenopus tropicalis62.538e-161 521
LLPS-Orn-0866Oreochromis niloticus62.58e-169 544
LLPS-Anc-3462Anolis carolinensis62.475e-169 545
LLPS-Xim-3806Xiphophorus maculatus61.752e-174 558
LLPS-Pof-0556Poecilia formosa61.353e-172 552
LLPS-Mod-0335Monodelphis domestica60.813e-167 540
LLPS-Tar-2982Takifugu rubripes60.742e-174 558
LLPS-Gog-4298Gorilla gorilla60.16e-175 530
LLPS-Fia-0187Ficedula albicollis51.767e-178 561
LLPS-Anp-0041Anas platyrhynchos51.632e-167 538
LLPS-Pes-1850Pelodiscus sinensis51.594e-171 549
LLPS-Tag-0434Taeniopygia guttata51.547e-167 537
LLPS-Eqc-2900Equus caballus50.561e-168 545
LLPS-Bot-4753Bos taurus50.292e-161 525
LLPS-Sus-4623Sus scrofa50.183e-170 547
LLPS-Cas-2934Carlito syrichta50.11e-163 530
LLPS-Mum-3635Mus musculus50.084e-177 565
LLPS-Fec-3218Felis catus50.01e-169 546
LLPS-Ict-2279Ictidomys tridecemlineatus50.02e-170 548
LLPS-Ran-4690Rattus norvegicus49.922e-176 564
LLPS-Myl-4004Myotis lucifugus49.91e-163 529
LLPS-Urm-4060Ursus maritimus49.722e-164 531
LLPS-Ova-2072Ovis aries49.724e-162 525
LLPS-Hos-2554Homo sapiens49.652e-171 551
LLPS-Caj-3686Callithrix jacchus49.645e-172 552
LLPS-Aon-1564Aotus nancymaae49.646e-172 552
LLPS-Caf-3685Canis familiaris49.611e-149 490
LLPS-Dio-2952Dipodomys ordii49.582e-174 558
LLPS-Chs-0201Chlorocebus sabaeus49.412e-173 555
LLPS-Pap-4605Pan paniscus49.393e-172 552
LLPS-Pat-4896Pan troglodytes49.392e-172 553
LLPS-Nol-4638Nomascus leucogenys49.392e-172 553
LLPS-Poa-3381Pongo abelii49.392e-172 553
LLPS-Gaga-3721Gallus gallus49.384e-172 555
LLPS-Otg-3859Otolemur garnettii49.35e-170 546
LLPS-Man-3462Macaca nemestrina49.243e-173 555
LLPS-Mam-1197Macaca mulatta49.243e-173 555
LLPS-Cea-3778Cercocebus atys49.244e-173 554
LLPS-Maf-0925Macaca fascicularis49.244e-173 555
LLPS-Mal-2884Mandrillus leucophaeus49.243e-173 555
LLPS-Paa-4483Papio anubis49.243e-173 555
LLPS-Aim-3675Ailuropoda melanoleuca49.242e-159 519
LLPS-Rhb-1764Rhinopithecus bieti49.212e-171 551
LLPS-Orc-4281Oryctolagus cuniculus49.075e-157 509
LLPS-Cap-3806Cavia porcellus48.786e-163 527
LLPS-Meg-3022Meleagris gallopavo48.717e-164 531
LLPS-Mup-1305Mustela putorius furo48.697e-170 546
LLPS-Fud-2389Fukomys damarensis48.454e-162 525
LLPS-Loa-3693Loxodonta africana47.851e-171 551
LLPS-Mea-4419Mesocricetus auratus45.083e-176 563
LLPS-Tum-0580Tuber melanosporum42.865e-84 290
LLPS-Orl-1095Oryzias latipes42.276e-172 552
LLPS-Lac-2831Latimeria chalumnae40.768e-172 553
LLPS-Abg-1404Absidia glauca40.744e-64 233
LLPS-Put-0632Puccinia triticina40.04e-64 226
LLPS-Drm-0211Drosophila melanogaster39.292e-81 298
LLPS-Yal-1495Yarrowia lipolytica39.271e-60 225
LLPS-Sem-1872Selaginella moellendorffii38.741e-59 213
LLPS-Pug-0795Puccinia graminis38.727e-60 221
LLPS-Glm-2155Glycine max38.364e-78 273
LLPS-Scp-1325Schizosaccharomyces pombe38.182e-60 223
LLPS-Asg-1095Ashbya gossypii38.162e-59 223
LLPS-Mel-1395Melampsora laricipopulina37.767e-60 221
LLPS-Scj-1139Schizosaccharomyces japonicus37.584e-60 222
LLPS-Trr-1396Trichoderma reesei37.394e-60 224
LLPS-Fuo-1216Fusarium oxysporum37.397e-61 226
LLPS-Fuv-1295Fusarium verticillioides37.397e-61 226
LLPS-Cogr-0691Colletotrichum graminicola36.97e-61 226
LLPS-Fus-1204Fusarium solani36.831e-59 222
LLPS-Trv-0668Trichoderma virens36.835e-61 226
LLPS-Blg-1051Blumeria graminis36.651e-61 228
LLPS-Nec-0765Neurospora crassa36.621e-60 225
LLPS-Sah-1967Sarcophilus harrisii36.392e-60 216
LLPS-Asm-2843Astyanax mexicanus36.366e-62 221
LLPS-Ved-1289Verticillium dahliae36.342e-59 220
LLPS-Coo-0545Colletotrichum orbiculare36.342e-59 221
LLPS-Asc-1043Aspergillus clavatus36.291e-59 222
LLPS-Dos-1433Dothistroma septosporum35.652e-60 225
LLPS-Tut-1998Tursiops truncatus35.471e-61 220